Yadong Huang, Robert W Mahley. Neurobiol Dis 2014
Times Cited: 287
Times Cited: 287
Times Cited
Times Co-cited
Similarity
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
E H Corder, A M Saunders, W J Strittmatter, D E Schmechel, P C Gaskell, G W Small, A D Roses, J L Haines, M A Pericak-Vance. Science 1993
E H Corder, A M Saunders, W J Strittmatter, D E Schmechel, P C Gaskell, G W Small, A D Roses, J L Haines, M A Pericak-Vance. Science 1993
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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Chia-Chen Liu, Chia-Chan Liu, Takahisa Kanekiyo, Huaxi Xu, Guojun Bu. Nat Rev Neurol 2013
Chia-Chen Liu, Chia-Chan Liu, Takahisa Kanekiyo, Huaxi Xu, Guojun Bu. Nat Rev Neurol 2013
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Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.
Robert W Mahley. J Mol Med (Berl) 2016
Robert W Mahley. J Mol Med (Berl) 2016
13
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
Joseph M Castellano, Jungsu Kim, Floy R Stewart, Hong Jiang, Ronald B DeMattos, Bruce W Patterson, Anne M Fagan, John C Morris, Kwasi G Mawuenyega, Carlos Cruchaga,[...]. Sci Transl Med 2011
Joseph M Castellano, Jungsu Kim, Floy R Stewart, Hong Jiang, Ronald B DeMattos, Bruce W Patterson, Anne M Fagan, John C Morris, Kwasi G Mawuenyega, Carlos Cruchaga,[...]. Sci Transl Med 2011
13
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.
Yu-Wen Alvin Huang, Bo Zhou, Marius Wernig, Thomas C Südhof. Cell 2017
Yu-Wen Alvin Huang, Bo Zhou, Marius Wernig, Thomas C Südhof. Cell 2017
13
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Chengzhong Wang, Ramsey Najm, Qin Xu, Dah-Eun Jeong, David Walker, Maureen E Balestra, Seo Yeon Yoon, Heidi Yuan, Gang Li, Zachary A Miller,[...]. Nat Med 2018
Chengzhong Wang, Ramsey Najm, Qin Xu, Dah-Eun Jeong, David Walker, Maureen E Balestra, Seo Yeon Yoon, Heidi Yuan, Gang Li, Zachary A Miller,[...]. Nat Med 2018
12
Apolipoprotein E: far more than a lipid transport protein.
R W Mahley, S C Rall. Annu Rev Genomics Hum Genet 2000
R W Mahley, S C Rall. Annu Rev Genomics Hum Genet 2000
12
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
Qin Xu, Aubrey Bernardo, David Walker, Tiffany Kanegawa, Robert W Mahley, Yadong Huang. J Neurosci 2006
Qin Xu, Aubrey Bernardo, David Walker, Tiffany Kanegawa, Robert W Mahley, Yadong Huang. J Neurosci 2006
10
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
R W Mahley. Science 1988
R W Mahley. Science 1988
10
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
L A Farrer, L A Cupples, J L Haines, B Hyman, W A Kukull, R Mayeux, R H Myers, M A Pericak-Vance, N Risch, C M van Duijn. JAMA 1997
L A Farrer, L A Cupples, J L Haines, B Hyman, W A Kukull, R Mayeux, R H Myers, M A Pericak-Vance, N Risch, C M van Duijn. JAMA 1997
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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.
E H Corder, A M Saunders, N J Risch, W J Strittmatter, D E Schmechel, P C Gaskell, J B Rimmler, P A Locke, P M Conneally, K E Schmader. Nat Genet 1994
E H Corder, A M Saunders, N J Risch, W J Strittmatter, D E Schmechel, P C Gaskell, J B Rimmler, P A Locke, P M Conneally, K E Schmader. Nat Genet 1994
10
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,[...]. Nat Genet 2009
Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,[...]. Nat Genet 2009
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Apolipoprotein E structure: insights into function.
