David W Wyatt, Wanjuan Feng, Michael P Conlin, Matthew J Yousefzadeh, Steven A Roberts, Piotr Mieczkowski, Richard D Wood, Gaorav P Gupta, Dale A Ramsden. Mol Cell 2016
Times Cited: 131
Times Cited: 131
Times Cited
Times Co-cited
Similarity
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
58
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
55
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
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Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Howard H Y Chang, Nicholas R Pannunzio, Noritaka Adachi, Michael R Lieber. Nat Rev Mol Cell Biol 2017
Howard H Y Chang, Nicholas R Pannunzio, Noritaka Adachi, Michael R Lieber. Nat Rev Mol Cell Biol 2017
35
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
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Genetic determinants of cellular addiction to DNA polymerase theta.
Wanjuan Feng, Dennis A Simpson, Juan Carvajal-Garcia, Brandon A Price, Rashmi J Kumar, Lisle E Mose, Richard D Wood, Naim Rashid, Jeremy E Purvis, Joel S Parker,[...]. Nat Commun 2019
Wanjuan Feng, Dennis A Simpson, Juan Carvajal-Garcia, Brandon A Price, Rashmi J Kumar, Lisle E Mose, Richard D Wood, Naim Rashid, Jeremy E Purvis, Joel S Parker,[...]. Nat Commun 2019
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DNA polymerase θ (POLQ), double-strand break repair, and cancer.
Richard D Wood, Sylvie Doublié. DNA Repair (Amst) 2016
Richard D Wood, Sylvie Doublié. DNA Repair (Amst) 2016
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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Pedro A Mateos-Gomez, Tatiana Kent, Sarah K Deng, Shane McDevitt, Ekaterina Kashkina, Trung M Hoang, Richard T Pomerantz, Agnel Sfeir. Nat Struct Mol Biol 2017
Pedro A Mateos-Gomez, Tatiana Kent, Sarah K Deng, Shane McDevitt, Ekaterina Kashkina, Trung M Hoang, Richard T Pomerantz, Agnel Sfeir. Nat Struct Mol Biol 2017
34
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.
Sze Ham Chan, Amy Marie Yu, Mitch McVey. PLoS Genet 2010
Sze Ham Chan, Amy Marie Yu, Mitch McVey. PLoS Genet 2010
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Mechanistic basis for microhomology identification and genome scarring by polymerase theta.
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D Wood, Jeff Sekelsky, Gaorav P Gupta, Steven A Roberts, Dale A Ramsden. Proc Natl Acad Sci U S A 2020
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia, Wanjuan Feng, Richard D Wood, Jeff Sekelsky, Gaorav P Gupta, Steven A Roberts, Dale A Ramsden. Proc Natl Acad Sci U S A 2020
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Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.
Joost Schimmel, Hanneke Kool, Robin van Schendel, Marcel Tijsterman. EMBO J 2017
Joost Schimmel, Hanneke Kool, Robin van Schendel, Marcel Tijsterman. EMBO J 2017
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A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
23
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc,[...]. Proc Natl Acad Sci U S A 2010
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc,[...]. Proc Natl Acad Sci U S A 2010
22
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Lan N Truong, Yongjiang Li, Linda Z Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W Berns, Xiaohua Wu. Proc Natl Acad Sci U S A 2013
Lan N Truong, Yongjiang Li, Linda Z Shi, Patty Yi-Hwa Hwang, Jing He, Hailong Wang, Niema Razavian, Michael W Berns, Xiaohua Wu. Proc Natl Acad Sci U S A 2013
22
Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.
Sophie F Roerink, Robin van Schendel, Marcel Tijsterman. Genome Res 2014
Sophie F Roerink, Robin van Schendel, Marcel Tijsterman. Genome Res 2014
22
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.
Mineaki Seki, Federica Marini, Richard D Wood. Nucleic Acids Res 2003
Mineaki Seki, Federica Marini, Richard D Wood. Nucleic Acids Res 2003
20
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.
