A citation-based method for searching scientific literature

William W Wheaton, Samuel E Weinberg, Robert B Hamanaka, Saul Soberanes, Lucas B Sullivan, Elena Anso, Andrea Glasauer, Eric Dufour, Gokhan M Mutlu, Gr Scott Budigner, Navdeep S Chandel. Elife 2014
Times Cited: 562







List of co-cited articles
970 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
20

An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Jennifer R Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi, Christopher Bristow, Timothy McAfoos, Pietro Morlacchi, Jeffrey Ackroyd, Ahmed-Noor A Agip,[...]. Nat Med 2018
266
20

On the origin of cancer cells.
O WARBURG. Science 1956
17


Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
13

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
352
13

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.
Lucas B Sullivan, Dan Y Gui, Aaron M Hosios, Lauren N Bush, Elizaveta Freinkman, Matthew G Vander Heiden. Cell 2015
498
11

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy.
Thomas M Ashton, W Gillies McKenna, Leoni A Kunz-Schughart, Geoff S Higgins. Clin Cancer Res 2018
244
11

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Andrea Viale, Piergiorgio Pettazzoni, Costas A Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani,[...]. Nature 2014
658
11

Immune-mediated antitumor effect by type 2 diabetes drug, metformin.
Shingo Eikawa, Mikako Nishida, Shusaku Mizukami, Chihiro Yamazaki, Eiichi Nakayama, Heiichiro Udono. Proc Natl Acad Sci U S A 2015
286
10

Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
10

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.
Kıvanç Birsoy, Tim Wang, Walter W Chen, Elizaveta Freinkman, Monther Abu-Remaileh, David M Sabatini. Cell 2015
566
10

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
926
9

THE METABOLISM OF TUMORS IN THE BODY.
O Warburg, F Wind, E Negelein. J Gen Physiol 1927
9

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.
Kıvanç Birsoy, Richard Possemato, Franziska K Lorbeer, Erol C Bayraktar, Prathapan Thiru, Burcu Yucel, Tim Wang, Walter W Chen, Clary B Clish, David M Sabatini. Nature 2014
404
9

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Xiaojing Liu, Iris L Romero, Lacey M Litchfield, Ernst Lengyel, Jason W Locasale. Cell Metab 2016
131
9

Mitochondrial metabolism and cancer.
Paolo Ettore Porporato, Nicoletta Filigheddu, José Manuel Bravo-San Pedro, Guido Kroemer, Lorenzo Galluzzi. Cell Res 2018
344
9

Metabolic Heterogeneity in Human Lung Tumors.
Christopher T Hensley, Brandon Faubert, Qing Yuan, Naama Lev-Cohain, Eunsook Jin, Jiyeon Kim, Lei Jiang, Bookyung Ko, Rachael Skelton, Laurin Loudat,[...]. Cell 2016
514
8

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Jiyoung Lee, Ali E Yesilkanal, Joseph P Wynne, Casey Frankenberger, Juan Liu, Jielin Yan, Mohamad Elbaz, Daniel C Rabe, Felicia D Rustandy, Payal Tiwari,[...]. Nature 2019
93
8

Targeting mitochondria metabolism for cancer therapy.
Samuel E Weinberg, Navdeep S Chandel. Nat Chem Biol 2015
687
8

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Mary A Selak, Sean M Armour, Elaine D MacKenzie, Houda Boulahbel, David G Watson, Kyle D Mansfield, Yi Pan, M Celeste Simon, Craig B Thompson, Eyal Gottlieb. Cancer Cell 2005
8

Lactate Metabolism in Human Lung Tumors.
Brandon Faubert, Kevin Y Li, Ling Cai, Christopher T Hensley, Jiyeon Kim, Lauren G Zacharias, Chendong Yang, Quyen N Do, Sarah Doucette, Daniel Burguete,[...]. Cell 2017
465
8


Mitochondrial Metabolism as a Target for Cancer Therapy.
Karthik Vasan, Marie Werner, Navdeep S Chandel. Cell Metab 2020
56
14

Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
7

Understanding the Intersections between Metabolism and Cancer Biology.
Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017
807
7

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
David R Wise, Ralph J DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B McMahon,[...]. Proc Natl Acad Sci U S A 2008
7

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand, Katrin Singer, Gudrun E Koehl, Marlene Kolitzus, Gabriele Schoenhammer, Annette Thiel, Carina Matos, Christina Bruss, Sebastian Klobuch, Katrin Peter,[...]. Cell Metab 2016
505
7

