Eyal Vardy, J Elliott Robinson, Chia Li, Reid H J Olsen, Jeffrey F DiBerto, Patrick M Giguere, Flori M Sassano, Xi-Ping Huang, Hu Zhu, Daniel J Urban, Kate L White, Joseph E Rittiner, Nicole A Crowley, Kristen E Pleil, Christopher M Mazzone, Philip D Mosier, Juan Song, Thomas L Kash, C J Malanga, Michael J Krashes, Bryan L Roth. Neuron 2015
Times Cited: 210
Times Cited: 210
Times Cited
Times Co-cited
Similarity
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Blaine N Armbruster, Xiang Li, Mark H Pausch, Stefan Herlitze, Bryan L Roth. Proc Natl Acad Sci U S A 2007
Blaine N Armbruster, Xiang Li, Mark H Pausch, Stefan Herlitze, Bryan L Roth. Proc Natl Acad Sci U S A 2007
51
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.
Juan L Gomez, Jordi Bonaventura, Wojciech Lesniak, William B Mathews, Polina Sysa-Shah, Lionel A Rodriguez, Randall J Ellis, Christopher T Richie, Brandon K Harvey, Robert F Dannals,[...]. Science 2017
Juan L Gomez, Jordi Bonaventura, Wojciech Lesniak, William B Mathews, Polina Sysa-Shah, Lionel A Rodriguez, Randall J Ellis, Christopher T Richie, Brandon K Harvey, Robert F Dannals,[...]. Science 2017
41
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.
Georgia M Alexander, Sarah C Rogan, Atheir I Abbas, Blaine N Armbruster, Ying Pei, John A Allen, Randal J Nonneman, John Hartmann, Sheryl S Moy, Miguel A Nicolelis,[...]. Neuron 2009
Georgia M Alexander, Sarah C Rogan, Atheir I Abbas, Blaine N Armbruster, Ying Pei, John A Allen, Randal J Nonneman, John Hartmann, Sheryl S Moy, Miguel A Nicolelis,[...]. Neuron 2009
29
The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
Xin Chen, Hyunah Choo, Xi-Ping Huang, Xiaobao Yang, Orrin Stone, Bryan L Roth, Jian Jin. ACS Chem Neurosci 2015
Xin Chen, Hyunah Choo, Xi-Ping Huang, Xiaobao Yang, Orrin Stone, Bryan L Roth, Jian Jin. ACS Chem Neurosci 2015
32
Chemical and genetic engineering of selective ion channel-ligand interactions.
Christopher J Magnus, Peter H Lee, Deniz Atasoy, Helen H Su, Loren L Looger, Scott M Sternson. Science 2011
Christopher J Magnus, Peter H Lee, Deniz Atasoy, Helen H Su, Loren L Looger, Scott M Sternson. Science 2011
22
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
Michael J Krashes, Shuichi Koda, ChianPing Ye, Sarah C Rogan, Andrew C Adams, Daniel S Cusher, Eleftheria Maratos-Flier, Bryan L Roth, Bradford B Lowell. J Clin Invest 2011
Michael J Krashes, Shuichi Koda, ChianPing Ye, Sarah C Rogan, Andrew C Adams, Daniel S Cusher, Eleftheria Maratos-Flier, Bryan L Roth, Bradford B Lowell. J Clin Invest 2011
22
Chemogenetic tools to interrogate brain functions.
Scott M Sternson, Bryan L Roth. Annu Rev Neurosci 2014
Scott M Sternson, Bryan L Roth. Annu Rev Neurosci 2014
21
A chemical-genetic approach to study G protein regulation of beta cell function in vivo.
Jean-Marc Guettier, Dinesh Gautam, Marco Scarselli, Inigo Ruiz de Azua, Jian Hua Li, Erica Rosemond, Xiaochao Ma, Frank J Gonzalez, Blaine N Armbruster, Huiyan Lu,[...]. Proc Natl Acad Sci U S A 2009
Jean-Marc Guettier, Dinesh Gautam, Marco Scarselli, Inigo Ruiz de Azua, Jian Hua Li, Erica Rosemond, Xiaochao Ma, Frank J Gonzalez, Blaine N Armbruster, Huiyan Lu,[...]. Proc Natl Acad Sci U S A 2009
21
Ultrapotent chemogenetics for research and potential clinical applications.
