Dennis J Selkoe, John Hardy. EMBO Mol Med 2016
Times Cited: 2647
Times Cited: 2647
Times Cited
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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.
Clifford R Jack, David A Bennett, Kaj Blennow, Maria C Carrillo, Billy Dunn, Samantha Budd Haeberlein, David M Holtzman, William Jagust, Frank Jessen, Jason Karlawish,[...]. Alzheimers Dement 2018
Clifford R Jack, David A Bennett, Kaj Blennow, Maria C Carrillo, Billy Dunn, Samantha Budd Haeberlein, David M Holtzman, William Jagust, Frank Jessen, Jason Karlawish,[...]. Alzheimers Dement 2018
15
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling,[...]. Nature 2016
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling,[...]. Nature 2016
12
11
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Holly Oakley, Sarah L Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John Disterhoft, Linda Van Eldik,[...]. J Neurosci 2006
Holly Oakley, Sarah L Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John Disterhoft, Linda Van Eldik,[...]. J Neurosci 2006
11
Amyloid beta: structure, biology and structure-based therapeutic development.
Guo-Fang Chen, Ting-Hai Xu, Yan Yan, Yu-Ren Zhou, Yi Jiang, Karsten Melcher, H Eric Xu. Acta Pharmacol Sin 2017
Guo-Fang Chen, Ting-Hai Xu, Yan Yan, Yu-Ren Zhou, Yi Jiang, Karsten Melcher, H Eric Xu. Acta Pharmacol Sin 2017
8
8
Donanemab in Early Alzheimer's Disease.
Mark A Mintun, Albert C Lo, Cynthia Duggan Evans, Alette M Wessels, Paul A Ardayfio, Scott W Andersen, Sergey Shcherbinin, JonDavid Sparks, John R Sims, Miroslaw Brys,[...]. N Engl J Med 2021
Mark A Mintun, Albert C Lo, Cynthia Duggan Evans, Alette M Wessels, Paul A Ardayfio, Scott W Andersen, Sergey Shcherbinin, JonDavid Sparks, John R Sims, Miroslaw Brys,[...]. N Engl J Med 2021
8
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
John Hardy, Dennis J Selkoe. Science 2002
John Hardy, Dennis J Selkoe. Science 2002
7
Neuroinflammation in Alzheimer's disease.
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff,[...]. Lancet Neurol 2015
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff,[...]. Lancet Neurol 2015
7
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Christian Haass, Dennis J Selkoe. Nat Rev Mol Cell Biol 2007
Christian Haass, Dennis J Selkoe. Nat Rev Mol Cell Biol 2007
6
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Ganesh M Shankar, Shaomin Li, Tapan H Mehta, Amaya Garcia-Munoz, Nina E Shepardson, Imelda Smith, Francesca M Brett, Michael A Farrell, Michael J Rowan, Cynthia A Lemere,[...]. Nat Med 2008
Ganesh M Shankar, Shaomin Li, Tapan H Mehta, Amaya Garcia-Munoz, Nina E Shepardson, Imelda Smith, Francesca M Brett, Michael A Farrell, Michael J Rowan, Cynthia A Lemere,[...]. Nat Med 2008
6
Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein. Acta Neuropathol 2015
Kirsten L Viola, William L Klein. Acta Neuropathol 2015
6
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism.
Samuel I A Cohen, Sara Linse, Leila M Luheshi, Erik Hellstrand, Duncan A White, Luke Rajah, Daniel E Otzen, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles. Proc Natl Acad Sci U S A 2013
Samuel I A Cohen, Sara Linse, Leila M Luheshi, Erik Hellstrand, Duncan A White, Luke Rajah, Daniel E Otzen, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles. Proc Natl Acad Sci U S A 2013
6
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.
Y Iturria-Medina, R C Sotero, P J Toussaint, J M Mateos-Pérez, A C Evans. Nat Commun 2016
Y Iturria-Medina, R C Sotero, P J Toussaint, J M Mateos-Pérez, A C Evans. Nat Commun 2016
6
The neuropathological diagnosis of Alzheimer's disease.
Michael A DeTure, Dennis W Dickson. Mol Neurodegener 2019
Michael A DeTure, Dennis W Dickson. Mol Neurodegener 2019
6
Neuropathological alterations in Alzheimer disease.
