Arielle Butts, Kristy Koselny, Yeissa Chabrier-Roselló, Camile P Semighini, Jessica C S Brown, Xuying Wang, Sivakumar Annadurai, Louis DiDone, Julie Tabroff, Wayne E Childers, Magid Abou-Gharbia, Melanie Wellington, Maria E Cardenas, Hiten D Madhani, Joseph Heitman, Damian J Krysan. mBio 2014
Times Cited: 75
Times Cited: 75
Times Cited
Times Co-cited
Similarity
Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.
Kristy Dolan, Sara Montgomery, Bradley Buchheit, Louis Didone, Melanie Wellington, Damian J Krysan. Antimicrob Agents Chemother 2009
Kristy Dolan, Sara Montgomery, Bradley Buchheit, Louis Didone, Melanie Wellington, Damian J Krysan. Antimicrob Agents Chemother 2009
37
The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections.
Bing Zhai, Cheng Wu, Linqi Wang, Matthew S Sachs, Xiaorong Lin. Antimicrob Agents Chemother 2012
Bing Zhai, Cheng Wu, Linqi Wang, Matthew S Sachs, Xiaorong Lin. Antimicrob Agents Chemother 2012
30
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.
Michaela Spitzer, Emma Griffiths, Kim M Blakely, Jan Wildenhain, Linda Ejim, Laura Rossi, Gianfranco De Pascale, Jasna Curak, Eric Brown, Mike Tyers,[...]. Mol Syst Biol 2011
Michaela Spitzer, Emma Griffiths, Kim M Blakely, Jan Wildenhain, Linda Ejim, Laura Rossi, Gianfranco De Pascale, Jasna Curak, Eric Brown, Mike Tyers,[...]. Mol Syst Biol 2011
29
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.
Benjamin J Park, Kathleen A Wannemuehler, Barbara J Marston, Nelesh Govender, Peter G Pappas, Tom M Chiller. AIDS 2009
Benjamin J Park, Kathleen A Wannemuehler, Barbara J Marston, Nelesh Govender, Peter G Pappas, Tom M Chiller. AIDS 2009
22
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
John R Perfect, William E Dismukes, Francoise Dromer, David L Goldman, John R Graybill, Richard J Hamill, Thomas S Harrison, Robert A Larsen, Olivier Lortholary, Minh-Hong Nguyen,[...]. Clin Infect Dis 2010
John R Perfect, William E Dismukes, Francoise Dromer, David L Goldman, John R Graybill, Richard J Hamill, Thomas S Harrison, Robert A Larsen, Olivier Lortholary, Minh-Hong Nguyen,[...]. Clin Infect Dis 2010
22
Hidden killers: human fungal infections.
Gordon D Brown, David W Denning, Neil A R Gow, Stuart M Levitz, Mihai G Netea, Theodore C White. Sci Transl Med 2012
Gordon D Brown, David W Denning, Neil A R Gow, Stuart M Levitz, Mihai G Netea, Theodore C White. Sci Transl Med 2012
20
Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study.
Joshua Rhein, Bozena M Morawski, Kathy Huppler Hullsiek, Henry W Nabeta, Reuben Kiggundu, Lillian Tugume, Abdu Musubire, Andrew Akampurira, Kyle D Smith, Ali Alhadab,[...]. Lancet Infect Dis 2016
Joshua Rhein, Bozena M Morawski, Kathy Huppler Hullsiek, Henry W Nabeta, Reuben Kiggundu, Lillian Tugume, Abdu Musubire, Andrew Akampurira, Kyle D Smith, Ali Alhadab,[...]. Lancet Infect Dis 2016
20
Combination antifungal therapy for cryptococcal meningitis.
Jeremy N Day, Tran T H Chau, Marcel Wolbers, Pham P Mai, Nguyen T Dung, Nguyen H Mai, Nguyen H Phu, Ho D Nghia, Nguyen D Phong, Cao Q Thai,[...]. N Engl J Med 2013
Jeremy N Day, Tran T H Chau, Marcel Wolbers, Pham P Mai, Nguyen T Dung, Nguyen H Mai, Nguyen H Phu, Ho D Nghia, Nguyen D Phong, Cao Q Thai,[...]. N Engl J Med 2013
18
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
Radha Rajasingham, Rachel M Smith, Benjamin J Park, Joseph N Jarvis, Nelesh P Govender, Tom M Chiller, David W Denning, Angela Loyse, David R Boulware. Lancet Infect Dis 2017
Radha Rajasingham, Rachel M Smith, Benjamin J Park, Joseph N Jarvis, Nelesh P Govender, Tom M Chiller, David W Denning, Angela Loyse, David R Boulware. Lancet Infect Dis 2017
18
Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.
