Alicia M Pickrell, Richard J Youle. Neuron 2015
Times Cited: 938
Times Cited: 938
Times Cited
Times Co-cited
Similarity
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle. PLoS Biol 2010
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle. PLoS Biol 2010
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
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Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
Noriyuki Matsuda, Shigeto Sato, Kahori Shiba, Kei Okatsu, Keiko Saisho, Clement A Gautier, Yu-Shin Sou, Shinji Saiki, Sumihiro Kawajiri, Fumiaki Sato,[...]. J Cell Biol 2010
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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.
Sarah Pickles, Pierre Vigié, Richard J Youle. Curr Biol 2018
Sarah Pickles, Pierre Vigié, Richard J Youle. Curr Biol 2018
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Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
Enza Maria Valente, Patrick M Abou-Sleiman, Viviana Caputo, Miratul M K Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G Healy,[...]. Science 2004
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
Sven Geisler, Kira M Holmström, Diana Skujat, Fabienne C Fiesel, Oliver C Rothfuss, Philipp J Kahle, Wolfdieter Springer. Nat Cell Biol 2010
Sven Geisler, Kira M Holmström, Diana Skujat, Fabienne C Fiesel, Oliver C Rothfuss, Philipp J Kahle, Wolfdieter Springer. Nat Cell Biol 2010
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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.
Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi,[...]. Nat Cell Biol 2012
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.
Seok Min Jin, Michael Lazarou, Chunxin Wang, Lesley A Kane, Derek P Narendra, Richard J Youle. J Cell Biol 2010
Seok Min Jin, Michael Lazarou, Chunxin Wang, Lesley A Kane, Derek P Narendra, Richard J Youle. J Cell Biol 2010
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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
Cristofol Vives-Bauza, Chun Zhou, Yong Huang, Mei Cui, Rosa L A de Vries, Jiho Kim, Jessica May, Maja Aleksandra Tocilescu, Wencheng Liu, Han Seok Ko,[...]. Proc Natl Acad Sci U S A 2010
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
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PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
Yun Chen, Gerald W Dorn. Science 2013
Yun Chen, Gerald W Dorn. Science 2013
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PINK1-induced mitophagy promotes neuroprotection in Huntington's disease.
B Khalil, N El Fissi, A Aouane, M-J Cabirol-Pol, T Rival, J-C Liévens. Cell Death Dis 2015
B Khalil, N El Fissi, A Aouane, M-J Cabirol-Pol, T Rival, J-C Liévens. Cell Death Dis 2015
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.
Jeehye Park, Sung Bae Lee, Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim,[...]. Nature 2006
Jeehye Park, Sung Bae Lee, Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim,[...]. Nature 2006
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.
Ira E Clark, Mark W Dodson, Changan Jiang, Joseph H Cao, Jun R Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A Hay, Ming Guo. Nature 2006
Ira E Clark, Mark W Dodson, Changan Jiang, Joseph H Cao, Jun R Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A Hay, Ming Guo. Nature 2006
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Ubiquitin is phosphorylated by PINK1 to activate parkin.
Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa,[...]. Nature 2014
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10
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
10
A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.
Guo Chen, Zhe Han, Du Feng, Yanfang Chen, Linbo Chen, Hao Wu, Li Huang, Changqian Zhou, Xiangyu Cai, Changying Fu,[...]. Mol Cell 2014
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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.
Nickie C Chan, Anna M Salazar, Anh H Pham, Michael J Sweredoski, Natalie J Kolawa, Robert L J Graham, Sonja Hess, David C Chan. Hum Mol Genet 2011
Nickie C Chan, Anna M Salazar, Anh H Pham, Michael J Sweredoski, Natalie J Kolawa, Robert L J Graham, Sonja Hess, David C Chan. Hum Mol Genet 2011
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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
Yongjie Wei, Wei-Chung Chiang, Rhea Sumpter, Prashant Mishra, Beth Levine. Cell 2017
Yongjie Wei, Wei-Chung Chiang, Rhea Sumpter, Prashant Mishra, Beth Levine. Cell 2017
9
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Patricia Martín-Maestro, Ricardo Gargini, George Perry, Jesús Avila, Vega García-Escudero. Hum Mol Genet 2016
Patricia Martín-Maestro, Ricardo Gargini, George Perry, Jesús Avila, Vega García-Escudero. Hum Mol Genet 2016
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Mitochondrial fission facilitates the selective mitophagy of protein aggregates.
