Rakesh K Jain. Cancer Cell 2014
Times Cited: 787
Times Cited: 787
Times Cited
Times Co-cited
Similarity
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Rakesh K Jain. Science 2005
Rakesh K Jain. Science 2005
20
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Dai Fukumura, Jonas Kloepper, Zohreh Amoozgar, Dan G Duda, Rakesh K Jain. Nat Rev Clin Oncol 2018
Dai Fukumura, Jonas Kloepper, Zohreh Amoozgar, Dan G Duda, Rakesh K Jain. Nat Rev Clin Oncol 2018
19
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers.
Rakesh K Jain. J Clin Oncol 2013
Rakesh K Jain. J Clin Oncol 2013
16
Molecular mechanisms and clinical applications of angiogenesis.
Peter Carmeliet, Rakesh K Jain. Nature 2011
Peter Carmeliet, Rakesh K Jain. Nature 2011
15
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Yuhui Huang, Jianping Yuan, Elda Righi, Walid S Kamoun, Marek Ancukiewicz, Jean Nezivar, Michael Santosuosso, John D Martin, Margaret R Martin, Fabrizio Vianello,[...]. Proc Natl Acad Sci U S A 2012
Yuhui Huang, Jianping Yuan, Elda Righi, Walid S Kamoun, Marek Ancukiewicz, Jean Nezivar, Michael Santosuosso, John D Martin, Margaret R Martin, Fabrizio Vianello,[...]. Proc Natl Acad Sci U S A 2012
15
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming.
Lin Tian, Amit Goldstein, Hai Wang, Hin Ching Lo, Ik Sun Kim, Thomas Welte, Kuanwei Sheng, Lacey E Dobrolecki, Xiaomei Zhang, Nagireddy Putluri,[...]. Nature 2017
Lin Tian, Amit Goldstein, Hai Wang, Hin Ching Lo, Ik Sun Kim, Thomas Welte, Kuanwei Sheng, Lacey E Dobrolecki, Xiaomei Zhang, Nagireddy Putluri,[...]. Nature 2017
14
Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Yuhui Huang, Shom Goel, Dan G Duda, Dai Fukumura, Rakesh K Jain. Cancer Res 2013
Yuhui Huang, Shom Goel, Dan G Duda, Dai Fukumura, Rakesh K Jain. Cancer Res 2013
12
Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa.
Kabir A Khan, Robert S Kerbel. Nat Rev Clin Oncol 2018
Kabir A Khan, Robert S Kerbel. Nat Rev Clin Oncol 2018
12
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Vikash P Chauhan, John D Martin, Hao Liu, Delphine A Lacorre, Saloni R Jain, Sergey V Kozin, Triantafyllos Stylianopoulos, Ahmed S Mousa, Xiaoxing Han, Pichet Adstamongkonkul,[...]. Nat Commun 2013
Vikash P Chauhan, John D Martin, Hao Liu, Delphine A Lacorre, Saloni R Jain, Sergey V Kozin, Triantafyllos Stylianopoulos, Ahmed S Mousa, Xiaoxing Han, Pichet Adstamongkonkul,[...]. Nat Commun 2013
11
Basic and therapeutic aspects of angiogenesis.
Michael Potente, Holger Gerhardt, Peter Carmeliet. Cell 2011
Michael Potente, Holger Gerhardt, Peter Carmeliet. Cell 2011
10
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji, Meriem Hasmim, Saoussen Karray, Philippe Dessen, Vincenzo Bronte, Salem Chouaib. J Exp Med 2014
Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji, Meriem Hasmim, Saoussen Karray, Philippe Dessen, Vincenzo Bronte, Salem Chouaib. J Exp Med 2014
9
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.
Richard S Finn, Shukui Qin, Masafumi Ikeda, Peter R Galle, Michel Ducreux, Tae-You Kim, Masatoshi Kudo, Valeriy Breder, Philippe Merle, Ahmed O Kaseb,[...]. N Engl J Med 2020
Richard S Finn, Shukui Qin, Masafumi Ikeda, Peter R Galle, Michel Ducreux, Tae-You Kim, Masatoshi Kudo, Valeriy Breder, Philippe Merle, Ahmed O Kaseb,[...]. N Engl J Med 2020
9
Normalization of the vasculature for treatment of cancer and other diseases.
