Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O'Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O'Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason R B Dyck, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg. Nat Med 2013
Times Cited: 459
Times Cited: 459
Times Cited
Times Co-cited
Similarity
Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
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AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
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AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
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AMP-activated protein kinase: the current landscape for drug development.
Gregory R Steinberg, David Carling. Nat Rev Drug Discov 2019
Gregory R Steinberg, David Carling. Nat Rev Drug Discov 2019
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The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M Kurtz, Maria Trujillo, Dinko Gonzalez Trotter,[...]. Science 2017
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M Kurtz, Maria Trujillo, Dinko Gonzalez Trotter,[...]. Science 2017
14
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
14
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Barbara Cool, Bradley Zinker, William Chiou, Lemma Kifle, Ning Cao, Matthew Perham, Robert Dickinson, Andrew Adler, Gerard Gagne, Rajesh Iyengar,[...]. Cell Metab 2006
Barbara Cool, Bradley Zinker, William Chiou, Lemma Kifle, Ning Cao, Matthew Perham, Robert Dickinson, Andrew Adler, Gerard Gagne, Rajesh Iyengar,[...]. Cell Metab 2006
14
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti,[...]. EBioMedicine 2018
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti,[...]. EBioMedicine 2018
18
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
12
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Yu Li, Shanqin Xu, Maria M Mihaylova, Bin Zheng, Xiuyun Hou, Bingbing Jiang, Ogyi Park, Zhijun Luo, Etienne Lefai, John Y-J Shyy,[...]. Cell Metab 2011
Yu Li, Shanqin Xu, Maria M Mihaylova, Bin Zheng, Xiuyun Hou, Bingbing Jiang, Ogyi Park, Zhijun Luo, Etienne Lefai, John Y-J Shyy,[...]. Cell Metab 2011
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Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Roger W Hunter, Curtis C Hughey, Louise Lantier, Elias I Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H Wasserman, Kei Sakamoto. Nat Med 2018
Roger W Hunter, Curtis C Hughey, Louise Lantier, Elias I Sundelin, Mark Peggie, Elton Zeqiraj, Frank Sicheri, Niels Jessen, David H Wasserman, Kei Sakamoto. Nat Med 2018
10
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M Esquejo,[...]. Cell Metab 2017
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Nicolas O Jørgensen, Jean-Luc Tran, Aditi Jatkar, Katherine Cialdea, Ryan M Esquejo,[...]. Cell Metab 2017
10
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Simon A Hawley, David A Pan, Kirsty J Mustard, Louise Ross, Jenny Bain, Arthur M Edelman, Bruno G Frenguelli, D Grahame Hardie. Cell Metab 2005
Simon A Hawley, David A Pan, Kirsty J Mustard, Louise Ross, Jenny Bain, Arthur M Edelman, Bruno G Frenguelli, D Grahame Hardie. Cell Metab 2005
10
Structure of mammalian AMPK and its regulation by ADP.
Bing Xiao, Matthew J Sanders, Elizabeth Underwood, Richard Heath, Faith V Mayer, David Carmena, Chun Jing, Philip A Walker, John F Eccleston, Lesley F Haire,[...]. Nature 2011
Bing Xiao, Matthew J Sanders, Elizabeth Underwood, Richard Heath, Faith V Mayer, David Carmena, Chun Jing, Philip A Walker, John F Eccleston, Lesley F Haire,[...]. Nature 2011
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Treatment of nonalcoholic fatty liver disease: role of AMPK.
Brennan K Smith, Katarina Marcinko, Eric M Desjardins, James S Lally, Rebecca J Ford, Gregory R Steinberg. Am J Physiol Endocrinol Metab 2016
Brennan K Smith, Katarina Marcinko, Eric M Desjardins, James S Lally, Rebecca J Ford, Gregory R Steinberg. Am J Physiol Endocrinol Metab 2016
10
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
James S V Lally, Sarani Ghoshal, Danielle K DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P Houde,[...]. Cell Metab 2019
James S V Lally, Sarani Ghoshal, Danielle K DePeralta, Omeed Moaven, Lan Wei, Ricard Masia, Derek J Erstad, Naoto Fujiwara, Vivian Leong, Vanessa P Houde,[...]. Cell Metab 2019
10
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
Russell A Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoit Viollet, Morris J Birnbaum. Nature 2013
9
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
9
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Reuben J Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L Hurley, Lee A Witters, Ronald A DePinho, Lewis C Cantley. Proc Natl Acad Sci U S A 2004
Reuben J Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L Hurley, Lee A Witters, Ronald A DePinho, Lewis C Cantley. Proc Natl Acad Sci U S A 2004
9
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Emilio P Mottillo, Eric M Desjardins, Justin D Crane, Brennan K Smith, Alex E Green, Serge Ducommun, Tora I Henriksen, Irena A Rebalka, Aida Razi, Kei Sakamoto,[...]. Cell Metab 2016
Emilio P Mottillo, Eric M Desjardins, Justin D Crane, Brennan K Smith, Alex E Green, Serge Ducommun, Tora I Henriksen, Irena A Rebalka, Aida Razi, Kei Sakamoto,[...]. Cell Metab 2016
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Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.
