Payam A Gammage, Edoardo Gaude, Lindsey Van Haute, Pedro Rebelo-Guiomar, Christopher B Jackson, Joanna Rorbach, Marcin L Pekalski, Alan J Robinson, Marine Charpentier, Jean-Paul Concordet, Christian Frezza, Michal Minczuk. Nucleic Acids Res 2016
Times Cited: 56
Times Cited: 56
Times Cited
Times Co-cited
Similarity
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
Sandra R Bacman, Siôn L Williams, Milena Pinto, Susana Peralta, Carlos T Moraes. Nat Med 2013
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Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.
Payam A Gammage, Joanna Rorbach, Anna I Vincent, Edward J Rebar, Michal Minczuk. EMBO Mol Med 2014
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Selective elimination of mitochondrial mutations in the germline by genome editing.
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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
Masami Hashimoto, Sandra R Bacman, Susana Peralta, Marni J Falk, Anne Chomyn, David C Chan, Sion L Williams, Carlos T Moraes. Mol Ther 2015
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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.
Michal Minczuk, Monika A Papworth, Jeffrey C Miller, Michael P Murphy, Aaron Klug. Nucleic Acids Res 2008
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Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.
Payam A Gammage, Carlos T Moraes, Michal Minczuk. Trends Genet 2018
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Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
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Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
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Sequence and organization of the human mitochondrial genome.
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Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
S Srivastava, C T Moraes. Hum Mol Genet 2001
S Srivastava, C T Moraes. Hum Mol Genet 2001
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase.
Michal Minczuk, Monika A Papworth, Paulina Kolasinska, Michael P Murphy, Aaron Klug. Proc Natl Acad Sci U S A 2006
Michal Minczuk, Monika A Papworth, Paulina Kolasinska, Michael P Murphy, Aaron Klug. Proc Natl Acad Sci U S A 2006
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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James B Stewart, Carlos T Moraes. Nat Med 2018
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Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
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Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
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Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
S R Bacman, S L Williams, D Duan, C T Moraes. Gene Ther 2012
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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Beverly Y Mok, Marcos H de Moraes, Jun Zeng, Dustin E Bosch, Anna V Kotrys, Aditya Raguram, FoSheng Hsu, Matthew C Radey, S Brook Peterson, Vamsi K Mootha,[...]. Nature 2020
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Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
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26
Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.
S R Bacman, S L Williams, S Garcia, C T Moraes. Gene Ther 2010
S R Bacman, S L Williams, S Garcia, C T Moraes. Gene Ther 2010
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Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
Maria Pilar Bayona-Bafaluy, Bas Blits, Brendan J Battersby, Eric A Shoubridge, Carlos T Moraes. Proc Natl Acad Sci U S A 2005
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Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.
M F Alexeyev, N Venediktova, V Pastukh, I Shokolenko, G Bonilla, G L Wilson. Gene Ther 2008
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25
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
Viktoriya Peeva, Daniel Blei, Genevieve Trombly, Sarah Corsi, Maciej J Szukszto, Pedro Rebelo-Guiomar, Payam A Gammage, Alexei P Kudin, Christian Becker, Janine Altmüller,[...]. Nat Commun 2018
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25
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan, Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee,[...]. Nature 2016
Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan, Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee,[...]. Nature 2016
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A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
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23
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Louise A Hyslop, Paul Blakeley, Lyndsey Craven, Jessica Richardson, Norah M E Fogarty, Elpida Fragouli, Mahdi Lamb, Sissy E Wamaitha, Nilendran Prathalingam, Qi Zhang,[...]. Nature 2016
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Modifying the Mitochondrial Genome.
Alexander N Patananan, Ting-Hsiang Wu, Pei-Yu Chiou, Michael A Teitell. Cell Metab 2016
Alexander N Patananan, Ting-Hsiang Wu, Pei-Yu Chiou, Michael A Teitell. Cell Metab 2016
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
James B Stewart, Patrick F Chinnery. Nat Rev Genet 2015
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Mitochondrial DNA mutations and human disease.
Helen A L Tuppen, Emma L Blakely, Douglass M Turnbull, Robert W Taylor. Biochim Biophys Acta 2010
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21
TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
Naoki Yahata, Yuji Matsumoto, Minoru Omi, Naoki Yamamoto, Ryuji Hata. Sci Rep 2017
Naoki Yahata, Yuji Matsumoto, Minoru Omi, Naoki Yamamoto, Ryuji Hata. Sci Rep 2017
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Maintenance and Expression of Mammalian Mitochondrial DNA.
Claes M Gustafsson, Maria Falkenberg, Nils-Göran Larsson. Annu Rev Biochem 2016
Claes M Gustafsson, Maria Falkenberg, Nils-Göran Larsson. Annu Rev Biochem 2016
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Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans.
Sarika Srivastava, Carlos T Moraes. Hum Mol Genet 2005
Sarika Srivastava, Carlos T Moraes. Hum Mol Genet 2005
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Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA.
Yann Tonin, Anne-Marie Heckel, Mikhail Vysokikh, Ilya Dovydenko, Mariya Meschaninova, Agnès Rötig, Arnold Munnich, Alya Venyaminova, Ivan Tarassov, Nina Entelis. J Biol Chem 2014
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Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.
Vasileios I Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred C W Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead,[...]. Nat Cell Biol 2018
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Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.
S R Bacman, S L Williams, D Hernandez, C T Moraes. Gene Ther 2007
S R Bacman, S L Williams, D Hernandez, C T Moraes. Gene Ther 2007
17
The use of mitochondria-targeted endonucleases to manipulate mtDNA.
Sandra R Bacman, Sion L Williams, Milena Pinto, Carlos T Moraes. Methods Enzymol 2014
Sandra R Bacman, Sion L Williams, Milena Pinto, Carlos T Moraes. Methods Enzymol 2014
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Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease.
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Selective mitochondrial DNA degradation following double-strand breaks.
Amandine Moretton, Frédéric Morel, Bertil Macao, Philippe Lachaume, Layal Ishak, Mathilde Lefebvre, Isabelle Garreau-Balandier, Patrick Vernet, Maria Falkenberg, Géraldine Farge. PLoS One 2017
Amandine Moretton, Frédéric Morel, Bertil Macao, Philippe Lachaume, Layal Ishak, Mathilde Lefebvre, Isabelle Garreau-Balandier, Patrick Vernet, Maria Falkenberg, Géraldine Farge. PLoS One 2017
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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
Nadee Nissanka, Sandra R Bacman, Melanie J Plastini, Carlos T Moraes. Nat Commun 2018
Nadee Nissanka, Sandra R Bacman, Melanie J Plastini, Carlos T Moraes. Nat Commun 2018
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Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks.
Sandra R Bacman, Sion L Williams, Carlos T Moraes. Nucleic Acids Res 2009
Sandra R Bacman, Sion L Williams, Carlos T Moraes. Nucleic Acids Res 2009
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A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
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Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy.
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Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA.
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21
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.