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Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
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Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis.
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Modeling early retinal development with human embryonic and induced pluripotent stem cells.
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Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.
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Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.
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Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency.
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From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium.
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Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.
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Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks.
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Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.
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Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
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Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids.
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Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.
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Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae.
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Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.
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Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.
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Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.
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Use of bioreactors for culturing human retinal organoids improves photoreceptor yields.
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Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells.
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Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange.
Tiago Santos-Ferreira, Sílvia Llonch, Oliver Borsch, Kai Postel, Jochen Haas, Marius Ader. Nat Commun 2016
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Restoration of vision after transplantation of photoreceptors.
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Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.
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Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.
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Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats.
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Thyroid hormone signaling specifies cone subtypes in human retinal organoids.
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Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
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Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.
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Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion.
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Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration.
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Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.
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Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.
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