Karl E Zahn, April M Averill, Pierre Aller, Richard D Wood, Sylvie Doublié. Nat Struct Mol Biol 2015
Karl E Zahn, April M Averill, Pierre Aller, Richard D Wood, Sylvie Doublié. Nat Struct Mol Biol 2015
24
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Samuel F Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao,[...]. Cell 2010
Samuel F Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao,[...]. Cell 2010
18
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Agnel Sfeir, Lorraine S Symington. Trends Biochem Sci 2015
Agnel Sfeir, Lorraine S Symington. Trends Biochem Sci 2015
18
DNA double-strand break repair-pathway choice in somatic mammalian cells.
Ralph Scully, Arvind Panday, Rajula Elango, Nicholas A Willis. Nat Rev Mol Cell Biol 2019
Ralph Scully, Arvind Panday, Rajula Elango, Nicholas A Willis. Nat Rev Mol Cell Biol 2019
18
Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA.
Alex N Zelensky, Joost Schimmel, Hanneke Kool, Roland Kanaar, Marcel Tijsterman. Nat Commun 2017
Alex N Zelensky, Joost Schimmel, Hanneke Kool, Roland Kanaar, Marcel Tijsterman. Nat Commun 2017
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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.
Nicole Bennardo, Anita Cheng, Nick Huang, Jeremy M Stark. PLoS Genet 2008
Nicole Bennardo, Anita Cheng, Nick Huang, Jeremy M Stark. PLoS Genet 2008
17
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.
Naoko Shima, Robert J Munroe, John C Schimenti. Mol Cell Biol 2004
Naoko Shima, Robert J Munroe, John C Schimenti. Mol Cell Biol 2004
16
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.
Minli Wang, Weizhong Wu, Wenqi Wu, Bustanur Rosidi, Lihua Zhang, Huichen Wang, George Iliakis. Nucleic Acids Res 2006
Minli Wang, Weizhong Wu, Wenqi Wu, Bustanur Rosidi, Lihua Zhang, Huichen Wang, George Iliakis. Nucleic Acids Res 2006
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Repair Pathway Choices and Consequences at the Double-Strand Break.
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea. Trends Cell Biol 2016
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea. Trends Cell Biol 2016
16
Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.
Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey. PLoS Genet 2017
Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey. PLoS Genet 2017
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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
Michael R Lieber. Annu Rev Biochem 2010
Michael R Lieber. Annu Rev Biochem 2010
15
The shieldin complex mediates 53BP1-dependent DNA repair.
Sylvie M Noordermeer, Salomé Adam, Dheva Setiaputra, Marco Barazas, Stephen J Pettitt, Alexanda K Ling, Michele Olivieri, Alejandro Álvarez-Quilón, Nathalie Moatti, Michal Zimmermann,[...]. Nature 2018
Sylvie M Noordermeer, Salomé Adam, Dheva Setiaputra, Marco Barazas, Stephen J Pettitt, Alexanda K Ling, Michele Olivieri, Alejandro Álvarez-Quilón, Nathalie Moatti, Michal Zimmermann,[...]. Nature 2018
15
DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
Zi Wang, Yadong Song, Shibo Li, Sunil Kurian, Rong Xiang, Takuya Chiba, Xiaohua Wu. J Biol Chem 2019
Zi Wang, Yadong Song, Shibo Li, Sunil Kurian, Rong Xiang, Takuya Chiba, Xiaohua Wu. J Biol Chem 2019
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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Joseph A Newman, Christopher D O Cooper, Hazel Aitkenhead, Opher Gileadi. Structure 2015
Joseph A Newman, Christopher D O Cooper, Hazel Aitkenhead, Opher Gileadi. Structure 2015
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Dual loss of human POLQ and LIG4 abolishes random integration.
Shinta Saito, Ryo Maeda, Noritaka Adachi. Nat Commun 2017
Shinta Saito, Ryo Maeda, Noritaka Adachi. Nat Commun 2017
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DNA Polymerase θ: A Unique Multifunctional End-Joining Machine.
