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Times Cited: 76
Times Cited
Times Co-cited
Similarity
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.
Douglas K Graham, Deborah DeRyckere, Kurtis D Davies, H Shelton Earp. Nat Rev Cancer 2014
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Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
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TAM receptors are pleiotropic inhibitors of the innate immune response.
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MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
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Diversification of TAM receptor tyrosine kinase function.
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Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer.
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Cloning and mRNA expression analysis of a novel human protooncogene, c-mer.
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axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.
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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.
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Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
Canan Kasikara, Viralkumar Davra, David Calianese, Ke Geng, Thomas E Spires, Michael Quigley, Michael Wichroski, Ganapathy Sriram, Lucia Suarez-Lopez, Michael B Yaffe,[...]. Cancer Res 2019
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T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
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TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.
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A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.
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Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response.
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Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
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Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
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A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
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UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
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Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment.
Kayla V Myers, Sarah R Amend, Kenneth J Pienta. Mol Cancer 2019
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Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases.
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Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.
Philip L Cohen, Roberto Caricchio, Valsamma Abraham, Todd D Camenisch, J Charles Jennette, Robert A S Roubey, H Shelton Earp, Glenn Matsushima, Elizabeth A Reap. J Exp Med 2002
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R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.
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MERTK as negative regulator of human T cell activation.
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The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.
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Targeting the TAM Receptors in Leukemia.
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Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.
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Galectin-3 is a new MerTK-specific eat-me signal.
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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
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Increased exposure of anionic phospholipids on the surface of tumor blood vessels.
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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
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Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.
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Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib.
Shengzhi Xie, Yongwu Li, Xiaoyan Li, Linxiong Wang, Na Yang, Yadi Wang, Huafeng Wei. Oncotarget 2015
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Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.
Greg Lemke. Trends Biochem Sci 2017
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.