Jeppe H Ekberg, Maria Hauge, Line V Kristensen, Andreas N Madsen, Maja S Engelstoft, Anna-Sofie Husted, Rasmus Sichlau, Kristoffer L Egerod, Pascal Timshel, Timothy J Kowalski, Fiona M Gribble, Frank Reiman, Harald S Hansen, Andrew D Howard, Birgitte Holst, Thue W Schwartz. Endocrinology 2016
Times Cited: 59
Times Cited: 59
Times Cited
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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto. Nat Med 2005
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki, Gozoh Tsujimoto. Nat Med 2005
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Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
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Sara Edfalk, Pär Steneberg, Helena Edlund. Diabetes 2008
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2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
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Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.
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Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.
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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima,[...]. Nature 2003
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A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.
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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
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Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine.
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Chylomicrons stimulate incretin secretion in mouse and human cells.
Arianna Psichas, Pierre F Larraufie, Deborah A Goldspink, Fiona M Gribble, Frank Reimann. Diabetologia 2017
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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.
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Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
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Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.
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GPR119 as a fat sensor.
Harald S Hansen, Mette M Rosenkilde, Jens J Holst, Thue W Schwartz. Trends Pharmacol Sci 2012
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Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.
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The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.
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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
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Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice.
Akiko Sankoda, Norio Harada, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Kimitaka Shibue, Yotsapon Thewjitcharoen, Kazuyo Suzuki, Takanari Harada, Yoshinori Kanemaru,[...]. Endocrinology 2017
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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
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GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell.
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The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.
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Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
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A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.
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Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.
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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
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A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
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GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
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G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges.
Kurt Ritter, Christian Buning, Nis Halland, Christoph Pöverlein, Lothar Schwink. J Med Chem 2016
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Gq and Gs signaling acting in synergy to control GLP-1 secretion.
Maria Hauge, Jeppe Pio Ekberg, Maja Storm Engelstoft, Pascal Timshel, Andreas N Madsen, Thue W Schwartz. Mol Cell Endocrinol 2017
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The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.
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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.