Christopher J Magnus, Peter H Lee, Jordi Bonaventura, Roland Zemla, Juan L Gomez, Melissa H Ramirez, Xing Hu, Adriana Galvan, Jayeeta Basu, Michael Michaelides,[...]. Science 2019
Christopher J Magnus, Peter H Lee, Jordi Bonaventura, Roland Zemla, Juan L Gomez, Melissa H Ramirez, Xing Hu, Adriana Galvan, Jayeeta Basu, Michael Michaelides,[...]. Science 2019
35
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.
Daniel J Urban, Bryan L Roth. Annu Rev Pharmacol Toxicol 2015
Daniel J Urban, Bryan L Roth. Annu Rev Pharmacol Toxicol 2015
18
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.
Karen J Thompson, Elham Khajehali, Sophie J Bradley, Jovana S Navarrete, Xi Ping Huang, Samuel Slocum, Jian Jin, Jing Liu, Yan Xiong, Reid H J Olsen,[...]. ACS Pharmacol Transl Sci 2018
Karen J Thompson, Elham Khajehali, Sophie J Bradley, Jovana S Navarrete, Xi Ping Huang, Samuel Slocum, Jian Jin, Jing Liu, Yan Xiong, Reid H J Olsen,[...]. ACS Pharmacol Transl Sci 2018
26
Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.
Tevye J Stachniak, Anirvan Ghosh, Scott M Sternson. Neuron 2014
Tevye J Stachniak, Anirvan Ghosh, Scott M Sternson. Neuron 2014
17
Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor.
Ken-ichiro Nakajima, Jürgen Wess. Mol Pharmacol 2012
Ken-ichiro Nakajima, Jürgen Wess. Mol Pharmacol 2012
20
Millisecond-timescale, genetically targeted optical control of neural activity.
Edward S Boyden, Feng Zhang, Ernst Bamberg, Georg Nagel, Karl Deisseroth. Nat Neurosci 2005
Edward S Boyden, Feng Zhang, Ernst Bamberg, Georg Nagel, Karl Deisseroth. Nat Neurosci 2005
16
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.
D Gowanlock R Tervo, Bum-Yeol Hwang, Sarada Viswanathan, Thomas Gaj, Maria Lavzin, Kimberly D Ritola, Sarah Lindo, Susan Michael, Elena Kuleshova, David Ojala,[...]. Neuron 2016
D Gowanlock R Tervo, Bum-Yeol Hwang, Sarada Viswanathan, Thomas Gaj, Maria Lavzin, Kimberly D Ritola, Sarah Lindo, Susan Michael, Elena Kuleshova, David Ojala,[...]. Neuron 2016
15
Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.
Duncan A A MacLaren, Richard W Browne, Jessica K Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, Stewart D Clark. eNeuro 2016
Duncan A A MacLaren, Richard W Browne, Jessica K Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, Stewart D Clark. eNeuro 2016
15
Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics.
Jessica Raper, Ryan D Morrison, J Scott Daniels, Leonard Howell, Jocelyne Bachevalier, Thomas Wichmann, Adriana Galvan. ACS Chem Neurosci 2017
Jessica Raper, Ryan D Morrison, J Scott Daniels, Leonard Howell, Jocelyne Bachevalier, Thomas Wichmann, Adriana Galvan. ACS Chem Neurosci 2017
23
The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice.
Daniel F Manvich, Kevin A Webster, Stephanie L Foster, Martilias S Farrell, James C Ritchie, Joseph H Porter, David Weinshenker. Sci Rep 2018
Daniel F Manvich, Kevin A Webster, Stephanie L Foster, Martilias S Farrell, James C Ritchie, Joseph H Porter, David Weinshenker. Sci Rep 2018
14
Ultrasensitive fluorescent proteins for imaging neuronal activity.
