Anna Zagórska, Paqui G Través, Erin D Lew, Ian Dransfield, Greg Lemke. Nat Immunol 2014
Times Cited: 254
Times Cited: 254
Times Cited
Times Co-cited
Similarity
TAM receptors are pleiotropic inhibitors of the innate immune response.
Carla V Rothlin, Sourav Ghosh, Elina I Zuniga, Michael B A Oldstone, Greg Lemke. Cell 2007
Carla V Rothlin, Sourav Ghosh, Elina I Zuniga, Michael B A Oldstone, Greg Lemke. Cell 2007
44
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke. Elife 2014
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke. Elife 2014
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Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.
Q Lu, G Lemke. Science 2001
Q Lu, G Lemke. Science 2001
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TAM receptor signaling in immune homeostasis.
Carla V Rothlin, Eugenio A Carrera-Silva, Lidia Bosurgi, Sourav Ghosh. Annu Rev Immunol 2015
Carla V Rothlin, Eugenio A Carrera-Silva, Lidia Bosurgi, Sourav Ghosh. Annu Rev Immunol 2015
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The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Douglas K Graham, Deborah DeRyckere, Kurtis D Davies, H Shelton Earp. Nat Rev Cancer 2014
Douglas K Graham, Deborah DeRyckere, Kurtis D Davies, H Shelton Earp. Nat Rev Cancer 2014
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TAM receptors regulate multiple features of microglial physiology.
Lawrence Fourgeaud, Paqui G Través, Yusuf Tufail, Humberto Leal-Bailey, Erin D Lew, Patrick G Burrola, Perri Callaway, Anna Zagórska, Carla V Rothlin, Axel Nimmerjahn,[...]. Nature 2016
Lawrence Fourgeaud, Paqui G Través, Yusuf Tufail, Humberto Leal-Bailey, Erin D Lew, Patrick G Burrola, Perri Callaway, Anna Zagórska, Carla V Rothlin, Axel Nimmerjahn,[...]. Nature 2016
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Phagocytosis and clearance of apoptotic cells is mediated by MER.
R S Scott, E J McMahon, S M Pop, E A Reap, R Caricchio, P L Cohen, H S Earp, G K Matsushima. Nature 2001
R S Scott, E J McMahon, S M Pop, E A Reap, R Caricchio, P L Cohen, H S Earp, G K Matsushima. Nature 2001
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Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
Wen-I Tsou, Khanh-Quynh N Nguyen, Daniel A Calarese, Scott J Garforth, Anita L Antes, Sergey V Smirnov, Steve C Almo, Raymond B Birge, Sergei V Kotenko. J Biol Chem 2014
Wen-I Tsou, Khanh-Quynh N Nguyen, Daniel A Calarese, Scott J Garforth, Anita L Antes, Sergey V Smirnov, Steve C Almo, Raymond B Birge, Sergei V Kotenko. J Biol Chem 2014
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Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.
Q Lu, M Gore, Q Zhang, T Camenisch, S Boast, F Casagranda, C Lai, M K Skinner, R Klein, G K Matsushima,[...]. Nature 1999
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Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells.
Heather M Seitz, Todd D Camenisch, Greg Lemke, H Shelton Earp, Glenn K Matsushima. J Immunol 2007
Heather M Seitz, Todd D Camenisch, Greg Lemke, H Shelton Earp, Glenn K Matsushima. J Immunol 2007
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Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Gaetano Zizzo, Brendan A Hilliard, Marc Monestier, Philip L Cohen. J Immunol 2012
Gaetano Zizzo, Brendan A Hilliard, Marc Monestier, Philip L Cohen. J Immunol 2012
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TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.
Rachel M A Linger, Amy K Keating, H Shelton Earp, Douglas K Graham. Adv Cancer Res 2008
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Magdalena Paolino, Axel Choidas, Stephanie Wallner, Blanka Pranjic, Iris Uribesalgo, Stefanie Loeser, Amanda M Jamieson, Wallace Y Langdon, Fumiyo Ikeda, Juan Pablo Fededa,[...]. Nature 2014
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TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis.
Jonathan H M van der Meer, Tom van der Poll, Cornelis van 't Veer. Blood 2014
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T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
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15
MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.
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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.
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Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment.
Kayla V Myers, Sarah R Amend, Kenneth J Pienta. Mol Cancer 2019
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The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.
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19
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.
