A citation-based method for searching scientific literature

Tsuyoshi Shirai, Rafal R Nazarewicz, Barbara B Wallis, Rolando E Yanes, Ryu Watanabe, Marc Hilhorst, Lu Tian, David G Harrison, John C Giacomini, Themistocles L Assimes, Jörg J Goronzy, Cornelia M Weyand. J Exp Med 2016
Times Cited: 269







List of co-cited articles
1065 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Eva M Palsson-McDermott, Anne M Curtis, Gautam Goel, Mario A R Lauterbach, Frederick J Sheedy, Laura E Gleeson, Mirjam W M van den Bosch, Susan R Quinn, Raquel Domingo-Fernandez, Daniel G W Johnston,[...]. Cell Metab 2015
544
35

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.
Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R Billiar, Haichao Wang,[...]. Nat Commun 2016
204
22

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
G M Tannahill, A M Curtis, J Adamik, E M Palsson-McDermott, A F McGettrick, G Goel, C Frezza, N J Bernard, B Kelly, N H Foley,[...]. Nature 2013
21

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.
Liangchun Yang, Min Xie, Minghua Yang, Yan Yu, Shan Zhu, Wen Hou, Rui Kang, Michael T Lotze, Timothy R Billiar, Haichao Wang,[...]. Nat Commun 2014
242
19

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Weibo Luo, Hongxia Hu, Ryan Chang, Jun Zhong, Matthew Knabel, Robert O'Meally, Robert N Cole, Akhilesh Pandey, Gregg L Semenza. Cell 2011
879
17

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
Anette Christ, Patrick Günther, Mario A R Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler,[...]. Cell 2018
432
15

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Paul M Ridker, Brendan M Everett, Tom Thuren, Jean G MacFadyen, William H Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D Anker,[...]. N Engl J Med 2017
15

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Heather R Christofk, Matthew G Vander Heiden, Marian H Harris, Arvind Ramanathan, Robert E Gerszten, Ru Wei, Mark D Fleming, Stuart L Schreiber, Lewis C Cantley. Nature 2008
15


Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.
Xueliang Gao, Haizhen Wang, Jenny J Yang, Xiaowei Liu, Zhi-Ren Liu. Mol Cell 2012
484
14

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.
Stefano Angiari, Marah C Runtsch, Caroline E Sutton, Eva M Palsson-McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L Pearce, Kingston H G Mills,[...]. Cell Metab 2020
88
15

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.
Siroon Bekkering, Inge van den Munckhof, Tim Nielen, Evert Lamfers, Charles Dinarello, Joost Rutten, Jacqueline de Graaf, Leo A B Joosten, Mihai G Netea, Marc E R Gomes,[...]. Atherosclerosis 2016
101
13

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation.
Jose C Alves-Filho, Eva M Pålsson-McDermott. Front Immunol 2016
83
14

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation.
Luis Eduardo Alves Damasceno, Douglas Silva Prado, Flavio Protasio Veras, Miriam M Fonseca, Juliana E Toller-Kawahisa, Marcos Henrique Rosa, Gabriel Azevedo Públio, Timna Varela Martins, Fernando S Ramalho, Ari Waisman,[...]. J Exp Med 2020
41
29

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Dimitrios Anastasiou, Yimin Yu, William J Israelsen, Jian-Kang Jiang, Matthew B Boxer, Bum Soo Hong, Wolfram Tempel, Svetoslav Dimov, Min Shen, Abhishek Jha,[...]. Nat Chem Biol 2012
462
11

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Dimitrios Anastasiou, George Poulogiannis, John M Asara, Matthew B Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, Atsuo T Sasaki, Jason W Locasale, Douglas S Auld,[...]. Science 2011
740
11

Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.
Alex J Freemerman, Amy R Johnson, Gina N Sacks, J Justin Milner, Erin L Kirk, Melissa A Troester, Andrew N Macintyre, Pankuri Goraksha-Hicks, Jeffery C Rathmell, Liza Makowski. J Biol Chem 2014
422
11

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Taro Hitosugi, Sumin Kang, Matthew G Vander Heiden, Tae-Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z Chen,[...]. Sci Signal 2009
523
10

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Weiwei Yang, Yan Xia, Haitao Ji, Yanhua Zheng, Ji Liang, Wenhua Huang, Xiang Gao, Kenneth Aldape, Zhimin Lu. Nature 2011
647
10

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
Ryan D Michalek, Valerie A Gerriets, Sarah R Jacobs, Andrew N Macintyre, Nancie J MacIver, Emily F Mason, Sarah A Sullivan, Amanda G Nichols, Jeffrey C Rathmell. J Immunol 2011
10


PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis.
Silin Lü, Jiacheng Deng, Huiying Liu, Bo Liu, Juan Yang, Yutong Miao, Jing Li, Nan Wang, Changtao Jiang, Qingbo Xu,[...]. J Mol Med (Berl) 2018
33
27

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Jan Van den Bossche, Jeroen Baardman, Natasja A Otto, Saskia van der Velden, Annette E Neele, Susan M van den Berg, Rosario Luque-Martin, Hung-Jen Chen, Marieke C S Boshuizen, Mohamed Ahmed,[...]. Cell Rep 2016
343
9

Macrophages in atherosclerosis: a dynamic balance.
Kathryn J Moore, Frederick J Sheedy, Edward A Fisher. Nat Rev Immunol 2013
9

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M Stewart, Juliet Ashall, Bart Everts,[...]. Immunity 2015
889
9

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Evanna L Mills, Beth Kelly, Angela Logan, Ana S H Costa, Mukund Varma, Clare E Bryant, Panagiotis Tourlomousis, J Henry M Däbritz, Eyal Gottlieb, Isabel Latorre,[...]. Cell 2016
839
9

