A citation-based method for searching scientific literature

Michalis Agathocleous, Corbin E Meacham, Rebecca J Burgess, Elena Piskounova, Zhiyu Zhao, Genevieve M Crane, Brianna L Cowin, Emily Bruner, Malea M Murphy, Weina Chen, Gerald J Spangrude, Zeping Hu, Ralph J DeBerardinis, Sean J Morrison. Nature 2017
Times Cited: 248







List of co-cited articles
1280 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Luisa Cimmino, Igor Dolgalev, Yubao Wang, Akihide Yoshimi, Gaëlle H Martin, Jingjing Wang, Victor Ng, Bo Xia, Matthew T Witkowski, Marisa Mitchell-Flack,[...]. Cell 2017
353
62

Age-related clonal hematopoiesis associated with adverse outcomes.
Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter V Grauman, Brenton G Mar, R Coleman Lindsley, Craig H Mermel, Noel Burtt, Alejandro Chavez,[...]. N Engl J Med 2014
22

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Kathryn Blaschke, Kevin T Ebata, Mohammad M Karimi, Jorge A Zepeda-Martínez, Preeti Goyal, Sahasransu Mahapatra, Angela Tam, Diana J Laird, Martin Hirst, Anjana Rao,[...]. Nature 2013
530
20

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.
Mamta Tahiliani, Kian Peng Koh, Yinghua Shen, William A Pastor, Hozefa Bandukwala, Yevgeny Brudno, Suneet Agarwal, Lakshminarayan M Iyer, David R Liu, L Aravind,[...]. Science 2009
20

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
Giulio Genovese, Anna K Kähler, Robert E Handsaker, Johan Lindberg, Samuel A Rose, Samuel F Bakhoum, Kimberly Chambert, Eran Mick, Benjamin M Neale, Menachem Fromer,[...]. N Engl J Med 2014
18

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Jihye Yun, Edouard Mullarky, Changyuan Lu, Kaitlyn N Bosch, Adam Kavalier, Keith Rivera, Jatin Roper, Iok In Christine Chio, Eugenia G Giannopoulou, Carlo Rago,[...]. Science 2015
465
17

Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.
Ruichuan Yin, Shi-Qing Mao, Bailin Zhao, Zechen Chong, Ying Yang, Chao Zhao, Dapeng Zhang, Hua Huang, Juan Gao, Zheng Li,[...]. J Am Chem Soc 2013
360
16

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Maria E Figueroa, Omar Abdel-Wahab, Chao Lu, Patrick S Ward, Jay Patel, Alan Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F Fernandez,[...]. Cancer Cell 2010
16

Mutation in TET2 in myeloid cancers.
François Delhommeau, Sabrina Dupont, Véronique Della Valle, Chloé James, Severine Trannoy, Aline Massé, Olivier Kosmider, Jean-Pierre Le Couedic, Fabienne Robert, Antonio Alberdi,[...]. N Engl J Med 2009
15

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
Shinsuke Ito, Li Shen, Qing Dai, Susan C Wu, Leonard B Collins, James A Swenberg, Chuan He, Yi Zhang. Science 2011
15

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li,[...]. Science 2011
15

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.
Myunggon Ko, Yun Huang, Anna M Jankowska, Utz J Pape, Mamta Tahiliani, Hozefa S Bandukwala, Jungeun An, Edward D Lamperti, Kian Peng Koh, Rebecca Ganetzky,[...]. Nature 2010
942
15

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
Keiyo Takubo, Go Nagamatsu, Chiharu I Kobayashi, Ayako Nakamura-Ishizu, Hiroshi Kobayashi, Eiji Ikeda, Nobuhito Goda, Yasmeen Rahimi, Randall S Johnson, Tomoyoshi Soga,[...]. Cell Stem Cell 2013
460
15

