Ming-Feng Tsai, Dawei Jiang, Linlin Zhao, David Clapham, Christopher Miller. J Gen Physiol 2014
Times Cited: 85
Times Cited: 85
Times Cited
Times Co-cited
Similarity
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
Dawei Jiang, Linlin Zhao, David E Clapham. Science 2009
Dawei Jiang, Linlin Zhao, David E Clapham. Science 2009
76
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto. Nature 2011
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto. Nature 2011
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Joshua M Baughman, Fabiana Perocchi, Hany S Girgis, Molly Plovanich, Casey A Belcher-Timme, Yasemin Sancak, X Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L Bogorad,[...]. Nature 2011
Joshua M Baughman, Fabiana Perocchi, Hany S Girgis, Molly Plovanich, Casey A Belcher-Timme, Yasemin Sancak, X Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L Bogorad,[...]. Nature 2011
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NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
Raz Palty, William F Silverman, Michal Hershfinkel, Teresa Caporale, Stefano L Sensi, Julia Parnis, Christiane Nolte, Daniel Fishman, Varda Shoshan-Barmatz, Sharon Herrmann,[...]. Proc Natl Acad Sci U S A 2010
Raz Palty, William F Silverman, Michal Hershfinkel, Teresa Caporale, Stefano L Sensi, Julia Parnis, Christiane Nolte, Daniel Fishman, Varda Shoshan-Barmatz, Sharon Herrmann,[...]. Proc Natl Acad Sci U S A 2010
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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.
Fabiana Perocchi, Vishal M Gohil, Hany S Girgis, X Robert Bao, Janet E McCombs, Amy E Palmer, Vamsi K Mootha. Nature 2010
Fabiana Perocchi, Vishal M Gohil, Hany S Girgis, X Robert Bao, Janet E McCombs, Amy E Palmer, Vamsi K Mootha. Nature 2010
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EMRE is an essential component of the mitochondrial calcium uniporter complex.
Yasemin Sancak, Andrew L Markhard, Toshimori Kitami, Erika Kovács-Bogdán, Kimberli J Kamer, Namrata D Udeshi, Steven A Carr, Dipayan Chaudhuri, David E Clapham, Andrew A Li,[...]. Science 2013
Yasemin Sancak, Andrew L Markhard, Toshimori Kitami, Erika Kovács-Bogdán, Kimberli J Kamer, Namrata D Udeshi, Steven A Carr, Dipayan Chaudhuri, David E Clapham, Andrew A Li,[...]. Science 2013
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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
Maria Patron, Vanessa Checchetto, Anna Raffaello, Enrico Teardo, Denis Vecellio Reane, Maura Mantoan, Veronica Granatiero, Ildikò Szabò, Diego De Stefani, Rosario Rizzuto. Mol Cell 2014
Maria Patron, Vanessa Checchetto, Anna Raffaello, Enrico Teardo, Denis Vecellio Reane, Maura Mantoan, Veronica Granatiero, Ildikò Szabò, Diego De Stefani, Rosario Rizzuto. Mol Cell 2014
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The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.
Karin Nowikovsky, Elisabeth M Froschauer, Gabor Zsurka, Jozef Samaj, Siegfried Reipert, Martin Kolisek, Gerlinde Wiesenberger, Rudolf J Schweyen. J Biol Chem 2004
Karin Nowikovsky, Elisabeth M Froschauer, Gabor Zsurka, Jozef Samaj, Siegfried Reipert, Martin Kolisek, Gerlinde Wiesenberger, Rudolf J Schweyen. J Biol Chem 2004
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MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Karthik Mallilankaraman, César Cárdenas, Patrick J Doonan, Harish C Chandramoorthy, Krishna M Irrinki, Tünde Golenár, György Csordás, Priyanka Madireddi, Jun Yang, Marioly Müller,[...]. Nat Cell Biol 2012
Karthik Mallilankaraman, César Cárdenas, Patrick J Doonan, Harish C Chandramoorthy, Krishna M Irrinki, Tünde Golenár, György Csordás, Priyanka Madireddi, Jun Yang, Marioly Müller,[...]. Nat Cell Biol 2012
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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
Anna Raffaello, Diego De Stefani, Davide Sabbadin, Enrico Teardo, Giulia Merli, Anne Picard, Vanessa Checchetto, Stefano Moro, Ildikò Szabò, Rosario Rizzuto. EMBO J 2013
Anna Raffaello, Diego De Stefani, Davide Sabbadin, Enrico Teardo, Giulia Merli, Anne Picard, Vanessa Checchetto, Stefano Moro, Ildikò Szabò, Rosario Rizzuto. EMBO J 2013
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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
György Csordás, Tünde Golenár, Erin L Seifert, Kimberli J Kamer, Yasemin Sancak, Fabiana Perocchi, Cynthia Moffat, David Weaver, Sergio de la Fuente Perez, Roman Bogorad,[...]. Cell Metab 2013
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40
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Dawei Jiang, Linlin Zhao, Clary B Clish, David E Clapham. Proc Natl Acad Sci U S A 2013
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The mitochondrial calcium uniporter is a highly selective ion channel.
