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Times Cited: 222
Times Cited: 222
Times Cited
Times Co-cited
Similarity
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Jake E Delmore, Ghayas C Issa, Madeleine E Lemieux, Peter B Rahl, Junwei Shi, Hannah M Jacobs, Efstathios Kastritis, Timothy Gilpatrick, Ronald M Paranal, Jun Qi,[...]. Cell 2011
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Selective inhibition of BET bromodomains.
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Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Florence M G Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, David J H Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nor, A Sorana Morrissy,[...]. Cancer Cell 2017
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Molecular subgroups of medulloblastoma: the current consensus.
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The whole-genome landscape of medulloblastoma subtypes.
Paul A Northcott, Ivo Buchhalter, A Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A Rudneva,[...]. Nature 2017
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
Yoon-Jae Cho, Aviad Tsherniak, Pablo Tamayo, Sandro Santagata, Azra Ligon, Heidi Greulich, Rameen Berhoukim, Vladimir Amani, Liliana Goumnerova, Charles G Eberhart,[...]. J Clin Oncol 2011
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Medulloblastoma comprises four distinct molecular variants.
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Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Paul A Northcott, David J H Shih, John Peacock, Livia Garzia, A Sorana Morrissy, Thomas Zichner, Adrian M Stütz, Andrey Korshunov, Jüri Reimand, Steven E Schumacher,[...]. Nature 2012
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.
Yanxin Pei, Kun-Wei Liu, Jun Wang, Alexandra Garancher, Ran Tao, Lourdes A Esparza, Donna L Maier, Yoko T Udaka, Najiba Murad, Sorana Morrissy,[...]. Cancer Cell 2016
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Targeting MYC dependence in cancer by inhibiting BET bromodomains.
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma.
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Novel mutations target distinct subgroups of medulloblastoma.
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Selective inhibition of tumor oncogenes by disruption of super-enhancers.
Jakob Lovén, Heather A Hoke, Charles Y Lin, Ashley Lau, David A Orlando, Christopher R Vakoc, James E Bradner, Tong Ihn Lee, Richard A Young. Cell 2013
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Paul A Northcott, Catherine Lee, Thomas Zichner, Adrian M Stütz, Serap Erkek, Daisuke Kawauchi, David J H Shih, Volker Hovestadt, Marc Zapatka, Dominik Sturm,[...]. Nature 2014
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Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Edward C Schwalbe, Janet C Lindsey, Sirintra Nakjang, Stephen Crosier, Amanda J Smith, Debbie Hicks, Gholamreza Rafiee, Rebecca M Hill, Alice Iliasova, Thomas Stone,[...]. Lancet Oncol 2017
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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Marcel Kool, Andrey Korshunov, Marc Remke, David T W Jones, Maria Schlanstein, Paul A Northcott, Yoon-Jae Cho, Jan Koster, Antoinette Schouten-van Meeteren, Dannis van Vuurden,[...]. Acta Neuropathol 2012
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Dissecting the genomic complexity underlying medulloblastoma.
David T W Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, Trevor J Pugh, Volker Hovestadt, Adrian M Stütz,[...]. Nature 2012
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Medulloblastomics: the end of the beginning.
Paul A Northcott, David T W Jones, Marcel Kool, Giles W Robinson, Richard J Gilbertson, Yoon-Jae Cho, Scott L Pomeroy, Andrey Korshunov, Peter Lichter, Michael D Taylor,[...]. Nat Rev Cancer 2012
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Trevor J Pugh, Shyamal Dilhan Weeraratne, Tenley C Archer, Daniel A Pomeranz Krummel, Daniel Auclair, James Bochicchio, Mauricio O Carneiro, Scott L Carter, Kristian Cibulskis, Rachel L Erlich,[...]. Nature 2012
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison. Acta Neuropathol 2016
David N Louis, Arie Perry, Guido Reifenberger, Andreas von Deimling, Dominique Figarella-Branger, Webster K Cavenee, Hiroko Ohgaki, Otmar D Wiestler, Paul Kleihues, David W Ellison. Acta Neuropathol 2016
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Yujie Tang, Sharareh Gholamin, Simone Schubert, Minde I Willardson, Alex Lee, Pratiti Bandopadhayay, Guillame Bergthold, Sabran Masoud, Brian Nguyen, Nujsaubnusi Vue,[...]. Nat Med 2014
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Simon Bailey, Steven C Clifford, Francois Doz, Marcel Kool, Christelle Dufour, Gilles Vassal, Till Milde,[...]. Acta Neuropathol 2016
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Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
Sara Bolin, Anna Borgenvik, Camilla U Persson, Anders Sundström, Jun Qi, James E Bradner, William A Weiss, Yoon-Jae Cho, Holger Weishaupt, Fredrik J Swartling. Oncogene 2018
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Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma.
