A citation-based method for searching scientific literature

Qi Chen, Lijun Sun, Zhijian J Chen. Nat Immunol 2016
Times Cited: 669







List of co-cited articles
660 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
28


STING: infection, inflammation and cancer.
Glen N Barber. Nat Rev Immunol 2015
479
20

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Seng-Ryong Woo, Mercedes B Fuertes, Leticia Corrales, Stefani Spranger, Michael J Furdyna, Michael Y K Leung, Ryan Duggan, Ying Wang, Glen N Barber, Katherine A Fitzgerald,[...]. Immunity 2014
717
18

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Jiaxi Wu, Lijun Sun, Xiang Chen, Fenghe Du, Heping Shi, Chuo Chen, Zhijian J Chen. Science 2013
16

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Leticia Corrales, Laura Hix Glickman, Sarah M McWhirter, David B Kanne, Kelsey E Sivick, George E Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J Leong,[...]. Cell Rep 2015
555
16

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
Liufu Deng, Hua Liang, Meng Xu, Xuanming Yang, Byron Burnette, Ainhoa Arina, Xiao-Dong Li, Helena Mauceri, Michael Beckett, Thomas Darga,[...]. Immunity 2014
822
16

cGAS surveillance of micronuclei links genome instability to innate immunity.
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch,[...]. Nature 2017
537
16


Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.
Xiao-Dong Li, Jiaxi Wu, Daxing Gao, Hua Wang, Lijun Sun, Zhijian J Chen. Science 2013
563
15



The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.
Xin Cai, Yu-Hsin Chiu, Zhijian J Chen. Mol Cell 2014
479
12

Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
509
12

STING is a direct innate immune sensor of cyclic di-GMP.
Dara L Burdette, Kathryn M Monroe, Katia Sotelo-Troha, Jeff S Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa, Russell E Vance. Nature 2011
803
11

DNA sensing by the cGAS-STING pathway in health and disease.
Mona Motwani, Scott Pesiridis, Katherine A Fitzgerald. Nat Rev Genet 2019
240
11

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Xu Zhang, Heping Shi, Jiaxi Wu, Xuewu Zhang, Lijun Sun, Chuo Chen, Zhijian J Chen. Mol Cell 2013
467
11


Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, You-Tong Wu, Nick V Grishin,[...]. Science 2015
650
10

cGAS in action: Expanding roles in immunity and inflammation.
Andrea Ablasser, Zhijian J Chen. Science 2019
205
10

Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Xin Li, Chang Shu, Guanghui Yi, Catherine T Chaton, Catherine L Shelton, Jiasheng Diao, Xiaobing Zuo, C Cheng Kao, Andrew B Herr, Pingwei Li. Immunity 2013
255
10

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Claire Vanpouille-Box, Amandine Alard, Molykutty J Aryankalayil, Yasmeen Sarfraz, Julie M Diamond, Robert J Schneider, Giorgio Inghirami, C Norman Coleman, Silvia C Formenti, Sandra Demaria. Nat Commun 2017
649
9

Type I interferons in anticancer immunity.
Laurence Zitvogel, Lorenzo Galluzzi, Oliver Kepp, Mark J Smyth, Guido Kroemer. Nat Rev Immunol 2015
510
9

cGAS is essential for cellular senescence.
Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
345
9

Activated STING in a vascular and pulmonary syndrome.
Y Liu, A A Jesus, B Marrero, D Yang, S E Ramsey, G A Montealegre Sanchez, K Tenbrock, H Wittkowski, O Y Jones, H S Kuehn,[...]. N Engl J Med 2014
606
8

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Xiang Gui, Hui Yang, Tuo Li, Xiaojun Tan, Peiqing Shi, Minghao Li, Fenghe Du, Zhijian J Chen. Nature 2019
223
8

cGAS is essential for the antitumor effect of immune checkpoint blockade.
Hua Wang, Shuiqing Hu, Xiang Chen, Heping Shi, Chuo Chen, Lijun Sun, Zhijian J Chen. Proc Natl Acad Sci U S A 2017
198
8

Mitochondrial DNA stress primes the antiviral innate immune response.
A Phillip West, William Khoury-Hanold, Matthew Staron, Michal C Tal, Cristiana M Pineda, Sabine M Lang, Megan Bestwick, Brett A Duguay, Nuno Raimundo, Donna A MacDuff,[...]. Nature 2015
676
8

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.
Qing Chen, Adrienne Boire, Xin Jin, Manuel Valiente, Ekrem Emrah Er, Alejandro Lopez-Soto, Leni Jacob, Ruzeen Patwa, Hardik Shah, Ke Xu,[...]. Nature 2016
364
8

