A citation-based method for searching scientific literature

Craig W Lindsley, Kyle A Emmitte, Corey R Hopkins, Thomas M Bridges, Karen J Gregory, Colleen M Niswender, P Jeffrey Conn. Chem Rev 2016
Times Cited: 115







List of co-cited articles
1053 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
32

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
292
20

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
P Jeffrey Conn, Craig W Lindsley, Jens Meiler, Colleen M Niswender. Nat Rev Drug Discov 2014
180
19

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
370
19

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
777
18

Trends in GPCR drug discovery: new agents, targets and indications.
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth, David E Gloriam. Nat Rev Drug Discov 2017
16

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
John A Christopher, Sarah J Aves, Kirstie A Bennett, Andrew S Doré, James C Errey, Ali Jazayeri, Fiona H Marshall, Krzysztof Okrasa, Maria J Serrano-Vega, Benjamin G Tehan,[...]. J Med Chem 2015
105
15

Structural insights into the activation of metabotropic glutamate receptors.
Antoine Koehl, Hongli Hu, Dan Feng, Bingfa Sun, Yan Zhang, Michael J Robertson, Matthew Chu, Tong Sun Kobilka, Toon Laeremans, Jan Steyaert,[...]. Nature 2019
140
15


Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, Margrith E Mattmann, Karen J Gregory, Rocio Zamorano, Darren W Engers, Sean R Bollinger, C David Weaver, Emily L Days,[...]. ACS Chem Neurosci 2014
38
31

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory,[...]. Biol Psychiatry 2013
79
15

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.
Katie Leach, Patrick M Sexton, Arthur Christopoulos. Trends Pharmacol Sci 2007
269
12

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
John A Christopher, Zoltán Orgován, Miles Congreve, Andrew S Doré, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega,[...]. J Med Chem 2019
45
26

Emerging paradigms in GPCR allostery: implications for drug discovery.
Denise Wootten, Arthur Christopoulos, Patrick M Sexton. Nat Rev Drug Discov 2013
289
11

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.
Laura Pérez-Benito, Maarten L J Doornbos, Arnau Cordomí, Luc Peeters, Hilde Lavreysen, Leonardo Pardo, Gary Tresadern. Structure 2017
35
31

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
Maarten L J Doornbos, Laura Pérez-Benito, Gary Tresadern, Thea Mulder-Krieger, Ilse Biesmans, Andrés A Trabanco, Jose María Cid, Hilde Lavreysen, Adriaan P IJzerman, Laura H Heitman. Br J Pharmacol 2016
30
36

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
68
14

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.
Xavier Rovira, Fanny Malhaire, Pauline Scholler, Jordi Rodrigo, Patricia Gonzalez-Bulnes, Amadeu Llebaria, Jean-Philippe Pin, Jesús Giraldo, Cyril Goudet. FASEB J 2015
42
23

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.
Kasper Harpsøe, Vignir Isberg, Benjamin G Tehan, Dahlia Weiss, Angela Arsova, Fiona H Marshall, Hans Bräuner-Osborne, David E Gloriam. Sci Rep 2015
32
31

Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs.
Miles Congreve, Christine Oswald, Fiona H Marshall. Trends Pharmacol Sci 2017
69
14

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
Robert Fredriksson, Malin C Lagerström, Lars-Gustav Lundin, Helgi B Schiöth. Mol Pharmacol 2003
10

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).
Darren W Engers, Anna L Blobaum, Rocco D Gogliotti, Yiu-Yin Cheung, James M Salovich, Pedro M Garcia-Barrantes, J Scott Daniels, Ryan Morrison, Carrie K Jones, Matthew G Soars,[...]. ACS Chem Neurosci 2016
29
34

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
M J Noetzel, K J Gregory, P N Vinson, J T Manka, S R Stauffer, C W Lindsley, C M Niswender, Z Xiang, P J Conn. Mol Pharmacol 2013
65
13

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.
Kathy Sengmany, Junaid Singh, Gregory D Stewart, P Jeffrey Conn, Arthur Christopoulos, Karen J Gregory. Neuropharmacology 2017
33
27

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
85
10

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
646
9


"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
Michael R Wood, Corey R Hopkins, John T Brogan, P Jeffrey Conn, Craig W Lindsley. Biochemistry 2011
126
9

Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G F Rasmussen, Brian T DeVree, Yaozhong Zou, Andrew C Kruse, Ka Young Chung, Tong Sun Kobilka, Foon Sun Thian, Pil Seok Chae, Els Pardon, Diane Calinski,[...]. Nature 2011
9

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Shen Yin, Meredith J Noetzel, Kari A Johnson, Rocio Zamorano, Nidhi Jalan-Sakrikar, Karen J Gregory, P Jeffrey Conn, Colleen M Niswender. J Neurosci 2014
82
9

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days,[...]. Mol Pharmacol 2010
146
8

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, Joachim Nozulak, Oliver Pescott, Snezana Lukic, Natacha Stoehr, Cedric Mombereau, Rainer Kuhn, Kevin H McAllister,[...]. Proc Natl Acad Sci U S A 2005
197
8

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization.
Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel,[...]. J Pharmacol Exp Ther 2013
69
11

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Sophie Parmentier-Batteur, Peter H Hutson, Karsten Menzel, Jason M Uslaner, Britta A Mattson, Julie A O'Brien, Brian C Magliaro, Thomas Forest, Craig A Stump, Robert M Tynebor,[...]. Neuropharmacology 2014
70
11

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Giuseppe Battaglia, Carla L Busceti, Gemma Molinaro, Francesca Biagioni, Anna Traficante, Ferdinando Nicoletti, Valeria Bruno. J Neurosci 2006
93
8

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor.
N Kunishima, Y Shimada, Y Tsuji, T Sato, M Yamamoto, T Kumasaka, S Nakanishi, H Jingami, K Morikawa. Nature 2000
938
8

Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.
Karen J Gregory, Elizabeth D Nguyen, Sean D Reiff, Emma F Squire, Shaun R Stauffer, Craig W Lindsley, Jens Meiler, P Jeffrey Conn. Mol Pharmacol 2013
60
13

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors.
Takanori Muto, Daisuke Tsuchiya, Kosuke Morikawa, Hisato Jingami. Proc Natl Acad Sci U S A 2007
267
8

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Christine E Gee, Daniel Peterlik, Christoph Neuhäuser, Rochdi Bouhelal, Klemens Kaupmann, Grit Laue, Nicole Uschold-Schmidt, Dominik Feuerbach, Kaspar Zimmermann, Silvio Ofner,[...]. J Biol Chem 2014
50
16

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.
Etienne Doumazane, Pauline Scholler, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin. FASEB J 2011
200
8

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
S Litschig, F Gasparini, D Rueegg, N Stoehr, P J Flor, I Vranesic, L Prézeau, J P Pin, C Thomsen, R Kuhn. Mol Pharmacol 1999
281
8

Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
F Knoflach, V Mutel, S Jolidon, J N Kew, P Malherbe, E Vieira, J Wichmann, J A Kemp. Proc Natl Acad Sci U S A 2001
197
8

A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.
François Tison, Charlotte Keywood, Mark Wakefield, Franck Durif, Jean-Christophe Corvol, Karla Eggert, Mark Lew, Stuart Isaacson, Erwan Bezard, Sonia-Maria Poli,[...]. Mov Disord 2016
87
9

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Bruce J Melancon, Corey R Hopkins, Michael R Wood, Kyle A Emmitte, Colleen M Niswender, Arthur Christopoulos, P Jeffrey Conn, Craig W Lindsley. J Med Chem 2012
166
8

Allosteric modulation of G protein-coupled receptors.
Lauren T May, Katie Leach, Patrick M Sexton, Arthur Christopoulos. Annu Rev Pharmacol Toxicol 2007
509
8


Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.
A Farinha, H Lavreysen, L Peeters, B Russo, S Masure, A A Trabanco, J Cid, G Tresadern. Br J Pharmacol 2015
33
24

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.
M Maj, V Bruno, Z Dragic, R Yamamoto, G Battaglia, W Inderbitzin, N Stoehr, T Stein, F Gasparini, I Vranesic,[...]. Neuropharmacology 2003
160
8

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
Darren W Engers, Colleen M Niswender, C David Weaver, Satyawan Jadhav, Usha N Menon, Rocio Zamorano, P Jeffrey Conn, Craig W Lindsley, Corey R Hopkins. J Med Chem 2009
64
12

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.
Eric A Wold, Jianping Chen, Kathryn A Cunningham, Jia Zhou. J Med Chem 2019
52
15


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.