A citation-based method for searching scientific literature

Holger K Eltzschig, Donna L Bratton, Sean P Colgan. Nat Rev Drug Discov 2014
Times Cited: 216







List of co-cited articles
772 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Hypoxia and inflammation.
Holger K Eltzschig, Peter Carmeliet. N Engl J Med 2011
18

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield,[...]. Science 2001
13


C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
A C Epstein, J M Gleadle, L A McNeill, K S Hewitson, J O'Rourke, D R Mole, M Mukherji, E Metzen, M I Wilson, A Dhanda,[...]. Cell 2001
12

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Tzu-Lan Yeh, Thomas M Leissing, Martine I Abboud, Cyrille C Thinnes, Onur Atasoylu, James P Holt-Martyn, Dong Zhang, Anthony Tumber, Kerstin Lippl, Christopher T Lohans,[...]. Chem Sci 2017
116
12

Regulation of immunity and inflammation by hypoxia in immunological niches.
Cormac T Taylor, Sean P Colgan. Nat Rev Immunol 2017
259
11

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond.
Patrick H Maxwell, Kai-Uwe Eckardt. Nat Rev Nephrol 2016
162
10


Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, B H Jiang, E A Rue, G L Semenza. Proc Natl Acad Sci U S A 1995
10

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Eoin P Cummins, Edurne Berra, Katrina M Comerford, Amandine Ginouves, Kathleen T Fitzgerald, Fergal Seeballuck, Catherine Godson, Jens E Nielsen, Paul Moynagh, Jacques Pouyssegur,[...]. Proc Natl Acad Sci U S A 2006
564
10

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.
Brian Keith, Randall S Johnson, M Celeste Simon. Nat Rev Cancer 2011
9

HIF-1alpha is essential for myeloid cell-mediated inflammation.
Thorsten Cramer, Yuji Yamanishi, Björn E Clausen, Irmgard Förster, Rafal Pawlinski, Nigel Mackman, Volker H Haase, Rudolf Jaenisch, Maripat Corr, Victor Nizet,[...]. Cell 2003
9

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.
Andreas Robinson, Simon Keely, Jörn Karhausen, Mark E Gerich, Glenn T Furuta, Sean P Colgan. Gastroenterology 2008
286
9

Oxygen sensing, homeostasis, and disease.
Gregg L Semenza. N Engl J Med 2011
667
9

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
Eoin P Cummins, Fergal Seeballuck, Stephen J Keely, Niamh E Mangan, John J Callanan, Padraic G Fallon, Cormac T Taylor. Gastroenterology 2008
311
9

Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.
Robert Provenzano, Anatole Besarab, Chao H Sun, Susan A Diamond, John H Durham, Jose L Cangiano, Joseph R Aiello, James E Novak, Tyson Lee, Robert Leong,[...]. Clin J Am Soc Nephrol 2016
184
9

Oxygen sensing by HIF hydroxylases.
Christopher J Schofield, Peter J Ratcliffe. Nat Rev Mol Cell Biol 2004
9

Ischemia and reperfusion--from mechanism to translation.
Holger K Eltzschig, Tobias Eckle. Nat Med 2011
9

Targeting renal cell carcinoma with a HIF-2 antagonist.
Wenfang Chen, Haley Hill, Alana Christie, Min Soo Kim, Eboni Holloman, Andrea Pavia-Jimenez, Farrah Homayoun, Yuanqing Ma, Nirav Patel, Paul Yell,[...]. Nature 2016
387
8

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Carsten C Scholz, Miguel A S Cavadas, Murtaza M Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G Fallon, Alex Cheong,[...]. Proc Natl Acad Sci U S A 2013
112
8

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.
Murtaza M Tambuwala, Eoin P Cummins, Colin R Lenihan, Judit Kiss, Markus Stauch, Carsten C Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P Saunders,[...]. Gastroenterology 2010
148
8

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.
Kristin Synnestvedt, Glenn T Furuta, Katrina M Comerford, Nancy Louis, Jorn Karhausen, Holger K Eltzschig, Karl R Hansen, Linda F Thompson, Sean P Colgan. J Clin Invest 2002
520
8

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher, P J Ratcliffe. Nature 1999
8

Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.
Tobias Eckle, Emily M Kewley, Kelley S Brodsky, Eunyoung Tak, Stephanie Bonney, Merit Gobel, Devon Anderson, Louise E Glover, Ann K Riegel, Sean P Colgan,[...]. J Immunol 2014
76
10

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning.
Tobias Eckle, David Köhler, Rainer Lehmann, Karim El Kasmi, Holger K Eltzschig. Circulation 2008
317
8