Jonathon L Burman, Sarah Pickles, Chunxin Wang, Shiori Sekine, Jose Norberto S Vargas, Zhe Zhang, Alice M Youle, Catherine L Nezich, Xufeng Wu, John A Hammer,[...]. J Cell Biol 2017
Jonathon L Burman, Sarah Pickles, Chunxin Wang, Shiori Sekine, Jose Norberto S Vargas, Zhe Zhang, Alice M Youle, Catherine L Nezich, Xufeng Wu, John A Hammer,[...]. J Cell Biol 2017
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Building and decoding ubiquitin chains for mitophagy.
J Wade Harper, Alban Ordureau, Jin-Mi Heo. Nat Rev Mol Cell Biol 2018
J Wade Harper, Alban Ordureau, Jin-Mi Heo. Nat Rev Mol Cell Biol 2018
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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Shireen A Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E Sowa, Edward L Huttlin, Steven P Gygi, J Wade Harper. Nature 2013
Shireen A Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E Sowa, Edward L Huttlin, Steven P Gygi, J Wade Harper. Nature 2013
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The pathways of mitophagy for quality control and clearance of mitochondria.
G Ashrafi, T L Schwarz. Cell Death Differ 2013
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Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging.
John J Lemasters. Rejuvenation Res 2005
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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.
Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis. Nat Cell Biol 2018
Konstantinos Palikaras, Eirini Lionaki, Nektarios Tavernarakis. Nat Cell Biol 2018
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Measuring In Vivo Mitophagy.
Nuo Sun, Jeanho Yun, Jie Liu, Daniela Malide, Chengyu Liu, Ilsa I Rovira, Kira M Holmström, Maria M Fergusson, Young Hyun Yoo, Christian A Combs,[...]. Mol Cell 2015
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.
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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.
Latha Devi, Badanavalu M Prabhu, Domenico F Galati, Narayan G Avadhani, Hindupur K Anandatheerthavarada. J Neurosci 2006
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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.
Atsushi Tanaka, Megan M Cleland, Shan Xu, Derek P Narendra, Der-Fen Suen, Mariusz Karbowski, Richard J Youle. J Cell Biol 2010
Atsushi Tanaka, Megan M Cleland, Shan Xu, Derek P Narendra, Der-Fen Suen, Mariusz Karbowski, Richard J Youle. J Cell Biol 2010
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
Olga Martins de Brito, Luca Scorrano. Nature 2008
Olga Martins de Brito, Luca Scorrano. Nature 2008
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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.
Charleen T Chu, Jing Ji, Ruben K Dagda, Jian Fei Jiang, Yulia Y Tyurina, Alexandr A Kapralov, Vladimir A Tyurin, Naveena Yanamala, Indira H Shrivastava, Dariush Mohammadyani,[...]. Nat Cell Biol 2013
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Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria.
Nadia Cummins, Andrea Tweedie, Steven Zuryn, Jesus Bertran-Gonzalez, Jürgen Götz. EMBO J 2019
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Maria Manczak, Marcus J Calkins, P Hemachandra Reddy. Hum Mol Genet 2011
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Mechanism of phospho-ubiquitin-induced PARKIN activation.
Tobias Wauer, Michal Simicek, Alexander Schubert, David Komander. Nature 2015
Tobias Wauer, Michal Simicek, Alexander Schubert, David Komander. Nature 2015
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
Michael T Lin, M Flint Beal. Nature 2006
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Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
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Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.
Latha Devi, Vijayendran Raghavendran, Badanavalu M Prabhu, Narayan G Avadhani, Hindupur K Anandatheerthavarada. J Biol Chem 2008
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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.