Joshua C Saldivar, David Cortez, Karlene A Cimprich. Nat Rev Mol Cell Biol 2017
Times Cited: 328
Times Cited: 328
Times Cited
Times Co-cited
Similarity
Causes and consequences of replication stress.
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
41
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Lee Zou, Stephen J Elledge. Science 2003
Lee Zou, Stephen J Elledge. Science 2003
30
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
Andrew N Blackford, Stephen P Jackson. Mol Cell 2017
Andrew N Blackford, Stephen P Jackson. Mol Cell 2017
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TopBP1 activates the ATR-ATRIP complex.
Akiko Kumagai, Joon Lee, Hae Yong Yoo, William G Dunphy. Cell 2006
Akiko Kumagai, Joon Lee, Hae Yong Yoo, William G Dunphy. Cell 2006
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ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas. Cell 2013
Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas. Cell 2013
18
The DNA damage response: making it safe to play with knives.
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
16
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.
Katharina Schlacher, Nicole Christ, Nicolas Siaud, Akinori Egashira, Hong Wu, Maria Jasin. Cell 2011
Katharina Schlacher, Nicole Christ, Nicolas Siaud, Akinori Egashira, Hong Wu, Maria Jasin. Cell 2011
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Activation of the ATR kinase by the RPA-binding protein ETAA1.
Peter Haahr, Saskia Hoffmann, Maxim A X Tollenaere, Teresa Ho, Luis Ignacio Toledo, Matthias Mann, Simon Bekker-Jensen, Markus Räschle, Niels Mailand. Nat Cell Biol 2016
Peter Haahr, Saskia Hoffmann, Maxim A X Tollenaere, Teresa Ho, Luis Ignacio Toledo, Matthias Mann, Simon Bekker-Jensen, Markus Räschle, Niels Mailand. Nat Cell Biol 2016
14
ETAA1 acts at stalled replication forks to maintain genome integrity.
Thomas E Bass, Jessica W Luzwick, Gina Kavanaugh, Clinton Carroll, Huzefa Dungrawala, Gloria G Glick, Michael D Feldkamp, Reid Putney, Walter J Chazin, David Cortez. Nat Cell Biol 2016
Thomas E Bass, Jessica W Luzwick, Gina Kavanaugh, Clinton Carroll, Huzefa Dungrawala, Gloria G Glick, Michael D Feldkamp, Reid Putney, Walter J Chazin, David Cortez. Nat Cell Biol 2016
14
Replication stress and cancer.
Hélène Gaillard, Tatiana García-Muse, Andrés Aguilera. Nat Rev Cancer 2015
Hélène Gaillard, Tatiana García-Muse, Andrés Aguilera. Nat Rev Cancer 2015
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Replication fork reversal in eukaryotes: from dead end to dynamic response.
Kai J Neelsen, Massimo Lopes. Nat Rev Mol Cell Biol 2015
Kai J Neelsen, Massimo Lopes. Nat Rev Mol Cell Biol 2015
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DNA damage sensing by the ATM and ATR kinases.
Alexandre Maréchal, Lee Zou. Cold Spring Harb Perspect Biol 2013
Alexandre Maréchal, Lee Zou. Cold Spring Harb Perspect Biol 2013
14
The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.
Huzefa Dungrawala, Kristie L Rose, Kamakoti P Bhat, Kareem N Mohni, Gloria G Glick, Frank B Couch, David Cortez. Mol Cell 2015
Huzefa Dungrawala, Kristie L Rose, Kamakoti P Bhat, Kareem N Mohni, Gloria G Glick, Frank B Couch, David Cortez. Mol Cell 2015
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DNA replication stress as a hallmark of cancer.
Morgane Macheret, Thanos D Halazonetis. Annu Rev Pathol 2015
Morgane Macheret, Thanos D Halazonetis. Annu Rev Pathol 2015
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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
Panagiotis Kotsantis, Eva Petermann, Simon J Boulton. Cancer Discov 2018
Panagiotis Kotsantis, Eva Petermann, Simon J Boulton. Cancer Discov 2018
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An intrinsic S/G2 checkpoint enforced by ATR.
Joshua C Saldivar, Stephan Hamperl, Michael J Bocek, Mingyu Chung, Thomas E Bass, Fernanda Cisneros-Soberanis, Kumiko Samejima, Linfeng Xie, James R Paulson, William C Earnshaw,[...]. Science 2018
Joshua C Saldivar, Stephan Hamperl, Michael J Bocek, Mingyu Chung, Thomas E Bass, Fernanda Cisneros-Soberanis, Kumiko Samejima, Linfeng Xie, James R Paulson, William C Earnshaw,[...]. Science 2018
11
ATR and ATRIP: partners in checkpoint signaling.
