Kole T Roybal, Levi J Rupp, Leonardo Morsut, Whitney J Walker, Krista A McNally, Jason S Park, Wendell A Lim. Cell 2016
Times Cited: 465
Times Cited: 465
Times Cited
Times Co-cited
Similarity
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor.
Chia-Yung Wu, Kole T Roybal, Elias M Puchner, James Onuffer, Wendell A Lim. Science 2015
Chia-Yung Wu, Kole T Roybal, Elias M Puchner, James Onuffer, Wendell A Lim. Science 2015
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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.
Richard A Morgan, James C Yang, Mio Kitano, Mark E Dudley, Carolyn M Laurencot, Steven A Rosenberg. Mol Ther 2010
Richard A Morgan, James C Yang, Mio Kitano, Mark E Dudley, Carolyn M Laurencot, Steven A Rosenberg. Mol Ther 2010
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PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.
Victor D Fedorov, Maria Themeli, Michel Sadelain. Sci Transl Med 2013
Victor D Fedorov, Maria Themeli, Michel Sadelain. Sci Transl Med 2013
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Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.
Jang Hwan Cho, James J Collins, Wilson W Wong. Cell 2018
Jang Hwan Cho, James J Collins, Wilson W Wong. Cell 2018
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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.
Christopher C Kloss, Maud Condomines, Marc Cartellieri, Michael Bachmann, Michel Sadelain. Nat Biotechnol 2013
Christopher C Kloss, Maud Condomines, Marc Cartellieri, Michael Bachmann, Michel Sadelain. Nat Biotechnol 2013
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Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.
Leonardo Morsut, Kole T Roybal, Xin Xiong, Russell M Gordley, Scott M Coyle, Matthew Thomson, Wendell A Lim. Cell 2016
Leonardo Morsut, Kole T Roybal, Xin Xiong, Russell M Gordley, Scott M Coyle, Matthew Thomson, Wendell A Lim. Cell 2016
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Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.
Shivani Srivastava, Alexander I Salter, Denny Liggitt, Sushma Yechan-Gunja, Megha Sarvothama, Kirsten Cooper, Kimberly S Smythe, Jarrod A Dudakov, Robert H Pierce, Christoph Rader,[...]. Cancer Cell 2019
Shivani Srivastava, Alexander I Salter, Denny Liggitt, Sushma Yechan-Gunja, Megha Sarvothama, Kirsten Cooper, Kimberly S Smythe, Jarrod A Dudakov, Robert H Pierce, Christoph Rader,[...]. Cancer Cell 2019
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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
Shannon L Maude, Theodore W Laetsch, Jochen Buechner, Susana Rives, Michael Boyer, Henrique Bittencourt, Peter Bader, Michael R Verneris, Heather E Stefanski, Gary D Myers,[...]. N Engl J Med 2018
Shannon L Maude, Theodore W Laetsch, Jochen Buechner, Susana Rives, Michael Boyer, Henrique Bittencourt, Peter Bader, Michael R Verneris, Heather E Stefanski, Gary D Myers,[...]. N Engl J Med 2018
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Chimeric antigen receptor T cells for sustained remissions in leukemia.
Shannon L Maude, Noelle Frey, Pamela A Shaw, Richard Aplenc, David M Barrett, Nancy J Bunin, Anne Chew, Vanessa E Gonzalez, Zhaohui Zheng, Simon F Lacey,[...]. N Engl J Med 2014
Shannon L Maude, Noelle Frey, Pamela A Shaw, Richard Aplenc, David M Barrett, Nancy J Bunin, Anne Chew, Vanessa E Gonzalez, Zhaohui Zheng, Simon F Lacey,[...]. N Engl J Med 2014
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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.
Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis, Sjoukje J C van der Stegen, Mohamad Hamieh, Kristen M Cunanan, Ashlesha Odak, Mithat Gönen, Michel Sadelain. Nature 2017
Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis, Sjoukje J C van der Stegen, Mohamad Hamieh, Kristen M Cunanan, Ashlesha Odak, Mithat Gönen, Michel Sadelain. Nature 2017
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Inducible apoptosis as a safety switch for adoptive cell therapy.
