Matthias Dobbelstein, Claus Storgaard Sørensen. Nat Rev Drug Discov 2015
Times Cited: 179
Times Cited: 179
Times Cited
Times Co-cited
Similarity
Causes and consequences of replication stress.
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
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Replication stress and cancer.
Hélène Gaillard, Tatiana García-Muse, Andrés Aguilera. Nat Rev Cancer 2015
Hélène Gaillard, Tatiana García-Muse, Andrés Aguilera. Nat Rev Cancer 2015
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DNA replication stress as a hallmark of cancer.
Morgane Macheret, Thanos D Halazonetis. Annu Rev Pathol 2015
Morgane Macheret, Thanos D Halazonetis. Annu Rev Pathol 2015
20
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino,[...]. Nature 2016
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino,[...]. Nature 2016
14
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Sophia X Pfister, Enni Markkanen, Yanyan Jiang, Sovan Sarkar, Mick Woodcock, Giulia Orlando, Ioanna Mavrommati, Chen-Chun Pai, Lykourgos-Panagiotis Zalmas, Neele Drobnitzky,[...]. Cancer Cell 2015
Sophia X Pfister, Enni Markkanen, Yanyan Jiang, Sovan Sarkar, Mick Woodcock, Giulia Orlando, Ioanna Mavrommati, Chen-Chun Pai, Lykourgos-Panagiotis Zalmas, Neele Drobnitzky,[...]. Cancer Cell 2015
14
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas. Cell 2013
Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas. Cell 2013
13
12
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
Andrew N Blackford, Stephen P Jackson. Mol Cell 2017
Andrew N Blackford, Stephen P Jackson. Mol Cell 2017
12
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase.
Rémi Buisson, Jessica L Boisvert, Cyril H Benes, Lee Zou. Mol Cell 2015
Rémi Buisson, Jessica L Boisvert, Cyril H Benes, Lee Zou. Mol Cell 2015
12
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.
Claus Storgaard Sørensen, Randi G Syljuåsen. Nucleic Acids Res 2012
Claus Storgaard Sørensen, Randi G Syljuåsen. Nucleic Acids Res 2012
12
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.
Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada, Tsuyoshi Arai, Toshihide Nishibata, Makiko Kobayashi, Toshifumi Kimura, Naoki Kaneko, Junko Ohtani, Kazunori Yamanaka,[...]. Mol Cancer Ther 2009
Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada, Tsuyoshi Arai, Toshihide Nishibata, Makiko Kobayashi, Toshifumi Kimura, Naoki Kaneko, Junko Ohtani, Kazunori Yamanaka,[...]. Mol Cancer Ther 2009
12
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
Jirina Bartkova, Zuzana Horejsí, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M Nesland, Claudia Lukas,[...]. Nature 2005
Jirina Bartkova, Zuzana Horejsí, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M Nesland, Claudia Lukas,[...]. Nature 2005
11
Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.
Suzanne Leijen, Robin M J M van Geel, Gabe S Sonke, Daphne de Jong, Efraim H Rosenberg, Serena Marchetti, Dick Pluim, Erik van Werkhoven, Shelonitda Rose, Mark A Lee,[...]. J Clin Oncol 2016
Suzanne Leijen, Robin M J M van Geel, Gabe S Sonke, Daphne de Jong, Efraim H Rosenberg, Serena Marchetti, Dick Pluim, Erik van Werkhoven, Shelonitda Rose, Mark A Lee,[...]. J Clin Oncol 2016
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The essential kinase ATR: ensuring faithful duplication of a challenging genome.
Joshua C Saldivar, David Cortez, Karlene A Cimprich. Nat Rev Mol Cell Biol 2017
Joshua C Saldivar, David Cortez, Karlene A Cimprich. Nat Rev Mol Cell Biol 2017
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Replication Catastrophe: When a Checkpoint Fails because of Exhaustion.
Luis Toledo, Kai John Neelsen, Jiri Lukas. Mol Cell 2017
Luis Toledo, Kai John Neelsen, Jiri Lukas. Mol Cell 2017
10
The DNA damage response: making it safe to play with knives.
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
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10
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.
Khanh Do, Deborah Wilsker, Jiuping Ji, Jennifer Zlott, Tomoko Freshwater, Robert J Kinders, Jerry Collins, Alice P Chen, James H Doroshow, Shivaani Kummar. J Clin Oncol 2015
Khanh Do, Deborah Wilsker, Jiuping Ji, Jennifer Zlott, Tomoko Freshwater, Robert J Kinders, Jerry Collins, Alice P Chen, James H Doroshow, Shivaani Kummar. J Clin Oncol 2015
10
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.