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A Lyssiotis, Kenneth Aldape, Lewis C Cantley, Zhimin Lu. Nat Cell Biol 2012
500
9

Pyruvate kinase M2: A simple molecule with complex functions.
Mohammed Alquraishi, Dexter L Puckett, Dina S Alani, Amal S Humidat, Victoria D Frankel, Dallas R Donohoe, Jay Whelan, Ahmed Bettaieb. Free Radic Biol Med 2019
38
23

A guide to immunometabolism for immunologists.
Luke A J O'Neill, Rigel J Kishton, Jeff Rathmell. Nat Rev Immunol 2016
9

Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease.
Cheryl van de Wetering, Reem Aboushousha, Allison M Manuel, Shi B Chia, Cuixia Erickson, Maximilian B MacPherson, Jos L van der Velden, Vikas Anathy, Anne E Dixon, Charles G Irvin,[...]. J Immunol 2020
18
50

Macrophage activation and polarization: nomenclature and experimental guidelines.
Peter J Murray, Judith E Allen, Subhra K Biswas, Edward A Fisher, Derek W Gilroy, Sergij Goerdt, Siamon Gordon, John A Hamilton, Lionel B Ivashkiv, Toby Lawrence,[...]. Immunity 2014
8

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice.
Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, Dan Ye, Yi Wang, Ying Xu, Lisha Zhou, Yiwei Chu, Cuiping Zhang,[...]. Cell Rep 2017
119
8

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
Connie M Krawczyk, Thomas Holowka, Jie Sun, Julianna Blagih, Eyal Amiel, Ralph J DeBerardinis, Justin R Cross, Euihye Jung, Craig B Thompson, Russell G Jones,[...]. Blood 2010
717
8

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.
Jong-Seok Moon, Shu Hisata, Mi-Ae Park, Gina M DeNicola, Stefan W Ryter, Kiichi Nakahira, Augustine M K Choi. Cell Rep 2015
221
8

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Shih-Chin Cheng, Jessica Quintin, Robert A Cramer, Kelly M Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J Giamarellos-Bourboulis, Joost H A Martens, Nagesha Appukudige Rao, Ali Aghajanirefah,[...]. Science 2014
975
8

Trained immunity: a memory for innate host defense.
Mihai G Netea, Jessica Quintin, Jos W M van der Meer. Cell Host Microbe 2011
724
8

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Sadia Saeed, Jessica Quintin, Hindrik H D Kerstens, Nagesha A Rao, Ali Aghajanirefah, Filomena Matarese, Shih-Chin Cheng, Jacqueline Ratter, Kim Berentsen, Martijn A van der Ent,[...]. Science 2014
839
8

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.
Juan-Carlos Rodríguez-Prados, Paqui G Través, Jimena Cuenca, Daniel Rico, Julián Aragonés, Paloma Martín-Sanz, Marta Cascante, Lisardo Boscá. J Immunol 2010
585
8

Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.
Siroon Bekkering, Jessica Quintin, Leo A B Joosten, Jos W M van der Meer, Mihai G Netea, Niels P Riksen. Arterioscler Thromb Vasc Biol 2014
301
8

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
William J Israelsen, Talya L Dayton, Shawn M Davidson, Brian P Fiske, Aaron M Hosios, Gary Bellinger, Jie Li, Yimin Yu, Mika Sasaki, James W Horner,[...]. Cell 2013
322
8

HIF-1alpha is essential for myeloid cell-mediated inflammation.
Thorsten Cramer, Yuji Yamanishi, Björn E Clausen, Irmgard Förster, Rafal Pawlinski, Nigel Mackman, Volker H Haase, Rudolf Jaenisch, Maripat Corr, Victor Nizet,[...]. Cell 2003
8


Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Heather R Christofk, Matthew G Vander Heiden, Ning Wu, John M Asara, Lewis C Cantley. Nature 2008
716
7

Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.
Prabhakara R Nagareddy, Andrew J Murphy, Roslynn A Stirzaker, Yunying Hu, Shiquing Yu, Rachel G Miller, Bhama Ramkhelawon, Emilie Distel, Marit Westerterp, Li-Shin Huang,[...]. Cell Metab 2013
335
7

Metabolic pathways in immune cell activation and quiescence.
Erika L Pearce, Edward J Pearce. Immunity 2013
858
7

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.
Lukas Tomas, Andreas Edsfeldt, Inês G Mollet, Ljubica Perisic Matic, Cornelia Prehn, Jerzy Adamski, Gabrielle Paulsson-Berne, Ulf Hedin, Jan Nilsson, Eva Bengtsson,[...]. Eur Heart J 2018
58
12

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.
Kyeongdae Kim, Dahee Shim, Jun Seong Lee, Konstantin Zaitsev, Jesse W Williams, Ki-Wook Kim, Man-Young Jang, Hyung Seok Jang, Tae Jin Yun, Seung Hyun Lee,[...]. Circ Res 2018
148
7

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.
Siroon Bekkering, Rob J W Arts, Boris Novakovic, Ioannis Kourtzelis, Charlotte D C C van der Heijden, Yang Li, Calin D Popa, Rob Ter Horst, Julia van Tuijl, Romana T Netea-Maier,[...]. Cell 2018
299
7

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
Bart Everts, Eyal Amiel, Stanley Ching-Cheng Huang, Amber M Smith, Chih-Hao Chang, Wing Y Lam, Veronika Redmann, Tori C Freitas, Julianna Blagih, Gerritje J W van der Windt,[...]. Nat Immunol 2014
596
7

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016
551
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.