Yuriy Kirichok, Grigory Krapivinsky, David E Clapham. Nature 2004
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Mitochondria as sensors and regulators of calcium signalling.
Rosario Rizzuto, Diego De Stefani, Anna Raffaello, Cristina Mammucari. Nat Rev Mol Cell Biol 2012
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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
Xin Pan, Jie Liu, Tiffany Nguyen, Chengyu Liu, Junhui Sun, Yanjie Teng, Maria M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Nat Cell Biol 2013
Xin Pan, Jie Liu, Tiffany Nguyen, Chengyu Liu, Junhui Sun, Yanjie Teng, Maria M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Nat Cell Biol 2013
36
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
Molly Plovanich, Roman L Bogorad, Yasemin Sancak, Kimberli J Kamer, Laura Strittmatter, Andrew A Li, Hany S Girgis, Satya Kuchimanchi, Jack De Groot, Lauren Speciner,[...]. PLoS One 2013
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36
LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.
Patrick J Doonan, Harish C Chandramoorthy, Nicholas E Hoffman, Xueqian Zhang, César Cárdenas, Santhanam Shanmughapriya, Sudarsan Rajan, Sandhya Vallem, Xiongwen Chen, J Kevin Foskett,[...]. FASEB J 2014
Patrick J Doonan, Harish C Chandramoorthy, Nicholas E Hoffman, Xueqian Zhang, César Cárdenas, Santhanam Shanmughapriya, Sudarsan Rajan, Sandhya Vallem, Xiongwen Chen, J Kevin Foskett,[...]. FASEB J 2014
36
NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.
Umberto De Marchi, Jaime Santo-Domingo, Cyril Castelbou, Israel Sekler, Andreas Wiederkehr, Nicolas Demaurex. J Biol Chem 2014
Umberto De Marchi, Jaime Santo-Domingo, Cyril Castelbou, Israel Sekler, Andreas Wiederkehr, Nicolas Demaurex. J Biol Chem 2014
35
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
Karthik Mallilankaraman, Patrick Doonan, César Cárdenas, Harish C Chandramoorthy, Marioly Müller, Russell Miller, Nicholas E Hoffman, Rajesh Kumar Gandhirajan, Jordi Molgó, Morris J Birnbaum,[...]. Cell 2012
Karthik Mallilankaraman, Patrick Doonan, César Cárdenas, Harish C Chandramoorthy, Marioly Müller, Russell Miller, Nicholas E Hoffman, Rajesh Kumar Gandhirajan, Jordi Molgó, Morris J Birnbaum,[...]. Cell 2012
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Calcium uptake by rat kidney mitochondria.
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Trypanosome Letm1 protein is essential for mitochondrial potassium homeostasis.
Hassan Hashimi, Lindsay McDonald, Eva Stríbrná, Julius Lukeš. J Biol Chem 2013
Hassan Hashimi, Lindsay McDonald, Eva Stríbrná, Julius Lukeš. J Biol Chem 2013
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LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability.
Kai Stefan Dimmer, Francesca Navoni, Alberto Casarin, Eva Trevisson, Sabine Endele, Andreas Winterpacht, Leonardo Salviati, Luca Scorrano. Hum Mol Genet 2008
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Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
Clare V Logan, György Szabadkai, Jenny A Sharpe, David A Parry, Silvia Torelli, Anne-Marie Childs, Marjolein Kriek, Rahul Phadke, Colin A Johnson, Nicola Y Roberts,[...]. Nat Genet 2014
Clare V Logan, György Szabadkai, Jenny A Sharpe, David A Parry, Silvia Torelli, Anne-Marie Childs, Marjolein Kriek, Rahul Phadke, Colin A Johnson, Nicola Y Roberts,[...]. Nat Genet 2014
25
78
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.
Nicholas E Hoffman, Harish C Chandramoorthy, Santhanam Shanmughapriya, Xueqian Q Zhang, Sandhya Vallem, Patrick J Doonan, Karthik Malliankaraman, Shuchi Guo, Sudarsan Rajan, John W Elrod,[...]. Mol Biol Cell 2014
Nicholas E Hoffman, Harish C Chandramoorthy, Santhanam Shanmughapriya, Xueqian Q Zhang, Sandhya Vallem, Patrick J Doonan, Karthik Malliankaraman, Shuchi Guo, Sudarsan Rajan, John W Elrod,[...]. Mol Biol Cell 2014
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Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.
Karin Nowikovsky, Tullio Pozzan, Rosario Rizzuto, Luca Scorrano, Paolo Bernardi. J Gen Physiol 2012
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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses.
