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Times Cited: 318
Times Cited: 318
Times Cited
Times Co-cited
Similarity
CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset.
. Cell 2019
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51
44
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones,[...]. Lancet Neurol 2017
39
DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
Conceição Bettencourt, Davina Hensman-Moss, Michael Flower, Sarah Wiethoff, Alexis Brice, Cyril Goizet, Giovanni Stevanin, Georgios Koutsis, Georgia Karadima, Marios Panas,[...]. Ann Neurol 2016
31
Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis,[...]. PLoS Genet 2013
Ricardo Mouro Pinto, Ella Dragileva, Andrew Kirby, Alejandro Lloret, Edith Lopez, Jason St Claire, Gagan B Panigrahi, Caixia Hou, Kim Holloway, Tammy Gillis,[...]. PLoS Genet 2013
28
A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes.
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
Marc Ciosi, Alastair Maxwell, Sarah A Cumming, Davina J Hensman Moss, Asma M Alshammari, Michael D Flower, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Peter Holmans,[...]. EBioMedicine 2019
51
A modifier of Huntington's disease onset at the MLH1 locus.
Jong-Min Lee, Michael J Chao, Denise Harold, Kawther Abu Elneel, Tammy Gillis, Peter Holmans, Lesley Jones, Michael Orth, Richard H Myers, Seung Kwak,[...]. Hum Mol Genet 2017
Jong-Min Lee, Michael J Chao, Denise Harold, Kawther Abu Elneel, Tammy Gillis, Peter Holmans, Lesley Jones, Michael Orth, Richard H Myers, Seung Kwak,[...]. Hum Mol Genet 2017
56
FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones,[...]. Hum Mol Genet 2019
48
MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.
Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, Darren G Monckton,[...]. Brain 2019
Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, Darren G Monckton,[...]. Brain 2019
42
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
Nancy S Wexler, Judith Lorimer, Julie Porter, Fidela Gomez, Carol Moskowitz, Edith Shackell, Karen Marder, Graciela Penchaszadeh, Simone A Roberts, Javier Gayán,[...]. Proc Natl Acad Sci U S A 2004
Nancy S Wexler, Judith Lorimer, Julie Porter, Fidela Gomez, Carol Moskowitz, Edith Shackell, Karen Marder, Graciela Penchaszadeh, Simone A Roberts, Javier Gayán,[...]. Proc Natl Acad Sci U S A 2004
20
Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis.
Laura Kennedy, Elizabeth Evans, Chiung-Mei Chen, Lyndsey Craven, Peter J Detloff, Margaret Ennis, Peggy F Shelbourne. Hum Mol Genet 2003
Laura Kennedy, Elizabeth Evans, Chiung-Mei Chen, Lyndsey Craven, Peter J Detloff, Margaret Ennis, Peggy F Shelbourne. Hum Mol Genet 2003
19
Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.
Ella Dragileva, Audrey Hendricks, Allison Teed, Tammy Gillis, Edith T Lopez, Errol C Friedberg, Raju Kucherlapati, Winfried Edelmann, Kathryn L Lunetta, Marcy E MacDonald,[...]. Neurobiol Dis 2009
Ella Dragileva, Audrey Hendricks, Allison Teed, Tammy Gillis, Edith T Lopez, Errol C Friedberg, Raju Kucherlapati, Winfried Edelmann, Kathryn L Lunetta, Marcy E MacDonald,[...]. Neurobiol Dis 2009
18
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
Meera Swami, Audrey E Hendricks, Tammy Gillis, Tiffany Massood, Jayalakshmi Mysore, Richard H Myers, Vanessa C Wheeler. Hum Mol Genet 2009
18
Huntington disease.
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
Gillian P Bates, Ray Dorsey, James F Gusella, Michael R Hayden, Chris Kay, Blair R Leavitt, Martha Nance, Christopher A Ross, Rachael I Scahill, Ronald Wetzel,[...]. Nat Rev Dis Primers 2015
18
Disease-associated repeat instability and mismatch repair.
Monika H M Schmidt, Christopher E Pearson. DNA Repair (Amst) 2016
Monika H M Schmidt, Christopher E Pearson. DNA Repair (Amst) 2016
17
Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.
Peggy F Shelbourne, Christine Keller-McGandy, Wenya Linda Bi, Song-Ro Yoon, Louis Dubeau, Nicola J Veitch, Jean Paul Vonsattel, Nancy S Wexler, Norman Arnheim, Sarah J Augood. Hum Mol Genet 2007
Peggy F Shelbourne, Christine Keller-McGandy, Wenya Linda Bi, Song-Ro Yoon, Louis Dubeau, Nicola J Veitch, Jean Paul Vonsattel, Nancy S Wexler, Norman Arnheim, Sarah J Augood. Hum Mol Genet 2007
17
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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17
Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease.
Galen E B Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen,[...]. Am J Hum Genet 2019
Galen E B Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen,[...]. Am J Hum Genet 2019
32
MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice.
Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer,[...]. PLoS Genet 2013
Stéphanie Tomé, Kevin Manley, Jodie P Simard, Greg W Clark, Meghan M Slean, Meera Swami, Peggy F Shelbourne, Elisabeth R M Tillier, Darren G Monckton, Anne Messer,[...]. PLoS Genet 2013
19
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.
Masayuki Nakamori, Gagan B Panigrahi, Stella Lanni, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata,[...]. Nat Genet 2020
Masayuki Nakamori, Gagan B Panigrahi, Stella Lanni, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata,[...]. Nat Genet 2020
34
Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion.
Mário Gomes-Pereira, M Teresa Fortune, Laura Ingram, John P McAbney, Darren G Monckton. Hum Mol Genet 2004
Mário Gomes-Pereira, M Teresa Fortune, Laura Ingram, John P McAbney, Darren G Monckton. Hum Mol Genet 2004
15
Trinucleotide repeat length instability and age of onset in Huntington's disease.
M Duyao, C Ambrose, R Myers, A Novelletto, F Persichetti, M Frontali, S Folstein, C Ross, M Franz, M Abbott. Nat Genet 1993
M Duyao, C Ambrose, R Myers, A Novelletto, F Persichetti, M Frontali, S Folstein, C Ross, M Franz, M Abbott. Nat Genet 1993
14
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards,[...]. N Engl J Med 2019
14
FAN1 protects against repeat expansions in a Fragile X mouse model.
Xiao-Nan Zhao, Karen Usdin. DNA Repair (Amst) 2018
Xiao-Nan Zhao, Karen Usdin. DNA Repair (Amst) 2018
39
The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.
S E Andrew, Y P Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, E Starr, F Squitieri, B Lin, M A Kalchman. Nat Genet 1993
S E Andrew, Y P Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, E Starr, F Squitieri, B Lin, M A Kalchman. Nat Genet 1993
13
DNA instability in postmitotic neurons.
Roman Gonitel, Hilary Moffitt, Kirupa Sathasivam, Ben Woodman, Peter J Detloff, Richard L M Faull, Gillian P Bates. Proc Natl Acad Sci U S A 2008
Roman Gonitel, Hilary Moffitt, Kirupa Sathasivam, Ben Woodman, Peter J Detloff, Richard L M Faull, Gillian P Bates. Proc Natl Acad Sci U S A 2008
13
Human MutLγ, the MLH1-MLH3 heterodimer, is an endonuclease that promotes DNA expansion.
Lyudmila Y Kadyrova, Vaibhavi Gujar, Vickers Burdett, Paul L Modrich, Farid A Kadyrov. Proc Natl Acad Sci U S A 2020
Lyudmila Y Kadyrova, Vaibhavi Gujar, Vickers Burdett, Paul L Modrich, Farid A Kadyrov. Proc Natl Acad Sci U S A 2020
52
The central role of DNA damage and repair in CAG repeat diseases.
Thomas H Massey, Lesley Jones. Dis Model Mech 2018
Thomas H Massey, Lesley Jones. Dis Model Mech 2018
29
Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.
Kyung-Hee Kim, Eun Pyo Hong, Jun Wan Shin, Michael J Chao, Jacob Loupe, Tammy Gillis, Jayalakshmi S Mysore, Peter Holmans, Lesley Jones, Michael Orth,[...]. Am J Hum Genet 2020
Kyung-Hee Kim, Eun Pyo Hong, Jun Wan Shin, Michael J Chao, Jacob Loupe, Tammy Gillis, Jayalakshmi S Mysore, Peter Holmans, Lesley Jones, Michael Orth,[...]. Am J Hum Genet 2020
65
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
Irina V Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H Wilson, Cynthia T McMurray. Nature 2007
Irina V Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H Wilson, Cynthia T McMurray. Nature 2007
12
A polymorphism in the MSH3 mismatch repair gene is associated with the levels of somatic instability of the expanded CTG repeat in the blood DNA of myotonic dystrophy type 1 patients.
Fernando Morales, Melissa Vásquez, Carolina Santamaría, Patricia Cuenca, Eyleen Corrales, Darren G Monckton. DNA Repair (Amst) 2016
Fernando Morales, Melissa Vásquez, Carolina Santamaría, Patricia Cuenca, Eyleen Corrales, Darren G Monckton. DNA Repair (Amst) 2016
23
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.
Anna Pluciennik, Vickers Burdett, Celia Baitinger, Ravi R Iyer, Kevin Shi, Paul Modrich. Proc Natl Acad Sci U S A 2013
Anna Pluciennik, Vickers Burdett, Celia Baitinger, Ravi R Iyer, Kevin Shi, Paul Modrich. Proc Natl Acad Sci U S A 2013
23
Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.
