Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
Times Cited: 231
Times Cited: 231
Times Cited
Times Co-cited
Similarity
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
18
The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
17
Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
14
Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
13
Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
Jared M Campbell, Susan M Bellman, Matthew D Stephenson, Karolina Lisy. Ageing Res Rev 2017
Jared M Campbell, Susan M Bellman, Matthew D Stephenson, Karolina Lisy. Ageing Res Rev 2017
12
Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
11
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
11
11
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann,[...]. Proc Natl Acad Sci U S A 2010
Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann,[...]. Proc Natl Acad Sci U S A 2010
11
Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.
Yoshiyuki Hattori, Kunihiro Suzuki, Sachiko Hattori, Kikuo Kasai. Hypertension 2006
Yoshiyuki Hattori, Kunihiro Suzuki, Sachiko Hattori, Kikuo Kasai. Hypertension 2006
11
10-year follow-up of intensive glucose control in type 2 diabetes.
Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil. N Engl J Med 2008
Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil. N Engl J Med 2008
11
Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
10
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
10
Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis.
Yechen Han, Hongzhi Xie, Yongtai Liu, Peng Gao, Xufei Yang, Zhujun Shen. Cardiovasc Diabetol 2019
Yechen Han, Hongzhi Xie, Yongtai Liu, Peng Gao, Xufei Yang, Zhujun Shen. Cardiovasc Diabetol 2019
10
Long-term metformin usage and cognitive function among older adults with diabetes.
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
9
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
9
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
Zhi Zheng, Haibing Chen, Jun Li, Tao Li, Bingqing Zheng, Ying Zheng, Huiyi Jin, Ying He, Qing Gu, Xun Xu. Diabetes 2012
Zhi Zheng, Haibing Chen, Jun Li, Tao Li, Bingqing Zheng, Ying Zheng, Huiyi Jin, Ying He, Qing Gu, Xun Xu. Diabetes 2012
8
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
8
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
8
Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages.
Bobae Hyun, Seulmee Shin, Aeri Lee, Sungwon Lee, Youngcheon Song, Nam-Joo Ha, Kyung-Hea Cho, Kyungjae Kim. Immune Netw 2013
Bobae Hyun, Seulmee Shin, Aeri Lee, Sungwon Lee, Youngcheon Song, Nam-Joo Ha, Kyung-Hea Cho, Kyungjae Kim. Immune Netw 2013
12
Cellular and molecular mechanisms of metformin: an overview.
Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli. Clin Sci (Lond) 2012
Benoit Viollet, Bruno Guigas, Nieves Sanz Garcia, Jocelyne Leclerc, Marc Foretz, Fabrizio Andreelli. Clin Sci (Lond) 2012
7
Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus.
Min Guo, Jia Mi, Qiu-Ming Jiang, Jin-Mei Xu, Ying-Ying Tang, Geng Tian, Bin Wang. Clin Exp Pharmacol Physiol 2014
Min Guo, Jia Mi, Qiu-Ming Jiang, Jin-Mei Xu, Ying-Ying Tang, Geng Tian, Bin Wang. Clin Exp Pharmacol Physiol 2014
7
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
7
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
7
The Therapeutic Potential of Metformin in Neurodegenerative Diseases.
Carola Rotermund, Gerrit Machetanz, Julia C Fitzgerald. Front Endocrinol (Lausanne) 2018
Carola Rotermund, Gerrit Machetanz, Julia C Fitzgerald. Front Endocrinol (Lausanne) 2018
7
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle K Pedersen,[...]. Nature 2015
Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle K Pedersen,[...]. Nature 2015
7
Metformin and the gastrointestinal tract.
Laura J McCreight, Clifford J Bailey, Ewan R Pearson. Diabetologia 2016
Laura J McCreight, Clifford J Bailey, Ewan R Pearson. Diabetologia 2016
7
Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis.
Pan Luo, Lin Qiu, Yi Liu, Xiu-Lan Liu, Jian-Ling Zheng, Hui-Ying Xue, Wen-Hua Liu, Dong Liu, Juan Li. Am J Trop Med Hyg 2020
Pan Luo, Lin Qiu, Yi Liu, Xiu-Lan Liu, Jian-Ling Zheng, Hui-Ying Xue, Wen-Hua Liu, Dong Liu, Juan Li. Am J Trop Med Hyg 2020
7
Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells.
Sun Ae Kim, Hyoung Chul Choi. Biochem Biophys Res Commun 2012
Sun Ae Kim, Hyoung Chul Choi. Biochem Biophys Res Commun 2012
7
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
6
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.
Zhonglin Xie, Kai Lau, Bonnie Eby, Pedro Lozano, Chaoyong He, Becky Pennington, Hongliang Li, Shradha Rathi, Yunzhou Dong, Rong Tian,[...]. Diabetes 2011
Zhonglin Xie, Kai Lau, Bonnie Eby, Pedro Lozano, Chaoyong He, Becky Pennington, Hongliang Li, Shradha Rathi, Yunzhou Dong, Rong Tian,[...]. Diabetes 2011
6
Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus.