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Dimers of mitochondrial ATP synthase form the permeability transition pore.
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Regulation of mitochondrial dehydrogenases by calcium ions.
Richard M Denton. Biochim Biophys Acta 2009
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A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome.
Angus G McQuibban, Nicholas Joza, Aram Megighian, Michele Scorzeto, Damiano Zanini, Siegfried Reipert, Constance Richter, Rudolf J Schweyen, Karin Nowikovsky. Hum Mol Genet 2010
Angus G McQuibban, Nicholas Joza, Aram Megighian, Michele Scorzeto, Damiano Zanini, Siegfried Reipert, Constance Richter, Rudolf J Schweyen, Karin Nowikovsky. Hum Mol Genet 2010
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CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.
Vincent Paupe, Julien Prudent, Emmanuel P Dassa, Olga Zurita Rendon, Eric A Shoubridge. Cell Metab 2015
Vincent Paupe, Julien Prudent, Emmanuel P Dassa, Olga Zurita Rendon, Eric A Shoubridge. Cell Metab 2015
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Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells.
Ayako Hasegawa, Alexander M van der Bliek. Hum Mol Genet 2007
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Activity of the mitochondrial calcium uniporter varies greatly between tissues.
Francesca Fieni, Sung Bae Lee, Yuh Nung Jan, Yuriy Kirichok. Nat Commun 2012
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Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins.
Elisabeth Froschauer, Karin Nowikovsky, Rudolf J Schweyen. Biochim Biophys Acta 2005
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Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter.
Juan Shao, Zhenglin Fu, Yanli Ji, Xiangchen Guan, Shang Guo, Zhanyu Ding, Xue Yang, Yao Cong, Yuequan Shen. Sci Rep 2016
Juan Shao, Zhenglin Fu, Yanli Ji, Xiangchen Guan, Shang Guo, Zhanyu Ding, Xue Yang, Yao Cong, Yuequan Shen. Sci Rep 2016
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LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients.
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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
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18
Reconstitution of the mitochondrial calcium uniporter in yeast.
Erika Kovács-Bogdán, Yasemin Sancak, Kimberli J Kamer, Molly Plovanich, Ashwini Jambhekar, Robert J Huber, Michael A Myre, Michael D Blower, Vamsi K Mootha. Proc Natl Acad Sci U S A 2014
Erika Kovács-Bogdán, Yasemin Sancak, Kimberli J Kamer, Molly Plovanich, Ashwini Jambhekar, Robert J Huber, Michael A Myre, Michael D Blower, Vamsi K Mootha. Proc Natl Acad Sci U S A 2014
18
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.
Dhanendra Tomar, Zhiwei Dong, Santhanam Shanmughapriya, Diana A Koch, Toby Thomas, Nicholas E Hoffman, Shrishiv A Timbalia, Samuel J Goldman, Sarah L Breves, Daniel P Corbally,[...]. Cell Rep 2016
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18
Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.
Shoko Tamai, Hiroshi Iida, Sadaki Yokota, Tomoko Sayano, Shoko Kiguchiya, Naotada Ishihara, Jun-Ichi Hayashi, Katsuyoshi Mihara, Toshihiko Oka. J Cell Sci 2008
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17
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
Lele Wang, Xue Yang, Siwei Li, Zheng Wang, Yu Liu, Jianrong Feng, Yushan Zhu, Yuequan Shen. EMBO J 2014
Lele Wang, Xue Yang, Siwei Li, Zheng Wang, Yu Liu, Jianrong Feng, Yushan Zhu, Yuequan Shen. EMBO J 2014
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Identification of a ryanodine receptor in rat heart mitochondria.
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17
The mitochondrial uniporter controls fight or flight heart rate increases.
Yuejin Wu, Tyler P Rasmussen, Olha M Koval, Mei-Ling A Joiner, Duane D Hall, Biyi Chen, Elizabeth D Luczak, Qiongling Wang, Adam G Rokita, Xander H T Wehrens,[...]. Nat Commun 2015
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17
Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.
Kira M Holmström, Xin Pan, Julia C Liu, Sara Menazza, Jie Liu, Tiffany T Nguyen, Haihui Pan, Randi J Parks, Stasia Anderson, Audrey Noguchi,[...]. J Mol Cell Cardiol 2015
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17
Enjoy the Trip: Calcium in Mitochondria Back and Forth.
Diego De Stefani, Rosario Rizzuto, Tullio Pozzan. Annu Rev Biochem 2016
Diego De Stefani, Rosario Rizzuto, Tullio Pozzan. Annu Rev Biochem 2016
17
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.
Michael Trenker, Roland Malli, Ismene Fertschai, Sanja Levak-Frank, Wolfgang F Graier. Nat Cell Biol 2007
Michael Trenker, Roland Malli, Ismene Fertschai, Sanja Levak-Frank, Wolfgang F Graier. Nat Cell Biol 2007
16
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.