Helen Budworth, Faye R Harris, Paul Williams, Do Yup Lee, Amy Holt, Jens Pahnke, Bartosz Szczesny, Karina Acevedo-Torres, Sylvette Ayala-Peña, Cynthia T McMurray. PLoS Genet 2015
Helen Budworth, Faye R Harris, Paul Williams, Do Yup Lee, Amy Holt, Jens Pahnke, Bartosz Szczesny, Karina Acevedo-Torres, Sylvette Ayala-Peña, Cynthia T McMurray. PLoS Genet 2015
19
Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Jacob M Loupe, Ricardo Mouro Pinto, Kyung-Hee Kim, Tammy Gillis, Jayalakshmi S Mysore, Marissa A Andrew, Marina Kovalenko, Ryan Murtha, IhnSik Seong, James F Gusella,[...]. Hum Mol Genet 2020
Jacob M Loupe, Ricardo Mouro Pinto, Kyung-Hee Kim, Tammy Gillis, Jayalakshmi S Mysore, Marissa A Andrew, Marina Kovalenko, Ryan Murtha, IhnSik Seong, James F Gusella,[...]. Hum Mol Genet 2020
57
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
Walther J A A van den Broek, Marcel R Nelen, Derick G Wansink, Marga M Coerwinkel, Hein te Riele, Patricia J T A Groenen, Bé Wieringa. Hum Mol Genet 2002
Walther J A A van den Broek, Marcel R Nelen, Derick G Wansink, Marga M Coerwinkel, Hein te Riele, Patricia J T A Groenen, Bé Wieringa. Hum Mol Genet 2002
11
Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group.
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11
Mutsβ generates both expansions and contractions in a mouse model of the Fragile X-associated disorders.
Xiao-Nan Zhao, Daman Kumari, Shikha Gupta, Di Wu, Maya Evanitsky, Wei Yang, Karen Usdin. Hum Mol Genet 2015
Xiao-Nan Zhao, Daman Kumari, Shikha Gupta, Di Wu, Maya Evanitsky, Wei Yang, Karen Usdin. Hum Mol Genet 2015
28
Repeat instability: mechanisms of dynamic mutations.
Christopher E Pearson, Kerrie Nichol Edamura, John D Cleary. Nat Rev Genet 2005
Christopher E Pearson, Kerrie Nichol Edamura, John D Cleary. Nat Rev Genet 2005
11
MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.
Xiaonan Zhao, Yongwei Zhang, Kenneth Wilkins, Winfried Edelmann, Karen Usdin. PLoS Genet 2018
Xiaonan Zhao, Yongwei Zhang, Kenneth Wilkins, Winfried Edelmann, Karen Usdin. PLoS Genet 2018
45
Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.
H Telenius, B Kremer, Y P Goldberg, J Theilmann, S E Andrew, J Zeisler, S Adam, C Greenberg, E J Ives, L A Clarke. Nat Genet 1994
H Telenius, B Kremer, Y P Goldberg, J Theilmann, S E Andrew, J Zeisler, S Adam, C Greenberg, E J Ives, L A Clarke. Nat Genet 1994
11
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
K Manley, T L Shirley, L Flaherty, A Messer. Nat Genet 1999
K Manley, T L Shirley, L Flaherty, A Messer. Nat Genet 1999
11
Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Vanessa C Wheeler, Lori-Anne Lebel, Vladimir Vrbanac, Allison Teed, Hein te Riele, Marcy E MacDonald. Hum Mol Genet 2003
Vanessa C Wheeler, Lori-Anne Lebel, Vladimir Vrbanac, Allison Teed, Hein te Riele, Marcy E MacDonald. Hum Mol Genet 2003
11
Huntington's disease: from molecular pathogenesis to clinical treatment.
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
Christopher A Ross, Sarah J Tabrizi. Lancet Neurol 2011
11
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
J-M Lee, E M Ramos, J-H Lee, T Gillis, J S Mysore, M R Hayden, S C Warby, P Morrison, M Nance, C A Ross,[...]. Neurology 2012
J-M Lee, E M Ramos, J-H Lee, T Gillis, J S Mysore, M R Hayden, S C Warby, P Morrison, M Nance, C A Ross,[...]. Neurology 2012
11
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland,[...]. Proc Natl Acad Sci U S A 2013
11
Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1.
Ricardo Mouro Pinto, Larissa Arning, James V Giordano, Pedram Razghandi, Marissa A Andrew, Tammy Gillis, Kevin Correia, Jayalakshmi S Mysore, Debora-M Grote Urtubey, Constanze R Parwez,[...]. Hum Mol Genet 2020
Ricardo Mouro Pinto, Larissa Arning, James V Giordano, Pedram Razghandi, Marissa A Andrew, Tammy Gillis, Kevin Correia, Jayalakshmi S Mysore, Debora-M Grote Urtubey, Constanze R Parwez,[...]. Hum Mol Genet 2020
47
Repeat instability as the basis for human diseases and as a potential target for therapy.
Arturo López Castel, John D Cleary, Christopher E Pearson. Nat Rev Mol Cell Biol 2010
Arturo López Castel, John D Cleary, Christopher E Pearson. Nat Rev Mol Cell Biol 2010
10
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
10
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao,[...]. Nat Neurosci 2016
10
GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one.
Anasheh Halabi, Kayla T B Fuselier, Ed Grabczyk. Nucleic Acids Res 2018
Anasheh Halabi, Kayla T B Fuselier, Ed Grabczyk. Nucleic Acids Res 2018
41
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.