Adriaan Kooy, Jolien de Jager, Philippe Lehert, Daniël Bets, Michiel G Wulffelé, Ab J M Donker, Coen D A Stehouwer. Arch Intern Med 2009
Adriaan Kooy, Jolien de Jager, Philippe Lehert, Daniël Bets, Michiel G Wulffelé, Ab J M Donker, Coen D A Stehouwer. Arch Intern Med 2009
6
Metformin limits ceramide-induced senescence in C2C12 myoblasts.
Kavita S Jadhav, Cory M Dungan, David L Williamson. Mech Ageing Dev 2013
Kavita S Jadhav, Cory M Dungan, David L Williamson. Mech Ageing Dev 2013
15
Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.
Adam R Konopka, Jaime L Laurin, Hayden M Schoenberg, Justin J Reid, William M Castor, Christopher A Wolff, Robert V Musci, Oscar D Safairad, Melissa A Linden, Laurie M Biela,[...]. Aging Cell 2019
Adam R Konopka, Jaime L Laurin, Hayden M Schoenberg, Justin J Reid, William M Castor, Christopher A Wolff, Robert V Musci, Oscar D Safairad, Melissa A Linden, Laurie M Biela,[...]. Aging Cell 2019
9
Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis.
Chin Cheng, Ching-Heng Lin, Yi-Wen Tsai, Chia-Jui Tsai, Po-Han Chou, Tsuo-Hung Lan. J Gerontol A Biol Sci Med Sci 2014
Chin Cheng, Ching-Heng Lin, Yi-Wen Tsai, Chia-Jui Tsai, Po-Han Chou, Tsuo-Hung Lan. J Gerontol A Biol Sci Med Sci 2014
7
Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study.
Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnold. Alzheimer Dis Assoc Disord 2017
Aaron M Koenig, Dawn Mechanic-Hamilton, Sharon X Xie, Martha F Combs, Anne R Cappola, Long Xie, John A Detre, David A Wolk, Steven E Arnold. Alzheimer Dis Assoc Disord 2017
6
Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.
Michael Fatt, Karolynn Hsu, Ling He, Fredric Wondisford, Freda D Miller, David R Kaplan, Jing Wang. Stem Cell Reports 2015
Michael Fatt, Karolynn Hsu, Ling He, Fredric Wondisford, Freda D Miller, David R Kaplan, Jing Wang. Stem Cell Reports 2015
8
Metformin and reduced risk of cancer in diabetic patients.
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
Josie M M Evans, Louise A Donnelly, Alistair M Emslie-Smith, Dario R Alessi, Andrew D Morris. BMJ 2005
6
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
M R Owen, E Doran, A P Halestrap. Biochem J 2000
M R Owen, E Doran, A P Halestrap. Biochem J 2000
6
Anti-inflammatory mechanism of metformin and its effects in intestinal inflammation and colitis-associated colon cancer.
Seong-Joon Koh, Jung Mogg Kim, In-Kyoung Kim, Su Hyuk Ko, Joo Sung Kim. J Gastroenterol Hepatol 2014
Seong-Joon Koh, Jung Mogg Kim, In-Kyoung Kim, Su Hyuk Ko, Joo Sung Kim. J Gastroenterol Hepatol 2014
6
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease.
Jie Hong, Yifei Zhang, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui,[...]. Diabetes Care 2013
Jie Hong, Yifei Zhang, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui,[...]. Diabetes Care 2013
6
Repurposing metformin for the prevention of cancer and cancer recurrence.
Brandy M Heckman-Stoddard, Andrea DeCensi, Vikrant V Sahasrabuddhe, Leslie G Ford. Diabetologia 2017
Brandy M Heckman-Stoddard, Andrea DeCensi, Vikrant V Sahasrabuddhe, Leslie G Ford. Diabetologia 2017
6
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
6
Metformin as an Anticancer Agent.
Ales Vancura, Pengli Bu, Madhura Bhagwat, Joey Zeng, Ivana Vancurova. Trends Pharmacol Sci 2018
Ales Vancura, Pengli Bu, Madhura Bhagwat, Joey Zeng, Ivana Vancurova. Trends Pharmacol Sci 2018
6
Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes.
Simon J Griffin, James K Leaver, Greg J Irving. Diabetologia 2017
Simon J Griffin, James K Leaver, Greg J Irving. Diabetologia 2017
6
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
6
Metformin pathways: pharmacokinetics and pharmacodynamics.
Li Gong, Srijib Goswami, Kathleen M Giacomini, Russ B Altman, Teri E Klein. Pharmacogenet Genomics 2012
Li Gong, Srijib Goswami, Kathleen M Giacomini, Russ B Altman, Teri E Klein. Pharmacogenet Genomics 2012
6
Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.
Sathish Babu Vasamsetti, Santosh Karnewar, Anantha Koteswararao Kanugula, Avinash Raj Thatipalli, Jerald Mahesh Kumar, Srigiridhar Kotamraju. Diabetes 2015
Sathish Babu Vasamsetti, Santosh Karnewar, Anantha Koteswararao Kanugula, Avinash Raj Thatipalli, Jerald Mahesh Kumar, Srigiridhar Kotamraju. Diabetes 2015
6
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.