Tsai-Wen Chen, Trevor J Wardill, Yi Sun, Stefan R Pulver, Sabine L Renninger, Amy Baohan, Eric R Schreiter, Rex A Kerr, Michael B Orger, Vivek Jayaraman,[...]. Nature 2013
Tsai-Wen Chen, Trevor J Wardill, Yi Sun, Stefan R Pulver, Sabine L Renninger, Amy Baohan, Eric R Schreiter, Rex A Kerr, Michael B Orger, Vivek Jayaraman,[...]. Nature 2013
13
Chemogenetic Tools for Causal Cellular and Neuronal Biology.
Deniz Atasoy, Scott M Sternson. Physiol Rev 2018
Deniz Atasoy, Scott M Sternson. Physiol Rev 2018
25
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Manami Takahashi, Xi-Ping Huang, Samuel T Slocum, Jeffrey F DiBerto,[...]. Nat Neurosci 2020
Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Manami Takahashi, Xi-Ping Huang, Samuel T Slocum, Jeffrey F DiBerto,[...]. Nat Neurosci 2020
22
Targeting cells with single vectors using multiple-feature Boolean logic.
Lief E Fenno, Joanna Mattis, Charu Ramakrishnan, Minsuk Hyun, Soo Yeun Lee, Miao He, Jason Tucciarone, Aslihan Selimbeyoglu, Andre Berndt, Logan Grosenick,[...]. Nat Methods 2014
Lief E Fenno, Joanna Mattis, Charu Ramakrishnan, Minsuk Hyun, Soo Yeun Lee, Miao He, Jason Tucciarone, Aslihan Selimbeyoglu, Andre Berndt, Logan Grosenick,[...]. Nat Methods 2014
12
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value.
Mark A G Eldridge, Walter Lerchner, Richard C Saunders, Hiroyuki Kaneko, Kristopher W Krausz, Frank J Gonzalez, Bin Ji, Makoto Higuchi, Takafumi Minamimoto, Barry J Richmond. Nat Neurosci 2016
Mark A G Eldridge, Walter Lerchner, Richard C Saunders, Hiroyuki Kaneko, Kristopher W Krausz, Frank J Gonzalez, Bin Ji, Makoto Higuchi, Takafumi Minamimoto, Barry J Richmond. Nat Neurosci 2016
14
Deconstruction of a neural circuit for hunger.
Deniz Atasoy, J Nicholas Betley, Helen H Su, Scott M Sternson. Nature 2012
Deniz Atasoy, J Nicholas Betley, Helen H Su, Scott M Sternson. Nature 2012
11
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten, Mark W Howe, Aaron Marley, Wei-Hong Xiong, Robert W Folk, Gerard Joey Broussard, Ruqiang Liang, Min Jee Jang,[...]. Science 2018
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten, Mark W Howe, Aaron Marley, Wei-Hong Xiong, Robert W Folk, Gerard Joey Broussard, Ruqiang Liang, Min Jee Jang,[...]. Science 2018
11
Engineering GPCR signaling pathways with RASSLs.
Bruce R Conklin, Edward C Hsiao, Sylvie Claeysen, Aline Dumuis, Supriya Srinivasan, John R Forsayeth, Jean-Marc Guettier, W C Chang, Ying Pei, Ken D McCarthy,[...]. Nat Methods 2008
Bruce R Conklin, Edward C Hsiao, Sylvie Claeysen, Aline Dumuis, Supriya Srinivasan, John R Forsayeth, Jean-Marc Guettier, W C Chang, Ying Pei, Ken D McCarthy,[...]. Nat Methods 2008
11
Controlling signaling with a specifically designed Gi-coupled receptor.
P Coward, H G Wada, M S Falk, S D Chan, F Meng, H Akil, B R Conklin. Proc Natl Acad Sci U S A 1998
P Coward, H G Wada, M S Falk, S D Chan, F Meng, H Akil, B R Conklin. Proc Natl Acad Sci U S A 1998
11
The Use of DREADDs to Deconstruct Behavior.
