Kevin H Wang, Aravind Penmatsa, Eric Gouaux. Nature 2015
Times Cited: 241
Times Cited: 241
Times Cited
Times Co-cited
Similarity
X-ray structures and mechanism of the human serotonin transporter.
Jonathan A Coleman, Evan M Green, Eric Gouaux. Nature 2016
Jonathan A Coleman, Evan M Green, Eric Gouaux. Nature 2016
52
X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Aravind Penmatsa, Kevin H Wang, Eric Gouaux. Nature 2013
Aravind Penmatsa, Kevin H Wang, Eric Gouaux. Nature 2013
47
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.
Atsuko Yamashita, Satinder K Singh, Toshimitsu Kawate, Yan Jin, Eric Gouaux. Nature 2005
Atsuko Yamashita, Satinder K Singh, Toshimitsu Kawate, Yan Jin, Eric Gouaux. Nature 2005
46
SLC6 neurotransmitter transporters: structure, function, and regulation.
Anders S Kristensen, Jacob Andersen, Trine N Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J Loland, Kristian Strømgaard, Ulrik Gether. Pharmacol Rev 2011
Anders S Kristensen, Jacob Andersen, Trine N Jørgensen, Lena Sørensen, Jacob Eriksen, Claus J Loland, Kristian Strømgaard, Ulrik Gether. Pharmacol Rev 2011
34
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Harini Krishnamurthy, Eric Gouaux. Nature 2012
Harini Krishnamurthy, Eric Gouaux. Nature 2012
25
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
Aravind Penmatsa, Kevin H Wang, Eric Gouaux. Nat Struct Mol Biol 2015
Aravind Penmatsa, Kevin H Wang, Eric Gouaux. Nat Struct Mol Biol 2015
22
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Jonathan A Coleman, Dongxue Yang, Zhiyu Zhao, Po-Chao Wen, Craig Yoshioka, Emad Tajkhorshid, Eric Gouaux. Nature 2019
Jonathan A Coleman, Dongxue Yang, Zhiyu Zhao, Po-Chao Wen, Craig Yoshioka, Emad Tajkhorshid, Eric Gouaux. Nature 2019
27
Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
Jonathan A Coleman, Eric Gouaux. Nat Struct Mol Biol 2018
Jonathan A Coleman, Eric Gouaux. Nat Struct Mol Biol 2018
32
Mechanism for alternating access in neurotransmitter transporters.
Lucy R Forrest, Yuan-Wei Zhang, Miriam T Jacobs, Joan Gesmonde, Li Xie, Barry H Honig, Gary Rudnick. Proc Natl Acad Sci U S A 2008
Lucy R Forrest, Yuan-Wei Zhang, Miriam T Jacobs, Joan Gesmonde, Li Xie, Barry H Honig, Gary Rudnick. Proc Natl Acad Sci U S A 2008
19
Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter.
Mary Hongying Cheng, Ivet Bahar. Structure 2015
Mary Hongying Cheng, Ivet Bahar. Structure 2015
32
A competitive inhibitor traps LeuT in an open-to-out conformation.
Satinder K Singh, Chayne L Piscitelli, Atsuko Yamashita, Eric Gouaux. Science 2008
Satinder K Singh, Chayne L Piscitelli, Atsuko Yamashita, Eric Gouaux. Science 2008
17
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Satinder K Singh, Atsuko Yamashita, Eric Gouaux. Nature 2007
Satinder K Singh, Atsuko Yamashita, Eric Gouaux. Nature 2007
16
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether,[...]. Nat Neurosci 2008
Thijs Beuming, Julie Kniazeff, Marianne L Bergmann, Lei Shi, Luis Gracia, Klaudia Raniszewska, Amy Hauck Newman, Jonathan A Javitch, Harel Weinstein, Ulrik Gether,[...]. Nat Neurosci 2008
16
Monoamine transporters: structure, intrinsic dynamics and allosteric regulation.
Mary Hongying Cheng, Ivet Bahar. Nat Struct Mol Biol 2019
Mary Hongying Cheng, Ivet Bahar. Nat Struct Mol Biol 2019
43
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.
Matthias Quick, Anne-Marie Lund Winther, Lei Shi, Poul Nissen, Harel Weinstein, Jonathan A Javitch. Proc Natl Acad Sci U S A 2009
Matthias Quick, Anne-Marie Lund Winther, Lei Shi, Poul Nissen, Harel Weinstein, Jonathan A Javitch. Proc Natl Acad Sci U S A 2009
15
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.
Lei Shi, Matthias Quick, Yongfang Zhao, Harel Weinstein, Jonathan A Javitch. Mol Cell 2008
Lei Shi, Matthias Quick, Yongfang Zhao, Harel Weinstein, Jonathan A Javitch. Mol Cell 2008
15
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus.
