A citation-based method for searching scientific literature

Jacob R Haling, Jawahar Sudhamsu, Ivana Yen, Steve Sideris, Wendy Sandoval, Wilson Phung, Brandon J Bravo, Anthony M Giannetti, Ariana Peck, Alexandre Masselot, Tony Morales, Darin Smith, Barbara J Brandhuber, Sarah G Hymowitz, Shiva Malek. Cancer Cell 2014
Times Cited: 129







List of co-cited articles
898 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Regulation of RAF protein kinases in ERK signalling.
Hugo Lavoie, Marc Therrien. Nat Rev Mol Cell Biol 2015
348
44

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
Paul T C Wan, Mathew J Garnett, S Mark Roe, Sharlene Lee, Dan Niculescu-Duvaz, Valerie M Good, C Michael Jones, Christopher J Marshall, Caroline J Springer, David Barford,[...]. Cell 2004
42

Mutations of the BRAF gene in human cancer.
Helen Davies, Graham R Bignell, Charles Cox, Philip Stephens, Sarah Edkins, Sheila Clegg, Jon Teague, Hayley Woffendin, Mathew J Garnett, William Bottomley,[...]. Nature 2002
36

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Poulikos I Poulikakos, Yogindra Persaud, Manickam Janakiraman, Xiangju Kong, Charles Ng, Gatien Moriceau, Hubing Shi, Mohammad Atefi, Bjoern Titz, May Tal Gabay,[...]. Nature 2011
34

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
Poulikos I Poulikakos, Chao Zhang, Gideon Bollag, Kevan M Shokat, Neal Rosen. Nature 2010
33

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Georgia Hatzivassiliou, Kyung Song, Ivana Yen, Barbara J Brandhuber, Daniel J Anderson, Ryan Alvarado, Mary J C Ludlam, David Stokoe, Susan L Gloor, Guy Vigers,[...]. Nature 2010
33

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Sonja J Heidorn, Carla Milagre, Steven Whittaker, Arnaud Nourry, Ion Niculescu-Duvas, Nathalie Dhomen, Jahan Hussain, Jorge S Reis-Filho, Caroline J Springer, Catrin Pritchard,[...]. Cell 2010
32

A dimerization-dependent mechanism drives RAF catalytic activation.
Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois, Frank Sicheri, Marc Therrien. Nature 2009
328
31

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.
Zhan Yao, Neilawattie M Torres, Anthony Tao, Yijun Gao, Lusong Luo, Qi Li, Elisa de Stanchina, Omar Abdel-Wahab, David B Solit, Poulikos I Poulikakos,[...]. Cancer Cell 2015
268
28

Allosteric activation of functionally asymmetric RAF kinase dimers.
Jiancheng Hu, Edward C Stites, Haiyang Yu, Elizabeth A Germino, Hiruy S Meharena, Philip J S Stork, Alexandr P Kornev, Susan S Taylor, Andrey S Shaw. Cell 2013
185
28

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
Neroshan Thevakumaran, Hugo Lavoie, David A Critton, Andrew Tebben, Anne Marinier, Frank Sicheri, Marc Therrien. Nat Struct Mol Biol 2015
92
29

Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Eunyoung Park, Shaun Rawson, Kunhua Li, Byeong-Won Kim, Scott B Ficarro, Gonzalo Gonzalez-Del Pino, Humayun Sharif, Jarrod A Marto, Hyesung Jeon, Michael J Eck. Nature 2019
101
27

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.
Matthew Holderfield, Marian M Deuker, Frank McCormick, Martin McMahon. Nat Rev Cancer 2014
501
21

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.
Mathew J Garnett, Sareena Rana, Hugh Paterson, David Barford, Richard Marais. Mol Cell 2005
308
21

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Sheng-Bin Peng, James R Henry, Michael D Kaufman, Wei-Ping Lu, Bryan D Smith, Subha Vogeti, Thomas J Rutkoski, Scott Wise, Lawrence Chun, Youyan Zhang,[...]. Cancer Cell 2015
177
20