Halfdan Beck, Viola Nähse-Kumpf, Marie Sofie Yoo Larsen, Karen A O'Hanlon, Sebastian Patzke, Christian Holmberg, Jakob Mejlvang, Anja Groth, Olaf Nielsen, Randi G Syljuåsen,[...]. Mol Cell Biol 2012
Halfdan Beck, Viola Nähse-Kumpf, Marie Sofie Yoo Larsen, Karen A O'Hanlon, Sebastian Patzke, Christian Holmberg, Jakob Mejlvang, Anja Groth, Olaf Nielsen, Randi G Syljuåsen,[...]. Mol Cell Biol 2012
10
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells.
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas, Michelle Debatisse. Nat Rev Genet 2017
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas, Michelle Debatisse. Nat Rev Genet 2017
10
10
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
Stephanie A Yazinski, Valentine Comaills, Rémi Buisson, Marie-Michelle Genois, Hai Dang Nguyen, Chu Kwen Ho, Tanya Todorova Kwan, Robert Morris, Sam Lauffer, André Nussenzweig,[...]. Genes Dev 2017
Stephanie A Yazinski, Valentine Comaills, Rémi Buisson, Marie-Michelle Genois, Hai Dang Nguyen, Chu Kwen Ho, Tanya Todorova Kwan, Robert Morris, Sam Lauffer, André Nussenzweig,[...]. Genes Dev 2017
10
Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.
Suzanne Leijen, Robin M J M van Geel, Anna C Pavlick, Raoul Tibes, Lee Rosen, Albiruni R Abdul Razak, Raymond Lam, Tim Demuth, Shelonitda Rose, Mark A Lee,[...]. J Clin Oncol 2016
Suzanne Leijen, Robin M J M van Geel, Anna C Pavlick, Raoul Tibes, Lee Rosen, Albiruni R Abdul Razak, Raymond Lam, Tim Demuth, Shelonitda Rose, Mark A Lee,[...]. J Clin Oncol 2016
10
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
Junko Murai, Shar-yin N Huang, Benu Brata Das, Amelie Renaud, Yiping Zhang, James H Doroshow, Jiuping Ji, Shunichi Takeda, Yves Pommier. Cancer Res 2012
Junko Murai, Shar-yin N Huang, Benu Brata Das, Amelie Renaud, Yiping Zhang, James H Doroshow, Jiuping Ji, Shunichi Takeda, Yves Pommier. Cancer Res 2012
10
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
10
Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis.
Amirali B Bukhari, Cody W Lewis, Joanna J Pearce, Deandra Luong, Gordon K Chan, Armin M Gamper. J Clin Invest 2019
Amirali B Bukhari, Cody W Lewis, Joanna J Pearce, Deandra Luong, Gordon K Chan, Armin M Gamper. J Clin Invest 2019
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Exploiting DNA Replication Stress for Cancer Treatment.
Tajinder Ubhi, Grant W Brown. Cancer Res 2019
Tajinder Ubhi, Grant W Brown. Cancer Res 2019
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An oncogene-induced DNA damage model for cancer development.
Thanos D Halazonetis, Vassilis G Gorgoulis, Jiri Bartek. Science 2008
Thanos D Halazonetis, Vassilis G Gorgoulis, Jiri Bartek. Science 2008
9
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Vassilis G Gorgoulis, Leandros-Vassilios F Vassiliou, Panagiotis Karakaidos, Panayotis Zacharatos, Athanassios Kotsinas, Triantafillos Liloglou, Monica Venere, Richard A Ditullio, Nikolaos G Kastrinakis, Brynn Levy,[...]. Nature 2005
Vassilis G Gorgoulis, Leandros-Vassilios F Vassiliou, Panagiotis Karakaidos, Panayotis Zacharatos, Athanassios Kotsinas, Triantafillos Liloglou, Monica Venere, Richard A Ditullio, Nikolaos G Kastrinakis, Brynn Levy,[...]. Nature 2005
9
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Ralph Zellweger, Damian Dalcher, Karun Mutreja, Matteo Berti, Jonas A Schmid, Raquel Herrador, Alessandro Vindigni, Massimo Lopes. J Cell Biol 2015
Ralph Zellweger, Damian Dalcher, Karun Mutreja, Matteo Berti, Jonas A Schmid, Raquel Herrador, Alessandro Vindigni, Massimo Lopes. J Cell Biol 2015
9
Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.
Yong Fang, Daniel J McGrail, Chaoyang Sun, Marilyne Labrie, Xiaohua Chen, Dong Zhang, Zhenlin Ju, Christopher P Vellano, Yiling Lu, Yongsheng Li,[...]. Cancer Cell 2019
Yong Fang, Daniel J McGrail, Chaoyang Sun, Marilyne Labrie, Xiaohua Chen, Dong Zhang, Zhenlin Ju, Christopher P Vellano, Yiling Lu, Yongsheng Li,[...]. Cancer Cell 2019
9
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
9
Replication stress: getting back on track.
