A citation-based method for searching scientific literature

Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama, Masayuki Yamamoto. Nat Commun 2016
Times Cited: 852







List of co-cited articles
486 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Evanna L Mills, Dylan G Ryan, Hiran A Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zaslona, Mark P Jedrychowski, Ana S H Costa, Maureen Higgins, Emily Hams,[...]. Nature 2018
718
17

Nrf2 signaling pathway: Pivotal roles in inflammation.
Syed Minhaj Uddin Ahmed, Lin Luo, Akhileshwar Namani, Xiu Jun Wang, Xiuwen Tang. Biochim Biophys Acta Mol Basis Dis 2017
855
16

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
Rajesh K Thimmulappa, Hannah Lee, Tirumalai Rangasamy, Sekhar P Reddy, Masayuki Yamamoto, Thomas W Kensler, Shyam Biswal. J Clin Invest 2006
747
13

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
John D Hayes, Albena T Dinkova-Kostova. Trends Biochem Sci 2014
12

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation.
Sarmistha Saha, Brigitta Buttari, Emiliano Panieri, Elisabetta Profumo, Luciano Saso. Molecules 2020
263
11

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.
Antonio Cuadrado, Gina Manda, Ahmed Hassan, María José Alcaraz, Coral Barbas, Andreas Daiber, Pietro Ghezzi, Rafael León, Manuela G López, Baldo Oliva,[...]. Pharmacol Rev 2018
313
10


An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, Y Katoh, T Oyake, N Hayashi, K Satoh, I Hatayama,[...]. Biochem Biophys Res Commun 1997
9

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways.
Joanna D Wardyn, Amy H Ponsford, Christopher M Sanderson. Biochem Soc Trans 2015
590
9

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Vicky Lampropoulou, Alexey Sergushichev, Monika Bambouskova, Sharmila Nair, Emma E Vincent, Ekaterina Loginicheva, Luisa Cervantes-Barragan, Xiucui Ma, Stanley Ching-Cheng Huang, Takla Griss,[...]. Cell Metab 2016
639
8

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.
Antonio Cuadrado, Ana I Rojo, Geoffrey Wells, John D Hayes, Sharon P Cousin, William L Rumsey, Otis C Attucks, Stephen Franklin, Anna-Liisa Levonen, Thomas W Kensler,[...]. Nat Rev Drug Discov 2019
533
8

Role of nrf2 in oxidative stress and toxicity.
Qiang Ma. Annu Rev Pharmacol Toxicol 2013
8

Nrf2-Keap1 signaling in oxidative and reductive stress.
Ilaria Bellezza, Ileana Giambanco, Alba Minelli, Rosario Donato. Biochim Biophys Acta Mol Cell Res 2018
630
7


Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.
Deepti Malhotra, Elodie Portales-Casamar, Anju Singh, Siddhartha Srivastava, David Arenillas, Christine Happel, Casper Shyr, Nobunao Wakabayashi, Thomas W Kensler, Wyeth W Wasserman,[...]. Nucleic Acids Res 2010
546
7

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Dung-Fang Lee, Hsu-Ping Kuo, Mo Liu, Chao-Kai Chou, Weiya Xia, Yi Du, Jia Shen, Chun-Te Chen, Longfei Huo, Ming-Chuan Hsu,[...]. Mol Cell 2009
288
7

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen,[...]. Nat Commun 2020
167
7

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Masayuki Yamamoto, Thomas W Kensler, Hozumi Motohashi. Physiol Rev 2018
644
7


Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Donna D Zhang, Shih-Ching Lo, Janet V Cross, Dennis J Templeton, Mark Hannink. Mol Cell Biol 2004
922
6

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang,[...]. Nature 2018
302
6

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
Tin Oo Khor, Mou-Tuan Huang, Ki Han Kwon, Jefferson Y Chan, Bandaru S Reddy, Ah-Ng Kong. Cancer Res 2006
368
6

NF-κB signaling in inflammation.
Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun. Signal Transduct Target Ther 2017
6

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy.
Veera Ganesh Yerra, Geeta Negi, Shyam S Sharma, Ashutosh Kumar. Redox Biol 2013
234
6

Reactive oxygen species in inflammation and tissue injury.
Manish Mittal, Mohammad Rizwan Siddiqui, Khiem Tran, Sekhar P Reddy, Asrar B Malik. Antioxid Redox Signal 2014
6

