Martin Picard, Jiangwen Zhang, Saege Hancock, Olga Derbeneva, Ryan Golhar, Pawel Golik, Sean O'Hearn, Shawn Levy, Prasanth Potluri, Maria Lvova, Antonio Davila, Chun Shi Lin, Juan Carlos Perin, Eric F Rappaport, Hakon Hakonarson, Ian A Trounce, Vincent Procaccio, Douglas C Wallace. Proc Natl Acad Sci U S A 2014
Times Cited: 168
Times Cited: 168
Times Cited
Times Co-cited
Similarity
A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.
Y Goto, I Nonaka, S Horai. Nature 1990
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
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Human mitochondrial DNA: roles of inherited and somatic mutations.
Eric A Schon, Salvatore DiMauro, Michio Hirano. Nat Rev Genet 2012
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Premature ageing in mice expressing defective mitochondrial DNA polymerase.
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Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.
Douglas C Wallace, Dimitra Chalkia. Cold Spring Harb Perspect Biol 2013
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Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy.
Piotr K Kopinski, Kevin A Janssen, Patrick M Schaefer, Sophie Trefely, Caroline E Perry, Prasanth Potluri, Jesus A Tintos-Hernandez, Larry N Singh, Kelly R Karch, Sydney L Campbell,[...]. Proc Natl Acad Sci U S A 2019
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Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
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Mitochondrial diseases.
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Gráinne S Gorman, Patrick F Chinnery, Salvatore DiMauro, Michio Hirano, Yasutoshi Koga, Robert McFarland, Anu Suomalainen, David R Thorburn, Massimo Zeviani, Douglass M Turnbull. Nat Rev Dis Primers 2016
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Sequence and organization of the human mitochondrial genome.
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Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
D C Wallace, G Singh, M T Lott, J A Hodge, T G Schurr, A M Lezza, L J Elsas, E K Nikoskelainen. Science 1988
D C Wallace, G Singh, M T Lott, J A Hodge, T G Schurr, A M Lezza, L J Elsas, E K Nikoskelainen. Science 1988
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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
Douglas C Wallace. Annu Rev Genet 2005
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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.
M P King, G Attardi. Science 1989
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Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.
Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fátima Sánchez-Cabo, Carlos Torroja, Rebeca Acín-Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan,[...]. Nature 2016
Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fátima Sánchez-Cabo, Carlos Torroja, Rebeca Acín-Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan,[...]. Nature 2016
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Maternal inheritance of human mitochondrial DNA.
R E Giles, H Blanc, H M Cann, D C Wallace. Proc Natl Acad Sci U S A 1980
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Energetics, epigenetics, mitochondrial genetics.
Douglas C Wallace, Weiwei Fan. Mitochondrion 2010
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Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder.
Yiqin Wang, Martin Picard, Zhenglong Gu. PLoS Genet 2016
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The rise of mitochondria in medicine.
Martin Picard, Douglas C Wallace, Yan Burelle. Mitochondrion 2016
Martin Picard, Douglas C Wallace, Yan Burelle. Mitochondrion 2016
10
Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.
Carla Giordano, Luisa Iommarini, Luca Giordano, Alessandra Maresca, Annalinda Pisano, Maria Lucia Valentino, Leonardo Caporali, Rocco Liguori, Stefania Deceglie, Marina Roberti,[...]. Brain 2014
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Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.
Kaixiong Ye, Jian Lu, Fei Ma, Alon Keinan, Zhenglong Gu. Proc Natl Acad Sci U S A 2014
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10
Pathogenic mitochondrial DNA mutations are common in the general population.
Hannah R Elliott, David C Samuels, James A Eden, Caroline L Relton, Patrick F Chinnery. Am J Hum Genet 2008
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Mitochondrial DNA mutations in human disease.
Robert W Taylor, Doug M Turnbull. Nat Rev Genet 2005
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9
Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.
Riikka H Hämäläinen, Tuula Manninen, Hanna Koivumäki, Mikhail Kislin, Timo Otonkoski, Anu Suomalainen. Proc Natl Acad Sci U S A 2013
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9
Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes.
M P King, Y Koga, M Davidson, E A Schon. Mol Cell Biol 1992
M P King, Y Koga, M Davidson, E A Schon. Mol Cell Biol 1992
9
MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.
A Chomyn, A Martinuzzi, M Yoneda, A Daga, O Hurko, D Johns, S T Lai, I Nonaka, C Angelini, G Attardi. Proc Natl Acad Sci U S A 1992
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Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.
An S Tan, James W Baty, Lan-Feng Dong, Ayenachew Bezawork-Geleta, Berwini Endaya, Jacob Goodwin, Martina Bajzikova, Jaromira Kovarova, Martin Peterka, Bing Yan,[...]. Cell Metab 2015
An S Tan, James W Baty, Lan-Feng Dong, Ayenachew Bezawork-Geleta, Berwini Endaya, Jacob Goodwin, Martina Bajzikova, Jaromira Kovarova, Martin Peterka, Bing Yan,[...]. Cell Metab 2015
9
mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease.
John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman,[...]. EMBO Mol Med 2018
John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman,[...]. EMBO Mol Med 2018
9
Mitochondrial threshold effects.