George Khelashvili, Nathaniel Stanley, Michelle A Sahai, Jaime Medina, Michael V LeVine, Lei Shi, Gianni De Fabritiis, Harel Weinstein. ACS Chem Neurosci 2015
George Khelashvili, Nathaniel Stanley, Michelle A Sahai, Jaime Medina, Michael V LeVine, Lei Shi, Gianni De Fabritiis, Harel Weinstein. ACS Chem Neurosci 2015
17
Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding.
Mary Hongying Cheng, Ethan Block, Feizhuo Hu, Murat Can Cobanoglu, Alexander Sorkin, Ivet Bahar. Front Neurol 2015
Mary Hongying Cheng, Ethan Block, Feizhuo Hu, Murat Can Cobanoglu, Alexander Sorkin, Ivet Bahar. Front Neurol 2015
30
Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith, Da-Neng Wang. Nat Struct Mol Biol 2009
Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith, Da-Neng Wang. Nat Struct Mol Biol 2009
12
A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.
Asghar M Razavi, George Khelashvili, Harel Weinstein. Sci Rep 2017
Asghar M Razavi, George Khelashvili, Harel Weinstein. Sci Rep 2017
26
Scalable molecular dynamics with NAMD.
James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten. J Comput Chem 2005
James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten. J Comput Chem 2005
11
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function.
Thijs Beuming, Lei Shi, Jonathan A Javitch, Harel Weinstein. Mol Pharmacol 2006
Thijs Beuming, Lei Shi, Jonathan A Javitch, Harel Weinstein. Mol Pharmacol 2006
11
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.
Lina Malinauskaite, Matthias Quick, Linda Reinhard, Joseph A Lyons, Hideaki Yano, Jonathan A Javitch, Poul Nissen. Nat Struct Mol Biol 2014
Lina Malinauskaite, Matthias Quick, Linda Reinhard, Joseph A Lyons, Hideaki Yano, Jonathan A Javitch, Poul Nissen. Nat Struct Mol Biol 2014
11
Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.
George Khelashvili, Milka Doktorova, Michelle A Sahai, Niklaus Johner, Lei Shi, Harel Weinstein. Proteins 2015
George Khelashvili, Milka Doktorova, Michelle A Sahai, Niklaus Johner, Lei Shi, Harel Weinstein. Proteins 2015
29
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.
Jufang Shan, Jonathan A Javitch, Lei Shi, Harel Weinstein. PLoS One 2011
Jufang Shan, Jonathan A Javitch, Lei Shi, Harel Weinstein. PLoS One 2011
11
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Hui Wang, April Goehring, Kevin H Wang, Aravind Penmatsa, Ryan Ressler, Eric Gouaux. Nature 2013
Hui Wang, April Goehring, Kevin H Wang, Aravind Penmatsa, Ryan Ressler, Eric Gouaux. Nature 2013
11
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
Yongfang Zhao, Daniel S Terry, Lei Shi, Matthias Quick, Harel Weinstein, Scott C Blanchard, Jonathan A Javitch. Nature 2011
Yongfang Zhao, Daniel S Terry, Lei Shi, Matthias Quick, Harel Weinstein, Scott C Blanchard, Jonathan A Javitch. Nature 2011
10
Comparative modeling of the human monoamine transporters: similarities in substrate binding.
Heidi Koldsø, Anja B Christiansen, Steffen Sinning, Birgit Schiøtt. ACS Chem Neurosci 2013
Heidi Koldsø, Anja B Christiansen, Steffen Sinning, Birgit Schiøtt. ACS Chem Neurosci 2013
23
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.
Jacob Andersen, Lars Olsen, Kasper B Hansen, Olivier Taboureau, Flemming S Jørgensen, Anne Marie Jørgensen, Benny Bang-Andersen, Jan Egebjerg, Kristian Strømgaard, Anders S Kristensen. J Biol Chem 2010
Jacob Andersen, Lars Olsen, Kasper B Hansen, Olivier Taboureau, Flemming S Jørgensen, Anne Marie Jørgensen, Benny Bang-Andersen, Jan Egebjerg, Kristian Strømgaard, Anders S Kristensen. J Biol Chem 2010
13
Mechanisms of dopamine transporter regulation in normal and disease states.
Roxanne A Vaughan, James D Foster. Trends Pharmacol Sci 2013
Roxanne A Vaughan, James D Foster. Trends Pharmacol Sci 2013
10
UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin. J Comput Chem 2004
Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin. J Comput Chem 2004
10
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.
Oleg Trott, Arthur J Olson. J Comput Chem 2010
Oleg Trott, Arthur J Olson. J Comput Chem 2010
10
Identification of a chloride ion binding site in Na+/Cl -dependent transporters.
Lucy R Forrest, Sotiria Tavoulari, Yuan-Wei Zhang, Gary Rudnick, Barry Honig. Proc Natl Acad Sci U S A 2007
Lucy R Forrest, Sotiria Tavoulari, Yuan-Wei Zhang, Gary Rudnick, Barry Honig. Proc Natl Acad Sci U S A 2007
10
Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.