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response.
Tao Jiang, Fei Tian, Hongting Zheng, Samantha A Whitman, Yifeng Lin, Zhigang Zhang, Nong Zhang, Donna D Zhang. Kidney Int 2014
152
6

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Jeong-Eun Kim, Dong-Joo You, Cheolju Lee, Curie Ahn, Jae Young Seong, Jong-Ik Hwang. Cell Signal 2010
150
6


Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Rajesh K Thimmulappa, Kim H Mai, Sorachai Srisuma, Thomas W Kensler, Masayuki Yamamoto, Shyam Biswal. Cancer Res 2002
959
5

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development.
Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda, Antonio Cuadrado. Oxid Med Cell Longev 2019
272
5

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K Jha, Stanley Ching-Cheng Huang, Alexey Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, Karina Chmielewski, Kelly M Stewart, Juliet Ashall, Bart Everts,[...]. Immunity 2015
5

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
G M Tannahill, A M Curtis, J Adamik, E M Palsson-McDermott, A F McGettrick, G Goel, C Frezza, N J Bernard, B Kelly, N H Foley,[...]. Nature 2013
5

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto. Genes Cells 2011
987
5

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Kit I Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto. Mol Cell Biol 2006
503
5

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Thomas W Kensler, Nobunao Wakabayashi, Shyam Biswal. Annu Rev Pharmacol Toxicol 2007
5

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I Tong,[...]. Nat Cell Biol 2010
5

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe Kotsuji, Fujio Otsuka, Dennis R Roop,[...]. Nat Genet 2003
641
5

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
Ryota Saito, Takafumi Suzuki, Keiichiro Hiramoto, Soichiro Asami, Eriko Naganuma, Hiromi Suda, Tatsuro Iso, Hirotaka Yamamoto, Masanobu Morita, Liam Baird,[...]. Mol Cell Biol 2015
152
5

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E Corcoran, Marah C Runtsch, Chris Ling, Melanie C Ruzek, Peter F Slivka, Anne F McGettrick, Kathy Banahan,[...]. Cell Metab 2020
133
5

Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.
Christopher J Harvey, Rajesh K Thimmulappa, Sanjay Sethi, Xiaoni Kong, Lonny Yarmus, Robert H Brown, David Feller-Kopman, Robert Wise, Shyam Biswal. Sci Transl Med 2011
229
5

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Yoshinobu Ichimura, Satoshi Waguri, Yu-Shin Sou, Shun Kageyama, Jun Hasegawa, Ryosuke Ishimura, Tetsuya Saito, Yinjie Yang, Tsuguka Kouno, Toshiaki Fukutomi,[...]. Mol Cell 2013
668
5

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi. Cancer Cell 2012
883
5

Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation.
Antonio Cuadrado, Zaira Martín-Moldes, Jianping Ye, Isabel Lastres-Becker. J Biol Chem 2014
210
5

Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming.
Xiuting Liu, Xin Zhang, Yang Ding, Wei Zhou, Lei Tao, Ping Lu, Yajing Wang, Rong Hu. Antioxid Redox Signal 2017
134
5

Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.
Kit I Tong, Balasundaram Padmanabhan, Akira Kobayashi, Chengwei Shang, Yosuke Hirotsu, Shigeyuki Yokoyama, Masayuki Yamamoto. Mol Cell Biol 2007
298
5

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Albena T Dinkova-Kostova, W David Holtzclaw, Robert N Cole, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Masayuki Yamamoto, Paul Talalay. Proc Natl Acad Sci U S A 2002
5

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Patricia Rada, Ana I Rojo, Sudhir Chowdhry, Michael McMahon, John D Hayes, Antonio Cuadrado. Mol Cell Biol 2011
509
5

Molecular basis of the Keap1-Nrf2 system.
Takafumi Suzuki, Masayuki Yamamoto. Free Radic Biol Med 2015
576
4

Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents.
Dhulfiqar Ali Abed, Melanie Goldstein, Haifa Albanyan, Huijuan Jin, Longqin Hu. Acta Pharm Sin B 2015
158
4

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
Dick de Zeeuw, Tadao Akizawa, Paul Audhya, George L Bakris, Melanie Chin, Heidi Christ-Schmidt, Angie Goldsberry, Mark Houser, Melissa Krauth, Hiddo J Lambers Heerspink,[...]. N Engl J Med 2013
651
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.