Yu-Jiao Liu, Chao Liu, ZeNan Chang, Brandon Wadas, Christopher S Brower, Zhen-Hua Song, Zhi-Liang Xu, Yong-Liang Shang, Wei-Xiao Liu, Li-Na Wang, Wen Dong, Alexander Varshavsky, Rong-Gui Hu, Wei Li. J Biol Chem 2016
Times Cited: 16
Times Cited: 16
Times Cited
Times Co-cited
Similarity
43
Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.
Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V Davydov, Jai Wha Seo, Jun Sheng, Youming Xie, Alexander Varshavsky. Mol Cell Biol 2003
Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V Davydov, Jai Wha Seo, Jun Sheng, Youming Xie, Alexander Varshavsky. Mol Cell Biol 2003
37
Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
37
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability.
H Rao, F Uhlmann, K Nasmyth, A Varshavsky. Nature 2001
H Rao, F Uhlmann, K Nasmyth, A Varshavsky. Nature 2001
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The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
37
Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway.
Sang-Eun Park, Jeong-Mok Kim, Ok-Hee Seok, Hanna Cho, Brandon Wadas, Seon-Young Kim, Alexander Varshavsky, Cheol-Sang Hwang. Science 2015
Sang-Eun Park, Jeong-Mok Kim, Ok-Hee Seok, Hanna Cho, Brandon Wadas, Seon-Young Kim, Alexander Varshavsky, Cheol-Sang Hwang. Science 2015
31
In vivo half-life of a protein is a function of its amino-terminal residue.
A Bachmair, D Finley, A Varshavsky. Science 1986
A Bachmair, D Finley, A Varshavsky. Science 1986
31
The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
31
The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
31
N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
31
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
25
An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
25
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
25
Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
25
The substrate recognition domains of the N-end rule pathway.
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
Takafumi Tasaki, Adriana Zakrzewska, Drew D Dudgeon, Yonghua Jiang, John S Lazo, Yong Tae Kwon. J Biol Chem 2009
25
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
Jee Young An, Euna Kim, Adriana Zakrzewska, Young Dong Yoo, Jun Min Jang, Dong Hoon Han, Min Jae Lee, Jai Wha Seo, Yong Jun Lee, Tae-You Kim,[...]. PLoS One 2012
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N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway.
Kang-Eun Lee, Ji-Eun Heo, Jeong-Mok Kim, Cheol-Sang Hwang. Mol Cells 2016
Kang-Eun Lee, Ji-Eun Heo, Jeong-Mok Kim, Cheol-Sang Hwang. Mol Cells 2016
25
Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.
Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain, Alexander Varshavsky. J Biol Chem 2008
Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain, Alexander Varshavsky. J Biol Chem 2008
25
Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.
Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, Alexander Varshavsky. Proc Natl Acad Sci U S A 2002
Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, Alexander Varshavsky. Proc Natl Acad Sci U S A 2002
25
Human aneuploidy: mechanisms and new insights into an age-old problem.
So I Nagaoka, Terry J Hassold, Patricia A Hunt. Nat Rev Genet 2012
So I Nagaoka, Terry J Hassold, Patricia A Hunt. Nat Rev Genet 2012
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Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization.
A R Bellvé, J C Cavicchia, C F Millette, D A O'Brien, Y M Bhatnagar, M Dym. J Cell Biol 1977
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A drying-down technique for the spreading of mammalian meiocytes from the male and female germline.
A H Peters, A W Plug, M J van Vugt, P de Boer. Chromosome Res 1997
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18
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
18
Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Haiqing Wang, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Mol Cell 2009
Haiqing Wang, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Mol Cell 2009
18
The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.
Zhizhong Xu, Roshani Payoe, Richard P Fahlman. J Biol Chem 2012
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Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.
Zanxian Xia, Glenn C Turner, Cheol-Sang Hwang, Christopher Byrd, Alexander Varshavsky. J Biol Chem 2008
Zanxian Xia, Glenn C Turner, Cheol-Sang Hwang, Christopher Byrd, Alexander Varshavsky. J Biol Chem 2008
18
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.
S Hauf, I C Waizenegger, J M Peters. Science 2001
S Hauf, I C Waizenegger, J M Peters. Science 2001
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Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
Christopher S Brower, Alexander Varshavsky. PLoS One 2009
Christopher S Brower, Alexander Varshavsky. PLoS One 2009
18
The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.
