A citation-based method for searching scientific literature

Jared M Campbell, Susan M Bellman, Matthew D Stephenson, Karolina Lisy. Ageing Res Rev 2017
Times Cited: 126







List of co-cited articles
1250 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
662
31

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
405
30

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie. Diabetes Obes Metab 2014
166
24

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Filipe Cabreiro, Catherine Au, Kit-Yi Leung, Nuria Vergara-Irigaray, Helena M Cochemé, Tahereh Noori, David Weinkove, Eugene Schuster, Nicholas D E Greene, David Gems. Cell 2013
494
19



The mechanisms of action of metformin.
Graham Rena, D Grahame Hardie, Ewan R Pearson. Diabetologia 2017
632
18

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
17

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.
Olga Moiseeva, Xavier Deschênes-Simard, Emmanuelle St-Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E Cadar, Véronique Bourdeau, Michael N Pollak, Gerardo Ferbeyre. Aging Cell 2013
225
17

Long-term metformin usage and cognitive function among older adults with diabetes.
Tze Pin Ng, Liang Feng, Keng Bee Yap, Tih Shih Lee, Chay Hoon Tan, Bengt Winblad. J Alzheimers Dis 2014
161
16

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Wouter De Haes, Lotte Frooninckx, Roel Van Assche, Arne Smolders, Geert Depuydt, Johan Billen, Bart P Braeckman, Liliane Schoofs, Liesbet Temmerman. Proc Natl Acad Sci U S A 2014
181
15

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan. N Engl J Med 2002
15


Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus.
Adriaan Kooy, Jolien de Jager, Philippe Lehert, Daniël Bets, Michiel G Wulffelé, Ab J M Donker, Coen D A Stehouwer. Arch Intern Med 2009
246
13

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Anila K Madiraju, Derek M Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T Braddock, Ronald A Albright, Brett J Prigaro, John L Wood, Sanjay Bhanot, Michael J MacDonald,[...]. Nature 2014
662
13

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
Yoshifumi Saisho. Endocr Metab Immune Disord Drug Targets 2015
205
13

Metformin slows down aging and extends life span of female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Margarita L Tyndyk, Maria V Yurova, Irina G Kovalenko, Tatiana E Poroshina,[...]. Cell Cycle 2008
214
13

Senolytics improve physical function and increase lifespan in old age.
Ming Xu, Tamar Pirtskhalava, Joshua N Farr, Bettina M Weigand, Allyson K Palmer, Megan M Weivoda, Christina L Inman, Mikolaj B Ogrodnik, Christine M Hachfeld, Daniel G Fraser,[...]. Nat Med 2018
554
13

Metformin: historical overview.
Clifford J Bailey. Diabetologia 2017
228
12

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Vladimir N Anisimov, Lev M Berstein, Irina G Popovich, Mark A Zabezhinski, Peter A Egormin, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Irina G Kovalenko,[...]. Aging (Albany NY) 2011
172
12

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults.
Ameya S Kulkarni, Erika F Brutsaert, Valentin Anghel, Kehao Zhang, Noah Bloomgarden, Michael Pollak, Jessica C Mar, Meredith Hawkins, Jill P Crandall, Nir Barzilai. Aging Cell 2018
50
24

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle K Pedersen,[...]. Nature 2015
876
12

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Amy R Cameron, Vicky L Morrison, Daniel Levin, Mohapradeep Mohan, Calum Forteath, Craig Beall, Alison D McNeilly, David J K Balfour, Terhi Savinko, Aaron K F Wong,[...]. Circ Res 2016
248
11

Fisetin is a senotherapeutic that extends health and lifespan.
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman,[...]. EBioMedicine 2018
179
11

Metformin as Anti-Aging Therapy: Is It for Everyone?
Alexander A Soukas, Haibin Hao, Lianfeng Wu. Trends Endocrinol Metab 2019
43
25


Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease.
Jie Hong, Yifei Zhang, Shenghan Lai, Ankang Lv, Qing Su, Yan Dong, Zhiguang Zhou, Weili Tang, Jiajun Zhao, Lianqun Cui,[...]. Diabetes Care 2013
196
10

10-year follow-up of intensive glucose control in type 2 diabetes.
Rury R Holman, Sanjoy K Paul, M Angelyn Bethel, David R Matthews, H Andrew W Neil. N Engl J Med 2008
10

