A citation-based method for searching scientific literature

Enrico Patrucco, Katrin Domes, Mauro Sbroggió, Anne Blaich, Jens Schlossmann, Matthias Desch, Sergei D Rybalkin, Joseph A Beavo, Robert Lukowski, Franz Hofmann. Proc Natl Acad Sci U S A 2014
Times Cited: 46







List of co-cited articles
512 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang, David A Kass. Nat Med 2005
624
56

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.
Robert Lukowski, Sergei D Rybalkin, Florian Loga, Veronika Leiss, Joseph A Beavo, Franz Hofmann. Proc Natl Acad Sci U S A 2010
77
45

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.
Margaret M Redfield, Horng H Chen, Barry A Borlaug, Marc J Semigran, Kerry L Lee, Gregory Lewis, Martin M LeWinter, Jean L Rouleau, David A Bull, Douglas L Mann,[...]. JAMA 2013
678
39

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
Dong I Lee, Guangshuo Zhu, Takashi Sasaki, Gun-Sik Cho, Nazha Hamdani, Ronald Holewinski, Su-Hyun Jo, Thomas Danner, Manling Zhang, Peter P Rainer,[...]. Nature 2015
170
34

Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.
Stefan Frantz, Michael Klaiber, Hideo A Baba, Heike Oberwinkler, Katharina Völker, Birgit Gaβner, Barbara Bayer, Marco Abeβer, Kai Schuh, Robert Feil,[...]. Eur Heart J 2013
65
32

Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice.
Peter Pokreisz, Sara Vandenwijngaert, Virginie Bito, An Van den Bergh, Ilse Lenaerts, Cornelius Busch, Glenn Marsboom, Olivier Gheysens, Pieter Vermeersch, Liesbeth Biesmans,[...]. Circulation 2009
129
23

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
Clint L Miller, Masayoshi Oikawa, Yujun Cai, Andrew P Wojtovich, David J Nagel, Xiangbin Xu, Haodong Xu, Vince Florio, Sergei D Rybalkin, Joseph A Beavo,[...]. Circ Res 2009
109
23

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.
Norimichi Koitabashi, Takeshi Aiba, Geoffrey G Hesketh, Janelle Rowell, Manling Zhang, Eiki Takimoto, Gordon F Tomaselli, David A Kass. J Mol Cell Cardiol 2010
117
23

Angiotensin-neprilysin inhibition versus enalapril in heart failure.
John J V McMurray, Milton Packer, Akshay S Desai, Jianjian Gong, Martin P Lefkowitz, Adel R Rizkala, Jean L Rouleau, Victor C Shi, Scott D Solomon, Karl Swedberg,[...]. N Engl J Med 2014
23

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.
Robert M Blanton, Eiki Takimoto, Angela M Lane, Mark Aronovitz, Robert Piotrowski, Richard H Karas, David A Kass, Michael E Mendelsohn. J Am Heart Assoc 2012
47
23

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.
Hideyuki Kinoshita, Koichiro Kuwahara, Motohiro Nishida, Zhong Jian, Xianglu Rong, Shigeki Kiyonaka, Yoshihiro Kuwabara, Hitoshi Kurose, Ryuji Inoue, Yasuo Mori,[...]. Circ Res 2010
100
21


Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.
Eiki Takimoto, Diego Belardi, Carlo G Tocchetti, Susan Vahebi, Gianfrancesco Cormaci, Elizabeth A Ketner, An L Moens, Hunter C Champion, David A Kass. Circulation 2007
118
21

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Jayan Nagendran, Stephen L Archer, Daniel Soliman, Vikram Gurtu, Rohit Moudgil, Alois Haromy, Chantal St Aubin, Linda Webster, Ivan M Rebeyka, David B Ross,[...]. Circulation 2007
346
21

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.
Motohiro Nishida, Kenta Watanabe, Yoji Sato, Michio Nakaya, Naoyuki Kitajima, Tomomi Ide, Ryuji Inoue, Hitoshi Kurose. J Biol Chem 2010
74
19

Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts.
Peng Li, Dajun Wang, Jason Lucas, Suzanne Oparil, Dongqi Xing, Xu Cao, Lea Novak, Matthew B Renfrow, Yiu-Fai Chen. Circ Res 2008
152
19