Paul D Whissell, Sarasa Tohyama, Loren J Martin. Front Genet 2016
Paul D Whissell, Sarasa Tohyama, Loren J Martin. Front Genet 2016
16
10
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
Martilias S Farrell, Ying Pei, Yehong Wan, Prem N Yadav, Tanya L Daigle, Daniel J Urban, Hyeong-Min Lee, Noah Sciaky, Arkeen Simmons, Randal J Nonneman,[...]. Neuropsychopharmacology 2013
Martilias S Farrell, Ying Pei, Yehong Wan, Prem N Yadav, Tanya L Daigle, Daniel J Urban, Hyeong-Min Lee, Noah Sciaky, Arkeen Simmons, Randal J Nonneman,[...]. Neuropsychopharmacology 2013
11
Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice.
Martin Jendryka, Monika Palchaudhuri, Daniel Ursu, Bastiaan van der Veen, Birgit Liss, Dennis Kätzel, Wiebke Nissen, Anton Pekcec. Sci Rep 2019
Martin Jendryka, Monika Palchaudhuri, Daniel Ursu, Bastiaan van der Veen, Birgit Liss, Dennis Kätzel, Wiebke Nissen, Anton Pekcec. Sci Rep 2019
13
Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration.
M W Jann, Y W Lam, W H Chang. Arch Int Pharmacodyn Ther 1994
M W Jann, Y W Lam, W H Chang. Arch Int Pharmacodyn Ther 1994
10
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.
Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-Ichi Inoue, Bin Ji, Mark A G Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori,[...]. Nat Commun 2016
Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-Ichi Inoue, Bin Ji, Mark A G Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori,[...]. Nat Commun 2016
16
Natural neural projection dynamics underlying social behavior.
Lisa A Gunaydin, Logan Grosenick, Joel C Finkelstein, Isaac V Kauvar, Lief E Fenno, Avishek Adhikari, Stephan Lammel, Julie J Mirzabekov, Raag D Airan, Kelly A Zalocusky,[...]. Cell 2014
Lisa A Gunaydin, Logan Grosenick, Joel C Finkelstein, Isaac V Kauvar, Lief E Fenno, Avishek Adhikari, Stephan Lammel, Julie J Mirzabekov, Raag D Airan, Kelly A Zalocusky,[...]. Cell 2014
9
Allele-specific activation of genetically engineered receptors.
C D Strader, T Gaffney, E E Sugg, M R Candelore, R Keys, A A Patchett, R A Dixon. J Biol Chem 1991
C D Strader, T Gaffney, E E Sugg, M R Candelore, R Keys, A A Patchett, R A Dixon. J Biol Chem 1991
9
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats.
Nathan J Marchant, Leslie R Whitaker, Jennifer M Bossert, Brandon K Harvey, Bruce T Hope, Konstantin Kaganovsky, Sweta Adhikary, Thomas E Prisinzano, Eyal Vardy, Bryan L Roth,[...]. Neuropsychopharmacology 2016
Nathan J Marchant, Leslie R Whitaker, Jennifer M Bossert, Brandon K Harvey, Bruce T Hope, Konstantin Kaganovsky, Sweta Adhikary, Thomas E Prisinzano, Eyal Vardy, Bryan L Roth,[...]. Neuropsychopharmacology 2016
20
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.
Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman,[...]. Nat Neurosci 2017
Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman,[...]. Nat Neurosci 2017
9
DREADDS: Use and application in behavioral neuroscience.
Kyle S Smith, David J Bucci, Bryan W Luikart, Stephen V Mahler. Behav Neurosci 2016
Kyle S Smith, David J Bucci, Bryan W Luikart, Stephen V Mahler. Behav Neurosci 2016
9
Chemical-genetic attenuation of focal neocortical seizures.
Dennis Kätzel, Elizabeth Nicholson, Stephanie Schorge, Matthew C Walker, Dimitri M Kullmann. Nat Commun 2014
Dennis Kätzel, Elizabeth Nicholson, Stephanie Schorge, Matthew C Walker, Dimitri M Kullmann. Nat Commun 2014
10
High-potency ligands for DREADD imaging and activation in rodents and monkeys.
Jordi Bonaventura, Mark A G Eldridge, Feng Hu, Juan L Gomez, Marta Sanchez-Soto, Ara M Abramyan, Sherry Lam, Matthew A Boehm, Christina Ruiz, Mitchell R Farrell,[...]. Nat Commun 2019
Jordi Bonaventura, Mark A G Eldridge, Feng Hu, Juan L Gomez, Marta Sanchez-Soto, Ara M Abramyan, Sherry Lam, Matthew A Boehm, Christina Ruiz, Mitchell R Farrell,[...]. Nat Commun 2019
17
Optogenetics in neural systems.