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
Ingo Flamme, Felix Oehme, Peter Ellinghaus, Mario Jeske, Jörg Keldenich, Uwe Thuss. PLoS One 2014
107
8

Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease.
Pablo E Pergola, Bruce S Spinowitz, Charlotte S Hartman, Bradley J Maroni, Volker H Haase. Kidney Int 2016
138
8

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, W G Kaelin. Science 2001
8

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis.
Nan Chen, Chuanming Hao, Xiaomei Peng, Hongli Lin, Aiping Yin, Li Hao, Ye Tao, Xinling Liang, Zhengrong Liu, Changying Xing,[...]. N Engl J Med 2019
241
8

Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis.
Nan Chen, Chuanming Hao, Bi-Cheng Liu, Hongli Lin, Caili Wang, Changying Xing, Xinling Liang, Gengru Jiang, Zhengrong Liu, Xuemei Li,[...]. N Engl J Med 2019
234
8

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis.
Norihiko Takeda, Ellen L O'Dea, Andrew Doedens, Jung-whan Kim, Alexander Weidemann, Christian Stockmann, Masataka Asagiri, M Celeste Simon, Alexander Hoffmann, Randall S Johnson. Genes Dev 2010
402
7

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development.
Mun Chiang Chan, James P Holt-Martyn, Christopher J Schofield, Peter J Ratcliffe. Mol Aspects Med 2016
92
7

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.
Lewis Z Shi, Ruoning Wang, Gonghua Huang, Peter Vogel, Geoffrey Neale, Douglas R Green, Hongbo Chi. J Exp Med 2011
7


Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Eric V Dang, Joseph Barbi, Huang-Yu Yang, Dilini Jinasena, Hong Yu, Ying Zheng, Zachary Bordman, Juan Fu, Young Kim, Hung-Rong Yen,[...]. Cell 2011
974
7

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Tobias Eckle, Kelley Brodsky, Megan Bonney, Thomas Packard, Jun Han, Christoph H Borchers, Thomas J Mariani, Douglas J Kominsky, Michel Mittelbronn, Holger K Eltzschig. PLoS Biol 2013
100
7

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
Jörn Karhausen, Glenn T Furuta, John E Tomaszewski, Randall S Johnson, Sean P Colgan, Volker H Haase. J Clin Invest 2004
434
7

Purinergic signaling during inflammation.
Holger K Eltzschig, Michail V Sitkovsky, Simon C Robson. N Engl J Med 2012
443
7

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Maija Hirsilä, Peppi Koivunen, Volkmar Günzler, Kari I Kivirikko, Johanna Myllyharju. J Biol Chem 2003
607
7

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Martin Schneider, Katie Van Geyte, Peter Fraisl, Judit Kiss, Julián Aragonés, Massimiliano Mazzone, Heimo Mairbäurl, Katrien De Bock, Nam Ho Jeoung, Martin Mollenhauer,[...]. Gastroenterology 2010
99
7

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.
Tobias Eckle, Katherine Hartmann, Stephanie Bonney, Susan Reithel, Michel Mittelbronn, Lori A Walker, Brian D Lowes, Jun Han, Christoph H Borchers, Peter M Buttrick,[...]. Nat Med 2012
217
7

Targeting Hypoxia Signaling for Perioperative Organ Injury.
Xiaoyi Yuan, Jae W Lee, Jessica L Bowser, Viola Neudecker, Srikanth Sridhar, Holger K Eltzschig. Anesth Analg 2018
38
18

Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease.
Edouard R Martin, Mark T Smith, Bradley J Maroni, Qing C Zuraw, Emil M deGoma. Am J Nephrol 2017
85
8

Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents.
Volker H Haase, Glenn M Chertow, Geoffrey A Block, Pablo E Pergola, Emil M deGoma, Zeeshan Khawaja, Amit Sharma, Bradley J Maroni, Peter A McCullough. Nephrol Dial Transplant 2019
53
13


HIF transcription factors, inflammation, and immunity.
Asis Palazon, Ananda W Goldrath, Victor Nizet, Randall S Johnson. Immunity 2014
604
7

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Neil S Sanghani, Volker H Haase. Adv Chronic Kidney Dis 2019
83
8

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.
Hyejin Cho, Xinlin Du, James P Rizzi, Ella Liberzon, Abhishek A Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K Bruick, John A Josey,[...]. Nature 2016
255
6

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
G M Tannahill, A M Curtis, J Adamik, E M Palsson-McDermott, A F McGettrick, G Goel, C Frezza, N J Bernard, B Kelly, N H Foley,[...]. Nature 2013
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.