A citation-based method for searching scientific literature

Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2016
Times Cited: 141







List of co-cited articles
1360 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Pengxiang Huang, Daniel Nedelcu, Miyako Watanabe, Cindy Jao, Youngchang Kim, Jing Liu, Adrian Salic. Cell 2016
209
74

Structural basis of Smoothened regulation by its extracellular domains.
Eamon F X Byrne, Ria Sircar, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo,[...]. Nature 2016
214
49

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Yunxiao Zhang, David P Bulkley, Yao Xin, Kelsey J Roberts, Daniel E Asarnow, Ashutosh Sharma, Benjamin R Myers, Wonhwa Cho, Yifan Cheng, Philip A Beachy. Cell 2018
118
35

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang, Kelsey J Roberts, Philip A Beachy. Proc Natl Acad Sci U S A 2017
75
45

Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Jiawei Wang, Xiaochun Li. Nature 2018
112
31

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He,[...]. Mol Cell 2017
113
30

Patched1 regulates hedgehog signaling at the primary cilium.
Rajat Rohatgi, Ljiljana Milenkovic, Matthew P Scott. Science 2007
989
29

Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Xin Gong, Hongwu Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan. Science 2018
122
29

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Ishan Deshpande, Jiahao Liang, Danielle Hedeen, Kelsey J Roberts, Yunxiao Zhang, Betty Ha, Naomi R Latorraca, Bryan Faust, Ron O Dror, Philip A Beachy,[...]. Nature 2019
84
33

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey,[...]. Elife 2019
55
50

The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
27

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Benjamin R Myers, Navdar Sever, Yong Chun Chong, James Kim, Jitendra D Belani, Scott Rychnovsky, J Fernando Bazan, Philip A Beachy. Dev Cell 2013
129
26

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
26


Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Xiaofeng Qi, Philip Schmiege, Elias Coutavas, Xiaochun Li. Science 2018
77
32

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis.
Michael K Cooper, Christopher A Wassif, Patrycja A Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I Kelley, Forbes D Porter, Philip A Beachy. Nat Genet 2003
288
24

Cilia-Associated Oxysterols Activate Smoothened.
David R Raleigh, Navdar Sever, Pervinder K Choksi, Monika Abedin Sigg, Kelly M Hines, Bonne M Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R Garcia-Gonzalo,[...]. Mol Cell 2018
67
35

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Daniel Nedelcu, Jing Liu, Yangqing Xu, Cindy Jao, Adrian Salic. Nat Chem Biol 2013
140
23

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.
Sigrid Nachtergaele, Daniel M Whalen, Laurel K Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W Ingham, Douglas F Covey, Christian Siebold, Rajat Rohatgi. Elife 2013
113
22

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Pengxiang Huang, Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C Kruse, Adrian Salic. Cell 2018
79
26

Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
588
20

Oxysterols are allosteric activators of the oncoprotein Smoothened.
Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey, Rajat Rohatgi. Nat Chem Biol 2012
186
19

Biochemical mechanisms of vertebrate hedgehog signaling.
Jennifer H Kong, Christian Siebold, Rajat Rohatgi. Development 2019
102
19

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Xiaofeng Qi, Heng Liu, Bonne Thompson, Jeffrey McDonald, Cheng Zhang, Xiaochun Li. Nature 2019
78
24

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.
Robert Blassberg, James I Macrae, James Briscoe, John Jacob. Hum Mol Genet 2016
58
29

Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Danwei Huangfu, Aimin Liu, Andrew S Rakeman, Noel S Murcia, Lee Niswander, Kathryn V Anderson. Nature 2003
996
17

Identification of a palmitic acid-modified form of human Sonic hedgehog.
R B Pepinsky, C Zeng, D Wen, P Rayhorn, D P Baker, K P Williams, S A Bixler, C M Ambrose, E A Garber, K Miatkowski,[...]. J Biol Chem 1998
538
16


The hedgehog receptor patched is involved in cholesterol transport.
Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat,[...]. PLoS One 2011
78
20

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
15

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.
Eamon Fx Byrne, Giovanni Luchetti, Rajat Rohatgi, Christian Siebold. Curr Opin Cell Biol 2018
39
38

Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Fujia Wu, Yu Zhang, Bo Sun, Andrew P McMahon, Yu Wang. Cell Chem Biol 2017
168
15

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
763
15

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong. Nat Commun 2019
49
30

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Hanna Tukachinsky, Ryan P Kuzmickas, Cindy Y Jao, Jing Liu, Adrian Salic. Cell Rep 2012
132
14

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
14

Biochemical evidence that patched is the Hedgehog receptor.
V Marigo, R A Davey, Y Zuo, J M Cunningham, C J Tabin. Nature 1996
672
14

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.
George Hedger, Heidi Koldsø, Matthieu Chavent, Christian Siebold, Rajat Rohatgi, Mark S P Sansom. Structure 2019
44
31


Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.
Christiane Kowatsch, Rachel E Woolley, Maia Kinnebrew, Rajat Rohatgi, Christian Siebold. Curr Opin Struct Biol 2019
29
48

Structure of the human smoothened receptor bound to an antitumour agent.
Chong Wang, Huixian Wu, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Wei Liu, Fai Yiu Siu, Bryan L Roth, Vadim Cherezov, Raymond C Stevens. Nature 2013
341
13

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Pengxiang Huang, Sanduo Zheng, Bradley M Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C Kruse, Adrian Salic. Cell 2018
23
56

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
D M Stone, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips,[...]. Nature 1996
904
13

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.
Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, Adrian Salic. Proc Natl Acad Sci U S A 2016
56
23

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
12

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Chong Wang, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J Hufeisen, Thomas J Mangano, Dan J Urban, Vsevolod Katritch,[...]. Nat Commun 2014
167
12

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
12

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
Z Chamoun, R K Mann, D Nellen, D P von Kessler, M Bellotto, P A Beachy, K Basler. Science 2001
310
12

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Amalie F Rudolf, Maia Kinnebrew, Christiane Kowatsch, T Bertie Ansell, Kamel El Omari, Benjamin Bishop, Els Pardon, Rebekka A Schwab, Tomas Malinauskas, Mingxing Qian,[...]. Nat Chem Biol 2019
34
35

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.
Marcelo Chávez, Sabrina Ena, Jacqueline Van Sande, Alban de Kerchove d'Exaerde, Stéphane Schurmans, Serge N Schiffmann. Dev Cell 2015
162
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.