Ofer Yizhar, Lief E Fenno, Thomas J Davidson, Murtaza Mogri, Karl Deisseroth. Neuron 2011
Ofer Yizhar, Lief E Fenno, Thomas J Davidson, Murtaza Mogri, Karl Deisseroth. Neuron 2011
8
Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.
Arjen J Boender, Johannes W de Jong, Linde Boekhoudt, Mieneke C M Luijendijk, Geoffrey van der Plasse, Roger A H Adan. PLoS One 2014
Arjen J Boender, Johannes W de Jong, Linde Boekhoudt, Mieneke C M Luijendijk, Geoffrey van der Plasse, Roger A H Adan. PLoS One 2014
10
Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.
Hu Zhu, Dipendra K Aryal, Reid H J Olsen, Daniel J Urban, Amanda Swearingen, Stacy Forbes, Bryan L Roth, Ute Hochgeschwender. Genesis 2016
Hu Zhu, Dipendra K Aryal, Reid H J Olsen, Daniel J Urban, Amanda Swearingen, Stacy Forbes, Bryan L Roth, Ute Hochgeschwender. Genesis 2016
9
Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks.
Michael Michaelides, Sarah Ann R Anderson, Mala Ananth, Denis Smirnov, Panayotis K Thanos, John F Neumaier, Gene-Jack Wang, Nora D Volkow, Yasmin L Hurd. J Clin Invest 2013
Michael Michaelides, Sarah Ann R Anderson, Mala Ananth, Denis Smirnov, Panayotis K Thanos, John F Neumaier, Gene-Jack Wang, Nora D Volkow, Yasmin L Hurd. J Clin Invest 2013
14
The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala.
David S Grayson, Eliza Bliss-Moreau, Christopher J Machado, Jeffrey Bennett, Kelly Shen, Kathleen A Grant, Damien A Fair, David G Amaral. Neuron 2016
David S Grayson, Eliza Bliss-Moreau, Christopher J Machado, Jeffrey Bennett, Kelly Shen, Kathleen A Grant, Damien A Fair, David G Amaral. Neuron 2016
8
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking.
Stephen V Mahler, Elena M Vazey, Jacob T Beckley, Colby R Keistler, Ellen M McGlinchey, Jennifer Kaufling, Steven P Wilson, Karl Deisseroth, John J Woodward, Gary Aston-Jones. Nat Neurosci 2014
Stephen V Mahler, Elena M Vazey, Jacob T Beckley, Colby R Keistler, Ellen M McGlinchey, Jennifer Kaufling, Steven P Wilson, Karl Deisseroth, John J Woodward, Gary Aston-Jones. Nat Neurosci 2014
8
Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.
Daniel J Urban, Hu Zhu, Catherine A Marcinkiewcz, Michael Michaelides, Hidehiro Oshibuchi, Darren Rhea, Dipendra K Aryal, Martilias S Farrell, Emily Lowery-Gionta, Reid H J Olsen,[...]. Neuropsychopharmacology 2016
Daniel J Urban, Hu Zhu, Catherine A Marcinkiewcz, Michael Michaelides, Hidehiro Oshibuchi, Darren Rhea, Dipendra K Aryal, Martilias S Farrell, Emily Lowery-Gionta, Reid H J Olsen,[...]. Neuropsychopharmacology 2016
10
A viral strategy for targeting and manipulating interneurons across vertebrate species.
Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu,[...]. Nat Neurosci 2016
Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu,[...]. Nat Neurosci 2016
8
Chronic activation of a designer G(q)-coupled receptor improves β cell function.
Shalini Jain, Inigo Ruiz de Azua, Huiyan Lu, Morris F White, Jean-Marc Guettier, Jürgen Wess. J Clin Invest 2013
Shalini Jain, Inigo Ruiz de Azua, Huiyan Lu, Morris F White, Jean-Marc Guettier, Jürgen Wess. J Clin Invest 2013
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.