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Times Cited: 163
Times Cited: 163
Times Cited
Times Co-cited
Similarity
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Paul M Ridker, Brendan M Everett, Tom Thuren, Jean G MacFadyen, William H Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D Anker,[...]. N Engl J Med 2017
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction.
Gerardus P J van Hout, Lena Bosch, Guilielmus H J M Ellenbroek, Judith J de Haan, Wouter W van Solinge, Matthew A Cooper, Fatih Arslan, Saskia C A de Jager, Avril A B Robertson, Gerard Pasterkamp,[...]. Eur Heart J 2017
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.
Jean-Claude Tardif, Simon Kouz, David D Waters, Olivier F Bertrand, Rafael Diaz, Aldo P Maggioni, Fausto J Pinto, Reda Ibrahim, Habib Gamra, Ghassan S Kiwan,[...]. N Engl J Med 2019
Jean-Claude Tardif, Simon Kouz, David D Waters, Olivier F Bertrand, Rafael Diaz, Aldo P Maggioni, Fausto J Pinto, Reda Ibrahim, Habib Gamra, Ghassan S Kiwan,[...]. N Engl J Med 2019
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
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Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
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A role for mitochondria in NLRP3 inflammasome activation.
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
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MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.
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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.
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Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
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Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
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MCC950 closes the active conformation of NLRP3 to an inactive state.
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Non-canonical inflammasome activation targets caspase-11.
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
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Targeting the NLRP3 inflammasome in inflammatory diseases.
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.
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Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
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The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study.
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Low-dose colchicine for secondary prevention of cardiovascular disease.
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Pharmacological Inhibitors of the NLRP3 Inflammasome.
Ayesha Zahid, Bofeng Li, Arnaud John Kombe Kombe, Tengchuan Jin, Jinhui Tao. Front Immunol 2019
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Colchicine in Patients with Chronic Coronary Disease.
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Mechanism and Regulation of NLRP3 Inflammasome Activation.
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases.
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Gout-associated uric acid crystals activate the NALP3 inflammasome.
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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.
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Inflammatory caspases are innate immune receptors for intracellular LPS.
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.
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Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice.
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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.
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Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.
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Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
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Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.