Antonio Di Stasi, Siok-Keen Tey, Gianpietro Dotti, Yuriko Fujita, Alana Kennedy-Nasser, Caridad Martinez, Karin Straathof, Enli Liu, April G Durett, Bambi Grilley,[...]. N Engl J Med 2011
Antonio Di Stasi, Siok-Keen Tey, Gianpietro Dotti, Yuriko Fujita, Alana Kennedy-Nasser, Caridad Martinez, Karin Straathof, Enli Liu, April G Durett, Bambi Grilley,[...]. N Engl J Med 2011
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Chimeric antigen receptor T-cell therapy - assessment and management of toxicities.
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver,[...]. Nat Rev Clin Oncol 2018
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver,[...]. Nat Rev Clin Oncol 2018
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Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.
Kole T Roybal, Jasper Z Williams, Leonardo Morsut, Levi J Rupp, Isabel Kolinko, Joseph H Choe, Whitney J Walker, Krista A McNally, Wendell A Lim. Cell 2016
Kole T Roybal, Jasper Z Williams, Leonardo Morsut, Levi J Rupp, Isabel Kolinko, Joseph H Choe, Whitney J Walker, Krista A McNally, Wendell A Lim. Cell 2016
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Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.
G Gross, T Waks, Z Eshhar. Proc Natl Acad Sci U S A 1989
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Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia.
Marco L Davila, Isabelle Riviere, Xiuyan Wang, Shirley Bartido, Jae Park, Kevin Curran, Stephen S Chung, Jolanta Stefanski, Oriana Borquez-Ojeda, Malgorzata Olszewska,[...]. Sci Transl Med 2014
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Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
Marco Ruella, David M Barrett, Saad S Kenderian, Olga Shestova, Ted J Hofmann, Jessica Perazzelli, Michael Klichinsky, Vania Aikawa, Farzana Nazimuddin, Miroslaw Kozlowski,[...]. J Clin Invest 2016
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The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.
Katrin Mestermann, Theodoros Giavridis, Justus Weber, Julian Rydzek, Silke Frenz, Thomas Nerreter, Andreas Mades, Michel Sadelain, Hermann Einsele, Michael Hudecek. Sci Transl Med 2019
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Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.
David T Rodgers, Magdalena Mazagova, Eric N Hampton, Yu Cao, Nitya S Ramadoss, Ian R Hardy, Andrew Schulman, Juanjuan Du, Feng Wang, Oded Singer,[...]. Proc Natl Acad Sci U S A 2016
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17
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial.
Daniel W Lee, James N Kochenderfer, Maryalice Stetler-Stevenson, Yongzhi K Cui, Cindy Delbrook, Steven A Feldman, Terry J Fry, Rimas Orentas, Marianna Sabatino, Nirali N Shah,[...]. Lancet 2015
Daniel W Lee, James N Kochenderfer, Maryalice Stetler-Stevenson, Yongzhi K Cui, Cindy Delbrook, Steven A Feldman, Terry J Fry, Rimas Orentas, Marianna Sabatino, Nirali N Shah,[...]. Lancet 2015
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TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy.
Zakaria Grada, Meenakshi Hegde, Tiara Byrd, Donald R Shaffer, Alexia Ghazi, Vita S Brawley, Amanda Corder, Kurt Schönfeld, Joachim Koch, Gianpietro Dotti,[...]. Mol Ther Nucleic Acids 2013
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16
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.
