Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
Times Cited: 397
Times Cited: 397
Times Cited
Times Co-cited
Similarity
Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
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The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
17
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
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Geroscience: linking aging to chronic disease.
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
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16
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
13
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
Brian Onken, Monica Driscoll. PLoS One 2010
Brian Onken, Monica Driscoll. PLoS One 2010
12
TORC1 inhibition enhances immune function and reduces infections in the elderly.
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
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Role of AMP-activated protein kinase in mechanism of metformin action.
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
11
Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
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mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
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From discoveries in ageing research to therapeutics for healthy ageing.
Judith Campisi, Pankaj Kapahi, Gordon J Lithgow, Simon Melov, John C Newman, Eric Verdin. Nature 2019
Judith Campisi, Pankaj Kapahi, Gordon J Lithgow, Simon Melov, John C Newman, Eric Verdin. Nature 2019
10
Fisetin is a senotherapeutic that extends health and lifespan.
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
10
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
LaTonya J Hickson, Larissa G P Langhi Prata, Shane A Bobart, Tamara K Evans, Nino Giorgadze, Shahrukh K Hashmi, Sandra M Herrmann, Michael D Jensen, Qingyi Jia, Kyra L Jordan,[...]. EBioMedicine 2019
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10
Metformin slows down aging and extends life span of female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Margarita L Tyndyk, Maria V Yurova, Irina G Kovalenko, Tatiana E Poroshina,[...]. Cell Cycle 2008
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10
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
10
Long-term metformin usage and cognitive function among older adults with diabetes.
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
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Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
Jared M Campbell, Susan M Bellman, Matthew D Stephenson, Karolina Lisy. Ageing Res Rev 2017
Jared M Campbell, Susan M Bellman, Matthew D Stephenson, Karolina Lisy. Ageing Res Rev 2017
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Metformin: A Hopeful Promise in Aging Research.
Marta G Novelle, Ahmed Ali, Carlos Diéguez, Michel Bernier, Rafael de Cabo. Cold Spring Harb Perspect Med 2016
Marta G Novelle, Ahmed Ali, Carlos Diéguez, Michel Bernier, Rafael de Cabo. Cold Spring Harb Perspect Med 2016
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The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Krishnamurthy Janakiraman, Norman E Sharpless, Sheng Ding, Wei Feng,[...]. Nat Med 2016
Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, Marco Demaria, Judith Campisi, Krishnamurthy Janakiraman, Norman E Sharpless, Sheng Ding, Wei Feng,[...]. Nat Med 2016
9
Metformin reduces endogenous reactive oxygen species and associated DNA damage.
Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre, Michael N Pollak. Cancer Prev Res (Phila) 2012
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9
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming,[...]. Aging Cell 2016
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming,[...]. Aging Cell 2016
9
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
Jingqi Fang, Jiping Yang, Xun Wu, Gangming Zhang, Tao Li, Xi'e Wang, Hong Zhang, Chih-Chen Wang, Guang-Hui Liu, Lei Wang. Aging Cell 2018
Jingqi Fang, Jiping Yang, Xun Wu, Gangming Zhang, Tao Li, Xi'e Wang, Hong Zhang, Chih-Chen Wang, Guang-Hui Liu, Lei Wang. Aging Cell 2018
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Benefits of Metformin in Attenuating the Hallmarks of Aging.
Ameya S Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metab 2020
Ameya S Kulkarni, Sriram Gubbi, Nir Barzilai. Cell Metab 2020
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Development of Clinical Trials to Extend Healthy Lifespan.
Jamie N Justice, Laura Niedernhofer, Paul D Robbins, Vanita R Aroda, Mark A Espeland, Stephen B Kritchevsky, George A Kuchel, Nir Barzilai. Cardiovasc Endocrinol Metab 2018
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Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
8
8
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
Hannah R Bridges, Andrew J Y Jones, Michael N Pollak, Judy Hirst. Biochem J 2014
8
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
8
Metformin as Anti-Aging Therapy: Is It for Everyone?
Alexander A Soukas, Haibin Hao, Lianfeng Wu. Trends Endocrinol Metab 2019
Alexander A Soukas, Haibin Hao, Lianfeng Wu. Trends Endocrinol Metab 2019
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Frailty in older adults: evidence for a phenotype.
L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke,[...]. J Gerontol A Biol Sci Med Sci 2001
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Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Peisu Zhang, Yuki Kishimoto, Ioannis Grammatikakis, Kamalvishnu Gottimukkala, Roy G Cutler, Shiliang Zhang, Kotb Abdelmohsen, Vilhelm A Bohr, Jyoti Misra Sen, Myriam Gorospe,[...]. Nat Neurosci 2019
Peisu Zhang, Yuki Kishimoto, Ioannis Grammatikakis, Kamalvishnu Gottimukkala, Roy G Cutler, Shiliang Zhang, Kotb Abdelmohsen, Vilhelm A Bohr, Jyoti Misra Sen, Myriam Gorospe,[...]. Nat Neurosci 2019
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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
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mTOR inhibition improves immune function in the elderly.
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Reversal of epigenetic aging and immunosenescent trends in humans.
Gregory M Fahy, Robert T Brooke, James P Watson, Zinaida Good, Shreyas S Vasanawala, Holden Maecker, Michael D Leipold, David T S Lin, Michael S Kobor, Steve Horvath. Aging Cell 2019
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Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
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Resveratrol improves health and survival of mice on a high-calorie diet.
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7
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
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7
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults.
Ameya S Kulkarni, Erika F Brutsaert, Valentin Anghel, Kehao Zhang, Noah Bloomgarden, Michael Pollak, Jessica C Mar, Meredith Hawkins, Jill P Crandall, Nir Barzilai. Aging Cell 2018
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14
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
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7
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
David E Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon,[...]. Aging Cell 2014
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7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.