Maarten E A Reith, Bruce E Blough, Weimin C Hong, Kymry T Jones, Kyle C Schmitt, Michael H Baumann, John S Partilla, Richard B Rothman, Jonathan L Katz. Drug Alcohol Depend 2015
Maarten E A Reith, Bruce E Blough, Weimin C Hong, Kymry T Jones, Kyle C Schmitt, Michael H Baumann, John S Partilla, Richard B Rothman, Jonathan L Katz. Drug Alcohol Depend 2015
11
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.
Per Plenge, Lei Shi, Thijs Beuming, Jerez Te, Amy Hauck Newman, Harel Weinstein, Ulrik Gether, Claus J Loland. J Biol Chem 2012
Per Plenge, Lei Shi, Thijs Beuming, Jerez Te, Amy Hauck Newman, Harel Weinstein, Ulrik Gether, Claus J Loland. J Biol Chem 2012
13
A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition.
Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøtt. PLoS Comput Biol 2018
Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Xavier Periole, Birgit Schiøtt. PLoS Comput Biol 2018
18
Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.
Louise Laursen, Kasper Severinsen, Kristina Birch Kristensen, Xavier Periole, Malene Overby, Heidi Kaastrup Müller, Birgit Schiøtt, Steffen Sinning. J Biol Chem 2018
Louise Laursen, Kasper Severinsen, Kristina Birch Kristensen, Xavier Periole, Malene Overby, Heidi Kaastrup Müller, Birgit Schiøtt, Steffen Sinning. J Biol Chem 2018
28
Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.
Weimin C Hong, Susan G Amara. J Biol Chem 2010
Weimin C Hong, Susan G Amara. J Biol Chem 2010
9
Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.
Sotiria Tavoulari, Lucy R Forrest, Gary Rudnick. J Neurosci 2009
Sotiria Tavoulari, Lucy R Forrest, Gary Rudnick. J Neurosci 2009
12
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Zheng Zhou, Juan Zhen, Nathan K Karpowich, Regina M Goetz, Christopher J Law, Maarten E A Reith, Da-Neng Wang. Science 2007
Zheng Zhou, Juan Zhen, Nathan K Karpowich, Regina M Goetz, Christopher J Law, Maarten E A Reith, Da-Neng Wang. Science 2007
9
The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.
Gary Rudnick, Reinhard Krämer, Randy D Blakely, Dennis L Murphy, Francois Verrey. Pflugers Arch 2014
Gary Rudnick, Reinhard Krämer, Randy D Blakely, Dennis L Murphy, Francois Verrey. Pflugers Arch 2014
10
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.
Jacob Andersen, Nicolai Stuhr-Hansen, Linda Zachariassen, Søren Toubro, Stinna M R Hansen, Jonas N N Eildal, Andrew D Bond, Klaus P Bøgesø, Benny Bang-Andersen, Anders S Kristensen,[...]. Proc Natl Acad Sci U S A 2011
Jacob Andersen, Nicolai Stuhr-Hansen, Linda Zachariassen, Søren Toubro, Stinna M R Hansen, Jonas N N Eildal, Andrew D Bond, Klaus P Bøgesø, Benny Bang-Andersen, Anders S Kristensen,[...]. Proc Natl Acad Sci U S A 2011
17
Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog.
Sotiria Tavoulari, Eleonora Margheritis, Anu Nagarajan, David C DeWitt, Yuan-Wei Zhang, Edwin Rosado, Silvia Ravera, Elizabeth Rhoades, Lucy R Forrest, Gary Rudnick. J Biol Chem 2016
Sotiria Tavoulari, Eleonora Margheritis, Anu Nagarajan, David C DeWitt, Yuan-Wei Zhang, Edwin Rosado, Silvia Ravera, Elizabeth Rhoades, Lucy R Forrest, Gary Rudnick. J Biol Chem 2016
19
Neurotransmitter transporters: molecular function of important drug targets.
Ulrik Gether, Peter H Andersen, Orla M Larsson, Arne Schousboe. Trends Pharmacol Sci 2006
Ulrik Gether, Peter H Andersen, Orla M Larsson, Arne Schousboe. Trends Pharmacol Sci 2006
8
SLC6 transporters: structure, function, regulation, disease association and therapeutics.
Akula Bala Pramod, James Foster, Lucia Carvelli, L Keith Henry. Mol Aspects Med 2013
Akula Bala Pramod, James Foster, Lucia Carvelli, L Keith Henry. Mol Aspects Med 2013
8
8
Mechanisms of neurotransmitter release by amphetamines: a review.
David Sulzer, Mark S Sonders, Nathan W Poulsen, Aurelio Galli. Prog Neurobiol 2005
David Sulzer, Mark S Sonders, Nathan W Poulsen, Aurelio Galli. Prog Neurobiol 2005
8
25
A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt,[...]. Nat Commun 2016
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt,[...]. Nat Commun 2016
22
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.