The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
Huihui Zhao, Huayuan Zhu, Jiayu Huang, Yu Zhu, Ming Hong, Han Zhu, Jingjing Zhang, Shan Li, Lijia Yang, Yun Lian,[...]. Leuk Res 2018
51
27

Clinical remission following ascorbate treatment in a case of acute myeloid leukemia with mutations in TET2 and WT1.
Andrew B Das, Purvi M Kakadia, Damian Wojcik, Lucy Pemberton, Peter J Browett, Stefan K Bohlander, Margreet C M Vissers. Blood Cancer J 2019
23
60

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
Qian Zhang, Kai Zhao, Qicong Shen, Yanmei Han, Yan Gu, Xia Li, Dezhi Zhao, Yiqi Liu, Chunmei Wang, Xiang Zhang,[...]. Nature 2015
411
13

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.
José J Fuster, Susan MacLauchlan, María A Zuriaga, Maya N Polackal, Allison C Ostriker, Raja Chakraborty, Chia-Ling Wu, Soichi Sano, Sujatha Muralidharan, Cristina Rius,[...]. Science 2017
603
13

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio, Linsey Reavie, Alan Shih, Omar Abdel-Wahab, Delphine Ndiaye-Lobry, Camille Lobry, Maria E Figueroa, Aparna Vasanthakumar, Jay Patel, Xinyang Zhao,[...]. Cancer Cell 2011
832
13

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.
M Mingay, A Chaturvedi, M Bilenky, Q Cao, L Jackson, T Hui, M Moksa, A Heravi-Moussavi, R K Humphries, M Heuser,[...]. Leukemia 2018
42
30

Regulation of the Epigenome by Vitamin C.
Juan I Young, Stephan Züchner, Gaofeng Wang. Annu Rev Nutr 2015
170
12

Vitamin C: the known and the unknown and Goldilocks.
S J Padayatty, M Levine. Oral Dis 2016
213
12


A family of mammalian Na+-dependent L-ascorbic acid transporters.
H Tsukaguchi, T Tokui, B Mackenzie, U V Berger, X Z Chen, Y Wang, R F Brubaker, M A Hediger. Nature 1999
639
11

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.
Kasper D Rasmussen, Guangshuai Jia, Jens V Johansen, Marianne T Pedersen, Nicolas Rapin, Frederik O Bagger, Bo T Porse, Olivier A Bernard, Jesper Christensen, Kristian Helin. Genes Dev 2015
162
11

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
Cyril Quivoron, Lucile Couronné, Véronique Della Valle, Cécile K Lopez, Isabelle Plo, Orianne Wagner-Ballon, Marcio Do Cruzeiro, Francois Delhommeau, Bertrand Arnulf, Marc-Henri Stern,[...]. Cancer Cell 2011
634
11

Histone demethylation by a family of JmjC domain-containing proteins.
Yu-ichi Tsukada, Jia Fang, Hediye Erdjument-Bromage, Maria E Warren, Christoph H Borchers, Paul Tempst, Yi Zhang. Nature 2006
11

Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Linn Gillberg, Andreas D Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W Hansen, Nicolas Rapin, Johanne B Mogensen, Minmin Liu, Inge H Dufva,[...]. Clin Epigenetics 2019
29
37


Targeting cancer vulnerabilities with high-dose vitamin C.
Bryan Ngo, Justin M Van Riper, Lewis C Cantley, Jihye Yun. Nat Rev Cancer 2019
116
11

Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
Minmin Liu, Hitoshi Ohtani, Wanding Zhou, Andreas Due Ørskov, Jessica Charlet, Yang W Zhang, Hui Shen, Stephen B Baylin, Gangning Liang, Kirsten Grønbæk,[...]. Proc Natl Acad Sci U S A 2016
104
10

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Qi Chen, Michael Graham Espey, Andrew Y Sun, Chaya Pooput, Kenneth L Kirk, Murali C Krishna, Deena Beneda Khosh, Jeanne Drisko, Mark Levine. Proc Natl Acad Sci U S A 2008
493
10


Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.
Omar Abdel-Wahab, Ann Mullally, Cyrus Hedvat, Guillermo Garcia-Manero, Jay Patel, Martha Wadleigh, Sebastien Malinge, JinJuan Yao, Outi Kilpivaara, Rukhmi Bhat,[...]. Blood 2009
535
10

Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation.
Lulu Hu, Ze Li, Jingdong Cheng, Qinhui Rao, Wei Gong, Mengjie Liu, Yujiang Geno Shi, Jiayu Zhu, Ping Wang, Yanhui Xu. Cell 2013
237
10

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino,[...]. N Engl J Med 2017
972
10

Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Mingchao Xie, Charles Lu, Jiayin Wang, Michael D McLellan, Kimberly J Johnson, Michael C Wendl, Joshua F McMichael, Heather K Schmidt, Venkata Yellapantula, Christopher A Miller,[...]. Nat Med 2014
10

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies.
Zhe Li, Xiaoqiang Cai, Chen-Leng Cai, Jiapeng Wang, Wenyong Zhang, Bruce E Petersen, Feng-Chun Yang, Mingjiang Xu. Blood 2011
437
10

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Qi Chen, Michael Graham Espey, Murali C Krishna, James B Mitchell, Christopher P Corpe, Garry R Buettner, Emily Shacter, Mark Levine. Proc Natl Acad Sci U S A 2005
616
9

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes.
David P Steensma, Rafael Bejar, Siddhartha Jaiswal, R Coleman Lindsley, Mikkael A Sekeres, Robert P Hasserjian, Benjamin L Ebert. Blood 2015
942
9

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.
Zhigang Cai, Jonathan J Kotzin, Baskar Ramdas, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, Ruchi Pandey, Raghuveer Singh Mali, Yan Liu, Mark R Kelley,[...]. Cell Stem Cell 2018
125
9

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.
Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Amina Barhdadi, Vincent Bourgoin, Guylaine Lépine, Luigina Mollica, Natasha Szuber, Marie-Pierre Dubé, Lambert Busque. Blood 2017
174
9

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, Li Chen, Zachary M Earley, Toufic Mayassi, Joseph F Pierre, Jordan D Ernest, Heather J Galipeau, Nikolaus Thuille,[...]. Nature 2018
158
9

Reprogramming the Epigenome With Vitamin C.
Taylor Lee Chong, Emily L Ahearn, Luisa Cimmino. Front Cell Dev Biol 2019
48
18

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Di Wu, Di Hu, Hao Chen, Guoming Shi, Irfete S Fetahu, Feizhen Wu, Kimberlie Rabidou, Rui Fang, Li Tan, Shuyun Xu,[...]. Nature 2018
198
9

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.
Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao,[...]. Cancer Cell 2011
9

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.
Yiping Wang, Mengtao Xiao, Xiufei Chen, Leilei Chen, Yanping Xu, Lei Lv, Pu Wang, Hui Yang, Shenghong Ma, Huaipeng Lin,[...]. Mol Cell 2015
183
9

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
Tugba Simsek, Fatih Kocabas, Junke Zheng, Ralph J Deberardinis, Ahmed I Mahmoud, Eric N Olson, Jay W Schneider, Cheng Cheng Zhang, Hesham A Sadek. Cell Stem Cell 2010
678
9

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Lenny Dang, David W White, Stefan Gross, Bryson D Bennett, Mark A Bittinger, Edward M Driggers, Valeria R Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C Keenan,[...]. Nature 2009
9

The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.
Tao Wang, Keshi Chen, Xiaoming Zeng, Jianguo Yang, Yun Wu, Xi Shi, Baoming Qin, Lingwen Zeng, Miguel Angel Esteban, Guangjin Pan,[...]. Cell Stem Cell 2011
318
9

Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence.
Margreet C M Vissers, Andrew B Das. Front Physiol 2018
69
13


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.