Sujatha Venkataraman, Irina Alimova, Ilango Balakrishnan, Peter Harris, Diane K Birks, Andrea Griesinger, Vladimir Amani, Brian Cristiano, Marc Remke, Michael D Taylor,[...]. Oncotarget 2014
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Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
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Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott,[...]. Lancet Oncol 2013
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
Marcel Kool, David T W Jones, Natalie Jäger, Paul A Northcott, Trevor J Pugh, Volker Hovestadt, Rosario M Piro, L Adriana Esparza, Shirley L Markant, Marc Remke,[...]. Cancer Cell 2014
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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Giles W Robinson, Brent A Orr, Gang Wu, Sridharan Gururangan, Tong Lin, Ibrahim Qaddoumi, Roger J Packer, Stewart Goldman, Michael D Prados, Annick Desjardins,[...]. J Clin Oncol 2015
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15
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Elke Pfaff, David J H Shih, Dianna C Martin, Pedro Castelo-Branco, Berivan Baskin, Peter N Ray, Eric Bouffet,[...]. J Clin Oncol 2013
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Elke Pfaff, David J H Shih, Dianna C Martin, Pedro Castelo-Branco, Berivan Baskin, Peter N Ray, Eric Bouffet,[...]. J Clin Oncol 2013
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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
Amar Gajjar, Murali Chintagumpala, David Ashley, Stewart Kellie, Larry E Kun, Thomas E Merchant, Shaio Woo, Greg Wheeler, Valerie Ahern, Matthew J Krasin,[...]. Lancet Oncol 2006
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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Johannes Zuber, Junwei Shi, Eric Wang, Amy R Rappaport, Harald Herrmann, Edward A Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich,[...]. Nature 2011
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An animal model of MYC-driven medulloblastoma.
Yanxin Pei, Colin E Moore, Jun Wang, Alok K Tewari, Alexey Eroshkin, Yoon-Jae Cho, Hendrik Witt, Andrey Korshunov, Tracy-Ann Read, Julia L Sun,[...]. Cancer Cell 2012
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Subtypes of medulloblastoma have distinct developmental origins.
Paul Gibson, Yiai Tong, Giles Robinson, Margaret C Thompson, D Spencer Currle, Christopher Eden, Tanya A Kranenburg, Twala Hogg, Helen Poppleton, Julie Martin,[...]. Nature 2010
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos,[...]. PLoS One 2008
Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos,[...]. PLoS One 2008
14
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Rebecca M Hill, Sanne Kuijper, Janet C Lindsey, Kevin Petrie, Ed C Schwalbe, Karen Barker, Jessica K R Boult, Daniel Williamson, Zai Ahmad, Albert Hallsworth,[...]. Cancer Cell 2015
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14
Cytogenetic prognostication within medulloblastoma subgroups.
David J H Shih, Paul A Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M Dubuc,[...]. J Clin Oncol 2014
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13
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Shaokun Shu, Charles Y Lin, Housheng Hansen He, Robert M Witwicki, Doris P Tabassum, Justin M Roberts, Michalina Janiszewska, Sung Jin Huh, Yi Liang, Jeremy Ryan,[...]. Nature 2016
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13
Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Charles Y Lin, Serap Erkek, Yiai Tong, Linlin Yin, Alexander J Federation, Marc Zapatka, Parthiv Haldipur, Daisuke Kawauchi, Thomas Risch, Hans-Jörg Warnatz,[...]. Nature 2016
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12
BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells.