Nicolas Delattin, Katrijn De Brucker, Katleen Vandamme, Els Meert, Arnaud Marchand, Patrick Chaltin, Bruno P A Cammue, Karin Thevissen. J Antimicrob Chemother 2014
Nicolas Delattin, Katrijn De Brucker, Katleen Vandamme, Els Meert, Arnaud Marchand, Patrick Chaltin, Bruno P A Cammue, Karin Thevissen. J Antimicrob Chemother 2014
20
Pharmacokinetics of selective estrogen receptor modulators.
Karla C Morello, Gregory T Wurz, Michael W DeGregorio. Clin Pharmacokinet 2003
Karla C Morello, Gregory T Wurz, Michael W DeGregorio. Clin Pharmacokinet 2003
16
A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
Arielle Butts, Louis DiDone, Kristy Koselny, Bonnie K Baxter, Yeissa Chabrier-Rosello, Melanie Wellington, Damian J Krysan. Eukaryot Cell 2013
Arielle Butts, Louis DiDone, Kristy Koselny, Bonnie K Baxter, Yeissa Chabrier-Rosello, Melanie Wellington, Damian J Krysan. Eukaryot Cell 2013
19
Antifungal drug development: challenges, unmet clinical needs, and new approaches.
Terry Roemer, Damian J Krysan. Cold Spring Harb Perspect Med 2014
Terry Roemer, Damian J Krysan. Cold Spring Harb Perspect Med 2014
16
Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen.
Arielle Butts, Jennifer A Martin, Louis DiDone, Erin K Bradley, Mitchell Mutz, Damian J Krysan. PLoS One 2015
Arielle Butts, Jennifer A Martin, Louis DiDone, Erin K Bradley, Mitchell Mutz, Damian J Krysan. PLoS One 2015
73
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.
Lisa M Johansen, Jennifer M Brannan, Sue E Delos, Charles J Shoemaker, Andrea Stossel, Calli Lear, Benjamin G Hoffstrom, Lisa Evans Dewald, Kathryn L Schornberg, Corinne Scully,[...]. Sci Transl Med 2013
Lisa M Johansen, Jennifer M Brannan, Sue E Delos, Charles J Shoemaker, Andrea Stossel, Calli Lear, Benjamin G Hoffstrom, Lisa Evans Dewald, Kathryn L Schornberg, Corinne Scully,[...]. Sci Transl Med 2013
13
Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.
Joseph N Jarvis, Graeme Meintjes, Kevin Rebe, Gertrude Ntombomzi Williams, Tihana Bicanic, Anthony Williams, Charlotte Schutz, Linda-Gail Bekker, Robin Wood, Thomas S Harrison. AIDS 2012
Joseph N Jarvis, Graeme Meintjes, Kevin Rebe, Gertrude Ntombomzi Williams, Tihana Bicanic, Anthony Williams, Charlotte Schutz, Linda-Gail Bekker, Robin Wood, Thomas S Harrison. AIDS 2012
13
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Leah E Cowen, Sheena D Singh, Julia R Köhler, Cathy Collins, Aimee K Zaas, Wiley A Schell, Hamza Aziz, Eleftherios Mylonakis, John R Perfect, Luke Whitesell,[...]. Proc Natl Acad Sci U S A 2009
Leah E Cowen, Sheena D Singh, Julia R Köhler, Cathy Collins, Aimee K Zaas, Wiley A Schell, Hamza Aziz, Eleftherios Mylonakis, John R Perfect, Luke Whitesell,[...]. Proc Natl Acad Sci U S A 2009
13
Observation and significance of growth inhibition of Saccharomyces cerevisiae (A224A) by the anti-oestrogen drug tamoxifen.
H Wiseman, M Cannon, H R Arnstein. Biochem Soc Trans 1989
H Wiseman, M Cannon, H R Arnstein. Biochem Soc Trans 1989
29
Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis.
