Andrew N Lane, Teresa W-M Fan. Nucleic Acids Res 2015
Times Cited: 365
Times Cited: 365
Times Cited
Times Co-cited
Similarity
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.
Kıvanç Birsoy, Tim Wang, Walter W Chen, Elizaveta Freinkman, Monther Abu-Remaileh, David M Sabatini. Cell 2015
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Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.
Elodie Villa, Eunus S Ali, Umakant Sahu, Issam Ben-Sahra. Cancers (Basel) 2019
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Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
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Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017
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Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.
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Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.
David R Evans, Hedeel I Guy. J Biol Chem 2004
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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
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Cell cycle-dependent regulation of pyrimidine biosynthesis.
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Metabolic regulation of cell growth and proliferation.
Jiajun Zhu, Craig B Thompson. Nat Rev Mol Cell Biol 2019
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Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy.
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A New View into the Regulation of Purine Metabolism: The Purinosome.
Anthony M Pedley, Stephen J Benkovic. Trends Biochem Sci 2017
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A roadmap for interpreting (13)C metabolite labeling patterns from cells.
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Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.
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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.
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Glutamine and cancer: cell biology, physiology, and clinical opportunities.
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Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.
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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
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The molecular determinants of de novo nucleotide biosynthesis in cancer cells.
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Targeting Metabolism for Cancer Therapy.
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Glucose feeds the TCA cycle via circulating lactate.
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Reversible compartmentalization of de novo purine biosynthetic complexes in living cells.
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Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.
Bjarne Hove-Jensen, Kasper R Andersen, Mogens Kilstrup, Jan Martinussen, Robert L Switzer, Martin Willemoës. Microbiol Mol Biol Rev 2016
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Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.
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The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand, Katrin Singer, Gudrun E Koehl, Marlene Kolitzus, Gabriele Schoenhammer, Annette Thiel, Carina Matos, Christina Bruss, Sebastian Klobuch, Katrin Peter,[...]. Cell Metab 2016
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Serine and glycine metabolism in cancer.
Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino. Trends Biochem Sci 2014
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Trimmomatic: a flexible trimmer for Illumina sequence data.
Anthony M Bolger, Marc Lohse, Bjoern Usadel. Bioinformatics 2014
Anthony M Bolger, Marc Lohse, Bjoern Usadel. Bioinformatics 2014
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HTSeq--a Python framework to work with high-throughput sequencing data.
Simon Anders, Paul Theodor Pyl, Wolfgang Huber. Bioinformatics 2015
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Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair.
Shujun Fu, Zhi Li, Lanbo Xiao, Wenfeng Hu, Lu Zhang, Bowen Xie, Qin Zhou, Junju He, Yanfang Qiu, Ming Wen,[...]. Cell Rep 2019
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Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.
Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C Vallabhaneni, Adriano Chan, Thuc Le, Krishna M Chauhan, Zunamys I Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt,[...]. Nat Commun 2015
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The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V Liberti, Jason W Locasale. Trends Biochem Sci 2016
Maria V Liberti, Jason W Locasale. Trends Biochem Sci 2016
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Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.
Sona Hubackova, Eliska Davidova, Stepana Boukalova, Jaromira Kovarova, Martina Bajzikova, Ana Coelho, Mikkel G Terp, Henrik J Ditzel, Jakub Rohlena, Jiri Neuzil. Cell Death Dis 2020
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