Ylli Doksani, John Y Wu, Titia de Lange, Xiaowei Zhuang. Cell 2013
Times Cited: 260
Times Cited: 260
Times Cited
Times Co-cited
Similarity
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Shelterin: the protein complex that shapes and safeguards human telomeres.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.
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TRF2 protects human telomeres from end-to-end fusions.
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Removal of shelterin reveals the telomere end-protection problem.
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Telomere Loop Dynamics in Chromosome End Protection.
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Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
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Specific association of human telomerase activity with immortal cells and cancer.
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Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K Diedrich, John R Yates, Eros Lazzerini Denchi. Nature 2013
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Rajika Arora, Yongwoo Lee, Harry Wischnewski, Catherine M Brun, Tobias Schwarz, Claus M Azzalin. Nat Commun 2014
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Pot1, the putative telomere end-binding protein in fission yeast and humans.
P Baumann, T R Cech. Science 2001
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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
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TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
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The POT1-TPP1 telomere complex is a telomerase processivity factor.
Feng Wang, Elaine R Podell, Arthur J Zaug, Yuting Yang, Paul Baciu, Thomas R Cech, Ming Lei. Nature 2007
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A DNA damage checkpoint response in telomere-initiated senescence.
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Homologous recombination generates T-loop-sized deletions at human telomeres.
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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.
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Telomere protection by TPP1/POT1 requires tethering to TIN2.
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Telomeres shorten during ageing of human fibroblasts.
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TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
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TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Michal Zimmermann, Tatsuya Kibe, Shaheen Kabir, Titia de Lange. Genes Dev 2014
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
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TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
Delphine Benarroch-Popivker, Sabrina Pisano, Aaron Mendez-Bermudez, Liudmyla Lototska, Parminder Kaur, Serge Bauwens, Nadir Djerbi, Chrysa M Latrick, Vincent Fraisier, Bei Pei,[...]. Mol Cell 2016
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Alternative lengthening of telomeres: models, mechanisms and implications.
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TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
Rekha Rai, Yong Chen, Ming Lei, Sandy Chang. Nat Commun 2016
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Break-induced telomere synthesis underlies alternative telomere maintenance.
Robert L Dilley, Priyanka Verma, Nam Woo Cho, Harrison D Winters, Anne R Wondisford, Roger A Greenberg. Nature 2016
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A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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Control of telomere length by the human telomeric protein TRF1.
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Control of human telomere length by TRF1 and TRF2.
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Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin.
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Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.
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Telomeres in cancer: tumour suppression and genome instability.
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DNA damage foci at dysfunctional telomeres.
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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Dirk Hockemeyer, Jan-Peter Daniels, Hiroyuki Takai, Titia de Lange. Cell 2006
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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase.
Huawei Xin, Dan Liu, Ma Wan, Amin Safari, Hyeung Kim, Wen Sun, Matthew S O'Connor, Zhou Songyang. Nature 2007
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Telomeric localization of TRF2, a novel human telobox protein.
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