Yasemin Akbulut, Hannah J Gaunt, Katsuhiko Muraki, Melanie J Ludlow, Mohamed S Amer, Alexander Bruns, Naveen S Vasudev, Lea Radtke, Matthieu Willot, Sven Hahn, Tobias Seitz, Slava Ziegler, Mathias Christmann, David J Beech, Herbert Waldmann. Angew Chem Int Ed Engl 2015
Times Cited: 113
Times Cited: 113
Times Cited
Times Co-cited
Similarity
Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J Martin Verkuyl,[...]. PLoS One 2015
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J Martin Verkuyl,[...]. PLoS One 2015
72
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Melissa Miller, Jie Shi, Yingmin Zhu, Maksym Kustov, Jin-bin Tian, Amy Stevens, Meng Wu, Jia Xu, Shunyou Long, Pu Yang,[...]. J Biol Chem 2011
Melissa Miller, Jie Shi, Yingmin Zhu, Maksym Kustov, Jin-bin Tian, Amy Stevens, Meng Wu, Jia Xu, Shunyou Long, Pu Yang,[...]. J Biol Chem 2011
35
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Ranjala Ratnayake, David Covell, Tanya T Ransom, Kirk R Gustafson, John A Beutler. Org Lett 2009
Ranjala Ratnayake, David Covell, Tanya T Ransom, Kirk R Gustafson, John A Beutler. Org Lett 2009
26
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
T Hofmann, A G Obukhov, M Schaefer, C Harteneck, T Gudermann, G Schultz. Nature 1999
T Hofmann, A G Obukhov, M Schaefer, C Harteneck, T Gudermann, G Schultz. Nature 1999
24
Essential role for TRPC5 in amygdala function and fear-related behavior.
Antonio Riccio, Yan Li, Jisook Moon, Kwang-Soo Kim, Kiersten S Smith, Uwe Rudolph, Svetlana Gapon, Gui Lan Yao, Evgeny Tsvetkov, Scott J Rodig,[...]. Cell 2009
Antonio Riccio, Yan Li, Jisook Moon, Kwang-Soo Kim, Kiersten S Smith, Uwe Rudolph, Svetlana Gapon, Gui Lan Yao, Evgeny Tsvetkov, Scott J Rodig,[...]. Cell 2009
21
Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes.
Ursula Storch, Anna-Lena Forst, Maximilian Philipp, Thomas Gudermann, Michael Mederos y Schnitzler. J Biol Chem 2012
Ursula Storch, Anna-Lena Forst, Maximilian Philipp, Thomas Gudermann, Michael Mederos y Schnitzler. J Biol Chem 2012
21
Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.
Jae-Pyo Jeon, Chansik Hong, Eun Jung Park, Ju-Hong Jeon, Nam-Hyuk Cho, In-Gyu Kim, Han Choe, Shmuel Muallem, Hyun Jin Kim, Insuk So. J Biol Chem 2012
Jae-Pyo Jeon, Chansik Hong, Eun Jung Park, Ju-Hong Jeon, Nam-Hyuk Cho, In-Gyu Kim, Han Choe, Shmuel Muallem, Hyun Jin Kim, Insuk So. J Biol Chem 2012
31
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.
C Strübing, G Krapivinsky, L Krapivinsky, D E Clapham. Neuron 2001
C Strübing, G Krapivinsky, L Krapivinsky, D E Clapham. Neuron 2001
20
Electron cryo-microscopy structure of the canonical TRPC4 ion channel.
Deivanayagabarathy Vinayagam, Thomas Mager, Amir Apelbaum, Arne Bothe, Felipe Merino, Oliver Hofnagel, Christos Gatsogiannis, Stefan Raunser. Elife 2018
Deivanayagabarathy Vinayagam, Thomas Mager, Amir Apelbaum, Arne Bothe, Felipe Merino, Oliver Hofnagel, Christos Gatsogiannis, Stefan Raunser. Elife 2018
33
Structure of the mouse TRPC4 ion channel.