Samuel J Black, Ekaterina Kashkina, Tatiana Kent, Richard T Pomerantz. Genes (Basel) 2016
Samuel J Black, Ekaterina Kashkina, Tatiana Kent, Richard T Pomerantz. Genes (Basel) 2016
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Signatures of mutational processes in human cancer.
Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Samuel A J R Aparicio, Sam Behjati, Andrew V Biankin, Graham R Bignell, Niccolò Bolli, Ake Borg, Anne-Lise Børresen-Dale,[...]. Nature 2013
Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Samuel A J R Aparicio, Sam Behjati, Andrew V Biankin, Graham R Bignell, Niccolò Bolli, Ake Borg, Anne-Lise Børresen-Dale,[...]. Nature 2013
14
Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining.
Joost Schimmel, Robin van Schendel, Johan T den Dunnen, Marcel Tijsterman. Trends Genet 2019
Joost Schimmel, Robin van Schendel, Johan T den Dunnen, Marcel Tijsterman. Trends Genet 2019
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Regulation of Single-Strand Annealing and its Role in Genome Maintenance.
Ragini Bhargava, David O Onyango, Jeremy M Stark. Trends Genet 2016
Ragini Bhargava, David O Onyango, Jeremy M Stark. Trends Genet 2016
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The DNA damage response: making it safe to play with knives.
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
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Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.
Amy Marie Yu, Mitch McVey. Nucleic Acids Res 2010
Amy Marie Yu, Mitch McVey. Nucleic Acids Res 2010
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DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig,[...]. Cell 2018
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig,[...]. Cell 2018
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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Amitabh V Nimonkar, Jochen Genschel, Eri Kinoshita, Piotr Polaczek, Judith L Campbell, Claire Wyman, Paul Modrich, Stephen C Kowalczykowski. Genes Dev 2011
Amitabh V Nimonkar, Jochen Genschel, Eri Kinoshita, Piotr Polaczek, Judith L Campbell, Claire Wyman, Paul Modrich, Stephen C Kowalczykowski. Genes Dev 2011
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53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange. Nature 2018
Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange. Nature 2018
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Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.
Annahita Sallmyr, Alan E Tomkinson. J Biol Chem 2018
Annahita Sallmyr, Alan E Tomkinson. J Biol Chem 2018
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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.
Geoff S Higgins, Remko Prevo, Yin-Fai Lee, Thomas Helleday, Ruth J Muschel, Steve Taylor, Michio Yoshimura, Ian D Hickson, Eric J Bernhard, W Gillies McKenna. Cancer Res 2010
Geoff S Higgins, Remko Prevo, Yin-Fai Lee, Thomas Helleday, Ruth J Muschel, Steve Taylor, Michio Yoshimura, Ian D Hickson, Eric J Bernhard, W Gillies McKenna. Cancer Res 2010
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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
Marc Audebert, Bernard Salles, Patrick Calsou. J Biol Chem 2004
Marc Audebert, Bernard Salles, Patrick Calsou. J Biol Chem 2004
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T-DNA integration in plants results from polymerase-θ-mediated DNA repair.
Maartje van Kregten, Sylvia de Pater, Ron Romeijn, Robin van Schendel, Paul J J Hooykaas, Marcel Tijsterman. Nat Plants 2016
Maartje van Kregten, Sylvia de Pater, Ron Romeijn, Robin van Schendel, Paul J J Hooykaas, Marcel Tijsterman. Nat Plants 2016
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Template and primer requirements for DNA Pol θ-mediated end joining.
Peng He, Wei Yang. Proc Natl Acad Sci U S A 2018
Peng He, Wei Yang. Proc Natl Acad Sci U S A 2018
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The repertoire of mutational signatures in human cancer.
Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik N Bergstrom,[...]. Nature 2020
Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik N Bergstrom,[...]. Nature 2020
12
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.