Adrienne H Long, Waleed M Haso, Jack F Shern, Kelsey M Wanhainen, Meera Murgai, Maria Ingaramo, Jillian P Smith, Alec J Walker, M Eric Kohler, Vikas R Venkateshwara,[...]. Nat Med 2015
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16
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
Donald M O'Rourke, MacLean P Nasrallah, Arati Desai, Jan J Melenhorst, Keith Mansfield, Jennifer J D Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen,[...]. Sci Transl Med 2017
Donald M O'Rourke, MacLean P Nasrallah, Arati Desai, Jan J Melenhorst, Keith Mansfield, Jennifer J D Morrissette, Maria Martinez-Lage, Steven Brem, Eileen Maloney, Angela Shen,[...]. Sci Transl Med 2017
16
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.
Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen, Dylan J Drakes, Mei Song, Matthew M Miele, Zhuoning Li, Pei Wang,[...]. Nat Biotechnol 2018
Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen, Dylan J Drakes, Mei Song, Matthew M Miele, Zhuoning Li, Pei Wang,[...]. Nat Biotechnol 2018
15
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.
Sattva S Neelapu, Frederick L Locke, Nancy L Bartlett, Lazaros J Lekakis, David B Miklos, Caron A Jacobson, Ira Braunschweig, Olalekan O Oluwole, Tanya Siddiqi, Yi Lin,[...]. N Engl J Med 2017
Sattva S Neelapu, Frederick L Locke, Nancy L Bartlett, Lazaros J Lekakis, David B Miklos, Caron A Jacobson, Ira Braunschweig, Olalekan O Oluwole, Tanya Siddiqi, Yi Lin,[...]. N Engl J Med 2017
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T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells.
Eugenia Zah, Meng-Yin Lin, Anne Silva-Benedict, Michael C Jensen, Yvonne Y Chen. Cancer Immunol Res 2016
Eugenia Zah, Meng-Yin Lin, Anne Silva-Benedict, Michael C Jensen, Yvonne Y Chen. Cancer Immunol Res 2016
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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.
Jae H Park, Isabelle Rivière, Mithat Gonen, Xiuyan Wang, Brigitte Sénéchal, Kevin J Curran, Craig Sauter, Yongzeng Wang, Bianca Santomasso, Elena Mead,[...]. N Engl J Med 2018
Jae H Park, Isabelle Rivière, Mithat Gonen, Xiuyan Wang, Brigitte Sénéchal, Kevin J Curran, Craig Sauter, Yongzeng Wang, Bianca Santomasso, Elena Mead,[...]. N Engl J Med 2018
14
CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment.
Marina Martinez, Edmund Kyung Moon. Front Immunol 2019
Marina Martinez, Edmund Kyung Moon. Front Immunol 2019
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Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
Meenakshi Hegde, Malini Mukherjee, Zakaria Grada, Antonella Pignata, Daniel Landi, Shoba A Navai, Amanda Wakefield, Kristen Fousek, Kevin Bielamowicz, Kevin K H Chow,[...]. J Clin Invest 2016
Meenakshi Hegde, Malini Mukherjee, Zakaria Grada, Antonella Pignata, Daniel Landi, Shoba A Navai, Amanda Wakefield, Kristen Fousek, Kevin Bielamowicz, Kevin K H Chow,[...]. J Clin Invest 2016
14
Engineering strategies to overcome the current roadblocks in CAR T cell therapy.
Sarwish Rafiq, Christopher S Hackett, Renier J Brentjens. Nat Rev Clin Oncol 2020
Sarwish Rafiq, Christopher S Hackett, Renier J Brentjens. Nat Rev Clin Oncol 2020
14
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.
Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M Young, John Scholler, Yangbing Zhao, Carl H June. Cell Rep 2017
Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M Young, John Scholler, Yangbing Zhao, Carl H June. Cell Rep 2017
13
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.
Bryan D Choi, Xiaoling Yu, Ana P Castano, Amanda A Bouffard, Andrea Schmidts, Rebecca C Larson, Stefanie R Bailey, Angela C Boroughs, Matthew J Frigault, Mark B Leick,[...]. Nat Biotechnol 2019
Bryan D Choi, Xiaoling Yu, Ana P Castano, Amanda A Bouffard, Andrea Schmidts, Rebecca C Larson, Stefanie R Bailey, Angela C Boroughs, Matthew J Frigault, Mark B Leick,[...]. Nat Biotechnol 2019
13
A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor.