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
Eiki Takimoto, Hunter C Champion, Diego Belardi, Javid Moslehi, Marco Mongillo, Evanthia Mergia, David C Montrose, Takayoshi Isoda, Kate Aufiero, Manuela Zaccolo,[...]. Circ Res 2005
148
19

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Eiki Takimoto, Norimichi Koitabashi, Steven Hsu, Elizabeth A Ketner, Manling Zhang, Takahiro Nagayama, Djahida Bedja, Kathleen L Gabrielson, Robert Blanton, David P Siderovski,[...]. J Clin Invest 2009
147
19

Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Takeshi Tokudome, Ichiro Kishimoto, Takeshi Horio, Yuji Arai, Daryl O Schwenke, Jun Hino, Ichiro Okano, Yuhei Kawano, Masakazu Kohno, Mikiya Miyazato,[...]. Circulation 2008
79
19

The emperor's new clothes: PDE5 and the heart.
Chantal V Degen, Kalkidan Bishu, Rosita Zakeri, Ozgur Ogut, Margaret M Redfield, Frank V Brozovich. PLoS One 2015
22
40

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Hind Mehel, Julius Emons, Christiane Vettel, Katrin Wittköpper, Danilo Seppelt, Matthias Dewenter, Susanne Lutz, Samuel Sossalla, Lars S Maier, Patrick Lechêne,[...]. J Am Coll Cardiol 2013
79
19

Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes.
Liliana R V Castro, Ignacio Verde, Dermot M F Cooper, Rodolphe Fischmeister. Circulation 2006
196
19

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate.
Robrecht Thoonen, Shewit Giovanni, Suresh Govindan, Dong I Lee, Guang-Rong Wang, Timothy D Calamaras, Eiki Takimoto, David A Kass, Sakthivel Sadayappan, Robert M Blanton. Circ Heart Fail 2015
21
42

Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
Manling Zhang, Eiki Takimoto, Steven Hsu, Dong I Lee, Takahiro Nagayama, Thomas Danner, Norimichi Koitabashi, Andreas S Barth, Djahida Bedja, Kathleen L Gabrielson,[...]. J Am Coll Cardiol 2010
57
17

cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium.
Fabrice Vandeput, Judith Krall, Ramzi Ockaili, Fadi N Salloum, Vincent Florio, Jackie D Corbin, Sharron H Francis, Rakesh C Kukreja, Matthew A Movsesian. J Pharmacol Exp Ther 2009
55
17

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use.
Andrew T Bender, Joseph A Beavo. Pharmacol Rev 2006
17


Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.
Robert Lukowski, Thomas Krieg, Sergei D Rybalkin, Joseph Beavo, Franz Hofmann. Trends Pharmacol Sci 2014
39
17

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes.
Manling Zhang, Norimichi Koitabashi, Takahiro Nagayama, Ryan Rambaran, Ning Feng, Eiki Takimoto, Trisha Koenke, Brian O'Rourke, Hunter C Champion, Michael T Crow,[...]. Cell Signal 2008
67
15

Differential expression of PDE5 in failing and nonfailing human myocardium.
Xiaoyin Shan, Michael P Quaile, Jeffery K Monk, Benjamin French, Thomas P Cappola, Kenneth B Margulies. Circ Heart Fail 2012
57
15

Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
Ramzi Ockaili, Fadi Salloum, John Hawkins, Rakesh C Kukreja. Am J Physiol Heart Circ Physiol 2002
197
15

Cardiac fibrosis in mice lacking brain natriuretic peptide.
N Tamura, Y Ogawa, H Chusho, K Nakamura, K Nakao, M Suda, M Kasahara, R Hashimoto, G Katsuura, M Mukoyama,[...]. Proc Natl Acad Sci U S A 2000
390
15

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Marco Mongillo, Carlo G Tocchetti, Anna Terrin, Valentina Lissandron, York-Fong Cheung, Wolfgang R Dostmann, Tullio Pozzan, David A Kass, Nazareno Paolocci, Miles D Houslay,[...]. Circ Res 2006
201
15

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.
Taishi Nakamura, Mark J Ranek, Dong I Lee, Virginia Shalkey Hahn, Choel Kim, Philip Eaton, David A Kass. J Clin Invest 2015
41
17

Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling.
Julia Straubinger, Verena Schöttle, Nadja Bork, Hariharan Subramanian, Sarah Dünnes, Michael Russwurm, Meinrad Gawaz, Andreas Friebe, Mona Nemer, Viacheslav O Nikolaev,[...]. J Pharmacol Exp Ther 2015
12
58

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
Anna Zoccarato, Nicoletta C Surdo, Jan M Aronsen, Laura A Fields, Luisa Mancuso, Giuliano Dodoni, Alessandra Stangherlin, Craig Livie, He Jiang, Yuan Yan Sin,[...]. Circ Res 2015
66
15

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.
Bo Ding, Jun-Ichi Abe, Heng Wei, Qunhua Huang, Richard A Walsh, Carlos A Molina, Allan Zhao, Junichi Sadoshima, Burns C Blaxall, Bradford C Berk,[...]. Circulation 2005
135
15

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
Beate Fiedler, Suzanne M Lohmann, Albert Smolenski, Stephan Linnemuller, Burkert Pieske, Frank Schroder, Jeffery D Molkentin, Helmut Drexler, Kai C Wollert. Proc Natl Acad Sci U S A 2002
186
15

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
Clint L Miller, Yujun Cai, Masayoshi Oikawa, Tamlyn Thomas, Wolfgang R Dostmann, Manuela Zaccolo, Keigi Fujiwara, Chen Yan. Basic Res Cardiol 2011
67
15

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.
Walter E Knight, Si Chen, Yishuai Zhang, Masayoshi Oikawa, Meiping Wu, Qian Zhou, Clint L Miller, Yujun Cai, Deanne M Mickelsen, Christine Moravec,[...]. Proc Natl Acad Sci U S A 2016
36
19

PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways.
C Vettel, S Lämmle, S Ewens, C Cervirgen, J Emons, A Ongherth, M Dewenter, D Lindner, D Westermann, V O Nikolaev,[...]. Am J Physiol Heart Circ Physiol 2014
30
20

TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.
Naoya Onohara, Motohiro Nishida, Ryuji Inoue, Hiroyuki Kobayashi, Hideki Sumimoto, Yoji Sato, Yasuo Mori, Taku Nagao, Hitoshi Kurose. EMBO J 2006
277
13

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.
Shinichi Takahashi, Hai Lin, Naomi Geshi, Yasuo Mori, Yasuhiro Kawarabayashi, Noboru Takami, Masayuki X Mori, Akira Honda, Ryuji Inoue. J Physiol 2008
78
13

Oxidative stress regulates left ventricular PDE5 expression in the failing heart.
Zhongbing Lu, Xin Xu, Xinli Hu, Sangjin Lee, Jay H Traverse, Guangshuo Zhu, John Fassett, Yi Tao, Ping Zhang, Cris dos Remedios,[...]. Circulation 2010
117
13

Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure.
H Senzaki, C J Smith, G J Juang, T Isoda, S P Mayer, A Ohler, N Paolocci, G F Tomaselli, J M Hare, D A Kass. FASEB J 2001
165
13

Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.
Fabrice Vandeput, Sharon L Wolda, Judith Krall, Ryan Hambleton, Lothar Uher, Kim N McCaw, Przemyslaw B Radwanski, Vincent Florio, Matthew A Movsesian. J Biol Chem 2007
69
13

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.
Mark J Ranek, Erin J M Terpstra, Jie Li, David A Kass, Xuejun Wang. Circulation 2013
79
13

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.
Martina Krüger, Sebastian Kötter, Anika Grützner, Patrick Lang, Christian Andresen, Margaret M Redfield, Elke Butt, Cris G dos Remedios, Wolfgang A Linke. Circ Res 2009
260
13

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.
Masayoshi Oikawa, Meiping Wu, Soyeon Lim, Walter E Knight, Clint L Miller, Yujun Cai, Yan Lu, Burns C Blaxall, Yasuchika Takeishi, Jun-ichi Abe,[...]. J Mol Cell Cardiol 2013
36
16

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling.
Koichiro Kuwahara, Yanggan Wang, John McAnally, James A Richardson, Rhonda Bassel-Duby, Joseph A Hill, Eric N Olson. J Clin Invest 2006
361
10


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.