A citation-based method for searching scientific literature

Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
Times Cited: 167







List of co-cited articles
1305 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin.
Chih-Cheng Hsu, Mark L Wahlqvist, Meei-Shyuan Lee, Hsin-Ni Tsai. J Alzheimers Dis 2011
208
37

Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis.
Chin Cheng, Ching-Heng Lin, Yi-Wen Tsai, Chia-Jui Tsai, Po-Han Chou, Tsuo-Hung Lan. J Gerontol A Biol Sci Med Sci 2014
79
39

Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.
Patrick Imfeld, Michael Bodmer, Susan S Jick, Christoph R Meier. J Am Geriatr Soc 2012
200
30

Increased risk of cognitive impairment in patients with diabetes is associated with metformin.
Eileen M Moore, Alastair G Mander, David Ames, Mark A Kotowicz, Ross P Carne, Henry Brodaty, Michael Woodward, Karyn Boundy, Kathryn A Ellis, Ashley I Bush,[...]. Diabetes Care 2013
192
27

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
426
23

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
690
22

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes.
Ariela R Orkaby, Kelly Cho, Jean Cormack, David R Gagnon, Jane A Driver. Neurology 2017
52
36

Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus.
Yi-Chun Kuan, Kuang-Wei Huang, Cheng-Li Lin, Chaur-Jong Hu, Chia-Hung Kao. Prog Neuropsychopharmacol Biol Psychiatry 2017
61
29


Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial.
José A Luchsinger, Thania Perez, Helena Chang, Pankaj Mehta, Jason Steffener, Gnanavalli Pradabhan, Masanori Ichise, Jennifer Manly, Davangere P Devanand, Emilia Bagiella. J Alzheimers Dis 2016
95
18

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.
Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnold. Alzheimer Dis Assoc Disord 2017
113
18

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann,[...]. Proc Natl Acad Sci U S A 2010
260
18

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
505
16

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.
Jing Wang, Denis Gallagher, Loren M DeVito, Gonzalo I Cancino, David Tsui, Ling He, Gordon M Keller, Paul W Frankland, David R Kaplan, Freda D Miller. Cell Stem Cell 2012
270
15

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.
Jiejie Li, Jiao Deng, Wenli Sheng, Zhiyi Zuo. Pharmacol Biochem Behav 2012
161
15

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
168
15

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus.
Min Guo, Jia Mi, Qiu-Ming Jiang, Jin-Mei Xu, Ying-Ying Tang, Geng Tian, Bin Wang. Clin Exp Pharmacol Physiol 2014
105
15

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis.
Jared M Campbell, Matthew D Stephenson, Barbora de Courten, Ian Chapman, Susan M Bellman, Edoardo Aromataris. J Alzheimers Dis 2018
64
23

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
220
14

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
234
14

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice.
Zhenri Ou, Xuejian Kong, Xiangdong Sun, Xiaosong He, Le Zhang, Zhuo Gong, Jingyi Huang, Biao Xu, Dahong Long, Jianhua Li,[...]. Brain Behav Immun 2018
114
14

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.
Yaomin Chen, Kun Zhou, Ruishan Wang, Yun Liu, Young-Don Kwak, Tao Ma, Robert C Thompson, Yongbo Zhao, Layton Smith, Laura Gasparini,[...]. Proc Natl Acad Sci U S A 2009
272
13


Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Konrad Talbot, Hoau-Yan Wang, Hala Kazi, Li-Ying Han, Kalindi P Bakshi, Andres Stucky, Robert L Fuino, Krista R Kawaguchi, Andrew J Samoyedny, Robert S Wilson,[...]. J Clin Invest 2012
13


Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
264
12

Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
12

The Therapeutic Potential of Metformin in Neurodegenerative Diseases.
Carola Rotermund, Gerrit Machetanz, Julia C Fitzgerald. Front Endocrinol (Lausanne) 2018
100
12

Effect of metformin on neurodegenerative disease among elderly adult US veterans with type 2 diabetes mellitus.
Qian Shi, Shuqian Liu, Vivian A Fonseca, Tina K Thethi, Lizheng Shi. BMJ Open 2019
25
48

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.
Hiranya Pintana, Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakorn. Life Sci 2012
145
11