Marie-Magdelaine Coudé, Thorsten Braun, Jeannig Berrou, Mélanie Dupont, Sibyl Bertrand, Aline Masse, Emmanuel Raffoux, Raphaël Itzykson, Marc Delord, Maria E Riveiro,[...]. Oncotarget 2015
Marie-Magdelaine Coudé, Thorsten Braun, Jeannig Berrou, Mélanie Dupont, Sibyl Bertrand, Aline Masse, Emmanuel Raffoux, Raphaël Itzykson, Marc Delord, Maria E Riveiro,[...]. Oncotarget 2015
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Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study.
Céline Berthon, Emmanuel Raffoux, Xavier Thomas, Norbert Vey, Carlos Gomez-Roca, Karen Yee, David Christopher Taussig, Keyvan Rezai, Christophe Roumier, Patrice Herait,[...]. Lancet Haematol 2016
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Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models.
Michelle L Cook Sangar, Laura A Genovesi, Madison W Nakamoto, Melissa J Davis, Sue E Knobluagh, Pengxiang Ji, Amanda Millar, Brandon J Wainwright, James M Olson. Clin Cancer Res 2017
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27
Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma.
Marie Morfouace, Anang Shelat, Megan Jacus, Burgess B Freeman, David Turner, Sarah Robinson, Frederique Zindy, Yong-Dong Wang, David Finkelstein, Olivier Ayrault,[...]. Cancer Cell 2014
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Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Adrian M Dubuc, Marc Remke, Andrey Korshunov, Paul A Northcott, Shing H Zhan, Maria Mendez-Lago, Marcel Kool, David T W Jones, Alexander Unterberger, A Sorana Morrissy,[...]. Acta Neuropathol 2013
Adrian M Dubuc, Marc Remke, Andrey Korshunov, Paul A Northcott, Shing H Zhan, Maria Mendez-Lago, Marcel Kool, David T W Jones, Alexander Unterberger, A Sorana Morrissy,[...]. Acta Neuropathol 2013
11
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.
Roger J Packer, Amar Gajjar, Gilbert Vezina, Lucy Rorke-Adams, Peter C Burger, Patricia L Robertson, Lisa Bayer, Deborah LaFond, Bernadine R Donahue, MaryAnne H Marymont,[...]. J Clin Oncol 2006
Roger J Packer, Amar Gajjar, Gilbert Vezina, Lucy Rorke-Adams, Peter C Burger, Patricia L Robertson, Lisa Bayer, Deborah LaFond, Bernadine R Donahue, MaryAnne H Marymont,[...]. J Clin Oncol 2006
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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
Margaret C Thompson, Christine Fuller, Twala L Hogg, James Dalton, David Finkelstein, Ching C Lau, Murali Chintagumpala, Adekunle Adesina, David M Ashley, Stewart J Kellie,[...]. J Clin Oncol 2006
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A mouse model of the most aggressive subgroup of human medulloblastoma.
Daisuke Kawauchi, Giles Robinson, Tamar Uziel, Paul Gibson, Jerold Rehg, Cuilan Gao, David Finkelstein, Chunxu Qu, Stanley Pounds, David W Ellison,[...]. Cancer Cell 2012
Daisuke Kawauchi, Giles Robinson, Tamar Uziel, Paul Gibson, Jerold Rehg, Cuilan Gao, David Finkelstein, Chunxu Qu, Stanley Pounds, David W Ellison,[...]. Cancer Cell 2012
11
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.
Bjoern Chapuy, Michael R McKeown, Charles Y Lin, Stefano Monti, Margaretha G M Roemer, Jun Qi, Peter B Rahl, Heather H Sun, Kelly T Yeda, John G Doench,[...]. Cancer Cell 2013
Bjoern Chapuy, Michael R McKeown, Charles Y Lin, Stefano Monti, Margaretha G M Roemer, Jun Qi, Peter B Rahl, Heather H Sun, Kelly T Yeda, John G Doench,[...]. Cancer Cell 2013
10
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.
Anton Henssen, Kristina Althoff, Andrea Odersky, Anneleen Beckers, Richard Koche, Frank Speleman, Simon Schäfers, Emma Bell, Maike Nortmeyer, Frank Westermann,[...]. Clin Cancer Res 2016
Anton Henssen, Kristina Althoff, Andrea Odersky, Anneleen Beckers, Richard Koche, Frank Speleman, Simon Schäfers, Emma Bell, Maike Nortmeyer, Frank Westermann,[...]. Clin Cancer Res 2016
10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.