Shom Goel, Dan G Duda, Lei Xu, Lance L Munn, Yves Boucher, Dai Fukumura, Rakesh K Jain. Physiol Rev 2011
Shom Goel, Dan G Duda, Lei Xu, Lance L Munn, Yves Boucher, Dai Fukumura, Rakesh K Jain. Physiol Rev 2011
9
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Teresa E Peterson, Nathaniel D Kirkpatrick, Yuhui Huang, Christian T Farrar, Koen A Marijt, Jonas Kloepper, Meenal Datta, Zohreh Amoozgar, Giorgio Seano, Keehoon Jung,[...]. Proc Natl Acad Sci U S A 2016
Teresa E Peterson, Nathaniel D Kirkpatrick, Yuhui Huang, Christian T Farrar, Koen A Marijt, Jonas Kloepper, Meenal Datta, Zohreh Amoozgar, Giorgio Seano, Keehoon Jung,[...]. Proc Natl Acad Sci U S A 2016
9
Microenvironmental regulation of tumour angiogenesis.
Michele De Palma, Daniela Biziato, Tatiana V Petrova. Nat Rev Cancer 2017
Michele De Palma, Daniela Biziato, Tatiana V Petrova. Nat Rev Cancer 2017
8
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis.
Marta Pàez-Ribes, Elizabeth Allen, James Hudock, Takaaki Takeda, Hiroaki Okuyama, Francesc Viñals, Masahiro Inoue, Gabriele Bergers, Douglas Hanahan, Oriol Casanovas. Cancer Cell 2009
Marta Pàez-Ribes, Elizabeth Allen, James Hudock, Takaaki Takeda, Hiroaki Okuyama, Francesc Viñals, Masahiro Inoue, Gabriele Bergers, Douglas Hanahan, Oriol Casanovas. Cancer Cell 2009
8
Improving immune-vascular crosstalk for cancer immunotherapy.
Yuhui Huang, Betty Y S Kim, Charles K Chan, Stephen M Hahn, Irving L Weissman, Wen Jiang. Nat Rev Immunol 2018
Yuhui Huang, Betty Y S Kim, Charles K Chan, Stephen M Hahn, Irving L Weissman, Wen Jiang. Nat Rev Immunol 2018
8
Increased vessel perfusion predicts the efficacy of immune checkpoint blockade.
Xichen Zheng, Zhaoxu Fang, Xiaomei Liu, Shengming Deng, Pei Zhou, Xuexiang Wang, Chenglin Zhang, Rongping Yin, Haitian Hu, Xiaolan Chen,[...]. J Clin Invest 2018
Xichen Zheng, Zhaoxu Fang, Xiaomei Liu, Shengming Deng, Pei Zhou, Xuexiang Wang, Chenglin Zhang, Rongping Yin, Haitian Hu, Xiaolan Chen,[...]. J Clin Invest 2018
10
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Vikash P Chauhan, Triantafyllos Stylianopoulos, John D Martin, Zoran Popović, Ou Chen, Walid S Kamoun, Moungi G Bawendi, Dai Fukumura, Rakesh K Jain. Nat Nanotechnol 2012
Vikash P Chauhan, Triantafyllos Stylianopoulos, John D Martin, Zoran Popović, Ou Chen, Walid S Kamoun, Moungi G Bawendi, Dai Fukumura, Rakesh K Jain. Nat Nanotechnol 2012
8
Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.
John D Martin, Giorgio Seano, Rakesh K Jain. Annu Rev Physiol 2019
John D Martin, Giorgio Seano, Rakesh K Jain. Annu Rev Physiol 2019
8
Tumor angiogenesis: causes, consequences, challenges and opportunities.
Roberta Lugano, Mohanraj Ramachandran, Anna Dimberg. Cell Mol Life Sci 2020
Roberta Lugano, Mohanraj Ramachandran, Anna Dimberg. Cell Mol Life Sci 2020
8
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Peter Carmeliet, Rakesh K Jain. Nat Rev Drug Discov 2011
Peter Carmeliet, Rakesh K Jain. Nat Rev Drug Discov 2011
8
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
8
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Gregory T Motz, Stephen P Santoro, Li-Ping Wang, Tom Garrabrant, Ricardo R Lastra, Ian S Hagemann, Priti Lal, Michael D Feldman, Fabian Benencia, George Coukos. Nat Med 2014
Gregory T Motz, Stephen P Santoro, Li-Ping Wang, Tom Garrabrant, Ricardo R Lastra, Ian S Hagemann, Priti Lal, Michael D Feldman, Fabian Benencia, George Coukos. Nat Med 2014
8
Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade.
