A citation-based method for searching scientific literature

Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason R B Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg. Nat Med 2013
Times Cited: 459







List of co-cited articles
734 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
21

AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
20

AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
17

AMP-activated protein kinase: the current landscape for drug development.
Gregory R Steinberg, David Carling. Nat Rev Drug Discov 2019
187
16

The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
751
15

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M Kurtz, Maria Trujillo, Dinko Gonzalez Trotter,[...]. Science 2017
148
14

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
835
14

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Barbara Cool, Bradley Zinker, William Chiou, Lemma Kifle, Ning Cao, Matthew Perham, Robert Dickinson, Andrew Adler, Gerard Gagne, Rajesh Iyengar,[...]. Cell Metab 2006
640
14

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti,[...]. EBioMedicine 2018
65
18

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
12

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Yu Li, Shanqin Xu, Maria M Mihaylova, Bin Zheng, Xiuyun Hou, Bingbing Jiang, Ogyi Park, Zhijun Luo, Etienne Lefai, John Y-J Shyy,[...]. Cell Metab 2011
961
11

AMPK in Health and Disease.
Gregory R Steinberg, Bruce E Kemp. Physiol Rev 2009
11

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Roger W Hunter, Curtis C Hughey, Louise Lantier, Elias I Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H Wasserman, Kei Sakamoto. Nat Med 2018
98
10

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M Esquejo,[...]. Cell Metab 2017
130
10

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Simon A Hawley, David A Pan, Kirsty J Mustard, Louise Ross, Jenny Bain, Arthur M Edelman, Bruno G Frenguelli, D Grahame Hardie. Cell Metab 2005
10

Structure of mammalian AMPK and its regulation by ADP.
Bing Xiao, Matthew J Sanders, Elizabeth Underwood, Richard Heath, Faith V Mayer, David Carmena, Chun Jing, Philip A Walker, John F Eccleston, Lesley F Haire,[...]. Nature 2011
584
10

Treatment of nonalcoholic fatty liver disease: role of AMPK.
Brennan K Smith, Katarina Marcinko, Eric M Desjardins, James S Lally, Rebecca J Ford, Gregory R Steinberg. Am J Physiol Endocrinol Metab 2016
219
10

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
James S V Lally, Sarani Ghoshal, Danielle K DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P Houde,[...]. Cell Metab 2019
116
10

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
526
9

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
9

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Reuben J Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L Hurley, Lee A Witters, Ronald A DePinho, Lewis C Cantley. Proc Natl Acad Sci U S A 2004
9

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Emilio P Mottillo, Eric M Desjardins, Justin D Crane, Brennan K Smith, Alex E Green, Serge Ducommun, Tora I Henriksen, Irena A Rebalka, Aida Razi, Kei Sakamoto,[...]. Cell Metab 2016
179
9

Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
661
9

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.
Marc Foretz, Bruno Guigas, Benoit Viollet. Nat Rev Endocrinol 2019
164
9

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
Angela Woods, Kristina Dickerson, Richard Heath, Seung-Pyo Hong, Milica Momcilovic, Stephen R Johnstone, Marian Carlson, David Carling. Cell Metab 2005
9

Structural basis of AMPK regulation by small molecule activators.
Bing Xiao, Matthew J Sanders, David Carmena, Nicola J Bright, Lesley F Haire, Elizabeth Underwood, Bhakti R Patel, Richard B Heath, Philip A Walker, Stefan Hallen,[...]. Nat Commun 2013
322
9



Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Frank A Duca, Clémence D Côté, Brittany A Rasmussen, Melika Zadeh-Tahmasebi, Guy A Rutter, Beatrice M Filippi, Tony K T Lam. Nat Med 2015
233
8

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
708
8

The ancient drug salicylate directly activates AMP-activated protein kinase.
Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard,[...]. Science 2012
490
8

Metformin action: concentrations matter.
Ling He, Fredric E Wondisford. Cell Metab 2015
239
8

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Reuben J Shaw, Katja A Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A Depinho, Marc Montminy, Lewis C Cantley. Science 2005
8

AMPK activators: mechanisms of action and physiological activities.
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, Joohun Ha. Exp Mol Med 2016
313
8

AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Emily A Day, Rebecca J Ford, Gregory R Steinberg. Trends Endocrinol Metab 2017
253
8

Design and validation of a histological scoring system for nonalcoholic fatty liver disease.
David E Kleiner, Elizabeth M Brunt, Mark Van Natta, Cynthia Behling, Melissa J Contos, Oscar W Cummings, Linda D Ferrell, Yao-Chang Liu, Michael S Torbenson, Aynur Unalp-Arida,[...]. Hepatology 2005
8


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp,[...]. Nat Med 2018
111
7

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
733
7

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
Nadia Boudaba, Allison Marion, Camille Huet, Rémi Pierre, Benoit Viollet, Marc Foretz. EBioMedicine 2018
75
9


Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N Anderson, Stanislaw Deja, Xiaorong Fu, Shawn C Burgess, Cai Li, Marcie Ruddy, Manu Chakravarthy,[...]. Cell Metab 2017
140
7


AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
380
7


PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients.
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist,[...]. JCI Insight 2018
44
15

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
275
7

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
7

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.
Eric J Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, Bryan J McColgan, Jacqueline M Tarrant, Tuan Nguyen, Ling Han, Chuhan Chung,[...]. Clin Gastroenterol Hepatol 2018
106
7

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Sibylle Jäger, Christoph Handschin, Julie St-Pierre, Bruce M Spiegelman. Proc Natl Acad Sci U S A 2007
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.