Danny M Hatters, Clare A Peters-Libeu, Karl H Weisgraber. Trends Biochem Sci 2006
Danny M Hatters, Clare A Peters-Libeu, Karl H Weisgraber. Trends Biochem Sci 2006
10
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas,[...]. Nature 2017
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas,[...]. Nature 2017
9
Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.
Joseph F Arboleda-Velasquez, Francisco Lopera, Michael O'Hare, Santiago Delgado-Tirado, Claudia Marino, Natalia Chmielewska, Kahira L Saez-Torres, Dhanesh Amarnani, Aaron P Schultz, Reisa A Sperling,[...]. Nat Med 2019
Joseph F Arboleda-Velasquez, Francisco Lopera, Michael O'Hare, Santiago Delgado-Tirado, Claudia Marino, Natalia Chmielewska, Kahira L Saez-Torres, Dhanesh Amarnani, Aaron P Schultz, Reisa A Sperling,[...]. Nat Med 2019
9
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf,[...]. Nat Genet 2019
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf,[...]. Nat Genet 2019
9
Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.
Robert W Mahley. Arterioscler Thromb Vasc Biol 2016
Robert W Mahley. Arterioscler Thromb Vasc Biol 2016
9
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton,[...]. J Clin Invest 2018
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton,[...]. J Clin Invest 2018
10
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Robert W Mahley, Karl H Weisgraber, Yadong Huang. J Lipid Res 2009
Robert W Mahley, Karl H Weisgraber, Yadong Huang. J Lipid Res 2009
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Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease.
A David Marais. Pathology 2019
A David Marais. Pathology 2019
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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
D E Schmechel, A M Saunders, W J Strittmatter, B J Crain, C M Hulette, S H Joo, M A Pericak-Vance, D Goldgaber, A D Roses. Proc Natl Acad Sci U S A 1993
D E Schmechel, A M Saunders, W J Strittmatter, B J Crain, C M Hulette, S H Joo, M A Pericak-Vance, D Goldgaber, A D Roses. Proc Natl Acad Sci U S A 1993
8
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
J C Lambert, C A Ibrahim-Verbaas, D Harold, A C Naj, R Sims, C Bellenguez, A L DeStafano, J C Bis, G W Beecham, B Grenier-Boley,[...]. Nat Genet 2013
J C Lambert, C A Ibrahim-Verbaas, D Harold, A C Naj, R Sims, C Bellenguez, A L DeStafano, J C Bis, G W Beecham, B Grenier-Boley,[...]. Nat Genet 2013
8
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Eric M Reiman, Joseph F Arboleda-Velasquez, Yakeel T Quiroz, Matthew J Huentelman, Thomas G Beach, Richard J Caselli, Yinghua Chen, Yi Su, Amanda J Myers, John Hardy,[...]. Nat Commun 2020
Eric M Reiman, Joseph F Arboleda-Velasquez, Yakeel T Quiroz, Matthew J Huentelman, Thomas G Beach, Richard J Caselli, Yinghua Chen, Yi Su, Amanda J Myers, John Hardy,[...]. Nat Commun 2020
8
The role of apolipoprotein E in Alzheimer's disease.
