A citation-based method for searching scientific literature

Henry E Pelish, Brian B Liau, Ioana I Nitulescu, Anupong Tangpeerachaikul, Zachary C Poss, Diogo H Da Silva, Brittany T Caruso, Alexander Arefolov, Olugbeminiyi Fadeyi, Amanda L Christie, Karrie Du, Deepti Banka, Elisabeth V Schneider, Anja Jestel, Ge Zou, Chong Si, Christopher C Ebmeier, Roderick T Bronson, Andrei V Krivtsov, Andrew G Myers, Nancy E Kohl, Andrew L Kung, Scott A Armstrong, Madeleine E Lemieux, Dylan J Taatjes, Matthew D Shair. Nature 2015
Times Cited: 221







List of co-cited articles
1190 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
Ron Firestein, Adam J Bass, So Young Kim, Ian F Dunn, Serena J Silver, Isil Guney, Ellen Freed, Azra H Ligon, Natalie Vena, Shuji Ogino,[...]. Nature 2008
486
35

Master transcription factors and mediator establish super-enhancers at key cell identity genes.
Warren A Whyte, David A Orlando, Denes Hnisz, Brian J Abraham, Charles Y Lin, Michael H Kagey, Peter B Rahl, Tong Ihn Lee, Richard A Young. Cell 2013
31

Super-enhancers in the control of cell identity and disease.
Denes Hnisz, Brian J Abraham, Tong Ihn Lee, Ashley Lau, Violaine Saint-André, Alla A Sigova, Heather A Hoke, Richard A Young. Cell 2013
28

The Mediator complex: a central integrator of transcription.
Benjamin L Allen, Dylan J Taatjes. Nat Rev Mol Cell Biol 2015
476
26

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Trevor Dale, Paul A Clarke, Christina Esdar, Dennis Waalboer, Olajumoke Adeniji-Popoola, Maria-Jesus Ortiz-Ruiz, Aurélie Mallinger, Rahul S Samant, Paul Czodrowski, Djordje Musil,[...]. Nat Chem Biol 2015
87
28

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Nicholas Kwiatkowski, Tinghu Zhang, Peter B Rahl, Brian J Abraham, Jessica Reddy, Scott B Ficarro, Anahita Dastur, Arnaud Amzallag, Sridhar Ramaswamy, Bethany Tesar,[...]. Nature 2014
487
24

Selective inhibition of tumor oncogenes by disruption of super-enhancers.
Jakob Lovén, Heather A Hoke, Charles Y Lin, Ashley Lau, David A Orlando, Christopher R Vakoc, James E Bradner, Tong Ihn Lee, Richard A Young. Cell 2013
24

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
Tomasz Rzymski, Michał Mikula, Eliza Żyłkiewicz, Agnieszka Dreas, Katarzyna Wiklik, Aniela Gołas, Katarzyna Wójcik, Magdalena Masiejczyk, Anna Wróbel, Izabela Dolata,[...]. Oncotarget 2017
58
39

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.
Zachary C Poss, Christopher C Ebmeier, Aaron T Odell, Anupong Tangpeerachaikul, Thomas Lee, Henry E Pelish, Matthew D Shair, Robin D Dowell, William M Old, Dylan J Taatjes. Cell Rep 2016
87
25

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
Joanna Bancerek, Zachary C Poss, Iris Steinparzer, Vitaly Sedlyarov, Thaddäus Pfaffenwimmer, Ivana Mikulic, Lars Dölken, Birgit Strobl, Mathias Müller, Dylan J Taatjes,[...]. Immunity 2013
157
21

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Donald C Porter, Elena Farmaki, Serena Altilia, Gary P Schools, Deborah K West, Mengqian Chen, Bey-Dih Chang, Anatoliy T Puzyrev, Chang-uk Lim, Rebecca Rokow-Kittell,[...]. Proc Natl Acad Sci U S A 2012
112
20

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.
Martina S J McDermott, Alexander A Chumanevich, Chang-Uk Lim, Jiaxin Liang, Mengqian Chen, Serena Altilia, David Oliver, James M Rae, Michael Shtutman, Hippokratis Kiaris,[...]. Oncotarget 2017
71
28