Martina Schmittnaegel, Nicolò Rigamonti, Ece Kadioglu, Antonino Cassará, Céline Wyser Rmili, Anna Kiialainen, Yvonne Kienast, Hans-Joachim Mueller, Chia-Huey Ooi, Damya Laoui,[...]. Sci Transl Med 2017
Martina Schmittnaegel, Nicolò Rigamonti, Ece Kadioglu, Antonino Cassará, Céline Wyser Rmili, Anna Kiialainen, Yvonne Kienast, Hans-Joachim Mueller, Chia-Huey Ooi, Damya Laoui,[...]. Sci Transl Med 2017
8
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.
Mark A Socinski, Robert M Jotte, Federico Cappuzzo, Francisco Orlandi, Daniil Stroyakovskiy, Naoyuki Nogami, Delvys Rodríguez-Abreu, Denis Moro-Sibilot, Christian A Thomas, Fabrice Barlesi,[...]. N Engl J Med 2018
Mark A Socinski, Robert M Jotte, Federico Cappuzzo, Francisco Orlandi, Daniil Stroyakovskiy, Naoyuki Nogami, Delvys Rodríguez-Abreu, Denis Moro-Sibilot, Christian A Thomas, Fabrice Barlesi,[...]. N Engl J Med 2018
8
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.
Anna Rita Cantelmo, Lena-Christin Conradi, Aleksandra Brajic, Jermaine Goveia, Joanna Kalucka, Andreas Pircher, Pallavi Chaturvedi, Johanna Hol, Bernard Thienpont, Laure-Anne Teuwen,[...]. Cancer Cell 2016
Anna Rita Cantelmo, Lena-Christin Conradi, Aleksandra Brajic, Jermaine Goveia, Joanna Kalucka, Andreas Pircher, Pallavi Chaturvedi, Johanna Hol, Bernard Thienpont, Laure-Anne Teuwen,[...]. Cancer Cell 2016
7
Modes of resistance to anti-angiogenic therapy.
Gabriele Bergers, Douglas Hanahan. Nat Rev Cancer 2008
Gabriele Bergers, Douglas Hanahan. Nat Rev Cancer 2008
7
Defining the role of the tumor vasculature in antitumor immunity and immunotherapy.
Marco B Schaaf, Abhishek D Garg, Patrizia Agostinis. Cell Death Dis 2018
Marco B Schaaf, Abhishek D Garg, Patrizia Agostinis. Cell Death Dis 2018
7
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.
D I Gabrilovich, H L Chen, K R Girgis, H T Cunningham, G M Meny, S Nadaf, D Kavanaugh, D P Carbone. Nat Med 1996
D I Gabrilovich, H L Chen, K R Girgis, H T Cunningham, G M Meny, S Nadaf, D Kavanaugh, D P Carbone. Nat Med 1996
7
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Brian I Rini, Elizabeth R Plimack, Viktor Stus, Rustem Gafanov, Robert Hawkins, Dmitry Nosov, Frédéric Pouliot, Boris Alekseev, Denis Soulières, Bohuslav Melichar,[...]. N Engl J Med 2019
Brian I Rini, Elizabeth R Plimack, Viktor Stus, Rustem Gafanov, Robert Hawkins, Dmitry Nosov, Frédéric Pouliot, Boris Alekseev, Denis Soulières, Bohuslav Melichar,[...]. N Engl J Med 2019
7
Tumor angiogenesis: molecular pathways and therapeutic targets.
Sara M Weis, David A Cheresh. Nat Med 2011
Sara M Weis, David A Cheresh. Nat Med 2011
7
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
Rakesh R Ramjiawan, Arjan W Griffioen, Dan G Duda. Angiogenesis 2017
Rakesh R Ramjiawan, Arjan W Griffioen, Dan G Duda. Angiogenesis 2017
7
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.