Jungsu Kim, Jacob M Basak, David M Holtzman. Neuron 2009
Jungsu Kim, Jacob M Basak, David M Holtzman. Neuron 2009
8
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
A M Saunders, W J Strittmatter, D Schmechel, P H George-Hyslop, M A Pericak-Vance, S H Joo, B L Rosi, J F Gusella, D R Crapper-MacLachlan, M J Alberts. Neurology 1993
A M Saunders, W J Strittmatter, D Schmechel, P H George-Hyslop, M A Pericak-Vance, S H Joo, B L Rosi, J F Gusella, D R Crapper-MacLachlan, M J Alberts. Neurology 1993
8
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Walter J Brecht, Faith M Harris, Shengjun Chang, Ina Tesseur, Gui-Qiu Yu, Qin Xu, Jo Dee Fish, Tony Wyss-Coray, Manuel Buttini, Lennart Mucke,[...]. J Neurosci 2004
Walter J Brecht, Faith M Harris, Shengjun Chang, Ina Tesseur, Gui-Qiu Yu, Qin Xu, Jo Dee Fish, Tony Wyss-Coray, Manuel Buttini, Lennart Mucke,[...]. J Neurosci 2004
7
Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
Kelly R Bales, Feng Liu, Su Wu, Suizhen Lin, Deanna Koger, Cynthia DeLong, Jeffrey C Hansen, Patrick M Sullivan, Steven M Paul. J Neurosci 2009
Kelly R Bales, Feng Liu, Su Wu, Suizhen Lin, Deanna Koger, Cynthia DeLong, Jeffrey C Hansen, Patrick M Sullivan, Steven M Paul. J Neurosci 2009
7
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions.
Jianglei Chen, Qianqian Li, Jianjun Wang. Proc Natl Acad Sci U S A 2011
Jianglei Chen, Qianqian Li, Jianjun Wang. Proc Natl Acad Sci U S A 2011
7
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
Suzanne E Wahrle, Hong Jiang, Maia Parsadanian, Justin Legleiter, Xianlin Han, John D Fryer, Tomasz Kowalewski, David M Holtzman. J Biol Chem 2004
Suzanne E Wahrle, Hong Jiang, Maia Parsadanian, Justin Legleiter, Xianlin Han, John D Fryer, Tomasz Kowalewski, David M Holtzman. J Biol Chem 2004
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ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
Takahisa Kanekiyo, Huaxi Xu, Guojun Bu. Neuron 2014
Takahisa Kanekiyo, Huaxi Xu, Guojun Bu. Neuron 2014
7
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
W J Strittmatter, K H Weisgraber, D Y Huang, L M Dong, G S Salvesen, M Pericak-Vance, D Schmechel, A M Saunders, D Goldgaber, A D Roses. Proc Natl Acad Sci U S A 1993
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7
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.
Na Zhao, Chia-Chen Liu, Wenhui Qiao, Guojun Bu. Biol Psychiatry 2018
Na Zhao, Chia-Chen Liu, Wenhui Qiao, Guojun Bu. Biol Psychiatry 2018
7
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
W J Strittmatter, A M Saunders, D Schmechel, M Pericak-Vance, J Enghild, G S Salvesen, A D Roses. Proc Natl Acad Sci U S A 1993
W J Strittmatter, A M Saunders, D Schmechel, M Pericak-Vance, J Enghild, G S Salvesen, A D Roses. Proc Natl Acad Sci U S A 1993
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A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward.
Michaël E Belloy, Valerio Napolioni, Michael D Greicius. Neuron 2019
Michaël E Belloy, Valerio Napolioni, Michael D Greicius. Neuron 2019
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Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
Angel C Y Mak, Clive R Pullinger, Ling Fung Tang, Jinny S Wong, Rahul C Deo, Jean-Marc Schwarz, Alejandro Gugliucci, Irina Movsesyan, Brian Y Ishida, Catherine Chu,[...]. JAMA Neurol 2014
Angel C Y Mak, Clive R Pullinger, Ling Fung Tang, Jinny S Wong, Rahul C Deo, Jean-Marc Schwarz, Alejandro Gugliucci, Irina Movsesyan, Brian Y Ishida, Catherine Chu,[...]. JAMA Neurol 2014
11
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Jean-Charles Lambert, Simon Heath, Gael Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Diana Zelenika, Maria J Bullido, Béatrice Tavernier,[...]. Nat Genet 2009
Jean-Charles Lambert, Simon Heath, Gael Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Diana Zelenika, Maria J Bullido, Béatrice Tavernier,[...]. Nat Genet 2009
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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.