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.
Avnish Kapoor, Matthew S Goldberg, Lara K Cumberland, Kajan Ratnakumar, Miguel F Segura, Patrick O Emanuel, Silvia Menendez, Chiara Vardabasso, Gary Leroy, Claudia I Vidal,[...]. Nature 2010
268
20

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.
Matthew T Knuesel, Krista D Meyer, Carrie Bernecky, Dylan J Taatjes. Genes Dev 2009
243
19

CDK8 is a positive regulator of transcriptional elongation within the serum response network.
Aaron J Donner, Christopher C Ebmeier, Dylan J Taatjes, Joaquín M Espinosa. Nat Struct Mol Biol 2010
243
19

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
Matthew D Galbraith, Mary A Allen, Claire L Bensard, Xiaoxing Wang, Marie K Schwinn, Bo Qin, Henry W Long, Danette L Daniels, William C Hahn, Robin D Dowell,[...]. Cell 2013
222
19

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?
Stephen Philip, Malika Kumarasiri, Theodosia Teo, Mingfeng Yu, Shudong Wang. J Med Chem 2018
57
31

Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.
Victor J Cee, David Y-K Chen, Matthew R Lee, K C Nicolaou. Angew Chem Int Ed Engl 2009
75
22

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Claudio Alarcón, Alexia-Ileana Zaromytidou, Qiaoran Xi, Sheng Gao, Jianzhong Yu, Sho Fujisawa, Afsar Barlas, Alexandria N Miller, Katia Manova-Todorova, Maria J Macias,[...]. Cell 2009
532
17

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.
John M Hatcher, Eric S Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim, Nathanael S Gray. ACS Med Chem Lett 2018
48
35

Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Johannes Brägelmann, Niklas Klümper, Anne Offermann, Anne von Mässenhausen, Diana Böhm, Mario Deng, Angela Queisser, Christine Sanders, Isabella Syring, Axel S Merseburger,[...]. Clin Cancer Res 2017
57
29

CDK7-dependent transcriptional addiction in triple-negative breast cancer.
Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin,[...]. Cell 2015
255
17

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.
Matthew T Knuesel, Krista D Meyer, Aaron J Donner, Joaquin M Espinosa, Dylan J Taatjes. Mol Cell Biol 2009
154
17

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.
Paul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, Olajumoke Adeniji-Popoola, Gary Box, Will Court, Stephanie Czasch, Samer El Bawab, Christina Esdar, Ken Ewan,[...]. Elife 2016
50
34

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.
Edmond Chipumuro, Eugenio Marco, Camilla L Christensen, Nicholas Kwiatkowski, Tinghu Zhang, Clark M Hatheway, Brian J Abraham, Bandana Sharma, Caleb Yeung, Abigail Altabef,[...]. Cell 2014
366
17

Regulatory functions of the Mediator kinases CDK8 and CDK19.
Charli B Fant, Dylan J Taatjes. Transcription 2019
53
30

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Mengqian Chen, Jiaxin Liang, Hao Ji, Zhengguan Yang, Serena Altilia, Bing Hu, Adam Schronce, Martina S J McDermott, Gary P Schools, Chang-Uk Lim,[...]. Proc Natl Acad Sci U S A 2017
54
29

Transcriptional Addiction in Cancer.
James E Bradner, Denes Hnisz, Richard A Young. Cell 2017
492
16

A Phase Separation Model for Transcriptional Control.
Denes Hnisz, Krishna Shrinivas, Richard A Young, Arup K Chakraborty, Phillip A Sharp. Cell 2017
770
16

CDK8 Kinase Activity Promotes Glycolysis.
Matthew D Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A Bonner, Amanda A Hill, Kelly D Sullivan, Joaquín M Espinosa. Cell Rep 2017
46
32

Cyclin-dependent kinases.
Marcos Malumbres. Genome Biol 2014
683
15

Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.
Dazhi Xu, Chien-Feng Li, Xian Zhang, Zhaohui Gong, Chia-Hsin Chan, Szu-Wei Lee, Guoxiang Jin, Abdol-Hossein Rezaeian, Fei Han, Jing Wang,[...]. Nat Commun 2015
78
19