Jingjing Duan, Jian Li, Bo Zeng, Gui-Lan Chen, Xiaogang Peng, Yixing Zhang, Jianbin Wang, David E Clapham, Zongli Li, Jin Zhang. Nat Commun 2018
Jingjing Duan, Jian Li, Bo Zeng, Gui-Lan Chen, Xiaogang Peng, Yixing Zhang, Jianbin Wang, David E Clapham, Zongli Li, Jin Zhang. Nat Commun 2018
33
(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase.
Melanie J Ludlow, Hannah J Gaunt, Hussein N Rubaiy, Katie E Musialowski, Nicola M Blythe, Naveen S Vasudev, Katsuhiko Muraki, David J Beech. J Biol Chem 2017
Melanie J Ludlow, Hannah J Gaunt, Hussein N Rubaiy, Katie E Musialowski, Nicola M Blythe, Naveen S Vasudev, Katsuhiko Muraki, David J Beech. J Biol Chem 2017
79
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Hussein N Rubaiy, Melanie J Ludlow, Matthias Henrot, Hannah J Gaunt, Katarina Miteva, Sin Ying Cheung, Yasuyuki Tanahashi, Nurasyikin Hamzah, Katie E Musialowski, Nicola M Blythe,[...]. J Biol Chem 2017
Hussein N Rubaiy, Melanie J Ludlow, Matthias Henrot, Hannah J Gaunt, Katarina Miteva, Sin Ying Cheung, Yasuyuki Tanahashi, Nurasyikin Hamzah, Katie E Musialowski, Nicola M Blythe,[...]. J Biol Chem 2017
42
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Carole Sourbier, Bradley T Scroggins, Ranjala Ratnayake, Thomas L Prince, Sunmin Lee, Min-Jung Lee, Peter Literati Nagy, Young H Lee, Jane B Trepel, John A Beutler,[...]. Cancer Cell 2013
Carole Sourbier, Bradley T Scroggins, Ranjala Ratnayake, Thomas L Prince, Sunmin Lee, Min-Jung Lee, Peter Literati Nagy, Young H Lee, Jane B Trepel, John A Beutler,[...]. Cancer Cell 2013
33
Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.
Jenny Bröker-Lai, Astrid Kollewe, Barbara Schindeldecker, Jörg Pohle, Vivan Nguyen Chi, Ilka Mathar, Raul Guzman, Yvonne Schwarz, Alan Lai, Petra Weißgerber,[...]. EMBO J 2017
Jenny Bröker-Lai, Astrid Kollewe, Barbara Schindeldecker, Jörg Pohle, Vivan Nguyen Chi, Ilka Mathar, Raul Guzman, Yvonne Schwarz, Alan Lai, Petra Weißgerber,[...]. EMBO J 2017
29
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.
Kevin D Phelan, U Thaung Shwe, Joel Abramowitz, Hong Wu, Sung W Rhee, Matthew D Howell, Paul E Gottschall, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer,[...]. Mol Pharmacol 2013
Kevin D Phelan, U Thaung Shwe, Joel Abramowitz, Hong Wu, Sung W Rhee, Matthew D Howell, Paul E Gottschall, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer,[...]. Mol Pharmacol 2013
19
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.
Volodymyr V Tsvilovskyy, Alexander V Zholos, Thomas Aberle, Stephan E Philipp, Alexander Dietrich, Michael X Zhu, Lutz Birnbaumer, Marc Freichel, Veit Flockerzi. Gastroenterology 2009
Volodymyr V Tsvilovskyy, Alexander V Zholos, Thomas Aberle, Stephan E Philipp, Alexander Dietrich, Michael X Zhu, Lutz Birnbaumer, Marc Freichel, Veit Flockerzi. Gastroenterology 2009
16
Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Julia M Richter, Michael Schaefer, Kerstin Hill. Mol Pharmacol 2014
Julia M Richter, Michael Schaefer, Kerstin Hill. Mol Pharmacol 2014
28
Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.