Justin Beardsley, Marcel Wolbers, Freddie M Kibengo, Abu-Baker M Ggayi, Anatoli Kamali, Ngo Thi Kim Cuc, Tran Quang Binh, Nguyen Van Vinh Chau, Jeremy Farrar, Laura Merson,[...]. N Engl J Med 2016
Justin Beardsley, Marcel Wolbers, Freddie M Kibengo, Abu-Baker M Ggayi, Anatoli Kamali, Ngo Thi Kim Cuc, Tran Quang Binh, Nguyen Van Vinh Chau, Jeremy Farrar, Laura Merson,[...]. N Engl J Med 2016
12
Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections.
Danilo C Miguel, Rogéria C Zauli-Nascimento, Jenicer K U Yokoyama-Yasunaka, Simone Katz, Clara L Barbiéri, Silvia R B Uliana. J Antimicrob Chemother 2009
Danilo C Miguel, Rogéria C Zauli-Nascimento, Jenicer K U Yokoyama-Yasunaka, Simone Katz, Clara L Barbiéri, Silvia R B Uliana. J Antimicrob Chemother 2009
16
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Kristy Koselny, Julianne Green, Louis DiDone, Justin P Halterman, Annette W Fothergill, Nathan P Wiederhold, Thomas F Patterson, Melanie T Cushion, Chad Rappelye, Melanie Wellington,[...]. Antimicrob Agents Chemother 2016
Kristy Koselny, Julianne Green, Louis DiDone, Justin P Halterman, Annette W Fothergill, Nathan P Wiederhold, Thomas F Patterson, Melanie T Cushion, Chad Rappelye, Melanie Wellington,[...]. Antimicrob Agents Chemother 2016
18
The combination of tamoxifen with amphotericin B, but not with fluconazole, has synergistic activity against the majority of clinical isolates of Cryptococcus neoformans.
Trieu Phan Hai, Anh Duong Van, Nguyen Thi Thuy Ngan, Le Thanh Hoang Nhat, Nguyen Phu Huong Lan, Nguyen V Vinh Chau, Guy E Thwaites, Damian Krysan, Jeremy N Day. Mycoses 2019
Trieu Phan Hai, Anh Duong Van, Nguyen Thi Thuy Ngan, Le Thanh Hoang Nhat, Nguyen Phu Huong Lan, Nguyen V Vinh Chau, Guy E Thwaites, Damian Krysan, Jeremy N Day. Mycoses 2019
52
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
William J Steinbach, Jennifer L Reedy, Robert A Cramer, John R Perfect, Joseph Heitman. Nat Rev Microbiol 2007
William J Steinbach, Jennifer L Reedy, Robert A Cramer, John R Perfect, Joseph Heitman. Nat Rev Microbiol 2007
10
Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients.
Tihana Bicanic, Conrad Muzoora, Annemarie E Brouwer, Graeme Meintjes, Nicky Longley, Kabanda Taseera, Kevin Rebe, Angela Loyse, Joseph Jarvis, Linda-Gail Bekker,[...]. Clin Infect Dis 2009
Tihana Bicanic, Conrad Muzoora, Annemarie E Brouwer, Graeme Meintjes, Nicky Longley, Kabanda Taseera, Kevin Rebe, Angela Loyse, Joseph Jarvis, Linda-Gail Bekker,[...]. Clin Infect Dis 2009
10
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis.
David R Boulware, David B Meya, Conrad Muzoora, Melissa A Rolfes, Katherine Huppler Hullsiek, Abdu Musubire, Kabanda Taseera, Henry W Nabeta, Charlotte Schutz, Darlisha A Williams,[...]. N Engl J Med 2014
David R Boulware, David B Meya, Conrad Muzoora, Melissa A Rolfes, Katherine Huppler Hullsiek, Abdu Musubire, Kabanda Taseera, Henry W Nabeta, Charlotte Schutz, Darlisha A Williams,[...]. N Engl J Med 2014
10
Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis.
Woong Sik Jang, Sukyung Kim, Biswajit Podder, Md Anirban Jyoti, Kung-Woo Nam, Byung-Eui Lee, Ho-Yeon Song. J Microbiol Biotechnol 2015
Woong Sik Jang, Sukyung Kim, Biswajit Podder, Md Anirban Jyoti, Kung-Woo Nam, Byung-Eui Lee, Ho-Yeon Song. J Microbiol Biotechnol 2015
32
Calcineurin is required for virulence of Cryptococcus neoformans.