Alberto Serrano-Pozo, Matthew P Frosch, Eliezer Masliah, Bradley T Hyman. Cold Spring Harb Perspect Med 2011
Alberto Serrano-Pozo, Matthew P Frosch, Eliezer Masliah, Bradley T Hyman. Cold Spring Harb Perspect Med 2011
5
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
E H Corder, A M Saunders, W J Strittmatter, D E Schmechel, P C Gaskell, G W Small, A D Roses, J L Haines, M A Pericak-Vance. Science 1993
E H Corder, A M Saunders, W J Strittmatter, D E Schmechel, P C Gaskell, G W Small, A D Roses, J L Haines, M A Pericak-Vance. Science 1993
5
Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.
Renaud La Joie, Adrienne V Visani, Suzanne L Baker, Jesse A Brown, Viktoriya Bourakova, Jungho Cha, Kiran Chaudhary, Lauren Edwards, Leonardo Iaccarino, Mustafa Janabi,[...]. Sci Transl Med 2020
Renaud La Joie, Adrienne V Visani, Suzanne L Baker, Jesse A Brown, Viktoriya Bourakova, Jungho Cha, Kiran Chaudhary, Lauren Edwards, Leonardo Iaccarino, Mustafa Janabi,[...]. Sci Transl Med 2020
5
Phases of A beta-deposition in the human brain and its relevance for the development of AD.
Dietmar R Thal, Udo Rüb, Mario Orantes, Heiko Braak. Neurology 2002
Dietmar R Thal, Udo Rüb, Mario Orantes, Heiko Braak. Neurology 2002
5
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Erik D Roberson, Kimberly Scearce-Levie, Jorge J Palop, Fengrong Yan, Irene H Cheng, Tiffany Wu, Hilary Gerstein, Gui-Qiu Yu, Lennart Mucke. Science 2007
Erik D Roberson, Kimberly Scearce-Levie, Jorge J Palop, Fengrong Yan, Irene H Cheng, Tiffany Wu, Hilary Gerstein, Gui-Qiu Yu, Lennart Mucke. Science 2007
5
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Justin M Long, David M Holtzman. Cell 2019
Justin M Long, David M Holtzman. Cell 2019
5
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.
Victor L Villemagne, Samantha Burnham, Pierrick Bourgeat, Belinda Brown, Kathryn A Ellis, Olivier Salvado, Cassandra Szoeke, S Lance Macaulay, Ralph Martins, Paul Maruff,[...]. Lancet Neurol 2013
Victor L Villemagne, Samantha Burnham, Pierrick Bourgeat, Belinda Brown, Kathryn A Ellis, Olivier Salvado, Cassandra Szoeke, S Lance Macaulay, Ralph Martins, Paul Maruff,[...]. Lancet Neurol 2013
5
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.
Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate,[...]. Nat Med 2020
Nicolas R Barthélemy, Yan Li, Nelly Joseph-Mathurin, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Virginia Buckles, Anne M Fagan, Richard J Perrin, Alison M Goate,[...]. Nat Med 2020
5
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
J C Lambert, C A Ibrahim-Verbaas, D Harold, A C Naj, R Sims, C Bellenguez, A L DeStafano, J C Bis, G W Beecham, B Grenier-Boley,[...]. Nat Genet 2013
J C Lambert, C A Ibrahim-Verbaas, D Harold, A C Naj, R Sims, C Bellenguez, A L DeStafano, J C Bis, G W Beecham, B Grenier-Boley,[...]. Nat Genet 2013
5
Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Melanie D Sweeney, Axel Montagne, Abhay P Sagare, Daniel A Nation, Lon S Schneider, Helena C Chui, Michael G Harrington, Judy Pa, Meng Law, Danny J J Wang,[...]. Alzheimers Dement 2019
Melanie D Sweeney, Axel Montagne, Abhay P Sagare, Daniel A Nation, Lon S Schneider, Helena C Chui, Michael G Harrington, Judy Pa, Meng Law, Danny J J Wang,[...]. Alzheimers Dement 2019
5
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.
Fabrizio Chiti, Christopher M Dobson. Annu Rev Biochem 2017
Fabrizio Chiti, Christopher M Dobson. Annu Rev Biochem 2017
5
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.
Iryna Benilova, Eric Karran, Bart De Strooper. Nat Neurosci 2012
Iryna Benilova, Eric Karran, Bart De Strooper. Nat Neurosci 2012
5
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Celeste M Karch, Alison M Goate. Biol Psychiatry 2015
Celeste M Karch, Alison M Goate. Biol Psychiatry 2015
5
Molecular genetics of early-onset Alzheimer's disease revisited.