Katarzyna Urbanska, Evripidis Lanitis, Mathilde Poussin, Rachel C Lynn, Brian P Gavin, Sander Kelderman, Jason Yu, Nathalie Scholler, Daniel J Powell. Cancer Res 2012
Katarzyna Urbanska, Evripidis Lanitis, Mathilde Poussin, Rachel C Lynn, Brian P Gavin, Sander Kelderman, Jason Yu, Nathalie Scholler, Daniel J Powell. Cancer Res 2012
13
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
Stephan A Grupp, Michael Kalos, David Barrett, Richard Aplenc, David L Porter, Susan R Rheingold, David T Teachey, Anne Chew, Bernd Hauck, J Fraser Wright,[...]. N Engl J Med 2013
Stephan A Grupp, Michael Kalos, David Barrett, Richard Aplenc, David L Porter, Susan R Rheingold, David T Teachey, Anne Chew, Bernd Hauck, J Fraser Wright,[...]. N Engl J Med 2013
13
IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression.
Markus Chmielewski, Caroline Kopecky, Andreas A Hombach, Hinrich Abken. Cancer Res 2011
Markus Chmielewski, Caroline Kopecky, Andreas A Hombach, Hinrich Abken. Cancer Res 2011
12
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication.
Christopher C Kloss, Jihyun Lee, Aaron Zhang, Fang Chen, Jan Joseph Melenhorst, Simon F Lacey, Marcela V Maus, Joseph A Fraietta, Yangbing Zhao, Carl H June. Mol Ther 2018
Christopher C Kloss, Jihyun Lee, Aaron Zhang, Fang Chen, Jan Joseph Melenhorst, Simon F Lacey, Marcela V Maus, Joseph A Fraietta, Yangbing Zhao, Carl H June. Mol Ther 2018
12
Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.
Scott Wilkie, May C I van Schalkwyk, Steve Hobbs, David M Davies, Sjoukje J C van der Stegen, Ana C Parente Pereira, Sophie E Burbridge, Carol Box, Suzanne A Eccles, John Maher. J Clin Immunol 2012
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12
Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo.
Evripidis Lanitis, Mathilde Poussin, Alex W Klattenhoff, Degang Song, Raphael Sandaltzopoulos, Carl H June, Daniel J Powell. Cancer Immunol Res 2013
Evripidis Lanitis, Mathilde Poussin, Alex W Klattenhoff, Degang Song, Raphael Sandaltzopoulos, Carl H June, Daniel J Powell. Cancer Immunol Res 2013
12
Versatile strategy for controlling the specificity and activity of engineered T cells.
Jennifer S Y Ma, Ji Young Kim, Stephanie A Kazane, Sei-Hyun Choi, Hwa Young Yun, Min Soo Kim, David T Rodgers, Holly M Pugh, Oded Singer, Sophie B Sun,[...]. Proc Natl Acad Sci U S A 2016
Jennifer S Y Ma, Ji Young Kim, Stephanie A Kazane, Sei-Hyun Choi, Hwa Young Yun, Min Soo Kim, David T Rodgers, Holly M Pugh, Oded Singer, Sophie B Sun,[...]. Proc Natl Acad Sci U S A 2016
12
Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts.
M Cartellieri, A Feldmann, S Koristka, C Arndt, S Loff, A Ehninger, M von Bonin, E P Bejestani, G Ehninger, M P Bachmann. Blood Cancer J 2016
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12
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Leonid Cherkassky, Aurore Morello, Jonathan Villena-Vargas, Yang Feng, Dimiter S Dimitrov, David R Jones, Michel Sadelain, Prasad S Adusumilli. J Clin Invest 2016
Leonid Cherkassky, Aurore Morello, Jonathan Villena-Vargas, Yang Feng, Dimiter S Dimitrov, David R Jones, Michel Sadelain, Prasad S Adusumilli. J Clin Invest 2016
12
Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma.