Lidia Bosurgi, Jochem H Bernink, Victor Delgado Cuevas, Nicola Gagliani, Leonel Joannas, Edward T Schmid, Carmen J Booth, Sourav Ghosh, Carla V Rothlin. Proc Natl Acad Sci U S A 2013
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13
A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.
T D Camenisch, B H Koller, H S Earp, G K Matsushima. J Immunol 1999
T D Camenisch, B H Koller, H S Earp, G K Matsushima. J Immunol 1999
13
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
Susan Sather, Karla D Kenyon, Jerry B Lefkowitz, Xiayuan Liang, Brian C Varnum, Peter M Henson, Douglas K Graham. Blood 2007
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MERTK as negative regulator of human T cell activation.
Raquel Cabezón, E Antonio Carrera-Silva, Georgina Flórez-Grau, Andrea E Errasti, Elisabeth Calderón-Gómez, Juan José Lozano, Carolina España, Elena Ricart, Julián Panés, Carla Vanina Rothlin,[...]. J Leukoc Biol 2015
Raquel Cabezón, E Antonio Carrera-Silva, Georgina Flórez-Grau, Andrea E Errasti, Elisabeth Calderón-Gómez, Juan José Lozano, Carolina España, Elena Ricart, Julián Panés, Carla Vanina Rothlin,[...]. J Leukoc Biol 2015
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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Christine Gjerdrum, Crina Tiron, Torill Høiby, Ingunn Stefansson, Hallvard Haugen, Tone Sandal, Karin Collett, Shan Li, Emmet McCormack, Bjørn Tore Gjertsen,[...]. Proc Natl Acad Sci U S A 2010
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12
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
Canan Kasikara, Viralkumar Davra, David Calianese, Ke Geng, Thomas E Spires, Michael Quigley, Michael Wichroski, Ganapathy Sriram, Lucia Suarez-Lopez, Michael B Yaffe,[...]. Cancer Res 2019
Canan Kasikara, Viralkumar Davra, David Calianese, Ke Geng, Thomas E Spires, Michael Quigley, Michael Wichroski, Ganapathy Sriram, Lucia Suarez-Lopez, Michael B Yaffe,[...]. Cancer Res 2019
23
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.
Yi Zhou, Mingjian Fei, Gu Zhang, Wei-Ching Liang, WeiYu Lin, Yan Wu, Robert Piskol, John Ridgway, Erin McNamara, Haochu Huang,[...]. Immunity 2020
Yi Zhou, Mingjian Fei, Gu Zhang, Wei-Ching Liang, WeiYu Lin, Yan Wu, Robert Piskol, John Ridgway, Erin McNamara, Haochu Huang,[...]. Immunity 2020
12
MERTK Acts as a Costimulatory Receptor on Human CD8+ T Cells.
Marlies J W Peeters, Donata Dulkeviciute, Arianna Draghi, Cathrin Ritter, Anne Rahbech, Signe K Skadborg, Tina Seremet, Ana Micaela Carnaz Simões, Evelina Martinenaite, Hólmfridur R Halldórsdóttir,[...]. Cancer Immunol Res 2019
Marlies J W Peeters, Donata Dulkeviciute, Arianna Draghi, Cathrin Ritter, Anne Rahbech, Signe K Skadborg, Tina Seremet, Ana Micaela Carnaz Simões, Evelina Martinenaite, Hólmfridur R Halldórsdóttir,[...]. Cancer Immunol Res 2019
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MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Alisa B Lee-Sherick, Kristen M Jacobsen, Curtis J Henry, Madeline G Huey, Rebecca E Parker, Lauren S Page, Amanda A Hill, Xiaodong Wang, Stephen V Frye, H Shelton Earp,[...]. JCI Insight 2018
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Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor.
Yumi Yokoyama, Erin D Lew, Ruth Seelige, Elizabeth A Tindall, Colin Walsh, Patrick C Fagan, Jack Y Lee, Robin Nevarez, Joanne Oh, Kathleen D Tucker,[...]. Cancer Res 2019
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TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages.
Federica Alciato, Pier Paolo Sainaghi, Daniele Sola, Luigi Castello, Gian Carlo Avanzi. J Leukoc Biol 2010
Federica Alciato, Pier Paolo Sainaghi, Daniele Sola, Luigi Castello, Gian Carlo Avanzi. J Leukoc Biol 2010
11
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis.
