A citation-based method for searching scientific literature

Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde. EMBO Mol Med 2017
Times Cited: 87







List of co-cited articles
1035 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
21

Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
326
19

Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
528
17

Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
17

The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
326
16

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
743
14

The many substrates of presenilin/γ-secretase.
Annakaisa Haapasalo, Dora M Kovacs. J Alzheimers Dis 2011
341
13

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.
Naoko Takebe, Lucio Miele, Pamela Jo Harris, Woondong Jeong, Hideaki Bando, Michael Kahn, Sherry X Yang, S Percy Ivy. Nat Rev Clin Oncol 2015
767
13

γ-Secretase inhibitors and modulators.
Todd E Golde, Edward H Koo, Kevin M Felsenstein, Barbara A Osborne, Lucio Miele. Biochim Biophys Acta 2013
196
13

Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma.
Katherine M Morgan, Bruce S Fischer, Francis Y Lee, Jamie J Shah, Joseph R Bertino, Jeffrey Rosenfeld, Amartya Singh, Hossein Khiabanian, Sharon R Pine. Mol Cancer Ther 2017
33
33

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston,[...]. Sci Transl Med 2019
53
20

A phase 3 trial of semagacestat for treatment of Alzheimer's disease.
Rachelle S Doody, Rema Raman, Martin Farlow, Takeshi Iwatsubo, Bruno Vellas, Steven Joffe, Karl Kieburtz, Feng He, Xiaoying Sun, Ronald G Thomas,[...]. N Engl J Med 2013
727
11

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, J S Mumm, E H Schroeter, V Schrijvers, M S Wolfe, W J Ray,[...]. Nature 1999
11

Direct inhibition of the NOTCH transcription factor complex.
Raymond E Moellering, Melanie Cornejo, Tina N Davis, Cristina Del Bianco, Jon C Aster, Stephen C Blacklow, Andrew L Kung, D Gary Gilliland, Gregory L Verdine, James E Bradner. Nature 2009
568
11

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko,[...]. PLoS One 2010
133
11

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.
Ian Krop, Tim Demuth, Tina Guthrie, Patrick Y Wen, Warren P Mason, Prakash Chinnaiyan, Nicholas Butowski, Morris D Groves, Santosh Kesari, Steven J Freedman,[...]. J Clin Oncol 2012
217
11

Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
413
11

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
10

Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
Wan-Ching Yen, Marcus M Fischer, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, William R Henner, Rene Meisner, Aaron Sato, Jalpa Shah,[...]. Clin Cancer Res 2015
168
10

Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors.
Anne F Schott, Melissa D Landis, Gabriela Dontu, Kent A Griffith, Rachel M Layman, Ian Krop, Lacey A Paskett, Helen Wong, Lacey E Dobrolecki, Michael T Lewis,[...]. Clin Cancer Res 2013
165
10

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
10

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.
C Massard, A Azaro, J-C Soria, U Lassen, C Le Tourneau, D Sarker, C Smith, U Ohnmacht, G Oakley, B K R Patel,[...]. Ann Oncol 2018
76
11

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.
Ingrid Espinoza, Radhika Pochampally, Fei Xing, Kounosuke Watabe, Lucio Miele. Onco Targets Ther 2013
134
9

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Irene Noguera-Troise, Christopher Daly, Nicholas J Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W Gale, Hsin Chieh Lin, George D Yancopoulos, Gavin Thurston. Nature 2006
783
9

Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.
Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton,[...]. Cancer Res 2009
146
9

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Giovanni Roti, Anne Carlton, Kenneth N Ross, Michele Markstein, Kostandin Pajcini, Angela H Su, Norbert Perrimon, Warren S Pear, Andrew L Kung, Stephen C Blacklow,[...]. Cancer Cell 2013
101
9

A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
C Papayannidis, D J DeAngelo, W Stock, B Huang, M N Shaik, R Cesari, X Zheng, J M Reynolds, P A English, M Ozeck,[...]. Blood Cancer J 2015
73
10

A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
Wells A Messersmith, Geoffrey I Shapiro, James M Cleary, Antonio Jimeno, Arvind Dasari, Bo Huang, M Naveed Shaik, Rossano Cesari, Xianxian Zheng, Jennifer M Reynolds,[...]. Clin Cancer Res 2015
136
9

