Jurre J Kamphorst, Michel Nofal, Cosimo Commisso, Sean R Hackett, Wenyun Lu, Elda Grabocka, Matthew G Vander Heiden, George Miller, Jeffrey A Drebin, Dafna Bar-Sagi, Craig B Thompson, Joshua D Rabinowitz. Cancer Res 2015
Times Cited: 438
Times Cited: 438
Times Cited
Times Co-cited
Similarity
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
Cosimo Commisso, Shawn M Davidson, Rengin G Soydaner-Azeloglu, Seth J Parker, Jurre J Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A Drebin, Craig B Thompson,[...]. Nature 2013
Cosimo Commisso, Shawn M Davidson, Rengin G Soydaner-Azeloglu, Seth J Parker, Jurre J Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A Drebin, Craig B Thompson,[...]. Nature 2013
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
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Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.
Shawn M Davidson, Oliver Jonas, Mark A Keibler, Han Wei Hou, Alba Luengo, Jared R Mayers, Jeffrey Wyckoff, Amanda M Del Rosario, Matthew Whitman, Christopher R Chin,[...]. Nat Med 2017
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
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The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.
Wilhelm Palm, Youngkyu Park, Kevin Wright, Natalya N Pavlova, David A Tuveson, Craig B Thompson. Cell 2015
Wilhelm Palm, Youngkyu Park, Kevin Wright, Natalya N Pavlova, David A Tuveson, Craig B Thompson. Cell 2015
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Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.
Mark R Sullivan, Laura V Danai, Caroline A Lewis, Sze Ham Chan, Dan Y Gui, Tenzin Kunchok, Emily A Dennstedt, Matthew G Vander Heiden, Alexander Muir. Elife 2019
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Pancreatic cancers require autophagy for tumor growth.
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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
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EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis.
Szu-Wei Lee, Yijuan Zhang, Michael Jung, Nathalia Cruz, Basheer Alas, Cosimo Commisso. Dev Cell 2019
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Metabolic Heterogeneity in Human Lung Tumors.
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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.
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Lactate Metabolism in Human Lung Tumors.
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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
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Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
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From Krebs to clinic: glutamine metabolism to cancer therapy.
Brian J Altman, Zachary E Stine, Chi V Dang. Nat Rev Cancer 2016
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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.
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Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins.
D Bar-Sagi, J R Feramisco. Science 1986
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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
Ralph J DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, Craig B Thompson. Proc Natl Acad Sci U S A 2007
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.
Douglas E Biancur, Joao A Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M Sousa, Xiaoxu Wang, Albert S W Sohn, Gerald C Chu, Steven P Gygi, J Wade Harper,[...]. Nat Commun 2017
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
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Critical role for PI3-kinase in regulating the use of proteins as an amino acid source.
Wilhelm Palm, Jingwen Araki, Bryan King, Raymond G DeMatteo, Craig B Thompson. Proc Natl Acad Sci U S A 2017
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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.
Wantong Yao, Johnathon L Rose, Wei Wang, Sahil Seth, Hong Jiang, Ayumu Taguchi, Jintan Liu, Liang Yan, Avnish Kapoor, Pingping Hou,[...]. Nature 2019
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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.
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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Kenneth P Olive, Michael A Jacobetz, Christian J Davidson, Aarthi Gopinathan, Dominick McIntyre, Davina Honess, Basetti Madhu, Mae A Goldgraben, Meredith E Caldwell, David Allard,[...]. Science 2009
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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.
Min Pan, Michael A Reid, Xazmin H Lowman, Rajan P Kulkarni, Thai Q Tran, Xiaojing Liu, Ying Yang, Jenny E Hernandez-Davies, Kimberly K Rosales, Haiqing Li,[...]. Nat Cell Biol 2016
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Understanding the Intersections between Metabolism and Cancer Biology.
Matthew G Vander Heiden, Ralph J DeBerardinis. Cell 2017
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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
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Nutrient scavenging in cancer.
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Macropinocytosis confers resistance to therapies targeting cancer anabolism.
Vaishali Jayashankar, Aimee L Edinger. Nat Commun 2020
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Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.
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Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.
Conan G Kinsey, Soledad A Camolotto, Amelie M Boespflug, Katrin P Guillen, Mona Foth, Amanda Truong, Sophia S Schuman, Jill E Shea, Michael T Seipp, Jeffrey T Yap,[...]. Nat Med 2019
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Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer.
Maria Victoria Recouvreux, Cosimo Commisso. Front Endocrinol (Lausanne) 2017
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Determining the macropinocytic index of cells through a quantitative image-based assay.
Cosimo Commisso, Rory J Flinn, Dafna Bar-Sagi. Nat Protoc 2014
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Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Richard Possemato, Kevin M Marks, Yoav D Shaul, Michael E Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun G Jang, Abhishek K Jha,[...]. Nature 2011
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Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.