Metformin slows down aging and extends life span of female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Margarita L Tyndyk, Maria V Yurova, Irina G Kovalenko, Tatiana E Poroshina,[...]. Cell Cycle 2008
217
11

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
184
11

Metformin - a Future Therapy for Neurodegenerative Diseases : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.
Magdalena Markowicz-Piasecka, Joanna Sikora, Aleksandra Szydłowska, Agata Skupień, Elżbieta Mikiciuk-Olasik, Kristiina M Huttunen. Pharm Res 2017
107
11

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.
Krzysztof Łabuzek, Dariusz Suchy, Bożena Gabryel, Anna Bielecka, Sebastian Liber, Bogusław Okopień. Pharmacol Rep 2010
213
11

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Irina G Kovalenko,[...]. Aging (Albany NY) 2011
174
10

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial.
Suzanne Craft, Laura D Baker, Thomas J Montine, Satoshi Minoshima, G Stennis Watson, Amy Claxton, Matthew Arbuckle, Maureen Callaghan, Elaine Tsai, Stephen R Plymate,[...]. Arch Neurol 2012
783
10

Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study.
José A Luchsinger, Yong Ma, Costas A Christophi, Hermes Florez, Sherita H Golden, Helen Hazuda, Jill Crandall, Elizabeth Venditti, Karol Watson, Susan Jeffries,[...]. Diabetes Care 2017
28
35

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype.
M A Reger, G S Watson, W H Frey, L D Baker, B Cholerton, M L Keeling, D A Belongia, M A Fishel, S R Plymate, G D Schellenberg,[...]. Neurobiol Aging 2006
438
10

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.
Paula L McClean, Vadivel Parthsarathy, Emilie Faivre, Christian Hölscher. J Neurosci 2011
441
10

Diabetes mellitus and the risk of dementia: The Rotterdam Study.
A Ott, R P Stolk, F van Harskamp, H A Pols, A Hofman, M M Breteler. Neurology 1999
10

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.
Theresa R Bomfim, Leticia Forny-Germano, Luciana B Sathler, Jordano Brito-Moreira, Jean-Christophe Houzel, Helena Decker, Michael A Silverman, Hala Kazi, Helen M Melo, Paula L McClean,[...]. J Clin Invest 2012
544
10

In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial.
Michael Gejl, Albert Gjedde, Lærke Egefjord, Arne Møller, Søren B Hansen, Kim Vang, Anders Rodell, Hans Brændgaard, Hanne Gottrup, Anna Schacht,[...]. Front Aging Neurosci 2016
174
10

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.
B I Pérez-Revuelta, M M Hettich, A Ciociaro, C Rotermund, P J Kahle, S Krauss, D A Di Monte. Cell Death Dis 2014
72
12

Metformin treatment alters memory function in a mouse model of Alzheimer's disease.
Kacee A DiTacchio, Stephen F Heinemann, Gustavo Dziewczapolski. J Alzheimers Dis 2015
60
15


Differential effects of metformin on age related comorbidities in older men with type 2 diabetes.
Chen-Pin Wang, Carlos Lorenzo, Samy L Habib, Booil Jo, Sara E Espinoza. J Diabetes Complications 2017
50
18

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
Eric Steen, Benjamin M Terry, Enrique J Rivera, Jennifer L Cannon, Thomas R Neely, Rose Tavares, X Julia Xu, Jack R Wands, Suzanne M de la Monte. J Alzheimers Dis 2005
9

Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition.
Sara Ahmed, Zahra Mahmood, Aneela Javed, Shoaib Naiyer Hashmi, Inga Zerr, Saima Zafar, Saadia Zahid. J Mol Neurosci 2017
33
27

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study.
G Stennis Watson, Brenna A Cholerton, Mark A Reger, Laura D Baker, Stephen R Plymate, Sanjay Asthana, Mark A Fishel, J Jacob Kulstad, Pattie S Green, David G Cook,[...]. Am J Geriatr Psychiatry 2005
440
9

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.
Joanne S Allard, Evelyn J Perez, Koji Fukui, Priscilla Carpenter, Donald K Ingram, Rafael de Cabo. Behav Brain Res 2016
44
20


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.