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Times Cited: 981
Times Cited: 981
Times Cited
Times Co-cited
Similarity
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle. PLoS Biol 2010
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Parkin and PINK1 mitigate STING-induced inflammation.
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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
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Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.
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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.
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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.
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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.
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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
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Ubiquitin is phosphorylated by PINK1 to activate parkin.
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PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.
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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.
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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
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The pathways of mitophagy for quality control and clearance of mitochondria.
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Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging.
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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.
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Measuring In Vivo Mitophagy.
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.
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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.
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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy.
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α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
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Building and decoding ubiquitin chains for mitophagy.
J Wade Harper, Alban Ordureau, Jin-Mi Heo. Nat Rev Mol Cell Biol 2018
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
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A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.
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Mitochondrial fission facilitates the selective mitophagy of protein aggregates.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.