Sarah J Bray. Nat Rev Mol Cell Biol 2016
Times Cited: 498
Times Cited: 498
Times Cited
Times Co-cited
Similarity
The canonical Notch signaling pathway: unfolding the activation mechanism.
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
26
The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
13
Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
Chris Siebel, Urban Lendahl. Physiol Rev 2017
11
Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
11
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Rui Benedito, Cristina Roca, Inga Sörensen, Susanne Adams, Achim Gossler, Marcus Fruttiger, Ralf H Adams. Cell 2009
Rui Benedito, Cristina Roca, Inga Sörensen, Susanne Adams, Achim Gossler, Marcus Fruttiger, Ralf H Adams. Cell 2009
10
9
9
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Mats Hellström, Li-Kun Phng, Jennifer J Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano,[...]. Nature 2007
Mats Hellström, Li-Kun Phng, Jennifer J Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano,[...]. Nature 2007
9
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
8
Notch signals control the fate of immature progenitor cells in the intestine.
Silvia Fre, Mathilde Huyghe, Philippos Mourikis, Sylvie Robine, Daniel Louvard, Spyros Artavanis-Tsakonas. Nature 2005
Silvia Fre, Mathilde Huyghe, Philippos Mourikis, Sylvie Robine, Daniel Louvard, Spyros Artavanis-Tsakonas. Nature 2005
7
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
Rhett A Kovall, Brian Gebelein, David Sprinzak, Raphael Kopan. Dev Cell 2017
Rhett A Kovall, Brian Gebelein, David Sprinzak, Raphael Kopan. Dev Cell 2017
7
Notch signalling in solid tumours: a little bit of everything but not all the time.
Prathibha Ranganathan, Kelly L Weaver, Anthony J Capobianco. Nat Rev Cancer 2011
Prathibha Ranganathan, Kelly L Weaver, Anthony J Capobianco. Nat Rev Cancer 2011
7
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.
A Rangarajan, C Talora, R Okuyama, M Nicolas, C Mammucari, H Oh, J C Aster, S Krishna, D Metzger, P Chambon,[...]. EMBO J 2001
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6
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
6
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.
I B Lobov, R A Renard, N Papadopoulos, N W Gale, G Thurston, G D Yancopoulos, S J Wiegand. Proc Natl Acad Sci U S A 2007
I B Lobov, R A Renard, N Papadopoulos, N W Gale, G Thurston, G D Yancopoulos, S J Wiegand. Proc Natl Acad Sci U S A 2007
6
Cis-activation in the Notch signaling pathway.
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz. Elife 2019
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz. Elife 2019
17
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.
Mara E Pitulescu, Inga Schmidt, Benedetto Daniele Giaimo, Tobiah Antoine, Frank Berkenfeld, Francesca Ferrante, Hongryeol Park, Manuel Ehling, Daniel Biljes, Susana F Rocha,[...]. Nat Cell Biol 2017
Mara E Pitulescu, Inga Schmidt, Benedetto Daniele Giaimo, Tobiah Antoine, Frank Berkenfeld, Francesca Ferrante, Hongryeol Park, Manuel Ehling, Daniel Biljes, Susana F Rocha,[...]. Nat Cell Biol 2017
6
The Notch signaling pathway: transcriptional regulation at Notch target genes.
T Borggrefe, F Oswald. Cell Mol Life Sci 2009
T Borggrefe, F Oswald. Cell Mol Life Sci 2009
6
Targeting Notch in oncology: the path forward.
Samarpan Majumder, Judy S Crabtree, Todd E Golde, Lisa M Minter, Barbara A Osborne, Lucio Miele. Nat Rev Drug Discov 2021
Samarpan Majumder, Judy S Crabtree, Todd E Golde, Lisa M Minter, Barbara A Osborne, Lucio Miele. Nat Rev Drug Discov 2021
12
5
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
Orbicia Riccio, Marielle E van Gijn, April C Bezdek, Luca Pellegrinet, Johan H van Es, Ursula Zimber-Strobl, Lothar J Strobl, Tasuku Honjo, Hans Clevers, Freddy Radtke. EMBO Rep 2008
Orbicia Riccio, Marielle E van Gijn, April C Bezdek, Luca Pellegrinet, Johan H van Es, Ursula Zimber-Strobl, Lothar J Strobl, Tasuku Honjo, Hans Clevers, Freddy Radtke. EMBO Rep 2008
5
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Laura R Saunders, Alexander J Bankovich, Wade C Anderson, Monette A Aujay, Sheila Bheddah, KristenAnn Black, Radhika Desai, Paul A Escarpe, Johannes Hampl, Amy Laysang,[...]. Sci Transl Med 2015
Laura R Saunders, Alexander J Bankovich, Wade C Anderson, Monette A Aujay, Sheila Bheddah, KristenAnn Black, Radhika Desai, Paul A Escarpe, Johannes Hampl, Amy Laysang,[...]. Sci Transl Med 2015
5
Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
5
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
Luika A Timmerman, Joaquín Grego-Bessa, Angel Raya, Esther Bertrán, José María Pérez-Pomares, Juan Díez, Sergi Aranda, Sergio Palomo, Frank McCormick, Juan Carlos Izpisúa-Belmonte,[...]. Genes Dev 2004
Luika A Timmerman, Joaquín Grego-Bessa, Angel Raya, Esther Bertrán, José María Pérez-Pomares, Juan Díez, Sergi Aranda, Sergio Palomo, Frank McCormick, Juan Carlos Izpisúa-Belmonte,[...]. Genes Dev 2004
5
Notch signaling: simplicity in design, versatility in function.