M Schaefer, T D Plant, A G Obukhov, T Hofmann, T Gudermann, G Schultz. J Biol Chem 2000
M Schaefer, T D Plant, A G Obukhov, T Hofmann, T Gudermann, G Schultz. J Biol Chem 2000
15
Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.
Stefan Just, Bertrand L Chenard, Angelo Ceci, Timothy Strassmaier, Jayhong A Chong, Nathaniel T Blair, Randall J Gallaschun, Donato Del Camino, Susan Cantin, Marc D'Amours,[...]. PLoS One 2018
Stefan Just, Bertrand L Chenard, Angelo Ceci, Timothy Strassmaier, Jayhong A Chong, Nathaniel T Blair, Randall J Gallaschun, Donato Del Camino, Susan Cantin, Marc D'Amours,[...]. PLoS One 2018
34
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Yiming Zhou, Philip Castonguay, Eriene-Heidi Sidhom, Abbe R Clark, Moran Dvela-Levitt, Sookyung Kim, Jonas Sieber, Nicolas Wieder, Ji Yong Jung, Svetlana Andreeva,[...]. Science 2017
Yiming Zhou, Philip Castonguay, Eriene-Heidi Sidhom, Abbe R Clark, Moran Dvela-Levitt, Sookyung Kim, Jonas Sieber, Nicolas Wieder, Ji Yong Jung, Svetlana Andreeva,[...]. Science 2017
21
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen. Cell Res 2018
Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen. Cell Res 2018
21
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol.
Ursula Storch, Anna-Lena Forst, Franziska Pardatscher, Serap Erdogmus, Maximilian Philipp, Manuel Gregoritza, Michael Mederos Y Schnitzler, Thomas Gudermann. Proc Natl Acad Sci U S A 2017
Ursula Storch, Anna-Lena Forst, Franziska Pardatscher, Serap Erdogmus, Maximilian Philipp, Manuel Gregoritza, Michael Mederos Y Schnitzler, Thomas Gudermann. Proc Natl Acad Sci U S A 2017
25
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate.
Ken-ichi Otsuguro, Jisen Tang, Yufang Tang, Rui Xiao, Marc Freichel, Volodymyr Tsvilovskyy, Shigeo Ito, Veit Flockerzi, Michael X Zhu, Alexander V Zholos. J Biol Chem 2008
Ken-ichi Otsuguro, Jisen Tang, Yufang Tang, Rui Xiao, Marc Freichel, Volodymyr Tsvilovskyy, Shigeo Ito, Veit Flockerzi, Michael X Zhu, Alexander V Zholos. J Biol Chem 2008
14
Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.
Antonio Riccio, Yan Li, Evgeny Tsvetkov, Svetlana Gapon, Gui Lan Yao, Kiersten S Smith, Elif Engin, Uwe Rudolph, Vadim Y Bolshakov, David E Clapham. J Neurosci 2014
Antonio Riccio, Yan Li, Evgeny Tsvetkov, Svetlana Gapon, Gui Lan Yao, Kiersten S Smith, Elif Engin, Uwe Rudolph, Vadim Y Bolshakov, David E Clapham. J Neurosci 2014
25
Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.
Hannah J Gaunt, Naveen S Vasudev, David J Beech. Eur Biophys J 2016
Hannah J Gaunt, Naveen S Vasudev, David J Beech. Eur Biophys J 2016
60
Formation of novel TRPC channels by complex subunit interactions in embryonic brain.
Carsten Strübing, Grigory Krapivinsky, Luba Krapivinsky, David E Clapham. J Biol Chem 2003
Carsten Strübing, Grigory Krapivinsky, Luba Krapivinsky, David E Clapham. J Biol Chem 2003
14
Englerins: A Comprehensive Review.
Zhenhua Wu, Senzhi Zhao, David M Fash, Zhenwu Li, William J Chain, John A Beutler. J Nat Prod 2017
Zhenhua Wu, Senzhi Zhao, David M Fash, Zhenwu Li, William J Chain, John A Beutler. J Nat Prod 2017
66
Natural and synthetic flavonoid modulation of TRPC5 channels.
