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Times Cited: 656
Times Cited
Times Co-cited
Similarity
Parkin and PINK1 mitigate STING-induced inflammation.
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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
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Mitochondrial DNA in innate immune responses and inflammatory pathology.
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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa, Glen N Barber. Nature 2008
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
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cGAS surveillance of micronuclei links genome instability to innate immunity.
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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
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DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
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Mitochondrial double-stranded RNA triggers antiviral signalling in humans.
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DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser. Nat Cell Biol 2017
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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Yasuo Tanaka, Zhijian J Chen. Sci Signal 2012
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Molecular mechanisms and cellular functions of cGAS-STING signalling.
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VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.
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Mitotic progression following DNA damage enables pattern recognition within micronuclei.
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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.
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Circulating mitochondrial DAMPs cause inflammatory responses to injury.
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Cytoplasmic chromatin triggers inflammation in senescence and cancer.
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Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
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Structural mechanism of cytosolic DNA sensing by cGAS.
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
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cGAS is essential for cellular senescence.
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Mitochondria are the powerhouses of immunity.
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Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
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cGAS in action: Expanding roles in immunity and inflammation.
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Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
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Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
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Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases.
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The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.
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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.
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cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.