Kevin Bielamowicz, Kristen Fousek, Tiara T Byrd, Hebatalla Samaha, Malini Mukherjee, Nikita Aware, Meng-Fen Wu, Jordan S Orange, Pavel Sumazin, Tsz-Kwong Man,[...]. Neuro Oncol 2018
Kevin Bielamowicz, Kristen Fousek, Tiara T Byrd, Hebatalla Samaha, Malini Mukherjee, Nikita Aware, Meng-Fen Wu, Jordan S Orange, Pavel Sumazin, Tsz-Kwong Man,[...]. Neuro Oncol 2018
12
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.
Terry J Fry, Nirali N Shah, Rimas J Orentas, Maryalice Stetler-Stevenson, Constance M Yuan, Sneha Ramakrishna, Pamela Wolters, Staci Martin, Cindy Delbrook, Bonnie Yates,[...]. Nat Med 2018
Terry J Fry, Nirali N Shah, Rimas J Orentas, Maryalice Stetler-Stevenson, Constance M Yuan, Sneha Ramakrishna, Pamela Wolters, Staci Martin, Cindy Delbrook, Bonnie Yates,[...]. Nat Med 2018
11
Redirecting gene-modified T cells toward various cancer types using tagged antibodies.
Koji Tamada, Degui Geng, Yukimi Sakoda, Navneeta Bansal, Ratika Srivastava, Zhaoyang Li, Eduardo Davila. Clin Cancer Res 2012
Koji Tamada, Degui Geng, Yukimi Sakoda, Navneeta Bansal, Ratika Srivastava, Zhaoyang Li, Eduardo Davila. Clin Cancer Res 2012
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A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines.
Dina Schneider, Ying Xiong, Darong Wu, Volker Nӧlle, Sarah Schmitz, Waleed Haso, Andrew Kaiser, Boro Dropulic, Rimas J Orentas. J Immunother Cancer 2017
Dina Schneider, Ying Xiong, Darong Wu, Volker Nӧlle, Sarah Schmitz, Waleed Haso, Andrew Kaiser, Boro Dropulic, Rimas J Orentas. J Immunother Cancer 2017
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IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor.
Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada. Nat Biotechnol 2018
Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada. Nat Biotechnol 2018
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Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.
Z Eshhar, T Waks, G Gross, D G Schindler. Proc Natl Acad Sci U S A 1993
Z Eshhar, T Waks, G Gross, D G Schindler. Proc Natl Acad Sci U S A 1993
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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.
Ignazio Caruana, Barbara Savoldo, Valentina Hoyos, Gerrit Weber, Hao Liu, Eugene S Kim, Michael M Ittmann, Dario Marchetti, Gianpietro Dotti. Nat Med 2015
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Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.
Stephen J Schuster, Michael R Bishop, Constantine S Tam, Edmund K Waller, Peter Borchmann, Joseph P McGuirk, Ulrich Jäger, Samantha Jaglowski, Charalambos Andreadis, Jason R Westin,[...]. N Engl J Med 2019
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Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.
Omkar U Kawalekar, Roddy S O'Connor, Joseph A Fraietta, Lili Guo, Shannon E McGettigan, Avery D Posey, Prachi R Patel, Sonia Guedan, John Scholler, Brian Keith,[...]. Immunity 2016
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Precise T cell recognition programs designed by transcriptionally linking multiple receptors.
Jasper Z Williams, Greg M Allen, Devan Shah, Igal S Sterin, Ki H Kim, Vivian P Garcia, Gavin E Shavey, Wei Yu, Cristina Puig-Saus, Jennifer Tsoi,[...]. Science 2020
Jasper Z Williams, Greg M Allen, Devan Shah, Igal S Sterin, Ki H Kim, Vivian P Garcia, Gavin E Shavey, Wei Yu, Cristina Puig-Saus, Jennifer Tsoi,[...]. Science 2020
34
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.