Jacqueline Naylor, Aisling Minard, Hannah J Gaunt, Mohamed S Amer, Lesley A Wilson, Marco Migliore, Sin Y Cheung, Hussein N Rubaiy, Nicola M Blythe, Katie E Musialowski,[...]. Br J Pharmacol 2016
Jacqueline Naylor, Aisling Minard, Hannah J Gaunt, Mohamed S Amer, Lesley A Wilson, Marco Migliore, Sin Y Cheung, Hussein N Rubaiy, Nicola M Blythe, Katie E Musialowski,[...]. Br J Pharmacol 2016
54
TRPC channel activation by extracellular thioredoxin.
Shang-Zhong Xu, Piruthivi Sukumar, Fanning Zeng, Jing Li, Amit Jairaman, Anne English, Jacqueline Naylor, Coziana Ciurtin, Yasser Majeed, Carol J Milligan,[...]. Nature 2008
Shang-Zhong Xu, Piruthivi Sukumar, Fanning Zeng, Jing Li, Amit Jairaman, Anne English, Jacqueline Naylor, Coziana Ciurtin, Yasser Majeed, Carol J Milligan,[...]. Nature 2008
13
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu,[...]. Br J Pharmacol 2015
Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu,[...]. Br J Pharmacol 2015
52
Riluzole activates TRPC5 channels independently of PLC activity.
Julia M Richter, Michael Schaefer, Kerstin Hill. Br J Pharmacol 2014
Julia M Richter, Michael Schaefer, Kerstin Hill. Br J Pharmacol 2014
46
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?
Robin S Bon, David J Beech. Br J Pharmacol 2013
Robin S Bon, David J Beech. Br J Pharmacol 2013
21
Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.
Dhananjay P Thakur, Jin-bin Tian, Jaepyo Jeon, Jian Xiong, Yu Huang, Veit Flockerzi, Michael X Zhu. Proc Natl Acad Sci U S A 2016
Dhananjay P Thakur, Jin-bin Tian, Jaepyo Jeon, Jian Xiong, Yu Huang, Veit Flockerzi, Michael X Zhu. Proc Natl Acad Sci U S A 2016
33
Subunit composition of mammalian transient receptor potential channels in living cells.
Thomas Hofmann, Michael Schaefer, Günter Schultz, Thomas Gudermann. Proc Natl Acad Sci U S A 2002
Thomas Hofmann, Michael Schaefer, Günter Schultz, Thomas Gudermann. Proc Natl Acad Sci U S A 2002
13
Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Tiago Rodrigues, Florian Sieglitz, Víctor J Somovilla, Pedro M S D Cal, Antony Galione, Francisco Corzana, Gonçalo J L Bernardes. Angew Chem Int Ed Engl 2016
Tiago Rodrigues, Florian Sieglitz, Víctor J Somovilla, Pedro M S D Cal, Antony Galione, Francisco Corzana, Gonçalo J L Bernardes. Angew Chem Int Ed Engl 2016
54
Structure of the human lipid-gated cation channel TRPC3.
Chen Fan, Wooyoung Choi, Weinan Sun, Juan Du, Wei Lü. Elife 2018
Chen Fan, Wooyoung Choi, Weinan Sun, Juan Du, Wei Lü. Elife 2018
24
Pico145 - powerful new tool for TRPC1/4/5 channels.
Hussein N Rubaiy, Melanie J Ludlow, Robin S Bon, David J Beech. Channels (Austin) 2017
Hussein N Rubaiy, Melanie J Ludlow, Robin S Bon, David J Beech. Channels (Austin) 2017
63
Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease.
Aisling Minard, Claudia C Bauer, David J Wright, Hussein N Rubaiy, Katsuhiko Muraki, David J Beech, Robin S Bon. Cells 2018
Aisling Minard, Claudia C Bauer, David J Wright, Hussein N Rubaiy, Katsuhiko Muraki, David J Beech, Robin S Bon. Cells 2018
54
18
Enantioselective synthesis of (-)-englerins A and B.
