A citation-based method for searching scientific literature

John D Hayes, Albena T Dinkova-Kostova. Trends Biochem Sci 2014
Times Cited: 957







List of co-cited articles
672 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Masayuki Yamamoto, Thomas W Kensler, Hozumi Motohashi. Physiol Rev 2018
386
14

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Patricia Rada, Ana I Rojo, Sudhir Chowdhry, Michael McMahon, John D Hayes, Antonio Cuadrado. Mol Cell Biol 2011
437
14

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.
Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama,[...]. Nat Commun 2016
589
12

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi. Cancer Cell 2012
754
12

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, Y Katoh, T Oyake, N Hayashi, K Satoh, I Hatayama,[...]. Biochem Biophys Res Commun 1997
12

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
K Itoh, N Wakabayashi, Y Katoh, T Ishii, K Igarashi, J D Engel, M Yamamoto. Genes Dev 1999
11



The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I Tong,[...]. Nat Cell Biol 2010
10

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.
Antonio Cuadrado, Ana I Rojo, Geoffrey Wells, John D Hayes, Sharon P Cousin, William L Rumsey, Otis C Attucks, Stephen Franklin, Anna-Liisa Levonen, Thomas W Kensler,[...]. Nat Rev Drug Discov 2019
332
9

The emerging role of Nrf2 in mitochondrial function.
Albena T Dinkova-Kostova, Andrey Y Abramov. Free Radic Biol Med 2015
399
9

Role of nrf2 in oxidative stress and toxicity.
Qiang Ma. Annu Rev Pharmacol Toxicol 2013
9

Transcriptional Regulation by Nrf2.
Claudia Tonelli, Iok In Christine Chio, David A Tuveson. Antioxid Redox Signal 2018
448
9

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.
Kira M Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M Land, Lee Stanyer, Masayuki Yamamoto, Albena T Dinkova-Kostova, Andrey Y Abramov. Biol Open 2013
236
8

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development.
Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda, Antonio Cuadrado. Oxid Med Cell Longev 2019
142
8

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.
Brian N Chorley, Michelle R Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R Kleeberger, Douglas A Bell. Nucleic Acids Res 2012
328
8

NRF2 and the Hallmarks of Cancer.
Montserrat Rojo de la Vega, Eli Chapman, Donna D Zhang. Cancer Cell 2018
399
8

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Albena T Dinkova-Kostova, W David Holtzclaw, Robert N Cole, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Masayuki Yamamoto, Paul Talalay. Proc Natl Acad Sci U S A 2002
7

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Øvervatn, Michael McMahon, John D Hayes, Terje Johansen. J Biol Chem 2010
839
7

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams,[...]. Nature 2018
466
7

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Kit I Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto. Mol Cell Biol 2006
442
7



Nrf2 signaling pathway: Pivotal roles in inflammation.
Syed Minhaj Uddin Ahmed, Lin Luo, Akhileshwar Namani, Xiu Jun Wang, Xiuwen Tang. Biochim Biophys Acta Mol Basis Dis 2017
583
7


Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Thomas W Kensler, Nobunao Wakabayashi, Shyam Biswal. Annu Rev Pharmacol Toxicol 2007
7

Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
7


Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways.
Joanna D Wardyn, Amy H Ponsford, Christopher M Sanderson. Biochem Soc Trans 2015
422
6

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.
Stuart A Rushworth, Lyubov Zaitseva, Megan Y Murray, Niraj M Shah, Kristian M Bowles, David J MacEwan. Blood 2012
170
6

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.
Patricia Rada, Ana I Rojo, Nathalie Evrard-Todeschi, Nadia G Innamorato, Axelle Cotte, Tomasz Jaworski, Julio C Tobón-Velasco, Herman Devijver, María Flor García-Mayoral, Fred Van Leuven,[...]. Mol Cell Biol 2012
192
6

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Nobunao Wakabayashi, Albena T Dinkova-Kostova, W David Holtzclaw, Moon-Il Kang, Akira Kobayashi, Masayuki Yamamoto, Thomas W Kensler, Paul Talalay. Proc Natl Acad Sci U S A 2004
738
6

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
Hongyan Wang, Kaihua Liu, Miao Geng, Peng Gao, Xiaoyuan Wu, Yan Hai, Yangxia Li, Yulong Li, Lin Luo, John D Hayes,[...]. Cancer Res 2013
156
6

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto. Genes Cells 2011
865
6

Modulation of oxidative stress as an anticancer strategy.
Chiara Gorrini, Isaac S Harris, Tak W Mak. Nat Rev Drug Discov 2013
6

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks.
Yosuke Hirotsu, Fumiki Katsuoka, Ryo Funayama, Takeshi Nagashima, Yuichiro Nishida, Keiko Nakayama, James Douglas Engel, Masayuki Yamamoto. Nucleic Acids Res 2012
213
6

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.
Y Katoh, K Itoh, E Yoshida, M Miyagishi, A Fukamizu, M Yamamoto. Genes Cells 2001
302
6

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.
Deepti Malhotra, Elodie Portales-Casamar, Anju Singh, Siddhartha Srivastava, David Arenillas, Christine Happel, Casper Shyr, Nobunao Wakabayashi, Thomas W Kensler, Wyeth W Wasserman,[...]. Nucleic Acids Res 2010
479
6

Oxidative Stress.
Helmut Sies, Carsten Berndt, Dean P Jones. Annu Rev Biochem 2017
930
6

Nrf2-Keap1 signaling in oxidative and reductive stress.
Ilaria Bellezza, Ileana Giambanco, Alba Minelli, Rosario Donato. Biochim Biophys Acta Mol Cell Res 2018
328
6

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
A Phillip West, Igor E Brodsky, Christoph Rahner, Dong Kyun Woo, Hediye Erdjument-Bromage, Paul Tempst, Matthew C Walsh, Yongwon Choi, Gerald S Shadel, Sankar Ghosh. Nature 2011
863
5

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
Liam Baird, David Llères, Sam Swift, Albena T Dinkova-Kostova. Proc Natl Acad Sci U S A 2013
191
5

The multifaceted role of Nrf2 in mitochondrial function.
Kira M Holmström, Rumen V Kostov, Albena T Dinkova-Kostova. Curr Opin Toxicol 2016
162
5

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.
Antonio Cuadrado, Gina Manda, Ahmed Hassan, María José Alcaraz, Coral Barbas, Andreas Daiber, Pietro Ghezzi, Rafael León, Manuela G López, Baldo Oliva,[...]. Pharmacol Rev 2018
205
5

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, Makiko Ohtsuji, Yukari Zenke, Tomoki Chiba, Kazuhiko Igarashi, Masayuki Yamamoto. Mol Cell Biol 2004
5



Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism.
Agnieszka Loboda, Milena Damulewicz, Elzbieta Pyza, Alicja Jozkowicz, Jozef Dulak. Cell Mol Life Sci 2016
794
5

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
Rajesh K Thimmulappa, Hannah Lee, Tirumalai Rangasamy, Sekhar P Reddy, Masayuki Yamamoto, Thomas W Kensler, Shyam Biswal. J Clin Invest 2006
674
5

Canonical and non-canonical mechanisms of Nrf2 activation.
Carlos Alfredo Silva-Islas, Perla D Maldonado. Pharmacol Res 2018
107
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.