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.
Daniel A Ritt, Daniel M Monson, Suzanne I Specht, Deborah K Morrison. Mol Cell Biol 2010
153
18

Active Ras induces heterodimerization of cRaf and BRaf.
C K Weber, J R Slupsky, H A Kalmes, U R Rapp. Cancer Res 2001
234
18

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Gideon Bollag, Peter Hirth, James Tsai, Jiazhong Zhang, Prabha N Ibrahim, Hanna Cho, Wayne Spevak, Chao Zhang, Ying Zhang, Gaston Habets,[...]. Nature 2010
17

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial.
Axel Hauschild, Jean-Jacques Grob, Lev V Demidov, Thomas Jouary, Ralf Gutzmer, Michael Millward, Piotr Rutkowski, Christian U Blank, Wilson H Miller, Eckhart Kaempgen,[...]. Lancet 2012
17

RAF inhibitors that evade paradoxical MAPK pathway activation.
Chao Zhang, Wayne Spevak, Ying Zhang, Elizabeth A Burton, Yan Ma, Gaston Habets, Jiazhong Zhang, Jack Lin, Todd Ewing, Bernice Matusow,[...]. Nature 2015
233
17

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.
Piro Lito, Anna Saborowski, Jingyin Yue, Martha Solomon, Eric Joseph, Sunyana Gadal, Michael Saborowski, Edward Kastenhuber, Christof Fellmann, Kazuhiro Ohara,[...]. Cancer Cell 2014
186
17

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
Zhan Yao, Rona Yaeger, Vanessa S Rodrik-Outmezguine, Anthony Tao, Neilawattie M Torres, Matthew T Chang, Matthias Drosten, Huiyong Zhao, Fabiola Cecchi, Todd Hembrough,[...]. Nature 2017
271
17

Kinases and pseudokinases: lessons from RAF.
Andrey S Shaw, Alexandr P Kornev, Jiancheng Hu, Lalima G Ahuja, Susan S Taylor. Mol Cell Biol 2014
100
17

New perspectives for targeting RAF kinase in human cancer.
Zoi Karoulia, Evripidis Gavathiotis, Poulikos I Poulikakos. Nat Rev Cancer 2017
201
17

MEK drives BRAF activation through allosteric control of KSR proteins.
Hugo Lavoie, Malha Sahmi, Pierre Maisonneuve, Sara A Marullo, Neroshan Thevakumaran, Ting Jin, Igor Kurinov, Frank Sicheri, Marc Therrien. Nature 2018
65
26

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.
Yasushi Kondo, Jana Ognjenović, Saikat Banerjee, Deepti Karandur, Alan Merk, Kayla Kulhanek, Kathryn Wong, Jeroen P Roose, Sriram Subramaniam, John Kuriyan. Science 2019
66
25

Regulation and role of Raf-1/B-Raf heterodimerization.
Linda K Rushworth, Alison D Hindley, Eric O'Neill, Walter Kolch. Mol Cell Biol 2006
291
16

Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
Paul B Chapman, Axel Hauschild, Caroline Robert, John B Haanen, Paolo Ascierto, James Larkin, Reinhard Dummer, Claus Garbe, Alessandro Testori, Michele Maio,[...]. N Engl J Med 2011
16

An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.
Zoi Karoulia, Yang Wu, Tamer A Ahmed, Qisheng Xin, Julien Bollard, Clemens Krepler, Xuewei Wu, Chao Zhang, Gideon Bollag, Meenhard Herlyn,[...]. Cancer Cell 2016
82
18

Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.
Alyson K Freeman, Daniel A Ritt, Deborah K Morrison. Mol Cell 2013
145
15

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.
James Tsai, John T Lee, Weiru Wang, Jiazhong Zhang, Hanna Cho, Shumeye Mamo, Ryan Bremer, Sam Gillette, Jun Kong, Nikolas K Haass,[...]. Proc Natl Acad Sci U S A 2008
964
15

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Damian F Brennan, Arvin C Dar, Nicholas T Hertz, William C H Chao, Alma L Burlingame, Kevan M Shokat, David Barford. Nature 2011
185
15