Kian Molawi, Nicolas Delpont, Antonio M Echavarren. Angew Chem Int Ed Engl 2010
Kian Molawi, Nicolas Delpont, Antonio M Echavarren. Angew Chem Int Ed Engl 2010
11
Total synthesis and absolute configuration of the guaiane sesquiterpene englerin A.
Matthieu Willot, Lea Radtke, Daniel Könning, Roland Fröhlich, Viktoria H Gessner, Carsten Strohmann, Mathias Christmann. Angew Chem Int Ed Engl 2009
Matthieu Willot, Lea Radtke, Daniel Könning, Roland Fröhlich, Viktoria H Gessner, Carsten Strohmann, Mathias Christmann. Angew Chem Int Ed Engl 2009
15
Total synthesis of englerin A.
K C Nicolaou, Qiang Kang, Sin Yee Ng, David Y-K Chen. J Am Chem Soc 2010
K C Nicolaou, Qiang Kang, Sin Yee Ng, David Y-K Chen. J Am Chem Soc 2010
14
Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile.
Lea Radtke, Matthieu Willot, Hongyan Sun, Slava Ziegler, Stephanie Sauerland, Carsten Strohmann, Roland Fröhlich, Peter Habenberger, Herbert Waldmann, Mathias Christmann. Angew Chem Int Ed Engl 2011
Lea Radtke, Matthieu Willot, Hongyan Sun, Slava Ziegler, Stephanie Sauerland, Carsten Strohmann, Roland Fröhlich, Peter Habenberger, Herbert Waldmann, Mathias Christmann. Angew Chem Int Ed Engl 2011
22
Inhibition of the TRPC5 ion channel protects the kidney filter.
Thomas Schaldecker, Sookyung Kim, Constantine Tarabanis, Dequan Tian, Samy Hakroush, Philip Castonguay, Wooin Ahn, Hanna Wallentin, Hans Heid, Corey R Hopkins,[...]. J Clin Invest 2013
Thomas Schaldecker, Sookyung Kim, Constantine Tarabanis, Dequan Tian, Samy Hakroush, Philip Castonguay, Wooin Ahn, Hanna Wallentin, Hans Heid, Corey R Hopkins,[...]. J Clin Invest 2013
11
Physiology and pathophysiology of canonical transient receptor potential channels.
Joel Abramowitz, Lutz Birnbaumer. FASEB J 2009
Joel Abramowitz, Lutz Birnbaumer. FASEB J 2009
11
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.
Anna Greka, Betsy Navarro, Elena Oancea, Anne Duggan, David E Clapham. Nat Neurosci 2003
Anna Greka, Betsy Navarro, Elena Oancea, Anne Duggan, David E Clapham. Nat Neurosci 2003
11
Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels.
Jinsung Kim, Misun Kwak, Jae-Pyo Jeon, Jongyun Myeong, Jinhong Wie, Chansik Hong, Sung-Young Kim, Ju-Hong Jeon, Hyun Jin Kim, Insuk So. Pflugers Arch 2014
Jinsung Kim, Misun Kwak, Jae-Pyo Jeon, Jongyun Myeong, Jinhong Wie, Chansik Hong, Sung-Young Kim, Ju-Hong Jeon, Hyun Jin Kim, Insuk So. Pflugers Arch 2014
45
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.
Stefan Alfred Gross, Gustavo Adolfo Guzmán, Ulrich Wissenbach, Stephan Ernst Philipp, Michael Xi Zhu, Dieter Bruns, Adolfo Cavalié. J Biol Chem 2009
Stefan Alfred Gross, Gustavo Adolfo Guzmán, Ulrich Wissenbach, Stephan Ernst Philipp, Michael Xi Zhu, Dieter Bruns, Adolfo Cavalié. J Biol Chem 2009
14
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels.
Tim D Plant, Michael Schaefer. Cell Calcium 2003
Tim D Plant, Michael Schaefer. Cell Calcium 2003
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.