Bishuang Cai, Edward B Thorp, Amanda C Doran, Brian E Sansbury, Mat J A P Daemen, Bernhard Dorweiler, Matthew Spite, Gabrielle Fredman, Ira Tabas. J Clin Invest 2017
Bishuang Cai, Edward B Thorp, Amanda C Doran, Brian E Sansbury, Mat J A P Daemen, Bernhard Dorweiler, Matthew Spite, Gabrielle Fredman, Ira Tabas. J Clin Invest 2017
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Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.
Philip L Cohen, Roberto Caricchio, Valsamma Abraham, Todd D Camenisch, J Charles Jennette, Robert A S Roubey, H Shelton Earp, Glenn Matsushima, Elizabeth A Reap. J Exp Med 2002
Philip L Cohen, Roberto Caricchio, Valsamma Abraham, Todd D Camenisch, J Charles Jennette, Robert A S Roubey, H Shelton Earp, Glenn Matsushima, Elizabeth A Reap. J Exp Med 2002
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MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.
Bishuang Cai, Edward B Thorp, Amanda C Doran, Manikandan Subramanian, Brian E Sansbury, Chyuan-Sheng Lin, Matthew Spite, Gabrielle Fredman, Ira Tabas. Proc Natl Acad Sci U S A 2016
Bishuang Cai, Edward B Thorp, Amanda C Doran, Manikandan Subramanian, Brian E Sansbury, Chyuan-Sheng Lin, Matthew Spite, Gabrielle Fredman, Ira Tabas. Proc Natl Acad Sci U S A 2016
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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
Emmanuel L Gautier, Tal Shay, Jennifer Miller, Melanie Greter, Claudia Jakubzick, Stoyan Ivanov, Julie Helft, Andrew Chow, Kutlu G Elpek, Simon Gordonov,[...]. Nat Immunol 2012
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TAM receptors and the clearance of apoptotic cells.
Greg Lemke, Tal Burstyn-Cohen. Ann N Y Acad Sci 2010
Greg Lemke, Tal Burstyn-Cohen. Ann N Y Acad Sci 2010
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Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers.
Aleksander M Grabiec, Anu Goenka, Mark E Fife, Toshifumi Fujimori, Tracy Hussell. Eur J Immunol 2018
Aleksander M Grabiec, Anu Goenka, Mark E Fife, Toshifumi Fujimori, Tracy Hussell. Eur J Immunol 2018
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Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression.
Canan Kasikara, Sushil Kumar, Stanley Kimani, Wen-I Tsou, Ke Geng, Viralkumar Davra, Ganapathy Sriram, Connor Devoe, Khanh-Quynh N Nguyen, Anita Antes,[...]. Mol Cancer Res 2017
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An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system.
C Lai, G Lemke. Neuron 1991
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TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.
Yemsratch T Akalu, Carla V Rothlin, Sourav Ghosh. Immunol Rev 2017
Yemsratch T Akalu, Carla V Rothlin, Sourav Ghosh. Immunol Rev 2017
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Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).
Edward Thorp, Tomas Vaisar, Manikandan Subramanian, Lauren Mautner, Carl Blobel, Ira Tabas. J Biol Chem 2011
Edward Thorp, Tomas Vaisar, Manikandan Subramanian, Lauren Mautner, Carl Blobel, Ira Tabas. J Biol Chem 2011
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Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.
Greg Lemke. Trends Biochem Sci 2017
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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
Lidia Bosurgi, Y Grace Cao, Mar Cabeza-Cabrerizo, Andrea Tucci, Lindsey D Hughes, Yong Kong, Jason S Weinstein, Paula Licona-Limon, Edward T Schmid, Facundo Pelorosso,[...]. Science 2017
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Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
Eric Ubil, Laura Caskey, Alisha Holtzhausen, Debra Hunter, Charlotte Story, H Shelton Earp. J Clin Invest 2018
Eric Ubil, Laura Caskey, Alisha Holtzhausen, Debra Hunter, Charlotte Story, H Shelton Earp. J Clin Invest 2018
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TAM receptor function in the retinal pigment epithelium.
Dipti Prasad, Carla Vanina Rothlin, Patrick Burrola, Tal Burstyn-Cohen, Qingxian Lu, Pablo Garcia de Frutos, Greg Lemke. Mol Cell Neurosci 2006
Dipti Prasad, Carla Vanina Rothlin, Patrick Burrola, Tal Burstyn-Cohen, Qingxian Lu, Pablo Garcia de Frutos, Greg Lemke. Mol Cell Neurosci 2006
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The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.
Edward M Behrens, Paul Gadue, Shun-you Gong, Stacey Garrett, Paul L Stein, Philip L Cohen. Eur J Immunol 2003
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.