A Odom, S Muir, E Lim, D L Toffaletti, J Perfect, J Heitman. EMBO J 1997
A Odom, S Muir, E Lim, D L Toffaletti, J Perfect, J Heitman. EMBO J 1997
9
Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.
Oliver W Liu, Cheryl D Chun, Eric D Chow, Changbin Chen, Hiten D Madhani, Suzanne M Noble. Cell 2008
Oliver W Liu, Cheryl D Chun, Eric D Chow, Changbin Chen, Hiten D Madhani, Suzanne M Noble. Cell 2008
9
Infectious Disease. How to bolster the antifungal pipeline.
David W Denning, Michael J Bromley. Science 2015
David W Denning, Michael J Bromley. Science 2015
9
Unraveling the biology of a fungal meningitis pathogen using chemical genetics.
Jessica C S Brown, Justin Nelson, Benjamin VanderSluis, Raamesh Deshpande, Arielle Butts, Sarah Kagan, Itzhack Polacheck, Damian J Krysan, Chad L Myers, Hiten D Madhani. Cell 2014
Jessica C S Brown, Justin Nelson, Benjamin VanderSluis, Raamesh Deshpande, Arielle Butts, Sarah Kagan, Itzhack Polacheck, Damian J Krysan, Chad L Myers, Hiten D Madhani. Cell 2014
13
Synergistic Effect of Fluconazole and Calcium Channel Blockers against Resistant Candida albicans.
Shuyuan Liu, Longtao Yue, Wenrui Gu, Xiuyun Li, Liuping Zhang, Shujuan Sun. PLoS One 2016
Shuyuan Liu, Longtao Yue, Wenrui Gu, Xiuyun Li, Liuping Zhang, Shujuan Sun. PLoS One 2016
11
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.
Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P Cerone, Anna K Averette, Yong-Sun Bahn, Joseph Heitman, Donald C Sheppard, Mike Tyers, Gerard D Wright. Cell Rep 2015
Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P Cerone, Anna K Averette, Yong-Sun Bahn, Joseph Heitman, Donald C Sheppard, Mike Tyers, Gerard D Wright. Cell Rep 2015
12
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B Konopka, Iwao Ojima, Erika Bullesbach,[...]. mBio 2015
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B Konopka, Iwao Ojima, Erika Bullesbach,[...]. mBio 2015
9
Amphotericin B formulations: a comparative review of efficacy and toxicity.
Richard J Hamill. Drugs 2013
Richard J Hamill. Drugs 2013
9
The Anti-helminthic Compound Mebendazole Has Multiple Antifungal Effects against Cryptococcus neoformans.
Luna S Joffe, Rafael Schneider, William Lopes, Renata Azevedo, Charley C Staats, Lívia Kmetzsch, Augusto Schrank, Maurizio Del Poeta, Marilene H Vainstein, Marcio L Rodrigues. Front Microbiol 2017
Luna S Joffe, Rafael Schneider, William Lopes, Renata Azevedo, Charley C Staats, Lívia Kmetzsch, Augusto Schrank, Maurizio Del Poeta, Marilene H Vainstein, Marcio L Rodrigues. Front Microbiol 2017
20
A randomized open label trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis.
Nguyen Thi Thuy Ngan, Nguyen Thi Hoang Mai, Nguyen Le Nhu Tung, Nguyen Phu Huong Lan, Luong Thi Hue Tai, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Tran Quang Binh, Le Quoc Hung, Justin Beardsley,[...]. Wellcome Open Res 2019
Nguyen Thi Thuy Ngan, Nguyen Thi Hoang Mai, Nguyen Le Nhu Tung, Nguyen Phu Huong Lan, Luong Thi Hue Tai, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Tran Quang Binh, Le Quoc Hung, Justin Beardsley,[...]. Wellcome Open Res 2019
53
Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease.
Marhiah C Montoya, Damian J Krysan. mBio 2018
Marhiah C Montoya, Damian J Krysan. mBio 2018
19
Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.