Mohamed A Eldeeb, Richard P Fahlman. Oncotarget 2014
Mohamed A Eldeeb, Richard P Fahlman. Oncotarget 2014
18
Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.
I C Waizenegger, S Hauf, A Meinke, J M Peters. Cell 2000
I C Waizenegger, S Hauf, A Meinke, J M Peters. Cell 2000
18
18
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
Jee Young An, Eun-A Kim, Yonghua Jiang, Adriana Zakrzewska, Dong Eun Kim, Min Jae Lee, Inhee Mook-Jung, Yi Zhang, Yong Tae Kwon. Proc Natl Acad Sci U S A 2010
Jee Young An, Eun-A Kim, Yonghua Jiang, Adriana Zakrzewska, Dong Eun Kim, Min Jae Lee, Inhee Mook-Jung, Yi Zhang, Yong Tae Kwon. Proc Natl Acad Sci U S A 2010
18
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Martin Zenker, Julia Mayerle, Markus M Lerch, Andreas Tagariello, Klaus Zerres, Peter R Durie, Matthias Beier, Georg Hülskamp, Celina Guzman, Helga Rehder,[...]. Nat Genet 2005
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18
Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast.
Tomoya S Kitajima, Yousuke Miyazaki, Masayuki Yamamoto, Yoshinori Watanabe. EMBO J 2003
Tomoya S Kitajima, Yousuke Miyazaki, Masayuki Yamamoto, Yoshinori Watanabe. EMBO J 2003
18
The N-end rule pathway is a sensor of heme.
Rong-Gui Hu, Haiqing Wang, Zanxian Xia, Alexander Varshavsky. Proc Natl Acad Sci U S A 2008
Rong-Gui Hu, Haiqing Wang, Zanxian Xia, Alexander Varshavsky. Proc Natl Acad Sci U S A 2008
18
The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
18
The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Cheol-Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander Varshavsky. Nat Cell Biol 2010
Cheol-Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander Varshavsky. Nat Cell Biol 2010
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Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy.
Satoshi Kurosaka, N Adrian Leu, Ivan Pavlov, Xuemei Han, Paula Aver Bretanha Ribeiro, Tao Xu, Ralph Bunte, Sougata Saha, Junling Wang, Anabelle Cornachione,[...]. J Mol Cell Cardiol 2012
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18
Identification of mammalian arginyltransferases that modify a specific subset of protein substrates.
Reena Rai, Anna Kashina. Proc Natl Acad Sci U S A 2005
Reena Rai, Anna Kashina. Proc Natl Acad Sci U S A 2005
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Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms.
Rong-Gui Hu, Christopher S Brower, Haiqing Wang, Ilia V Davydov, Jun Sheng, Jianmin Zhou, Yong Tae Kwon, Alexander Varshavsky. J Biol Chem 2006
Rong-Gui Hu, Christopher S Brower, Haiqing Wang, Ilia V Davydov, Jun Sheng, Jianmin Zhou, Yong Tae Kwon, Alexander Varshavsky. J Biol Chem 2006
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Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
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Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo.
Junling Wang, Xuemei Han, Sougata Saha, Tao Xu, Reena Rai, Fangliang Zhang, Yuri I Wolf, Alexey Wolfson, John R Yates, Anna Kashina. Chem Biol 2011
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Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
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18
The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.
Fang Yang, Yong Cheng, Jee Young An, Yong Tae Kwon, Sigrid Eckardt, N Adrian Leu, K John McLaughlin, Peijing Jeremy Wang. PLoS One 2010
Fang Yang, Yong Cheng, Jee Young An, Yong Tae Kwon, Sigrid Eckardt, N Adrian Leu, K John McLaughlin, Peijing Jeremy Wang. PLoS One 2010
18
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Giselle Román-Hernández, Robert A Grant, Robert T Sauer, Tania A Baker. Proc Natl Acad Sci U S A 2009
Giselle Román-Hernández, Robert A Grant, Robert T Sauer, Tania A Baker. Proc Natl Acad Sci U S A 2009
18
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
Takafumi Tasaki, Lubbertus C F Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V Davydov, Alexander Varshavsky, Mark Muesing, Yong Tae Kwon. Mol Cell Biol 2005
18
Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.
Mary Ann Handel, John C Schimenti. Nat Rev Genet 2010
Mary Ann Handel, John C Schimenti. Nat Rev Genet 2010
18
An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
18
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.