A Phillip West, Gerald S Shadel. Nat Rev Immunol 2017
Times Cited: 284
Times Cited: 284
Times Cited
Times Co-cited
Similarity
Circulating mitochondrial DAMPs cause inflammatory responses to injury.
Qin Zhang, Mustafa Raoof, Yu Chen, Yuka Sumi, Tolga Sursal, Wolfgang Junger, Karim Brohi, Kiyoshi Itagaki, Carl J Hauser. Nature 2010
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Mitochondrial DNA stress primes the antiviral innate immune response.
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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
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Parkin and PINK1 mitigate STING-induced inflammation.
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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.
Christian Lood, Luz P Blanco, Monica M Purmalek, Carmelo Carmona-Rivera, Suk S De Ravin, Carolyne K Smith, Harry L Malech, Jeffrey A Ledbetter, Keith B Elkon, Mariana J Kaplan. Nat Med 2016
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VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease.
Jeonghan Kim, Rajeev Gupta, Luz P Blanco, Shutong Yang, Anna Shteinfer-Kuzmine, Kening Wang, Jun Zhu, Hee Eun Yoon, Xinghao Wang, Martijn Kerkhofs,[...]. Science 2019
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
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Mitochondria in innate immune responses.
A Phillip West, Gerald S Shadel, Sankar Ghosh. Nat Rev Immunol 2011
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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
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Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus.
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Mitochondrial double-stranded RNA triggers antiviral signalling in humans.
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Mitochondria are the powerhouses of immunity.
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Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
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Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses.
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Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases.
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The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases.
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A role for mitochondria in NLRP3 inflammasome activation.
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cGAS in action: Expanding roles in immunity and inflammation.
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Mitochondrial diseases.
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Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
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Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
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Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.
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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J Chen. Science 2013
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
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Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
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Mitochondrial TCA cycle metabolites control physiology and disease.
Inmaculada Martínez-Reyes, Navdeep S Chandel. Nat Commun 2020
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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
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Neutrophil extracellular traps kill bacteria.
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Volker Brinkmann, Ulrike Reichard, Christian Goosmann, Beatrix Fauler, Yvonne Uhlemann, David S Weiss, Yvette Weinrauch, Arturo Zychlinsky. Science 2004
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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
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Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue.
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
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The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.
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Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.
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Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration.
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Mitochondrial permeability transition triggers the release of mtDNA fragments.
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Mitochondrial transcription factor A regulates mtDNA copy number in mammals.
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The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies.
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Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase.
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Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps.
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.