Coactivator condensation at super-enhancers links phase separation and gene control.
Benjamin R Sabari, Alessandra Dall'Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey, Krishna Shrinivas, Brian J Abraham, Nancy M Hannett, Alicia V Zamudio, John C Manteiga,[...]. Science 2018
881
15

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
Aurélie Mallinger, Kai Schiemann, Christian Rink, Frank Stieber, Michel Calderini, Simon Crumpler, Mark Stubbs, Olajumoke Adeniji-Popoola, Oliver Poeschke, Michael Busch,[...]. J Med Chem 2016
63
22

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Tinghu Zhang, Nicholas Kwiatkowski, Calla M Olson, Sarah E Dixon-Clarke, Brian J Abraham, Ann K Greifenberg, Scott B Ficarro, Jonathan M Elkins, Yanke Liang, Nancy M Hannett,[...]. Nat Chem Biol 2016
158
14

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements.
Anand S Bhagwat, Jae-Seok Roe, Beverly Y L Mok, Anja F Hohmann, Junwei Shi, Christopher R Vakoc. Cell Rep 2016
95
14

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.
Philippe Bergeron, Michael F T Koehler, Elizabeth M Blackwood, Krista Bowman, Kevin Clark, Ron Firestein, James R Kiefer, Klaus Maskos, Mark L McCleland, Linda Orren,[...]. ACS Med Chem Lett 2016
35
37

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
Stéphane Larochelle, Ramon Amat, Kira Glover-Cutter, Miriam Sansó, Chao Zhang, Jasmina J Allen, Kevan M Shokat, David L Bentley, Robert P Fisher. Nat Struct Mol Biol 2012
239
13

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
Michael F T Koehler, Philippe Bergeron, Elizabeth M Blackwood, Krista Bowman, Kevin R Clark, Ron Firestein, James R Kiefer, Klaus Maskos, Mark L McCleland, Linda Orren,[...]. ACS Med Chem Lett 2016
56
23

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Ann Boija, Isaac A Klein, Benjamin R Sabari, Alessandra Dall'Agnese, Eliot L Coffey, Alicia V Zamudio, Charles H Li, Krishna Shrinivas, John C Manteiga, Nancy M Hannett,[...]. Cell 2018
588
13

Structure-kinetic relationship study of CDK8/CycC specific compounds.
Elisabeth V Schneider, Jark Böttcher, Robert Huber, Klaus Maskos, Lars Neumann. Proc Natl Acad Sci U S A 2013
85
14

CDK8: a positive regulator of transcription.
Matthew D Galbraith, Aaron J Donner, Joaquín M Espinosa. Transcription 2010
144
12


Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
Paul Czodrowski, Aurélie Mallinger, Dirk Wienke, Christina Esdar, Oliver Pöschke, Michael Busch, Felix Rohdich, Suzanne A Eccles, Maria-Jesus Ortiz-Ruiz, Richard Schneider,[...]. J Med Chem 2016
59
20

Mediator kinase module and human tumorigenesis.
Alison D Clark, Marieke Oldenbroek, Thomas G Boyer. Crit Rev Biochem Mol Biol 2015
82
14

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.
Kuang-Lei Tsai, Shigeo Sato, Chieri Tomomori-Sato, Ronald C Conaway, Joan W Conaway, Francisco J Asturias. Nat Struct Mol Biol 2013
144
12

Cdk8 is essential for preimplantation mouse development.
Thomas Westerling, Emilia Kuuluvainen, Tomi P Mäkelä. Mol Cell Biol 2007
80
15

CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance.
Eva Maria Putz, Dagmar Gotthardt, Gregor Hoermann, Agnes Csiszar, Silvia Wirth, Angelika Berger, Elisabeth Straka, Doris Rigler, Barbara Wallner, Amanda M Jamieson,[...]. Cell Rep 2013
84
13

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
E V Schneider, J Böttcher, M Blaesse, L Neumann, R Huber, K Maskos. J Mol Biol 2011
94
11

Transcription regulation by the Mediator complex.
Julie Soutourina. Nat Rev Mol Cell Biol 2018
221
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.