Yu Yamazaki, Na Zhao, Thomas R Caulfield, Chia-Chen Liu, Guojun Bu. Nat Rev Neurol 2019
Yu Yamazaki, Na Zhao, Thomas R Caulfield, Chia-Chen Liu, Guojun Bu. Nat Rev Neurol 2019
7
6
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis.
Jungsu Kim, Adam E M Eltorai, Hong Jiang, Fan Liao, Philip B Verghese, Jaekwang Kim, Floy R Stewart, Jacob M Basak, David M Holtzman. J Exp Med 2012
Jungsu Kim, Adam E M Eltorai, Hong Jiang, Fan Liao, Philip B Verghese, Jaekwang Kim, Floy R Stewart, Jacob M Basak, David M Holtzman. J Exp Med 2012
6
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Y Huang, X Q Liu, T Wyss-Coray, W J Brecht, D A Sanan, R W Mahley. Proc Natl Acad Sci U S A 2001
Y Huang, X Q Liu, T Wyss-Coray, W J Brecht, D A Sanan, R W Mahley. Proc Natl Acad Sci U S A 2001
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Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments.
J Ma, A Yee, H B Brewer, S Das, H Potter. Nature 1994
J Ma, A Yee, H B Brewer, S Das, H Potter. Nature 1994
6
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.
Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu, Mary Jo LaDu. Mol Neurodegener 2014
Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu, Mary Jo LaDu. Mol Neurodegener 2014
6
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Philip B Verghese, Joseph M Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Aarti Shah, Guojun Bu, Carl Frieden, David M Holtzman. Proc Natl Acad Sci U S A 2013
Philip B Verghese, Joseph M Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Aarti Shah, Guojun Bu, Carl Frieden, David M Holtzman. Proc Natl Acad Sci U S A 2013
6
Age, APOE and sex: Triad of risk of Alzheimer's disease.
Brandalyn C Riedel, Paul M Thompson, Roberta Diaz Brinton. J Steroid Biochem Mol Biol 2016
Brandalyn C Riedel, Paul M Thompson, Roberta Diaz Brinton. J Steroid Biochem Mol Biol 2016
6
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Kenneth W Adams, Shuko Takeda, Adrian Olaf Banerji, Akinori Mitani, Daniel Joyner, Diana H Thyssen, Brian J Bacskai,[...]. J Neurosci 2012
Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Kenneth W Adams, Shuko Takeda, Adrian Olaf Banerji, Akinori Mitani, Daniel Joyner, Diana H Thyssen, Brian J Bacskai,[...]. J Neurosci 2012
6
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
K R Bales, T Verina, R C Dodel, Y Du, L Altstiel, M Bender, P Hyslop, E M Johnstone, S P Little, D J Cummins,[...]. Nat Genet 1997
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6
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.
Robert M Koffie, Tadafumi Hashimoto, Hwan-Ching Tai, Kevin R Kay, Alberto Serrano-Pozo, Daniel Joyner, Steven Hou, Katherine J Kopeikina, Matthew P Frosch, Virginia M Lee,[...]. Brain 2012
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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease.
Tosha Williams, David R Borchelt, Paramita Chakrabarty. Mol Neurodegener 2020
Tosha Williams, David R Borchelt, Paramita Chakrabarty. Mol Neurodegener 2020
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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Faith M Harris, Walter J Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C Hopkins, Kimberly Scearce-Levie,[...]. Proc Natl Acad Sci U S A 2003
Faith M Harris, Walter J Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C Hopkins, Kimberly Scearce-Levie,[...]. Proc Natl Acad Sci U S A 2003
6
Apolipoprotein E in Alzheimer's disease: an update.
Jin-Tai Yu, Lan Tan, John Hardy. Annu Rev Neurosci 2014
Jin-Tai Yu, Lan Tan, John Hardy. Annu Rev Neurosci 2014
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.