RAS Proteins and Their Regulators in Human Disease.
Dhirendra K Simanshu, Dwight V Nissley, Frank McCormick. Cell 2017
729
15

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
Thierry O Fischmann, Catherine K Smith, Todd W Mayhood, Joseph E Myers, Paul Reichert, Anthony Mannarino, Donna Carr, Hugh Zhu, Jesse Wong, Rong-Sheng Yang,[...]. Biochemistry 2009
124
14

Autoregulation of the Raf-1 serine/threonine kinase.
R E Cutler, R M Stephens, M R Saracino, D K Morrison. Proc Natl Acad Sci U S A 1998
126
14

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
Nicholas P D Liau, Timothy J Wendorff, John G Quinn, Micah Steffek, Wilson Phung, Peter Liu, Jia Tang, Flaviyan J Irudayanathan, Saeed Izadi, Andrey S Shaw,[...]. Nat Struct Mol Biol 2020
34
41

Regulation of Raf-1 by direct feedback phosphorylation.
Michele K Dougherty, Jürgen Müller, Daniel A Ritt, Ming Zhou, Xiao Zhen Zhou, Terry D Copeland, Thomas P Conrads, Timothy D Veenstra, Kun Ping Lu, Deborah K Morrison. Mol Cell 2005
434
13

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.
Britta Diedrich, Kristoffer Tg Rigbolt, Michael Röring, Ricarda Herr, Stephanie Kaeser-Pebernard, Christine Gretzmeier, Robert F Murphy, Tilman Brummer, Jörn Dengjel. EMBO J 2017
39
30

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Georgia Hatzivassiliou, Jacob R Haling, Huifen Chen, Kyung Song, Steve Price, Robert Heald, Joanne F M Hewitt, Mark Zak, Ariana Peck, Christine Orr,[...]. Nature 2013
203
12

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
Hugo Lavoie, Neroshan Thevakumaran, Gwenaëlle Gavory, John J Li, Abbas Padeganeh, Sébastien Guiral, Jean Duchaine, Daniel Y L Mao, Michel Bouvier, Frank Sicheri,[...]. Nat Chem Biol 2013
111
12

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.
Nancy H Tran, Xiaochong Wu, Jeffrey A Frost. J Biol Chem 2005
100
12

PHENIX: a comprehensive Python-based system for macromolecular structure solution.
Paul D Adams, Pavel V Afonine, Gábor Bunkóczi, Vincent B Chen, Ian W Davis, Nathaniel Echols, Jeffrey J Headd, Li-Wei Hung, Gary J Kapral, Ralf W Grosse-Kunstleve,[...]. Acta Crystallogr D Biol Crystallogr 2010
12

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
Jiancheng Hu, Haiyang Yu, Alexandr P Kornev, Jianping Zhao, Erin L Filbert, Susan S Taylor, Andrey S Shaw. Proc Natl Acad Sci U S A 2011
101
12

Kinase regulation by hydrophobic spine assembly in cancer.
Jiancheng Hu, Lalima G Ahuja, Hiruy S Meharena, Natarajan Kannan, Alexandr P Kornev, Susan S Taylor, Andrey S Shaw. Mol Cell Biol 2015
68
17


Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.
Michael Röring, Ricarda Herr, Gina J Fiala, Katharina Heilmann, Sandra Braun, Anja E Eisenhardt, Sebastian Halbach, David Capper, Andreas von Deimling, Wolfgang W Schamel,[...]. EMBO J 2012
90
12

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism.
Alexandr P Kornev, Nina M Haste, Susan S Taylor, Lynn F Ten Eyck. Proc Natl Acad Sci U S A 2006
500
11

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Scott A Foster, Daniel M Whalen, Ayşegül Özen, Matthew J Wongchenko, JianPing Yin, Ivana Yen, Gabriele Schaefer, John D Mayfield, Juliann Chmielecki, Philip J Stephens,[...]. Cancer Cell 2016
125
11

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.
H R Mott, J W Carpenter, S Zhong, S Ghosh, R M Bell, S L Campbell. Proc Natl Acad Sci U S A 1996
159
11



Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.