D Cortez, S Guntuku, J Qin, S J Elledge. Science 2001
D Cortez, S Guntuku, J Qin, S J Elledge. Science 2001
11
ATR phosphorylates SMARCAL1 to prevent replication fork collapse.
Frank B Couch, Carol E Bansbach, Robert Driscoll, Jessica W Luzwick, Gloria G Glick, Rémy Bétous, Clinton M Carroll, Sung Yun Jung, Jun Qin, Karlene A Cimprich,[...]. Genes Dev 2013
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11
The plasticity of DNA replication forks in response to clinically relevant genotoxic stress.
Matteo Berti, David Cortez, Massimo Lopes. Nat Rev Mol Cell Biol 2020
Matteo Berti, David Cortez, Massimo Lopes. Nat Rev Mol Cell Biol 2020
18
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Angelo Taglialatela, Silvia Alvarez, Giuseppe Leuzzi, Vincenzo Sannino, Lepakshi Ranjha, Jen-Wei Huang, Chioma Madubata, Roopesh Anand, Brynn Levy, Raul Rabadan,[...]. Mol Cell 2017
Angelo Taglialatela, Silvia Alvarez, Giuseppe Leuzzi, Vincenzo Sannino, Lepakshi Ranjha, Jen-Wei Huang, Chioma Madubata, Roopesh Anand, Brynn Levy, Raul Rabadan,[...]. Mol Cell 2017
11
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase.
Rémi Buisson, Jessica L Boisvert, Cyril H Benes, Lee Zou. Mol Cell 2015
Rémi Buisson, Jessica L Boisvert, Cyril H Benes, Lee Zou. Mol Cell 2015
11
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Ralph Zellweger, Damian Dalcher, Karun Mutreja, Matteo Berti, Jonas A Schmid, Raquel Herrador, Alessandro Vindigni, Massimo Lopes. J Cell Biol 2015
Ralph Zellweger, Damian Dalcher, Karun Mutreja, Matteo Berti, Jonas A Schmid, Raquel Herrador, Alessandro Vindigni, Massimo Lopes. J Cell Biol 2015
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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
Sinny Delacroix, Jill M Wagner, Masahiko Kobayashi, Ken-ichi Yamamoto, Larry M Karnitz. Genes Dev 2007
Sinny Delacroix, Jill M Wagner, Masahiko Kobayashi, Ken-ichi Yamamoto, Larry M Karnitz. Genes Dev 2007
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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.
Tony S Byun, Marcin Pacek, Muh-ching Yee, Johannes C Walter, Karlene A Cimprich. Genes Dev 2005
Tony S Byun, Marcin Pacek, Muh-ching Yee, Johannes C Walter, Karlene A Cimprich. Genes Dev 2005
11
RPA and RAD51: fork reversal, fork protection, and genome stability.
Kamakoti P Bhat, David Cortez. Nat Struct Mol Biol 2018
Kamakoti P Bhat, David Cortez. Nat Struct Mol Biol 2018
11
Replication stress activates DNA repair synthesis in mitosis.
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
Sheroy Minocherhomji, Songmin Ying, Victoria A Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W Mankouri, Huahao Shen, Ying Liu, Ian D Hickson. Nature 2015
10
Replication Fork Reversal: Players and Guardians.
Annabel Quinet, Delphine Lemaçon, Alessandro Vindigni. Mol Cell 2017
Annabel Quinet, Delphine Lemaçon, Alessandro Vindigni. Mol Cell 2017
10
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino,[...]. Nature 2016
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino,[...]. Nature 2016
10
Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.
Arun Mouli Kolinjivadi, Vincenzo Sannino, Anna De Antoni, Karina Zadorozhny, Mairi Kilkenny, Hervé Técher, Giorgio Baldi, Rong Shen, Alberto Ciccia, Luca Pellegrini,[...]. Mol Cell 2017
Arun Mouli Kolinjivadi, Vincenzo Sannino, Anna De Antoni, Karina Zadorozhny, Mairi Kilkenny, Hervé Técher, Giorgio Baldi, Rong Shen, Alberto Ciccia, Luca Pellegrini,[...]. Mol Cell 2017
10
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
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Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway.
Stephanie A Yazinski, Lee Zou. Annu Rev Genet 2016
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
Hannah Farmer, Nuala McCabe, Christopher J Lord, Andrew N J Tutt, Damian A Johnson, Tobias B Richardson, Manuela Santarosa, Krystyna J Dillon, Ian Hickson, Charlotte Knights,[...]. Nature 2005
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RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.