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
5
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation.
Jun Xu, Feng Chi, Tongsheng Guo, Vasu Punj, W N Paul Lee, Samuel W French, Hidekazu Tsukamoto. J Clin Invest 2015
Jun Xu, Feng Chi, Tongsheng Guo, Vasu Punj, W N Paul Lee, Samuel W French, Hidekazu Tsukamoto. J Clin Invest 2015
5
The molecular logic of Notch signaling--a structural and biochemical perspective.
Wendy R Gordon, Kelly L Arnett, Stephen C Blacklow. J Cell Sci 2008
Wendy R Gordon, Kelly L Arnett, Stephen C Blacklow. J Cell Sci 2008
5
Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.
Maria J Gomez-Lamarca, Julia Falo-Sanjuan, Robert Stojnic, Sohaib Abdul Rehman, Leila Muresan, Matthew L Jones, Zoe Pillidge, Gustavo Cerda-Moya, Zhenyu Yuan, Sarah Baloul,[...]. Dev Cell 2018
Maria J Gomez-Lamarca, Julia Falo-Sanjuan, Robert Stojnic, Sohaib Abdul Rehman, Leila Muresan, Matthew L Jones, Zoe Pillidge, Gustavo Cerda-Moya, Zhenyu Yuan, Sarah Baloul,[...]. Dev Cell 2018
13
Cis-interactions between Notch and Delta generate mutually exclusive signalling states.
David Sprinzak, Amit Lakhanpal, Lauren Lebon, Leah A Santat, Michelle E Fontes, Graham A Anderson, Jordi Garcia-Ojalvo, Michael B Elowitz. Nature 2010
David Sprinzak, Amit Lakhanpal, Lauren Lebon, Leah A Santat, Michelle E Fontes, Graham A Anderson, Jordi Garcia-Ojalvo, Michael B Elowitz. Nature 2010
5
Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Vincent C Luca, Kevin M Jude, Nathan W Pierce, Maxence V Nachury, Suzanne Fischer, K Christopher Garcia. Science 2015
Vincent C Luca, Kevin M Jude, Nathan W Pierce, Maxence V Nachury, Suzanne Fischer, K Christopher Garcia. Science 2015
5
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia. Science 2017
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia. Science 2017
5
Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.
Laurence Meloty-Kapella, Bhupinder Shergill, Jane Kuon, Elliot Botvinick, Gerry Weinmaster. Dev Cell 2012
Laurence Meloty-Kapella, Bhupinder Shergill, Jane Kuon, Elliot Botvinick, Gerry Weinmaster. Dev Cell 2012
5
Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Wendy R Gordon, Brandon Zimmerman, Li He, Laura J Miles, Jiuhong Huang, Kittichoat Tiyanont, Debbie G McArthur, Jon C Aster, Norbert Perrimon, Joseph J Loparo,[...]. Dev Cell 2015
Wendy R Gordon, Brandon Zimmerman, Li He, Laura J Miles, Jiuhong Huang, Kittichoat Tiyanont, Debbie G McArthur, Jon C Aster, Norbert Perrimon, Joseph J Loparo,[...]. Dev Cell 2015
5
HES and HERP families: multiple effectors of the Notch signaling pathway.
Tatsuya Iso, Larry Kedes, Yasuo Hamamori. J Cell Physiol 2003
Tatsuya Iso, Larry Kedes, Yasuo Hamamori. J Cell Physiol 2003
5
Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning.
