A citation-based method for searching scientific literature

Stefan Offermanns. Annu Rev Pharmacol Toxicol 2014
Times Cited: 98







List of co-cited articles
967 articles co-cited >1



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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto. Nat Med 2005
30

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Andrew J Brown, Susan M Goldsworthy, Ashley A Barnes, Michelle M Eilert, Lili Tcheang, Dion Daniels, Alison I Muir, Mark J Wigglesworth, Ian Kinghorn, Neil J Fraser,[...]. J Biol Chem 2003
29

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima,[...]. Nature 2003
27

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Da Young Oh, Saswata Talukdar, Eun Ju Bae, Takeshi Imamura, Hidetaka Morinaga, WuQiang Fan, Pingping Li, Wendell J Lu, Steven M Watkins, Jerrold M Olefsky. Cell 2010
24

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul, Cecile Loison, Sofie Struyf, Jean-Yves Springael, Vincent Lannoy, Marie-Eve Decobecq, Stephane Brezillon, Vincent Dupriez, Gilbert Vassart, Jo Van Damme,[...]. J Biol Chem 2003
950
22

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Celia P Briscoe, Mohammad Tadayyon, John L Andrews, William G Benson, Jon K Chambers, Michelle M Eilert, Catherine Ellis, Nabil A Elshourbagy, Aaron S Goetz, Dana T Minnick,[...]. J Biol Chem 2003
820
22

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain-Godefroy, Amélie Bonnefond, Takafumi Hara, Loïc Yengo, Ikuo Kimura, Audrey Leloire, Ning Liu, Keiko Iida,[...]. Nature 2012
449
22

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Helen E Parker, Abdella M Habib, Eleftheria Diakogiannaki, Jennifer Cameron, Johannes Grosse, Frank Reimann, Fiona M Gribble. Diabetes 2012
19

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.
Ikuo Kimura, Kentaro Ozawa, Daisuke Inoue, Takeshi Imamura, Kumi Kimura, Takeshi Maeda, Kazuya Terasawa, Daiji Kashihara, Kanako Hirano, Taeko Tani,[...]. Nat Commun 2013
728
17

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
Ikuo Kimura, Daisuke Inoue, Takeshi Maeda, Takafumi Hara, Atsuhiko Ichimura, Satoshi Miyauchi, Makio Kobayashi, Akira Hirasawa, Gozoh Tsujimoto. Proc Natl Acad Sci U S A 2011
520
17

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Celia P Briscoe, Andrew J Peat, Stephen C McKeown, David F Corbett, Aaron S Goetz, Thomas R Littleton, David C McCoy, Terry P Kenakin, John L Andrews, Carina Ammala,[...]. Br J Pharmacol 2006
324
16

Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
Hongfei Ge, Xiaofan Li, Jennifer Weiszmann, Ping Wang, Helene Baribault, Jin-Long Chen, Hui Tian, Yang Li. Endocrinology 2008
320
16

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.
Virginia M Stone, Shalinee Dhayal, Katy J Brocklehurst, Carol Lenaghan, Maria Sörhede Winzell, Mårten Hammar, Xiufeng Xu, David M Smith, Noel G Morgan. Diabetologia 2014
92
16

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.
Niclas E Nilsson, Knut Kotarsky, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
370
15

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.
Buck S Samuel, Abdullah Shaito, Toshiyuki Motoike, Federico E Rey, Fredrik Backhed, Jill K Manchester, Robert E Hammer, S Clay Williams, Jan Crowley, Masashi Yanagisawa,[...]. Proc Natl Acad Sci U S A 2008
924
15

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
Maja S Engelstoft, Won-Mee Park, Ichiro Sakata, Line V Kristensen, Anna Sofie Husted, Sherri Osborne-Lawrence, Paul K Piper, Angela K Walker, Maria H Pedersen, Mark K Nøhr,[...]. Mol Metab 2013
213
15

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Kendle M Maslowski, Angelica T Vieira, Aylwin Ng, Jan Kranich, Frederic Sierro, Di Yu, Heidi C Schilter, Michael S Rolph, Fabienne Mackay, David Artis,[...]. Nature 2009
15

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Da Young Oh, Evelyn Walenta, Taro E Akiyama, William S Lagakos, Denise Lackey, Ariane R Pessentheiner, Roman Sasik, Nasun Hah, Tyler J Chi, Jason M Cox,[...]. Nat Med 2014
242
15


The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.
Alice P Liou, Xinping Lu, Yoshitatsu Sei, Xilin Zhao, Susanne Pechhold, Ricardo J Carrero, Helen E Raybould, Stephen Wank. Gastroenterology 2011
192
14


The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Brian D Hudson, Bharat Shimpukade, Amanda E Mackenzie, Adrian J Butcher, John D Pediani, Elisabeth Christiansen, Helen Heathcote, Andrew B Tobin, Trond Ulven, Graeme Milligan. Mol Pharmacol 2013
142
13

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
Cong Tang, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Gröne, Sorin Tunaru, Stefan Offermanns. Nat Med 2015
182
13

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Knut Kotarsky, Niclas E Nilsson, Erik Flodgren, Christer Owman, Björn Olde. Biochem Biophys Res Commun 2003
293
12

G protein-coupled receptors for energy metabolites as new therapeutic targets.
Clara C Blad, Cong Tang, Stefan Offermanns. Nat Rev Drug Discov 2012
154
12


Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.
Brian D Hudson, Maria E Due-Hansen, Elisabeth Christiansen, Anna Mette Hansen, Amanda E Mackenzie, Hannah Murdoch, Sunil K Pandey, Richard J Ward, Rudi Marquez, Irina G Tikhonova,[...]. J Biol Chem 2013
75
14

GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.
Mark K Nøhr, Maria H Pedersen, Andreas Gille, Kristoffer L Egerod, Maja S Engelstoft, Anna Sofie Husted, Rasmus M Sichlau, Kaare V Grunddal, Steen Seier Poulsen, Sangdon Han,[...]. Endocrinology 2013
311
11

Short chain fatty acids in human large intestine, portal, hepatic and venous blood.
J H Cummings, E W Pomare, W J Branch, C P Naylor, G T Macfarlane. Gut 1987
11

Free fatty acid receptors as therapeutic targets for the treatment of diabetes.
Atsuhiko Ichimura, Sae Hasegawa, Mayu Kasubuchi, Ikuo Kimura. Front Pharmacol 2014
96
11

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.
G Milligan, E Alvarez-Curto, K R Watterson, T Ulven, B D Hudson. Br J Pharmacol 2015
53
20

Complex Pharmacology of Free Fatty Acid Receptors.
Graeme Milligan, Bharat Shimpukade, Trond Ulven, Brian D Hudson. Chem Rev 2017
129
11

The regulation of adipogenesis through GPR120.
Chizu Gotoh, Yeon-Hee Hong, Tomoyo Iga, Daisuke Hishikawa, Yasuki Suzuki, Sang-Houn Song, Ki-Choon Choi, Tetsuya Adachi, Akira Hirasawa, Gozoh Tsujimoto,[...]. Biochem Biophys Res Commun 2007
179
10

Role of free fatty acid receptors in the regulation of energy metabolism.
Takafumi Hara, Daiji Kashihara, Atsuhiko Ichimura, Ikuo Kimura, Gozoh Tsujimoto, Akira Hirasawa. Biochim Biophys Acta 2014
108
10

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).
Brian D Hudson, Bharat Shimpukade, Graeme Milligan, Trond Ulven. J Biol Chem 2014
50
20

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
Arturo D Mancini, Vincent Poitout. Trends Endocrinol Metab 2013
113
10

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Pär Steneberg, Nir Rubins, Reut Bartoov-Shifman, Michael D Walker, Helena Edlund. Cell Metab 2005
326
10

Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.
Yeon-Hee Hong, Yukihiko Nishimura, Daisuke Hishikawa, Hiroaki Tsuzuki, Hisae Miyahara, Chizu Gotoh, Ki-Choon Choi, Dan Dan Feng, Chen Chen, Hong-Gu Lee,[...]. Endocrinology 2005
383
10

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.
Kashan Ahmed, Sorin Tunaru, Cong Tang, Michaela Müller, Andreas Gille, Antonia Sassmann, Julien Hanson, Stefan Offermanns. Cell Metab 2010
201
10

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.
Patrick M Smith, Michael R Howitt, Nicolai Panikov, Monia Michaud, Carey Ann Gallini, Mohammad Bohlooly-Y, Jonathan N Glickman, Wendy S Garrett. Science 2013
10

Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Sarah-Jane Watson, Alastair J H Brown, Nicholas D Holliday. Mol Pharmacol 2012
101
10

Free Fatty Acid Receptors in Health and Disease.
Ikuo Kimura, Atsuhiko Ichimura, Ryuji Ohue-Kitano, Miki Igarashi. Physiol Rev 2020
187
10

Taste preference for fatty acids is mediated by GPR40 and GPR120.
Cristina Cartoni, Keiko Yasumatsu, Tadahiro Ohkuri, Noriatsu Shigemura, Ryusuke Yoshida, Nicolas Godinot, Johannes le Coutre, Yuzo Ninomiya, Sami Damak. J Neurosci 2010
261
9

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.
Mohamed S Zaibi, Claire J Stocker, Jacqueline O'Dowd, Alison Davies, Mohamed Bellahcene, Michael A Cawthorne, Alastair J H Brown, David M Smith, Jonathan R S Arch. FEBS Lett 2010
208
9

Discovery of a potent and selective GPR120 agonist.
Bharat Shimpukade, Brian D Hudson, Christine Kiel Hovgaard, Graeme Milligan, Trond Ulven. J Med Chem 2012
119
9

Expression of short-chain fatty acid receptor GPR41 in the human colon.
Hideaki Tazoe, Yasuko Otomo, Shin-Ichiro Karaki, Ikuo Kato, Yasuyuki Fukami, Masaki Terasaki, Atsukazu Kuwahara. Biomed Res 2009
191
9

Free fatty acid receptors and their role in regulation of energy metabolism.
Takafumi Hara, Ikuo Kimura, Daisuke Inoue, Atsuhiko Ichimura, Akira Hirasawa. Rev Physiol Biochem Pharmacol 2013
81
11

Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.
Filipe De Vadder, Petia Kovatcheva-Datchary, Daisy Goncalves, Jennifer Vinera, Carine Zitoun, Adeline Duchampt, Fredrik Bäckhed, Gilles Mithieux. Cell 2014
9

Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.
Changlu Liu, Jiejun Wu, Jessica Zhu, Chester Kuei, Jingxue Yu, Jonathan Shelton, Steven W Sutton, Xiaorong Li, Su Jin Yun, Taraneh Mirzadegan,[...]. J Biol Chem 2009
284
9

Treatment of type 2 diabetes by free Fatty Acid receptor agonists.
Kenneth R Watterson, Brian D Hudson, Trond Ulven, Graeme Milligan. Front Endocrinol (Lausanne) 2014
60
15


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.