A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors.
Elena Gabriela Chiorean, Patricia LoRusso, Robert Matthew Strother, Jennifer R Diamond, Anne Younger, Wells A Messersmith, Lieve Adriaens, Liming Liu, Richard J Kao, Albert Thomas DiCioccio,[...]. Clin Cancer Res 2015
84
9

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
9

An atomic structure of human γ-secretase.
Xiao-Chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H W Scheres, Yigong Shi. Nature 2015
353
8

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Ashvinikumar V Gavai, Claude Quesnelle, Derek Norris, Wen-Ching Han, Patrice Gill, Weifang Shan, Aaron Balog, Ke Chen, Andrew Tebben, Richard Rampulla,[...]. ACS Med Chem Lett 2015
50
14

Reconstitution of gamma-secretase activity.
Dieter Edbauer, Edith Winkler, Joerg T Regula, Brigitte Pesold, Harald Steiner, Christian Haass. Nat Cell Biol 2003
719
8

Notch signaling: an emerging therapeutic target for cancer treatment.
Xun Yuan, Hua Wu, Hanxiao Xu, Huihua Xiong, Qian Chu, Shiying Yu, Gen Sheng Wu, Kongming Wu. Cancer Lett 2015
251
8

Alterations of the Notch pathway in lung cancer.
Britta Westhoff, Ivan N Colaluca, Giovanni D'Ario, Maddalena Donzelli, Daniela Tosoni, Sara Volorio, Giuseppe Pelosi, Lorenzo Spaggiari, Giovanni Mazzarol, Giuseppe Viale,[...]. Proc Natl Acad Sci U S A 2009
299
8

Notch signalling: a simple pathway becomes complex.
Sarah J Bray. Nat Rev Mol Cell Biol 2006
8

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Nicholas J Wang, Zachary Sanborn, Kelly L Arnett, Laura J Bayston, Wilson Liao, Charlotte M Proby, Irene M Leigh, Eric A Collisson, Patricia B Gordon, Lakshmi Jakkula,[...]. Proc Natl Acad Sci U S A 2011
321
8

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.
Michael Reedijk, Silvia Odorcic, Lynn Chang, Hui Zhang, Naomi Miller, David R McCready, Gina Lockwood, Sean E Egan. Cancer Res 2005
574
8

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,[...]. Nat Med 2009
330
8

Notch inhibitors for cancer treatment.
Ingrid Espinoza, Lucio Miele. Pharmacol Ther 2013
208
8

Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer.
Marzia A Locatelli, Philippe Aftimos, E Claire Dees, Patricia M LoRusso, Mark D Pegram, Ahmad Awada, Bo Huang, Rossano Cesari, Yuqiu Jiang, M Naveed Shaik,[...]. Oncotarget 2017
52
13

Gamma-secretase: proteasome of the membrane?
Raphael Kopan, Ma Xenia G Ilagan. Nat Rev Mol Cell Biol 2004
470
8


Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.
Ping Wei, Marlena Walls, Ming Qiu, Richard Ding, Robert H Denlinger, Anthony Wong, Kosta Tsaparikos, Jitesh P Jani, Natilie Hosea, Michelle Sands,[...]. Mol Cancer Ther 2010
146
8

Notch signalling in context.
Sarah J Bray. Nat Rev Mol Cell Biol 2016
516
8

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma.
Natalie Cook, Bristi Basu, Donna-Michelle Smith, Aarthi Gopinathan, Jeffry Evans, William P Steward, Daniel Palmer, David Propper, Balaji Venugopal, Mirela Hategan,[...]. Br J Cancer 2018
56
12

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
J S Mumm, E H Schroeter, M T Saxena, A Griesemer, X Tian, D J Pan, W J Ray, R Kopan. Mol Cell 2000
660
6

The role of presenilin cofactors in the gamma-secretase complex.
Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi, Makiko Tsuruoka, Manabu Niimura, Yasuko Takahashi, Gopal Thinakaran, Takeshi Iwatsubo. Nature 2003
716
6

A phase II study of RO4929097 in metastatic colorectal cancer.
Jonathan R Strosberg, Timothy Yeatman, Jill Weber, Domenico Coppola, Michael J Schell, Gang Han, Khaldoun Almhanna, Richard Kim, Tiffany Valone, Helen Jump,[...]. Eur J Cancer 2012
96
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.