Oren Shaya, Udi Binshtok, Micha Hersch, Dmitri Rivkin, Sheila Weinreb, Liat Amir-Zilberstein, Bassma Khamaisi, Olya Oppenheim, Ravi A Desai, Richard J Goodyear,[...]. Dev Cell 2017
Oren Shaya, Udi Binshtok, Micha Hersch, Dmitri Rivkin, Sheila Weinreb, Liat Amir-Zilberstein, Bassma Khamaisi, Olya Oppenheim, Ravi A Desai, Richard J Goodyear,[...]. Dev Cell 2017
6
Fringe is a glycosyltransferase that modifies Notch.
D J Moloney, V M Panin, S H Johnston, J Chen, L Shao, R Wilson, Y Wang, P Stanley, K D Irvine, R S Haltiwanger,[...]. Nature 2000
D J Moloney, V M Panin, S H Johnston, J Chen, L Shao, R Wilson, Y Wang, P Stanley, K D Irvine, R S Haltiwanger,[...]. Nature 2000
5
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.
Ryan McDaniell, Daniel M Warthen, Pedro A Sanchez-Lara, Athma Pai, Ian D Krantz, David A Piccoli, Nancy B Spinner. Am J Hum Genet 2006
Ryan McDaniell, Daniel M Warthen, Pedro A Sanchez-Lara, Athma Pai, Ian D Krantz, David A Piccoli, Nancy B Spinner. Am J Hum Genet 2006
5
O-fucosylation of DLL3 is required for its function during somitogenesis.
Katrin Serth, Karin Schuster-Gossler, Elisabeth Kremmer, Birte Hansen, Britta Marohn-Köhn, Achim Gossler. PLoS One 2015
Katrin Serth, Karin Schuster-Gossler, Elisabeth Kremmer, Birte Hansen, Britta Marohn-Köhn, Achim Gossler. PLoS One 2015
13
Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models.
Federico Bocci, José Nelson Onuchic, Mohit Kumar Jolly. Front Physiol 2020
Federico Bocci, José Nelson Onuchic, Mohit Kumar Jolly. Front Physiol 2020
27
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,[...]. Proc Natl Acad Sci U S A 2006
5
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray. CA Cancer J Clin 2021
5
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Roel Nusse, Hans Clevers. Cell 2017
Roel Nusse, Hans Clevers. Cell 2017
4
WNT signalling pathways as therapeutic targets in cancer.
Jamie N Anastas, Randall T Moon. Nat Rev Cancer 2013
Jamie N Anastas, Randall T Moon. Nat Rev Cancer 2013
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Control of endodermal endocrine development by Hes-1.
J Jensen, E E Pedersen, P Galante, J Hald, R S Heller, M Ishibashi, R Kageyama, F Guillemot, P Serup, O D Madsen. Nat Genet 2000
J Jensen, E E Pedersen, P Galante, J Hald, R S Heller, M Ishibashi, R Kageyama, F Guillemot, P Serup, O D Madsen. Nat Genet 2000
4
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study.
Daniel Morgensztern, Benjamin Besse, Laurent Greillier, Rafael Santana-Davila, Neal Ready, Christine L Hann, Bonnie S Glisson, Anna F Farago, Afshin Dowlati, Charles M Rudin,[...]. Clin Cancer Res 2019
Daniel Morgensztern, Benjamin Besse, Laurent Greillier, Rafael Santana-Davila, Neal Ready, Christine L Hann, Bonnie S Glisson, Anna F Farago, Afshin Dowlati, Charles M Rudin,[...]. Clin Cancer Res 2019
4
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Shadmehr Demehri, Ahu Turkoz, Raphael Kopan. Cancer Cell 2009
Shadmehr Demehri, Ahu Turkoz, Raphael Kopan. Cancer Cell 2009
4
Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses.
Yao-Chun Wang, Fei He, Fan Feng, Xiao-Wei Liu, Guang-Ying Dong, Hong-Yan Qin, Xing-Bin Hu, Min-Hua Zheng, Liang Liang, Lei Feng,[...]. Cancer Res 2010
Yao-Chun Wang, Fei He, Fan Feng, Xiao-Wei Liu, Guang-Ying Dong, Hong-Yan Qin, Xing-Bin Hu, Min-Hua Zheng, Liang Liang, Lei Feng,[...]. Cancer Res 2010
4
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Dan R Robinson, Shanker Kalyana-Sundaram, Yi-Mi Wu, Sunita Shankar, Xuhong Cao, Bushra Ateeq, Irfan A Asangani, Matthew Iyer, Christopher A Maher, Catherine S Grasso,[...]. Nat Med 2011
Dan R Robinson, Shanker Kalyana-Sundaram, Yi-Mi Wu, Sunita Shankar, Xuhong Cao, Bushra Ateeq, Irfan A Asangani, Matthew Iyer, Christopher A Maher, Catherine S Grasso,[...]. Nat Med 2011
4
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