Marc Foretz, Bruno Guigas, Benoit Viollet. Nat Rev Endocrinol 2019
Marc Foretz, Bruno Guigas, Benoit Viollet. Nat Rev Endocrinol 2019
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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
Angela Woods, Kristina Dickerson, Richard Heath, Seung-Pyo Hong, Milica Momcilovic, Stephen R Johnstone, Marian Carlson, David Carling. Cell Metab 2005
Angela Woods, Kristina Dickerson, Richard Heath, Seung-Pyo Hong, Milica Momcilovic, Stephen R Johnstone, Marian Carlson, David Carling. Cell Metab 2005
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Structural basis of AMPK regulation by small molecule activators.
Bing Xiao, Matthew J Sanders, David Carmena, Nicola J Bright, Lesley F Haire, Elizabeth Underwood, Bhakti R Patel, Richard B Heath, Philip A Walker, Stefan Hallen,[...]. Nat Commun 2013
Bing Xiao, Matthew J Sanders, David Carmena, Nicola J Bright, Lesley F Haire, Elizabeth Underwood, Bhakti R Patel, Richard B Heath, Philip A Walker, Stefan Hallen,[...]. Nat Commun 2013
9
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
M R Owen, E Doran, A P Halestrap. Biochem J 2000
M R Owen, E Doran, A P Halestrap. Biochem J 2000
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Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Frank A Duca, Clémence D Côté, Brittany A Rasmussen, Melika Zadeh-Tahmasebi, Guy A Rutter, Beatrice M Filippi, Tony K T Lam. Nat Med 2015
Frank A Duca, Clémence D Côté, Brittany A Rasmussen, Melika Zadeh-Tahmasebi, Guy A Rutter, Beatrice M Filippi, Tony K T Lam. Nat Med 2015
8
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
8
The ancient drug salicylate directly activates AMP-activated protein kinase.
Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard,[...]. Science 2012
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8
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Reuben J Shaw, Katja A Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A Depinho, Marc Montminy, Lewis C Cantley. Science 2005
Reuben J Shaw, Katja A Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A Depinho, Marc Montminy, Lewis C Cantley. Science 2005
8
AMPK activators: mechanisms of action and physiological activities.
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, Joohun Ha. Exp Mol Med 2016
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim, Joohun Ha. Exp Mol Med 2016
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AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Emily A Day, Rebecca J Ford, Gregory R Steinberg. Trends Endocrinol Metab 2017
Emily A Day, Rebecca J Ford, Gregory R Steinberg. Trends Endocrinol Metab 2017
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease.
David E Kleiner, Elizabeth M Brunt, Mark Van Natta, Cynthia Behling, Melissa J Contos, Oscar W Cummings, Linda D Ferrell, Yao-Chang Liu, Michael S Torbenson, Aynur Unalp-Arida,[...]. Hepatology 2005
David E Kleiner, Elizabeth M Brunt, Mark Van Natta, Cynthia Behling, Melissa J Contos, Oscar W Cummings, Linda D Ferrell, Yao-Chang Liu, Michael S Torbenson, Aynur Unalp-Arida,[...]. Hepatology 2005
8
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.
Graeme J Gowans, Simon A Hawley, Fiona A Ross, D Grahame Hardie. Cell Metab 2013
Graeme J Gowans, Simon A Hawley, Fiona A Ross, D Grahame Hardie. Cell Metab 2013
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Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp,[...]. Nat Med 2018
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp,[...]. Nat Med 2018
7
Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
7
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
Nadia Boudaba, Allison Marion, Camille Huet, Rémi Pierre, Benoit Viollet, Marc Foretz. EBioMedicine 2018
Nadia Boudaba, Allison Marion, Camille Huet, Rémi Pierre, Benoit Viollet, Marc Foretz. EBioMedicine 2018
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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
D Carling, V A Zammit, D G Hardie. FEBS Lett 1987
D Carling, V A Zammit, D G Hardie. FEBS Lett 1987
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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N Anderson, Stanislaw Deja, Xiaorong Fu, Shawn C Burgess, Cai Li, Marcie Ruddy, Manu Chakravarthy,[...]. Cell Metab 2017
Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N Anderson, Stanislaw Deja, Xiaorong Fu, Shawn C Burgess, Cai Li, Marcie Ruddy, Manu Chakravarthy,[...]. Cell Metab 2017
7
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.
Sang-Min Jeon, Navdeep S Chandel, Nissim Hay. Nature 2012
Sang-Min Jeon, Navdeep S Chandel, Nissim Hay. Nature 2012
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AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
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TSC2 mediates cellular energy response to control cell growth and survival.
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
7
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients.
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist,[...]. JCI Insight 2018
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist,[...]. JCI Insight 2018
15
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
7
7
Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.
Eric J Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, Bryan J McColgan, Jacqueline M Tarrant, Tuan Nguyen, Ling Han, Chuhan Chung,[...]. Clin Gastroenterol Hepatol 2018
Eric J Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, Bryan J McColgan, Jacqueline M Tarrant, Tuan Nguyen, Ling Han, Chuhan Chung,[...]. Clin Gastroenterol Hepatol 2018
7
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Sibylle Jäger, Christoph Handschin, Julie St-Pierre, Bruce M Spiegelman. Proc Natl Acad Sci U S A 2007
Sibylle Jäger, Christoph Handschin, Julie St-Pierre, Bruce M Spiegelman. Proc Natl Acad Sci U S A 2007
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.