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.
Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, Elham Zarrinpashneh, Maud Soty, Gilles Mithieux, Kei Sakamoto, Fabrizio Andreelli, Benoit Viollet. J Clin Invest 2010
800
10

mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
349
10

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Yi Zhu, Tamara Tchkonia, Tamar Pirtskhalava, Adam C Gower, Husheng Ding, Nino Giorgadze, Allyson K Palmer, Yuji Ikeno, Gene B Hubbard, Marc Lenburg,[...]. Aging Cell 2015
733
10

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.
Randy Strong, Richard A Miller, Adam Antebi, Clinton M Astle, Molly Bogue, Martin S Denzel, Elizabeth Fernandez, Kevin Flurkey, Karyn L Hamilton, Dudley W Lamming,[...]. Aging Cell 2016
131
10

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.
Adam R Konopka, Jaime L Laurin, Hayden M Schoenberg, Justin J Reid, William M Castor, Christopher A Wolff, Robert V Musci, Oscar D Safairad, Melissa A Linden, Laurie M Biela,[...]. Aging Cell 2019
50
20

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
10


Metformin: from mechanisms of action to therapies.
Marc Foretz, Bruno Guigas, Luc Bertrand, Michael Pollak, Benoit Viollet. Cell Metab 2014
598
10

Role of AMP-activated protein kinase in mechanism of metformin action.
G Zhou, R Myers, Y Li, Y Chen, X Shen, J Fenyk-Melody, M Wu, J Ventre, T Doebber, N Fujii,[...]. J Clin Invest 2001
10

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi,[...]. EBioMedicine 2019
296
10

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix,[...]. Nat Med 2017
552
10

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation.
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez,[...]. Front Endocrinol (Lausanne) 2018
52
19

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders.
Sara Gandini, Matteo Puntoni, Brandy M Heckman-Stoddard, Barbara K Dunn, Leslie Ford, Andrea DeCensi, Eva Szabo. Cancer Prev Res (Phila) 2014
216
9

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Darren J Baker, Bennett G Childs, Matej Durik, Melinde E Wijers, Cynthia J Sieben, Jian Zhong, Rachel A Saltness, Karthik B Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki,[...]. Nature 2016
9

Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis.
Chin Cheng, Ching-Heng Lin, Yi-Wen Tsai, Chia-Jui Tsai, Po-Han Chou, Tsuo-Hung Lan. J Gerontol A Biol Sci Med Sci 2014
75
12

Metformin Activates AMPK through the Lysosomal Pathway.
Chen-Song Zhang, Mengqi Li, Teng Ma, Yue Zong, Jiwen Cui, Jin-Wei Feng, Yu-Qing Wu, Shu-Yong Lin, Sheng-Cai Lin. Cell Metab 2016
106
9

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing.
Francesco Prattichizzo, Angelica Giuliani, Emanuela Mensà, Jacopo Sabbatinelli, Valeria De Nigris, Maria Rita Rippo, Lucia La Sala, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello. Ageing Res Rev 2018
44
20

Metformin use and mortality among patients with diabetes and atherothrombosis.
Ronan Roussel, Florence Travert, Blandine Pasquet, Peter W F Wilson, Sidney C Smith, Shinya Goto, Philippe Ravaud, Michel Marre, Avi Porath, Deepak L Bhatt,[...]. Arch Intern Med 2010
241
9

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
M Y El-Mir, V Nogueira, E Fontaine, N Avéret, M Rigoulet, X Leverve. J Biol Chem 2000
922
9

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
LaTonya J Hickson, Larissa G P Langhi Prata, Shane A Bobart, Tamara K Evans, Nino Giorgadze, Shahrukh K Hashmi, Sandra M Herrmann, Michael D Jensen, Qingyi Jia, Kyra L Jordan,[...]. EBioMedicine 2019
232
9

Metformin and the gastrointestinal tract.
Laura J McCreight, Clifford J Bailey, Ewan R Pearson. Diabetologia 2016
264
8

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Vladimir N Anisimov, Lev M Berstein, Peter A Egormin, Tatiana S Piskunova, Irina G Popovich, Mark A Zabezhinski, Irina G Kovalenko, Tatiana E Poroshina, Anna V Semenchenko, Mauro Provinciali,[...]. Exp Gerontol 2005
293
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.