Guilhem Janbon, Kate L Ormerod, Damien Paulet, Edmond J Byrnes, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, Chung-Chau Hon, R Blake Billmyre, François Brunel,[...]. PLoS Genet 2014
Guilhem Janbon, Kate L Ormerod, Damien Paulet, Edmond J Byrnes, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, Chung-Chau Hon, R Blake Billmyre, François Brunel,[...]. PLoS Genet 2014
8
Antifungal drug discovery: something old and something new.
Arielle Butts, Damian J Krysan. PLoS Pathog 2012
Arielle Butts, Damian J Krysan. PLoS Pathog 2012
8
Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients.
E A Lien, K Wester, P E Lønning, E Solheim, P M Ueland. Br J Cancer 1991
E A Lien, K Wester, P E Lønning, E Solheim, P M Ueland. Br J Cancer 1991
8
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
Fred Widmer, Lesley C Wright, Daniel Obando, Rosemary Handke, Ranjini Ganendren, David H Ellis, Tania C Sorrell. Antimicrob Agents Chemother 2006
Fred Widmer, Lesley C Wright, Daniel Obando, Rosemary Handke, Ranjini Ganendren, David H Ellis, Tania C Sorrell. Antimicrob Agents Chemother 2006
8
T-2307 causes collapse of mitochondrial membrane potential in yeast.
Tatsuya Shibata, Toshinari Takahashi, Eio Yamada, Akiko Kimura, Hiroshi Nishikawa, Hiroyoshi Hayakawa, Nobuhiko Nomura, Junichi Mitsuyama. Antimicrob Agents Chemother 2012
Tatsuya Shibata, Toshinari Takahashi, Eio Yamada, Akiko Kimura, Hiroshi Nishikawa, Hiroyoshi Hayakawa, Nobuhiko Nomura, Junichi Mitsuyama. Antimicrob Agents Chemother 2012
10
Calcineurin is essential for Candida albicans survival in serum and virulence.
Jill R Blankenship, Floyd L Wormley, Molly K Boyce, Wiley A Schell, Scott G Filler, John R Perfect, Joseph Heitman. Eukaryot Cell 2003
Jill R Blankenship, Floyd L Wormley, Molly K Boyce, Wiley A Schell, Scott G Filler, John R Perfect, Joseph Heitman. Eukaryot Cell 2003
8
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
A Odom, M Del Poeta, J Perfect, J Heitman. Antimicrob Agents Chemother 1997
A Odom, M Del Poeta, J Perfect, J Heitman. Antimicrob Agents Chemother 1997
8
Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries.
Angela Loyse, Harry Thangaraj, Philippa Easterbrook, Nathan Ford, Monika Roy, Tom Chiller, Nelesh Govender, Thomas S Harrison, Tihana Bicanic. Lancet Infect Dis 2013
Angela Loyse, Harry Thangaraj, Philippa Easterbrook, Nathan Ford, Monika Roy, Tom Chiller, Nelesh Govender, Thomas S Harrison, Tihana Bicanic. Lancet Infect Dis 2013
8
Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs.
Damian J Krysan. Fungal Genet Biol 2015
Damian J Krysan. Fungal Genet Biol 2015
18
Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes.
Edward Sionov, Hyeseung Lee, Yun C Chang, Kyung J Kwon-Chung. PLoS Pathog 2010
Edward Sionov, Hyeseung Lee, Yun C Chang, Kyung J Kwon-Chung. PLoS Pathog 2010
8
In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds.
Mamiko Miyazaki, Takaaki Horii, Katsura Hata, Nao-Aki Watanabe, Kazutaka Nakamoto, Keigo Tanaka, Syuji Shirotori, Norio Murai, Satoshi Inoue, Masayuki Matsukura,[...]. Antimicrob Agents Chemother 2011
Mamiko Miyazaki, Takaaki Horii, Katsura Hata, Nao-Aki Watanabe, Kazutaka Nakamoto, Keigo Tanaka, Syuji Shirotori, Norio Murai, Satoshi Inoue, Masayuki Matsukura,[...]. Antimicrob Agents Chemother 2011
8
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial.
Annemarie E Brouwer, Adul Rajanuwong, Wirongrong Chierakul, George E Griffin, Robert A Larsen, Nicholas J White, Thomas S Harrison. Lancet 2004
Annemarie E Brouwer, Adul Rajanuwong, Wirongrong Chierakul, George E Griffin, Robert A Larsen, Nicholas J White, Thomas S Harrison. Lancet 2004
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.