Thibault Voron, Orianne Colussi, Elie Marcheteau, Simon Pernot, Mevyn Nizard, Anne-Laure Pointet, Sabrina Latreche, Sonia Bergaya, Nadine Benhamouda, Corinne Tanchot,[...]. J Exp Med 2015
Thibault Voron, Orianne Colussi, Elie Marcheteau, Simon Pernot, Mevyn Nizard, Anne-Laure Pointet, Sabrina Latreche, Sonia Bergaya, Nadine Benhamouda, Corinne Tanchot,[...]. J Exp Med 2015
7
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
Alan Sandler, Robert Gray, Michael C Perry, Julie Brahmer, Joan H Schiller, Afshin Dowlati, Rogerio Lilenbaum, David H Johnson. N Engl J Med 2006
Alan Sandler, Robert Gray, Michael C Perry, Julie Brahmer, Joan H Schiller, Afshin Dowlati, Rogerio Lilenbaum, David H Johnson. N Engl J Med 2006
7
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Frank Winkler, Sergey V Kozin, Ricky T Tong, Sung-Suk Chae, Michael F Booth, Igor Garkavtsev, Lei Xu, Daniel J Hicklin, Dai Fukumura, Emmanuelle di Tomaso,[...]. Cancer Cell 2004
Frank Winkler, Sergey V Kozin, Ricky T Tong, Sung-Suk Chae, Michael F Booth, Igor Garkavtsev, Lei Xu, Daniel J Hicklin, Dai Fukumura, Emmanuelle di Tomaso,[...]. Cancer Cell 2004
7
Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma.
Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Rakesh R Ramjiawan,[...]. Hepatology 2020
Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Rakesh R Ramjiawan,[...]. Hepatology 2020
7
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Yanxia Zhao, Jinghong Cao, Alexander Melamed, Michael Worley, Allison Gockley, Dennis Jones, Hadi T Nia, Yanling Zhang, Triantafyllos Stylianopoulos, Ashwin S Kumar,[...]. Proc Natl Acad Sci U S A 2019
Yanxia Zhao, Jinghong Cao, Alexander Melamed, Michael Worley, Allison Gockley, Dennis Jones, Hadi T Nia, Yanling Zhang, Triantafyllos Stylianopoulos, Ashwin S Kumar,[...]. Proc Natl Acad Sci U S A 2019
8
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity.
Won Suk Lee, Hannah Yang, Hong Jae Chon, Chan Kim. Exp Mol Med 2020
Won Suk Lee, Hannah Yang, Hong Jae Chon, Chan Kim. Exp Mol Med 2020
8
Antiangiogenic therapy in oncology: current status and future directions.
Gordon C Jayson, Robert Kerbel, Lee M Ellis, Adrian L Harris. Lancet 2016
Gordon C Jayson, Robert Kerbel, Lee M Ellis, Adrian L Harris. Lancet 2016
7
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Sara M Tolaney, Yves Boucher, Dan G Duda, John D Martin, Giorgio Seano, Marek Ancukiewicz, William T Barry, Shom Goel, Johanna Lahdenrata, Steven J Isakoff,[...]. Proc Natl Acad Sci U S A 2015
Sara M Tolaney, Yves Boucher, Dan G Duda, John D Martin, Giorgio Seano, Marek Ancukiewicz, William T Barry, Shom Goel, Johanna Lahdenrata, Steven J Isakoff,[...]. Proc Natl Acad Sci U S A 2015
7
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer.
Napoleone Ferrara, Kenneth J Hillan, Hans-Peter Gerber, William Novotny. Nat Rev Drug Discov 2004
Napoleone Ferrara, Kenneth J Hillan, Hans-Peter Gerber, William Novotny. Nat Rev Drug Discov 2004
6
Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
Robert J Motzer, Konstantin Penkov, John Haanen, Brian Rini, Laurence Albiges, Matthew T Campbell, Balaji Venugopal, Christian Kollmannsberger, Sylvie Negrier, Motohide Uemura,[...]. N Engl J Med 2019
Robert J Motzer, Konstantin Penkov, John Haanen, Brian Rini, Laurence Albiges, Matthew T Campbell, Balaji Venugopal, Christian Kollmannsberger, Sylvie Negrier, Motohide Uemura,[...]. N Engl J Med 2019
6
Role of hypoxia in cancer therapy by regulating the tumor microenvironment.
Xinming Jing, Fengming Yang, Chuchu Shao, Ke Wei, Mengyan Xie, Hua Shen, Yongqian Shu. Mol Cancer 2019
Xinming Jing, Fengming Yang, Chuchu Shao, Ke Wei, Mengyan Xie, Hua Shen, Yongqian Shu. Mol Cancer 2019
6
Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain. Trends Cancer 2018
Triantafyllos Stylianopoulos, Lance L Munn, Rakesh K Jain. Trends Cancer 2018
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.