Robert A Saxton, David M Sabatini. Cell 2017
Times Cited: 2525
Times Cited: 2525
Times Cited
Times Co-cited
Similarity
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
8
mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
8
7
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
6
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
6
Biological Functions of Autophagy Genes: A Disease Perspective.
Beth Levine, Guido Kroemer. Cell 2019
Beth Levine, Guido Kroemer. Cell 2019
6
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
6
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
6
mTOR: a pharmacologic target for autophagy regulation.
Young Chul Kim, Kun-Liang Guan. J Clin Invest 2015
Young Chul Kim, Kun-Liang Guan. J Clin Invest 2015
6
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
6
mTORC1 as the main gateway to autophagy.
Yoana Rabanal-Ruiz, Elsje G Otten, Viktor I Korolchuk. Essays Biochem 2017
Yoana Rabanal-Ruiz, Elsje G Otten, Viktor I Korolchuk. Essays Biochem 2017
5
AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
5
TFEB links autophagy to lysosomal biogenesis.
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
5
5
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
Rachel L Wolfson, David M Sabatini. Cell Metab 2017
Rachel L Wolfson, David M Sabatini. Cell Metab 2017
5
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.
Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander,[...]. Proc Natl Acad Sci U S A 2005
Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander,[...]. Proc Natl Acad Sci U S A 2005
5
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
5
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle,[...]. Nature 2005
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle,[...]. Nature 2005
4
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy.
Tian Tian, Xiaoyi Li, Jinhua Zhang. Int J Mol Sci 2019
Tian Tian, Xiaoyi Li, Jinhua Zhang. Int J Mol Sci 2019
4
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
4
Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes.
Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata. J Biomed Sci 2020
Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata. J Biomed Sci 2020
12
4
A guide to immunometabolism for immunologists.
Luke A J O'Neill, Rigel J Kishton, Jeff Rathmell. Nat Rev Immunol 2016
Luke A J O'Neill, Rigel J Kishton, Jeff Rathmell. Nat Rev Immunol 2016
4
4
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
4
4
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
A C Gingras, S P Gygi, B Raught, R D Polakiewicz, R T Abraham, M F Hoekstra, R Aebersold, N Sonenberg. Genes Dev 1999
A C Gingras, S P Gygi, B Raught, R D Polakiewicz, R T Abraham, M F Hoekstra, R Aebersold, N Sonenberg. Genes Dev 1999
4
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
K J Livak, T D Schmittgen. Methods 2001
K J Livak, T D Schmittgen. Methods 2001
4
mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
4
The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Andrew C Hsieh, Yi Liu, Merritt P Edlind, Nicholas T Ingolia, Matthew R Janes, Annie Sher, Evan Y Shi, Craig R Stumpf, Carly Christensen, Michael J Bonham,[...]. Nature 2012
Andrew C Hsieh, Yi Liu, Merritt P Edlind, Nicholas T Ingolia, Matthew R Janes, Annie Sher, Evan Y Shi, Craig R Stumpf, Carly Christensen, Michael J Bonham,[...]. Nature 2012
4
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
4
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.
John T Cunningham, Joseph T Rodgers, Daniel H Arlow, Francisca Vazquez, Vamsi K Mootha, Pere Puigserver. Nature 2007
John T Cunningham, Joseph T Rodgers, Daniel H Arlow, Francisca Vazquez, Vamsi K Mootha, Pere Puigserver. Nature 2007
4
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo-Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu,[...]. Nature 2008
Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang, Satoshi Uematsu, Bo-Gie Yang, Takashi Satoh, Hiroko Omori, Takeshi Noda, Naoki Yamamoto, Masaaki Komatsu,[...]. Nature 2008
3
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Maria M Mihaylova, Reuben J Shaw. Nat Cell Biol 2011
Maria M Mihaylova, Reuben J Shaw. Nat Cell Biol 2011
3
Autophagy: cellular and molecular mechanisms.
Danielle Glick, Sandra Barth, Kay F Macleod. J Pathol 2010
Danielle Glick, Sandra Barth, Kay F Macleod. J Pathol 2010
3
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Timothy R Peterson, Shomit S Sengupta, Thurl E Harris, Anne E Carmack, Seong A Kang, Eric Balderas, David A Guertin, Katherine L Madden, Anne E Carpenter, Brian N Finck,[...]. Cell 2011
Timothy R Peterson, Shomit S Sengupta, Thurl E Harris, Anne E Carmack, Seong A Kang, Eric Balderas, David A Guertin, Katherine L Madden, Anne E Carpenter, Brian N Finck,[...]. Cell 2011
3
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
Adem Kalender, Anand Selvaraj, So Young Kim, Pawan Gulati, Sophie Brûlé, Benoit Viollet, Bruce E Kemp, Nabeel Bardeesy, Patrick Dennis, John J Schlager,[...]. Cell Metab 2010
3
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
Douglas R Bolster, Stephen J Crozier, Scot R Kimball, Leonard S Jefferson. J Biol Chem 2002
Douglas R Bolster, Stephen J Crozier, Scot R Kimball, Leonard S Jefferson. J Biol Chem 2002
3
AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
3
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Andrew R Tee, Brendan D Manning, Philippe P Roux, Lewis C Cantley, John Blenis. Curr Biol 2003
Andrew R Tee, Brendan D Manning, Philippe P Roux, Lewis C Cantley, John Blenis. Curr Biol 2003
3
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
3
The mammalian ULK1 complex and autophagy initiation.
Maria Zachari, Ian G Ganley. Essays Biochem 2017
Maria Zachari, Ian G Ganley. Essays Biochem 2017
3
Regulation of mammalian autophagy in physiology and pathophysiology.
Brinda Ravikumar, Sovan Sarkar, Janet E Davies, Marie Futter, Moises Garcia-Arencibia, Zeyn W Green-Thompson, Maria Jimenez-Sanchez, Viktor I Korolchuk, Maike Lichtenberg, Shouqing Luo,[...]. Physiol Rev 2010
Brinda Ravikumar, Sovan Sarkar, Janet E Davies, Marie Futter, Moises Garcia-Arencibia, Zeyn W Green-Thompson, Maria Jimenez-Sanchez, Viktor I Korolchuk, Maike Lichtenberg, Shouqing Luo,[...]. Physiol Rev 2010
3
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.
Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Ballabio. EMBO J 2018
Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Ballabio. EMBO J 2018
3
The role of Atg proteins in autophagosome formation.
Noboru Mizushima, Tamotsu Yoshimori, Yoshinori Ohsumi. Annu Rev Cell Dev Biol 2011
Noboru Mizushima, Tamotsu Yoshimori, Yoshinori Ohsumi. Annu Rev Cell Dev Biol 2011
3
Metabolic Control of Longevity.
Carlos López-Otín, Lorenzo Galluzzi, José M P Freije, Frank Madeo, Guido Kroemer. Cell 2016
Carlos López-Otín, Lorenzo Galluzzi, José M P Freije, Frank Madeo, Guido Kroemer. Cell 2016
3
Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition.
David J Roberts, Valerie P Tan-Sah, Eric Y Ding, Jeffery M Smith, Shigeki Miyamoto. Mol Cell 2014
David J Roberts, Valerie P Tan-Sah, Eric Y Ding, Jeffery M Smith, Shigeki Miyamoto. Mol Cell 2014
3
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.