Yuan-Cho Lee, Qing Zhou, Junjie Chen, Jingsong Yuan. Curr Biol 2016
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ATR: an essential regulator of genome integrity.
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
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DNA damage kinase signaling: checkpoint and repair at 30 years.
Michael Charles Lanz, Diego Dibitetto, Marcus Bustamante Smolka. EMBO J 2019
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Replication fork reversal triggers fork degradation in BRCA2-defective cells.
Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti, Kurt Jacobs, Karun Mutreja, Sebastian Ursich, Arnab Ray Chaudhuri, Andre Nussenzweig, Pavel Janscak,[...]. Nat Commun 2017
Sofija Mijic, Ralph Zellweger, Nagaraja Chappidi, Matteo Berti, Kurt Jacobs, Karun Mutreja, Sebastian Ursich, Arnab Ray Chaudhuri, Andre Nussenzweig, Pavel Janscak,[...]. Nat Commun 2017
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MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.
Delphine Lemaçon, Jessica Jackson, Annabel Quinet, Joshua R Brickner, Shan Li, Stephanie Yazinski, Zhongsheng You, Grzegorz Ira, Lee Zou, Nima Mosammaparast,[...]. Nat Commun 2017
Delphine Lemaçon, Jessica Jackson, Annabel Quinet, Joshua R Brickner, Shan Li, Stephanie Yazinski, Zhongsheng You, Grzegorz Ira, Lee Zou, Nima Mosammaparast,[...]. Nat Commun 2017
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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Yosef Shiloh, Yael Ziv. Nat Rev Mol Cell Biol 2013
Yosef Shiloh, Yael Ziv. Nat Rev Mol Cell Biol 2013
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ATR disruption leads to chromosomal fragmentation and early embryonic lethality.
E J Brown, D Baltimore. Genes Dev 2000
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State-of-the-art strategies for targeting the DNA damage response in cancer.
Patrick G Pilié, Chad Tang, Gordon B Mills, Timothy A Yap. Nat Rev Clin Oncol 2019
Patrick G Pilié, Chad Tang, Gordon B Mills, Timothy A Yap. Nat Rev Clin Oncol 2019
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An oncogene-induced DNA damage model for cancer development.
Thanos D Halazonetis, Vassilis G Gorgoulis, Jiri Bartek. Science 2008
Thanos D Halazonetis, Vassilis G Gorgoulis, Jiri Bartek. Science 2008
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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.
Eva Petermann, Manuel Luís Orta, Natalia Issaeva, Niklas Schultz, Thomas Helleday. Mol Cell 2010
Eva Petermann, Manuel Luís Orta, Natalia Issaeva, Niklas Schultz, Thomas Helleday. Mol Cell 2010
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TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication.
Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib. Elife 2019
Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib. Elife 2019
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DNA2 drives processing and restart of reversed replication forks in human cells.
Saravanabhavan Thangavel, Matteo Berti, Maryna Levikova, Cosimo Pinto, Shivasankari Gomathinayagam, Marko Vujanovic, Ralph Zellweger, Hayley Moore, Eu Han Lee, Eric A Hendrickson,[...]. J Cell Biol 2015
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A Genetic Map of the Response to DNA Damage in Human Cells.
Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, Matthew J Schellenberg, Michal Zimmermann, Nicole Hustedt, Silvia Emma Rossi, Salomé Adam, Henrique Melo,[...]. Cell 2020
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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.
Gongshi Bai, Chames Kermi, Henriette Stoy, Carl J Schiltz, Julien Bacal, Angela M Zaino, M Kyle Hadden, Brandt F Eichman, Massimo Lopes, Karlene A Cimprich. Mol Cell 2020
Gongshi Bai, Chames Kermi, Henriette Stoy, Carl J Schiltz, Julien Bacal, Angela M Zaino, M Kyle Hadden, Brandt F Eichman, Massimo Lopes, Karlene A Cimprich. Mol Cell 2020
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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells.
Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T Vessoni, Emily Cybulla, Matthew Wood,[...]. Mol Cell 2020
Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T Vessoni, Emily Cybulla, Matthew Wood,[...]. Mol Cell 2020
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Nucleotide deficiency promotes genomic instability in early stages of cancer development.
Assaf C Bester, Maayan Roniger, Yifat S Oren, Michael M Im, Dan Sarni, Malka Chaoat, Aaron Bensimon, Gideon Zamir, Donna S Shewach, Batsheva Kerem. Cell 2011
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8
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