Rita Cacace, Kristel Sleegers, Christine Van Broeckhoven. Alzheimers Dement 2016
Rita Cacace, Kristel Sleegers, Christine Van Broeckhoven. Alzheimers Dement 2016
4
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Joanna L Jankowsky, Daniel J Fadale, Jeffrey Anderson, Guilian M Xu, Victoria Gonzales, Nancy A Jenkins, Neal G Copeland, Michael K Lee, Linda H Younkin, Steven L Wagner,[...]. Hum Mol Genet 2004
Joanna L Jankowsky, Daniel J Fadale, Jeffrey Anderson, Guilian M Xu, Victoria Gonzales, Nancy A Jenkins, Neal G Copeland, Michael K Lee, Linda H Younkin, Steven L Wagner,[...]. Hum Mol Genet 2004
4
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris,[...]. N Engl J Med 2014
Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris,[...]. N Engl J Med 2014
4
4
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,[...]. Nat Genet 2009
Denise Harold, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Marian L Hamshere, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Amy Williams,[...]. Nat Genet 2009
4
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas,[...]. Nature 2017
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas,[...]. Nature 2017
4
LRP1 is a master regulator of tau uptake and spread.
Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman,[...]. Nature 2020
Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman,[...]. Nature 2020
4
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf,[...]. Nat Genet 2019
Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf,[...]. Nat Genet 2019
4
Alzheimer's disease.
Philip Scheltens, Bart De Strooper, Miia Kivipelto, Henne Holstege, Gael Chételat, Charlotte E Teunissen, Jeffrey Cummings, Wiesje M van der Flier. Lancet 2021
Philip Scheltens, Bart De Strooper, Miia Kivipelto, Henne Holstege, Gael Chételat, Charlotte E Teunissen, Jeffrey Cummings, Wiesje M van der Flier. Lancet 2021
4
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu,[...]. Nat Genet 2019
Iris E Jansen, Jeanne E Savage, Kyoko Watanabe, Julien Bryois, Dylan M Williams, Stacy Steinberg, Julia Sealock, Ida K Karlsson, Sara Hägg, Lavinia Athanasiu,[...]. Nat Genet 2019
4
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth,[...]. Cell 2017
Hadas Keren-Shaul, Amit Spinrad, Assaf Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beata Toth,[...]. Cell 2017
4
Clinical trials of new drugs for Alzheimer disease.
Li-Kai Huang, Shu-Ping Chao, Chaur-Jong Hu. J Biomed Sci 2020
Li-Kai Huang, Shu-Ping Chao, Chaur-Jong Hu. J Biomed Sci 2020
4
A phase 3 trial of semagacestat for treatment of Alzheimer's disease.
Rachelle S Doody, Rema Raman, Martin Farlow, Takeshi Iwatsubo, Bruno Vellas, Steven Joffe, Karl Kieburtz, Feng He, Xiaoying Sun, Ronald G Thomas,[...]. N Engl J Med 2013
Rachelle S Doody, Rema Raman, Martin Farlow, Takeshi Iwatsubo, Bruno Vellas, Steven Joffe, Karl Kieburtz, Feng He, Xiaoying Sun, Ronald G Thomas,[...]. N Engl J Med 2013
4
Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise.
Christopher H van Dyck. Biol Psychiatry 2018
Christopher H van Dyck. Biol Psychiatry 2018
4
Single App knock-in mouse models of Alzheimer's disease.
Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata, Takaomi C Saido. Nat Neurosci 2014
Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata, Takaomi C Saido. Nat Neurosci 2014
4
Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
Randall J Bateman, Chengjie Xiong, Tammie L S Benzinger, Anne M Fagan, Alison Goate, Nick C Fox, Daniel S Marcus, Nigel J Cairns, Xianyun Xie, Tyler M Blazey,[...]. N Engl J Med 2012
Randall J Bateman, Chengjie Xiong, Tammie L S Benzinger, Anne M Fagan, Alison Goate, Nick C Fox, Daniel S Marcus, Nigel J Cairns, Xianyun Xie, Tyler M Blazey,[...]. N Engl J Med 2012
4
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.
J Götz, F Chen, J van Dorpe, R M Nitsch. Science 2001
J Götz, F Chen, J van Dorpe, R M Nitsch. Science 2001
4
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