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.
Matt I Gross, Susan D Demo, Jennifer B Dennison, Lijing Chen, Tania Chernov-Rogan, Bindu Goyal, Julie R Janes, Guy J Laidig, Evan R Lewis, Jim Li,[...]. Mol Cancer Ther 2014
488
7

Mitochondria and cancer.
Douglas C Wallace. Nat Rev Cancer 2012
7

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Kyung-Min Lee, Jennifer M Giltnane, Justin M Balko, Luis J Schwarz, Angel L Guerrero-Zotano, Katherine E Hutchinson, Mellissa J Nixon, Mónica V Estrada, Violeta Sánchez, Melinda E Sanders,[...]. Cell Metab 2017
195
7

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung-Oe Lim, Chia-Wei Li, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee,[...]. Mol Cell 2018
203
7

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics.
Danielle Golub, Nishanth Iyengar, Siddhant Dogra, Taylor Wong, Devin Bready, Karen Tang, Aram S Modrek, Dimitris G Placantonakis. Front Oncol 2019
96
7

Metformin directly acts on mitochondria to alter cellular bioenergetics.
Sylvia Andrzejewski, Simon-Pierre Gravel, Michael Pollak, Julie St-Pierre. Cancer Metab 2014
241
7

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.
Rebecca Lamb, Bela Ozsvari, Camilla L Lisanti, Herbert B Tanowitz, Anthony Howell, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti. Oncotarget 2015
270
6

Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells.
Marco Fiorillo, Rebecca Lamb, Herbert B Tanowitz, Luciano Mutti, Marija Krstic-Demonacos, Anna Rita Cappello, Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti. Oncotarget 2016
108
6

The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
652
6

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?
Navdeep S Chandel, Dania Avizonis, Colleen R Reczek, Samuel E Weinberg, Stephan Menz, Roland Neuhaus, Sven Christian, Andrea Haegebarth, Carolyn Algire, Michael Pollak. Cell Metab 2016
92
6

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
669
6

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
569
6

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Ping Gao, Irina Tchernyshyov, Tsung-Cheng Chang, Yun-Sil Lee, Kayoko Kita, Takafumi Ochi, Karen I Zeller, Angelo M De Marzo, Jennifer E Van Eyk, Joshua T Mendell,[...]. Nature 2009
6

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
Don Benjamin, Dimitri Robay, Sravanth K Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A Lane, Michael N Hall. Cell Rep 2018
94
6

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Dan Y Gui, Lucas B Sullivan, Alba Luengo, Aaron M Hosios, Lauren N Bush, Nadege Gitego, Shawn M Davidson, Elizaveta Freinkman, Craig J Thomas, Matthew G Vander Heiden. Cell Metab 2016
156
6

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
Marko Skrtić, Shrivani Sriskanthadevan, Bozhena Jhas, Marinella Gebbia, Xiaoming Wang, Zezhou Wang, Rose Hurren, Yulia Jitkova, Marcela Gronda, Neil Maclean,[...]. Cancer Cell 2011
369
6

Regulation of cancer cell metabolism.
Rob A Cairns, Isaac S Harris, Tak W Mak. Nat Rev Cancer 2011
6

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.
Simon R Lord, Wei-Chen Cheng, Dan Liu, Edoardo Gaude, Syed Haider, Tom Metcalf, Neel Patel, Eugene J Teoh, Fergus Gleeson, Kevin Bradley,[...]. Cell Metab 2018
47
12

Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.
Alexander Roesch, Adina Vultur, Ivan Bogeski, Huan Wang, Katharina M Zimmermann, David Speicher, Christina Körbel, Matthias W Laschke, Phyllis A Gimotty, Stephan E Philipp,[...]. Cancer Cell 2013
396
6

Metabolic state of glioma stem cells and nontumorigenic cells.
Erina Vlashi, Chann Lagadec, Laurent Vergnes, Tomoo Matsutani, Kenta Masui, Maria Poulou, Ruxandra Popescu, Lorenza Della Donna, Patrick Evers, Carmen Dekmezian,[...]. Proc Natl Acad Sci U S A 2011
306
6

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
Michalina Janiszewska, Mario L Suvà, Nicolo Riggi, Riekelt H Houtkooper, Johan Auwerx, Virginie Clément-Schatlo, Ivan Radovanovic, Esther Rheinbay, Paolo Provero, Ivan Stamenkovic. Genes Dev 2012
245
6

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.
Patricia Sancho, Emma Burgos-Ramos, Alejandra Tavera, Tony Bou Kheir, Petra Jagust, Matthieu Schoenhals, David Barneda, Katherine Sellers, Ramon Campos-Olivas, Osvaldo Graña,[...]. Cell Metab 2015
366
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.