A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Sara Ahrabi, Sovan Sarkar, Sophia X Pfister, Giacomo Pirovano, Geoff S Higgins, Andrew C G Porter, Timothy C Humphrey. Nucleic Acids Res 2016
Times Cited: 58
Times Cited: 58
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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
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Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
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Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Lan N Truong, Yongjiang Li, Linda Z Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W Berns, Xiaohua Wu. Proc Natl Acad Sci U S A 2013
Lan N Truong, Yongjiang Li, Linda Z Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W Berns, Xiaohua Wu. Proc Natl Acad Sci U S A 2013
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Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
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Repair Pathway Choices and Consequences at the Double-Strand Break.
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea. Trends Cell Biol 2016
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Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.
David W Wyatt, Wanjuan Feng, Michael P Conlin, Matthew J Yousefzadeh, Steven A Roberts, Piotr Mieczkowski, Richard D Wood, Gaorav P Gupta, Dale A Ramsden. Mol Cell 2016
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Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Agnel Sfeir, Lorraine S Symington. Trends Biochem Sci 2015
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DNA double-strand break repair-pathway choice in somatic mammalian cells.
Ralph Scully, Arvind Panday, Rajula Elango, Nicholas A Willis. Nat Rev Mol Cell Biol 2019
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RPA antagonizes microhomology-mediated repair of DNA double-strand breaks.
Sarah K Deng, Bryan Gibb, Mariana Justino de Almeida, Eric C Greene, Lorraine S Symington. Nat Struct Mol Biol 2014
Sarah K Deng, Bryan Gibb, Mariana Justino de Almeida, Eric C Greene, Lorraine S Symington. Nat Struct Mol Biol 2014
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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
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Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.
Sze Ham Chan, Amy Marie Yu, Mitch McVey. PLoS Genet 2010
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Regulation of Single-Strand Annealing and its Role in Genome Maintenance.
Ragini Bhargava, David O Onyango, Jeremy M Stark. Trends Genet 2016
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Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Howard H Y Chang, Nicholas R Pannunzio, Noritaka Adachi, Michael R Lieber. Nat Rev Mol Cell Biol 2017
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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.
Nicole Bennardo, Anita Cheng, Nick Huang, Jeremy M Stark. PLoS Genet 2008
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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
Marc Audebert, Bernard Salles, Patrick Calsou. J Biol Chem 2004
Marc Audebert, Bernard Salles, Patrick Calsou. J Biol Chem 2004
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Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations.
George Iliakis, Tamara Murmann, Aashish Soni. Mutat Res Genet Toxicol Environ Mutagen 2015
George Iliakis, Tamara Murmann, Aashish Soni. Mutat Res Genet Toxicol Environ Mutagen 2015
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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Samuel F Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao,[...]. Cell 2010
Samuel F Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao,[...]. Cell 2010
20
A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
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The DNA-damage response in human biology and disease.
Stephen P Jackson, Jiri Bartek. Nature 2009
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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.
Minli Wang, Weizhong Wu, Wenqi Wu, Bustanur Rosidi, Lihua Zhang, Huichen Wang, George Iliakis. Nucleic Acids Res 2006
Minli Wang, Weizhong Wu, Wenqi Wu, Bustanur Rosidi, Lihua Zhang, Huichen Wang, George Iliakis. Nucleic Acids Res 2006
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
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An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway.
Yu Zhang, Maria Jasin. Nat Struct Mol Biol 2011
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17
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
Michael R Lieber. Annu Rev Biochem 2010
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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Amitabh V Nimonkar, Jochen Genschel, Eri Kinoshita, Piotr Polaczek, Judith L Campbell, Claire Wyman, Paul Modrich, Stephen C Kowalczykowski. Genes Dev 2011
Amitabh V Nimonkar, Jochen Genschel, Eri Kinoshita, Piotr Polaczek, Judith L Campbell, Claire Wyman, Paul Modrich, Stephen C Kowalczykowski. Genes Dev 2011
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MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.
Mitch McVey, Sang Eun Lee. Trends Genet 2008
Mitch McVey, Sang Eun Lee. Trends Genet 2008
17
Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.
Annahita Sallmyr, Alan E Tomkinson. J Biol Chem 2018
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17
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
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Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.
Sophie F Roerink, Robin van Schendel, Marcel Tijsterman. Genome Res 2014
Sophie F Roerink, Robin van Schendel, Marcel Tijsterman. Genome Res 2014
15
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc,[...]. Proc Natl Acad Sci U S A 2010
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15
Is non-homologous end-joining really an inherently error-prone process?
Mireille Bétermier, Pascale Bertrand, Bernard S Lopez. PLoS Genet 2014
Mireille Bétermier, Pascale Bertrand, Bernard S Lopez. PLoS Genet 2014
15
15
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Pedro A Mateos-Gomez, Tatiana Kent, Sarah K Deng, Shane McDevitt, Ekaterina Kashkina, Trung M Hoang, Richard T Pomerantz, Agnel Sfeir. Nat Struct Mol Biol 2017
Pedro A Mateos-Gomez, Tatiana Kent, Sarah K Deng, Shane McDevitt, Ekaterina Kashkina, Trung M Hoang, Richard T Pomerantz, Agnel Sfeir. Nat Struct Mol Biol 2017
15
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Guangqing Lu, Jinzhi Duan, Sheng Shu, Xuxiang Wang, Linlin Gao, Jing Guo, Yu Zhang. Proc Natl Acad Sci U S A 2016
Guangqing Lu, Jinzhi Duan, Sheng Shu, Xuxiang Wang, Linlin Gao, Jing Guo, Yu Zhang. Proc Natl Acad Sci U S A 2016
14
Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.
