Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Times Cited: 246
Times Cited: 246
Times Cited
Times Co-cited
Similarity
Mammalian telomeres end in a large duplex loop.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
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TRF2 protects human telomeres from end-to-end fusions.
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Specific association of human telomerase activity with immortal cells and cancer.
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Telomere Loop Dynamics in Chromosome End Protection.
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Telomeres shorten during ageing of human fibroblasts.
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
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RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
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RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
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TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
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DNA damage foci at dysfunctional telomeres.
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
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TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
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TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
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The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
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Homologous recombination generates T-loop-sized deletions at human telomeres.
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Control of human telomere length by TRF1 and TRF2.
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin.
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TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
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Alternative lengthening of telomeres: models, mechanisms and implications.
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A topological mechanism for TRF2-enhanced strand invasion.
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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
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Control of telomere length by the human telomeric protein TRF1.
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Dirk Hockemeyer, Jan-Peter Daniels, Hiroyuki Takai, Titia de Lange. Cell 2006
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TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
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Break-induced telomere synthesis underlies alternative telomere maintenance.
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Telomeres in cancer: tumour suppression and genome instability.
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
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POT1 as a terminal transducer of TRF1 telomere length control.
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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
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Stop pulling my strings - what telomeres taught us about the DNA damage response.
Eros Lazzerini-Denchi, Agnel Sfeir. Nat Rev Mol Cell Biol 2016
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