Matteo Berti, Alessandro Vindigni. Nat Struct Mol Biol 2016
Matteo Berti, Alessandro Vindigni. Nat Struct Mol Biol 2016
8
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Shuhei Matsuoka, Bryan A Ballif, Agata Smogorzewska, E Robert McDonald, Kristen E Hurov, Ji Luo, Corey E Bakalarski, Zhenming Zhao, Nicole Solimini, Yaniv Lerenthal,[...]. Science 2007
Shuhei Matsuoka, Bryan A Ballif, Agata Smogorzewska, E Robert McDonald, Kristen E Hurov, Ji Luo, Corey E Bakalarski, Zhenming Zhao, Nicole Solimini, Yaniv Lerenthal,[...]. Science 2007
8
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Q Liu, S Guntuku, X S Cui, S Matsuoka, D Cortez, K Tamai, G Luo, S Carattini-Rivera, F DeMayo, A Bradley,[...]. Genes Dev 2000
Q Liu, S Guntuku, X S Cui, S Matsuoka, D Cortez, K Tamai, G Luo, S Carattini-Rivera, F DeMayo, A Bradley,[...]. Genes Dev 2000
8
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Marieke Aarts, Rachel Sharpe, Isaac Garcia-Murillas, Heidrun Gevensleben, Melissa S Hurd, Stuart D Shumway, Carlo Toniatti, Alan Ashworth, Nicholas C Turner. Cancer Discov 2012
Marieke Aarts, Rachel Sharpe, Isaac Garcia-Murillas, Heidrun Gevensleben, Melissa S Hurd, Stuart D Shumway, Carlo Toniatti, Alan Ashworth, Nicholas C Turner. Cancer Discov 2012
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State-of-the-art strategies for targeting the DNA damage response in cancer.
Patrick G Pilié, Chad Tang, Gordon B Mills, Timothy A Yap. Nat Rev Clin Oncol 2019
Patrick G Pilié, Chad Tang, Gordon B Mills, Timothy A Yap. Nat Rev Clin Oncol 2019
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Targeting the replication stress response in cancer.
Josep V Forment, Mark J O'Connor. Pharmacol Ther 2018
Josep V Forment, Mark J O'Connor. Pharmacol Ther 2018
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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models.
Hyoung Kim, Erin George, Ryan Ragland, Stavros Rafail, Rugang Zhang, Clemens Krepler, Mark Morgan, Meenhard Herlyn, Eric Brown, Fiona Simpkins. Clin Cancer Res 2017
Hyoung Kim, Erin George, Ryan Ragland, Stavros Rafail, Rugang Zhang, Clemens Krepler, Mark Morgan, Meenhard Herlyn, Eric Brown, Fiona Simpkins. Clin Cancer Res 2017
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Principles of cancer therapy: oncogene and non-oncogene addiction.
Ji Luo, Nicole L Solimini, Stephen J Elledge. Cell 2009
Ji Luo, Nicole L Solimini, Stephen J Elledge. Cell 2009
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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
Panagiotis Kotsantis, Eva Petermann, Simon J Boulton. Cancer Discov 2018
Panagiotis Kotsantis, Eva Petermann, Simon J Boulton. Cancer Discov 2018
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Replication stress activates DNA repair synthesis in mitosis.
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
7
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.
Claudia Lukas, Velibor Savic, Simon Bekker-Jensen, Carsten Doil, Beate Neumann, Ronni Sølvhøj Pedersen, Merete Grøfte, Kok Lung Chan, Ian David Hickson, Jiri Bartek,[...]. Nat Cell Biol 2011
Claudia Lukas, Velibor Savic, Simon Bekker-Jensen, Carsten Doil, Beate Neumann, Ronni Sølvhøj Pedersen, Merete Grøfte, Kok Lung Chan, Ian David Hickson, Jiri Bartek,[...]. Nat Cell Biol 2011
7
Maintaining genome stability at the replication fork.
Dana Branzei, Marco Foiani. Nat Rev Mol Cell Biol 2010
Dana Branzei, Marco Foiani. Nat Rev Mol Cell Biol 2010
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Jirina Bartkova, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C Zoumpourlis,[...]. Nature 2006
Jirina Bartkova, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C Zoumpourlis,[...]. Nature 2006
7
DNA replication stress and cancer chemotherapy.
Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara. Cancer Sci 2018
Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara. Cancer Sci 2018
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ATR: an essential regulator of genome integrity.
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
7
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.
Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G Syljuåsen, Cecilia Lundin, Jiri Bartek, Thomas Helleday. Nat Cell Biol 2005
Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G Syljuåsen, Cecilia Lundin, Jiri Bartek, Thomas Helleday. Nat Cell Biol 2005
7
Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.
Mike R Russell, Kirill Levin, JulieAnn Rader, Lili Belcastro, Yimei Li, Daniel Martinez, Bruce Pawel, Stuart D Shumway, John M Maris, Kristina A Cole. Cancer Res 2013
Mike R Russell, Kirill Levin, JulieAnn Rader, Lili Belcastro, Yimei Li, Daniel Martinez, Bruce Pawel, Stuart D Shumway, John M Maris, Kristina A Cole. Cancer Res 2013
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.