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig, Veit Hornung. Nature 2013
688
8

NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
Run Fang, Chenguang Wang, Qifei Jiang, Mengze Lv, Pengfei Gao, Xiaoyu Yu, Ping Mu, Rui Zhang, Sheng Bi, Ji-Ming Feng,[...]. J Immunol 2017
79
8

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response.
Assaf Marcus, Amy J Mao, Monisha Lensink-Vasan, LeeAnn Wang, Russell E Vance, David H Raulet. Immunity 2018
134
7

Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Shushu Song, Peike Peng, Zhaoqing Tang, Junjie Zhao, Weicheng Wu, Haojie Li, Miaomiao Shao, Lili Li, Caiting Yang, Fangfang Duan,[...]. Sci Rep 2017
66
10

Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H Christian Eberl,[...]. Nature 2018
183
7

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.
Olivier Demaria, Aude De Gassart, Sanja Coso, Nicolas Gestermann, Jeremy Di Domizio, Lukas Flatz, Olivier Gaide, Olivier Michielin, Patrick Hwu, Tatiana V Petrova,[...]. Proc Natl Acad Sci U S A 2015
207
7

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Emily N Chin, Chenguang Yu, Vincent F Vartabedian, Ying Jia, Manoj Kumar, Ana M Gamo, William Vernier, Sabrina H Ali, Mildred Kissai, Daniel C Lazar,[...]. Science 2020
47
14

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Joseph Conlon, Dara L Burdette, Shruti Sharma, Numana Bhat, Mikayla Thompson, Zhaozhao Jiang, Vijay A K Rathinam, Brian Monks, Tengchuan Jin, T Sam Xiao,[...]. J Immunol 2013
201
7

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Christian Zierhut, Norihiro Yamaguchi, Maria Paredes, Ji-Dung Luo, Thomas Carroll, Hironori Funabiki. Cell 2019
109
7

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.
Juan Fu, David B Kanne, Meredith Leong, Laura Hix Glickman, Sarah M McWhirter, Edward Lemmens, Ken Mechette, Justin J Leong, Peter Lauer, Weiqun Liu,[...]. Sci Transl Med 2015
353
7

Chromosomal instability drives metastasis through a cytosolic DNA response.
Samuel F Bakhoum, Bryan Ngo, Ashley M Laughney, Julie-Ann Cavallo, Charles J Murphy, Peter Ly, Pragya Shah, Roshan K Sriram, Thomas B K Watkins, Neil K Taunk,[...]. Nature 2018
418
7

IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner, Sinead E Keating, Marcin Baran, Kristy A Horan, Søren B Jensen, Shruti Sharma, Cherilyn M Sirois, Tengchuan Jin, Eicke Latz, T Sam Xiao,[...]. Nat Immunol 2010
7

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu, Haiping Zhang, Xiangyang Wu, Dapeng Ma, Juehui Wu, Lin Wang, Yan Jiang, Yiyan Fei, Chenggang Zhu, Rong Tan,[...]. Nature 2018
187
7

Structural mechanism of cytosolic DNA sensing by cGAS.
Filiz Civril, Tobias Deimling, Carina C de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner. Nature 2013
346
7

Pattern recognition receptors and inflammation.
Osamu Takeuchi, Shizuo Akira. Cell 2010
7

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells.
Zhiqiang Zhang, Bin Yuan, Musheng Bao, Ning Lu, Taeil Kim, Yong-Jun Liu. Nat Immunol 2011
535
7

Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
399
6

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.
Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander,[...]. Proc Natl Acad Sci U S A 2005
6

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.
Kelsey E Sivick, Anthony L Desbien, Laura Hix Glickman, Gabrielle L Reiner, Leticia Corrales, Natalie H Surh, Thomas E Hudson, Uyen T Vu, Brian J Francica, Tamara Banda,[...]. Cell Rep 2018
100
6

An orally available non-nucleotide STING agonist with antitumor activity.
Bo-Sheng Pan, Samanthi A Perera, Jennifer A Piesvaux, Jeremy P Presland, Gottfried K Schroeder, Jared N Cumming, B Wesley Trotter, Michael D Altman, Alexei V Buevich, Brandon Cash,[...]. Science 2020
52
11

Innate immune sensing and signaling of cytosolic nucleic acids.
Jiaxi Wu, Zhijian J Chen. Annu Rev Immunol 2014
601
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.