Rodrigue Rossignol, Benjamin Faustin, Christophe Rocher, Monique Malgat, Jean-Pierre Mazat, Thierry Letellier. Biochem J 2003
Rodrigue Rossignol, Benjamin Faustin, Christophe Rocher, Monique Malgat, Jean-Pierre Mazat, Thierry Letellier. Biochem J 2003
9
Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition.
Mark S Sharpley, Christine Marciniak, Kristin Eckel-Mahan, Meagan McManus, Marco Crimi, Katrina Waymire, Chun Shi Lin, Satoru Masubuchi, Nicole Friend, Maya Koike,[...]. Cell 2012
Mark S Sharpley, Christine Marciniak, Kristin Eckel-Mahan, Meagan McManus, Marco Crimi, Katrina Waymire, Chun Shi Lin, Satoru Masubuchi, Nicole Friend, Maya Koike,[...]. Cell 2012
8
The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2.
Florin Sasarman, Hana Antonicka, Eric A Shoubridge. Hum Mol Genet 2008
Florin Sasarman, Hana Antonicka, Eric A Shoubridge. Hum Mol Genet 2008
8
MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
8
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
8
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells.
Der-Fen Suen, Derek P Narendra, Atsushi Tanaka, Giovanni Manfredi, Richard J Youle. Proc Natl Acad Sci U S A 2010
Der-Fen Suen, Derek P Narendra, Atsushi Tanaka, Giovanni Manfredi, Richard J Youle. Proc Natl Acad Sci U S A 2010
8
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
Kaori Ishikawa, Keizo Takenaga, Miho Akimoto, Nobuko Koshikawa, Aya Yamaguchi, Hirotake Imanishi, Kazuto Nakada, Yoshio Honma, Jun-Ichi Hayashi. Science 2008
Kaori Ishikawa, Keizo Takenaga, Miho Akimoto, Nobuko Koshikawa, Aya Yamaguchi, Hirotake Imanishi, Kazuto Nakada, Yoshio Honma, Jun-Ichi Hayashi. Science 2008
8
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
8
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti,[...]. Nat Med 2018
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti,[...]. Nat Med 2018
8
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
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7
Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress.
Martin Picard, Meagan J McManus, Jason D Gray, Carla Nasca, Cynthia Moffat, Piotr K Kopinski, Erin L Seifert, Bruce S McEwen, Douglas C Wallace. Proc Natl Acad Sci U S A 2015
Martin Picard, Meagan J McManus, Jason D Gray, Carla Nasca, Cynthia Moffat, Piotr K Kopinski, Erin L Seifert, Bruce S McEwen, Douglas C Wallace. Proc Natl Acad Sci U S A 2015
7
The genetics and pathology of mitochondrial disease.
Charlotte L Alston, Mariana C Rocha, Nichola Z Lax, Doug M Turnbull, Robert W Taylor. J Pathol 2017
Charlotte L Alston, Mariana C Rocha, Nichola Z Lax, Doug M Turnbull, Robert W Taylor. J Pathol 2017
7
Psychological Stress and Mitochondria: A Systematic Review.
Martin Picard, Bruce S McEwen. Psychosom Med 2018
Martin Picard, Bruce S McEwen. Psychosom Med 2018
8
A systems approach for decoding mitochondrial retrograde signaling pathways.
Sehyun Chae, Byung Yong Ahn, Kyunghee Byun, Young Min Cho, Myeong-Hee Yu, Bonghee Lee, Daehee Hwang, Kyong Soo Park. Sci Signal 2013
Sehyun Chae, Byung Yong Ahn, Kyunghee Byun, Young Min Cho, Myeong-Hee Yu, Bonghee Lee, Daehee Hwang, Kyong Soo Park. Sci Signal 2013
7
Mitochondrial mutations drive prostate cancer aggression.
Julia F Hopkins, Veronica Y Sabelnykova, Joachim Weischenfeldt, Ronald Simon, Jennifer A Aguiar, Rached Alkallas, Lawrence E Heisler, Junyan Zhang, John D Watson, Melvin L K Chua,[...]. Nat Commun 2017
Julia F Hopkins, Veronica Y Sabelnykova, Joachim Weischenfeldt, Ronald Simon, Jennifer A Aguiar, Rached Alkallas, Lawrence E Heisler, Junyan Zhang, John D Watson, Melvin L K Chua,[...]. Nat Commun 2017
11
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Hsiuchen Chen, Marc Vermulst, Yun E Wang, Anne Chomyn, Tomas A Prolla, J Michael McCaffery, David C Chan. Cell 2010
Hsiuchen Chen, Marc Vermulst, Yun E Wang, Anne Chomyn, Tomas A Prolla, J Michael McCaffery, David C Chan. Cell 2010
7
The clinical maze of mitochondrial neurology.
Salvatore DiMauro, Eric A Schon, Valerio Carelli, Michio Hirano. Nat Rev Neurol 2013
Salvatore DiMauro, Eric A Schon, Valerio Carelli, Michio Hirano. Nat Rev Neurol 2013
7
Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet,[...]. Nucleic Acids Res 2016
Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet,[...]. Nucleic Acids Res 2016
12
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.