Hind Ghezraoui, Marion Piganeau, Benjamin Renouf, Jean-Baptiste Renaud, Annahita Sallmyr, Brian Ruis, Sehyun Oh, Alan E Tomkinson, Eric A Hendrickson, Carine Giovannangeli,[...]. Mol Cell 2014
Hind Ghezraoui, Marion Piganeau, Benjamin Renouf, Jean-Baptiste Renaud, Annahita Sallmyr, Brian Ruis, Sehyun Oh, Alan E Tomkinson, Eric A Hendrickson, Carine Giovannangeli,[...]. Mol Cell 2014
13
Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.
Amy Marie Yu, Mitch McVey. Nucleic Acids Res 2010
Amy Marie Yu, Mitch McVey. Nucleic Acids Res 2010
13
Double-strand break end resection and repair pathway choice.
Lorraine S Symington, Jean Gautier. Annu Rev Genet 2011
Lorraine S Symington, Jean Gautier. Annu Rev Genet 2011
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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.
Geoff S Higgins, Adrian L Harris, Remko Prevo, Thomas Helleday, W Gillies McKenna, Francesca M Buffa. Oncotarget 2010
Geoff S Higgins, Adrian L Harris, Remko Prevo, Thomas Helleday, W Gillies McKenna, Francesca M Buffa. Oncotarget 2010
13
DNA polymerase θ (POLQ), double-strand break repair, and cancer.
Richard D Wood, Sylvie Doublié. DNA Repair (Amst) 2016
Richard D Wood, Sylvie Doublié. DNA Repair (Amst) 2016
13
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.
Cristina Escribano-Díaz, Alexandre Orthwein, Amélie Fradet-Turcotte, Mengtan Xing, Jordan T F Young, Ján Tkáč, Michael A Cook, Adam P Rosebrock, Meagan Munro, Marella D Canny,[...]. Mol Cell 2013
Cristina Escribano-Díaz, Alexandre Orthwein, Amélie Fradet-Turcotte, Mengtan Xing, Jordan T F Young, Ján Tkáč, Michael A Cook, Adam P Rosebrock, Meagan Munro, Marella D Canny,[...]. Mol Cell 2013
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Mechanistic basis for microhomology identification and genome scarring by polymerase theta.
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D Wood, Jeff Sekelsky, Gaorav P Gupta, Steven A Roberts, Dale A Ramsden. Proc Natl Acad Sci U S A 2020
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D Wood, Jeff Sekelsky, Gaorav P Gupta, Steven A Roberts, Dale A Ramsden. Proc Natl Acad Sci U S A 2020
13
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.
Ludovic Deriano, David B Roth. Annu Rev Genet 2013
Ludovic Deriano, David B Roth. Annu Rev Genet 2013
12
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.
Deniz Simsek, Erika Brunet, Sunnie Yan-Wai Wong, Sachin Katyal, Yankun Gao, Peter J McKinnon, Jacqueline Lou, Lei Zhang, James Li, Edward J Rebar,[...]. PLoS Genet 2011
Deniz Simsek, Erika Brunet, Sunnie Yan-Wai Wong, Sachin Katyal, Yankun Gao, Peter J McKinnon, Jacqueline Lou, Lei Zhang, James Li, Edward J Rebar,[...]. PLoS Genet 2011
12
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Joseph A Newman, Christopher D O Cooper, Hazel Aitkenhead, Opher Gileadi. Structure 2015
Joseph A Newman, Christopher D O Cooper, Hazel Aitkenhead, Opher Gileadi. Structure 2015
14
Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining.
Tatiana Kent, Pedro A Mateos-Gomez, Agnel Sfeir, Richard T Pomerantz. Elife 2016
Tatiana Kent, Pedro A Mateos-Gomez, Agnel Sfeir, Richard T Pomerantz. Elife 2016
12
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.
Diego M Muzzini, Paolo Plevani, Simon J Boulton, Giuseppe Cassata, Federica Marini. DNA Repair (Amst) 2008
Diego M Muzzini, Paolo Plevani, Simon J Boulton, Giuseppe Cassata, Federica Marini. DNA Repair (Amst) 2008
12
Mechanism of eukaryotic homologous recombination.
Joseph San Filippo, Patrick Sung, Hannah Klein. Annu Rev Biochem 2008
Joseph San Filippo, Patrick Sung, Hannah Klein. Annu Rev Biochem 2008
12
Low-fidelity DNA synthesis by human DNA polymerase theta.
Mercedes E Arana, Mineaki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel. Nucleic Acids Res 2008
Mercedes E Arana, Mineaki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel. Nucleic Acids Res 2008
12
53BP1 promotes microhomology-mediated end-joining in G1-phase cells.
Xiahui Xiong, Zhanwen Du, Ying Wang, Zhihui Feng, Pan Fan, Chunhong Yan, Henning Willers, Junran Zhang. Nucleic Acids Res 2015
Xiahui Xiong, Zhanwen Du, Ying Wang, Zhihui Feng, Pan Fan, Chunhong Yan, Henning Willers, Junran Zhang. Nucleic Acids Res 2015
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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.
A J Pierce, R D Johnson, L H Thompson, M Jasin. Genes Dev 1999
A J Pierce, R D Johnson, L H Thompson, M Jasin. Genes Dev 1999
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Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.
Roopesh Anand, Lepakshi Ranjha, Elda Cannavo, Petr Cejka. Mol Cell 2016
Roopesh Anand, Lepakshi Ranjha, Elda Cannavo, Petr Cejka. Mol Cell 2016
12
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.